当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > The cellular and molecular determinants of emphysematous destruction in COPD.

The cellular and molecular determinants of emphysematous destruction in COPD.

Abstract：

:The introduction of microCT has made it possible to show that the terminal bronchioles are narrowed and destroyed before the onset of emphysematous destruction in COPD. This report extends those observations to the cellular and molecular level in the centrilobular phenotype of emphysematous destruction in lungs donated by persons with very severe COPD (n = 4) treated by lung transplantation with unused donor lungs (n = 4) serving as controls. These lung specimens provided companion samples to those previously examined by microCT (n = 61) that we examined using quantitative histology (n = 61) and gene expression profiling (n = 48). The histological analysis showed that remodeling and destruction of the bronchiolar and alveolar tissue is associated with macrophage, CD4, CD8, and B cell infiltration with increased formation of tertiary lymphoid organs. Moreover, gene set enrichment analysis showed that genes known to be expressed by natural killer (NK), lymphoid tissue inducer (LTi), and innate lymphoid cell 1 (ILC1) cells, but not ILC2 or ILC3 cells, were enriched in the expression profiles associated with CD4, CD8, and B cell infiltration. Based on these findings, we postulate that the centrilobular phenotype of emphysematous destruction COPD is driven by a Th1 response activated by infiltrating ILC1, NK, and LTi cells.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Suzuki M,Sze MA,Campbell JD,Brothers JF 2nd,Lenburg ME,McDonough JE,Elliott WM,Cooper JD,Spira A,Hogg JC

doi

10.1038/s41598-017-10126-2

subject

Has Abstract

pub_date

2017-08-25 00:00:00

pages

9562

issue

1

issn

2045-2322

pii

10.1038/s41598-017-10126-2

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62.

    abstract：:ES-62 is a secreted parasitic worm-derived immunomodulator that exhibits therapeutic potential in allergy by downregulating aberrant MyD88 signalling to normalise the inflammatory phenotype and mast cell responses. IL-33 plays an important role in driving mast cell responses and promoting type-2 allergic inflammation,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22716-9

    authors： Ball DH,Al-Riyami L,Harnett W,Harnett MM

    更新日期：2018-03-14 00:00:00

  • Freshwater lake ecosystem shift caused by social-economic transitions in Yangtze River Basin over the past century.

    abstract：:Global lake systems have undergone rapid degradation over the past century. Scientists and managers are struggling to manage the highly degraded lake systems to cope with escalating anthropogenic pressures. Improved knowledge of how lakes and social systems co-evolved up to the present is vital for understanding, mode...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35482-5

    authors： Zhang K,Yang X,Kattel G,Lin Q,Shen J

    更新日期：2018-11-21 00:00:00

  • Enhanced thermoelectric performance of a chalcopyrite compound CuIn3Se5-xTex (x = 0~0.5) through crystal structure engineering.

    abstract：:In this work the chalcopyrite CuIn3Se5-xTex (x = 0~0.5) with space group through isoelectronic substitution of Te for Se have been prepared, and the crystal structure dilation has been observed with increasing Te content. This substitution allows the anion position displacement ∆u = 0.25-u to be zero at x ≈ 0.15. Howe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40224

    authors： Lu Y,Chen S,Wu W,Du Z,Chao Y,Cui J

    更新日期：2017-01-06 00:00:00

  • Effect of high slice energy spread of an electron beam on the generation of isolated, terawatt, attosecond X-ray free-electron laser pulse.

    abstract：:Attosecond (asec) X-ray free-electron laser (XFEL) has attracted considerable interest over the past years. Nowadays typical XFEL application experiments demand 1010-1011 photons per pulse, which corresponds to a peak power of terawatts (TW) in case of asec hard X-ray pulse. To the realization of such TW asec-XFEL pul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57905-y

    authors： Shim CH,Parc YW,Kim DE

    更新日期：2020-01-28 00:00:00

  • Using global isotopic data to constrain the role of shale gas production in recent increases in atmospheric methane.

    abstract：:The accelerated increase in global methane (CH4) in the atmosphere, accompanied by a decrease in its 13C/12C isotopic ratio (δ13CCH4) from -47.1‰ to -47.3‰ observed since 2008, has been attributed to increased emissions from wetlands and cattle, as well as from shale gas and shale oil developments. To date both explan...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61035-w

    authors： Milkov AV,Schwietzke S,Allen G,Sherwood OA,Etiope G

    更新日期：2020-03-06 00:00:00

  • Cell-free DNA promotes malignant transformation in non-tumor cells.

    abstract：:Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of cells adjacent to the tumor and metastasis. Thus, this study analyzed the effect of tumor cell-free DNA, isolated from the blood of prostate cancer patients, o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78766-5

    authors： Souza AG,Bastos VAF,Fujimura PT,Ferreira ICC,Leal LF,da Silva LS,Laus AC,Reis RM,Martins MM,Santos PS,Corrêa NCR,Marangoni K,Thomé CH,Colli LM,Goulart LR,Goulart VA

    更新日期：2020-12-10 00:00:00

  • Interference in speaking while hearing and vice versa.

    abstract：:Even when speakers are not actively doing another task, they can be interfered in their speech planning by concurrent auditory stimuli. In this study, we used picture naming with passive hearing, or active listening, combined to high-density electroencephalographic (EEG) recordings to investigate the locus and origin ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41752-7

    authors： Fargier R,Laganaro M

    更新日期：2019-03-29 00:00:00

  • Bisphenol S rapidly depresses heart function through estrogen receptor-β and decreases phospholamban phosphorylation in a sex-dependent manner.

    abstract：:The health effects of the endocrine disruptor Bisphenol A (BPA) led to its partial replacement with Bisphenol S (BPS) in several products including food containers, toys, and thermal paper receipts. The acute effects of BPS on myocardial contractility are unknown. We perfused mouse hearts from both sexes for 15 min wi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52350-y

    authors： Ferguson M,Lorenzen-Schmidt I,Pyle WG

    更新日期：2019-11-04 00:00:00

  • Proton-solute coupling mechanism of the maltose transporter from Saccharomyces cerevisiae.

    abstract：:Mal11 catalyzes proton-coupled maltose transport across the plasma membrane of Saccharomyces cerevisiae. We used structure-based design of mutants and a kinetic analysis of maltose transport to determine the energy coupling mechanism of transport. We find that wildtype Mal11 is extremely well coupled and allows yeast ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14438-1

    authors： Henderson R,Poolman B

    更新日期：2017-10-30 00:00:00

  • RhoA phosphorylation mediated by Rho/RhoA-associated kinase pathway improves the anti-freezing potentiality of murine hatched and diapaused blastocysts.

    abstract：:Embryonic cryopreservation has a relatively low survival rate because of cytoskeletal damage. However, molecular anti-freezing mechanisms have been largely unexplored. This study investigated the significance of RhoA, involved in embryonic development, and the Rho/RhoA-associated kinase (ROCK) signalling pathway in cr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07066-2

    authors： Gu M,Ni H,Sheng X,Pauciullo A,Liu Y,Guo Y

    更新日期：2017-07-27 00:00:00

  • Automatic choroidal segmentation in OCT images using supervised deep learning methods.

    abstract：:The analysis of the choroid in the eye is crucial for our understanding of a range of ocular diseases and physiological processes. Optical coherence tomography (OCT) imaging provides the ability to capture highly detailed cross-sectional images of the choroid yet only a very limited number of commercial OCT instrument...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49816-4

    authors： Kugelman J,Alonso-Caneiro D,Read SA,Hamwood J,Vincent SJ,Chen FK,Collins MJ

    更新日期：2019-09-16 00:00:00

  • The effect of chemical erosion on mechanical properties and fracture of sandstone under shear loading: an experimental study.

    abstract：:In order to study the effect of water-rock interactions on shear strength characteristics, we performed shearing tests under varying hydrochemical environments. Moreover, a custom meso-shear test equipment for coal rock was used for the tests. Through 3D scanning of the shear fractures and scanning electron microscope...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56196-2

    authors： Chen C,Peng S,Wu S,Xu J

    更新日期：2019-12-27 00:00:00

  • Approximating the maximum tibial coverage in total knee arthroplasty does not necessarily result in implant malrotation.

    abstract：:Traditionally, the practice of the tibial component placement in total knee arthroplasty has focused on achieving maximum coverage without malrotation. However, the concept of maximizing coverage has not been well defined or researched and yet biased results are often produced. This study aimed to evaluate the effect ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67613-2

    authors： Shao L,Wu XD,Wang T,Liu XK,Xu W,Huang W,Zeng ZM

    更新日期：2020-06-29 00:00:00

  • Selective cognitive dysfunction and physical disability improvement after autologous hematopoietic stem cell transplantation in highly active multiple sclerosis.

    abstract：:The aim was to assess the cognitive dysfunction and physical disability after autologous hematopoietic stem cell transplantation (AHSCT), to explore the potential factors influencing disability regression after AHSCT and to estimate the safety of low-dose immunosuppressive therapy in highly active Multiple Sclerosis (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78160-1

    authors： Giedraitiene N,Kizlaitiene R,Peceliunas V,Griskevicius L,Kaubrys G

    更新日期：2020-12-04 00:00:00

  • High efficiency dielectric photonic crystal fiber metalens.

    abstract：:Optical fibers have been utilized in various fields owing to their superior guiding performance. However, the modification of optical properties and light manipulation in fibers are restricted by the limitation of the core and cladding materials. In addition, the spot size of the light is constrained by the diffractio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77821-5

    authors： Kim M,Kim S

    更新日期：2020-12-01 00:00:00

  • Three-dimensional reconstruction of laryngeal cancer with whole organ serial immunohistochemical sections.

    abstract：:Three-dimensional (3D) image reconstruction of tumors based on serial histological sectioning is one of the most powerful methods for accurate high-resolution visualization of tumor structures. However, 3D histological reconstruction of whole tumor has not yet been achieved. We established a high-resolution 3D model o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76081-7

    authors： Tian J,Qian B,Zhang S,Guo R,Zhang H,Jeannon JP,Jin R,Feng X,Zhan Y,Liu J,He P,Guo J,Li L,Jia Y,Huang F,Wang B

    更新日期：2020-11-03 00:00:00

  • New insights into the biodiversity of coliphages in the intestine of poultry.

    abstract：:Despite phages' ubiquitous presence and great importance in shaping microbial communities, little is known about the diversity of specific phages in different ecological niches. Here, we isolated, sequenced, and characterized 38 Escherichia coli-infecting phages (coliphages) from poultry faeces to gain a better unders...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72177-2

    authors： Sørensen PE,Van Den Broeck W,Kiil K,Jasinskyte D,Moodley A,Garmyn A,Ingmer H,Butaye P

    更新日期：2020-09-16 00:00:00

  • Study on dose-dependent, frequency-dependent, and accumulative effects of 1.5 GHz and 2.856 GHz microwave on cognitive functions in Wistar rats.

    abstract：:Many studies have revealed the cognitive decline induced by microwave radiation. However, the systematic study on dose-dependent, frequency-dependent and accumulative effects of microwave exposure at different frequencies was lacking. Here, we studied the relationship between the effects and the power and frequency of...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11420-9

    authors： Tan S,Wang H,Xu X,Zhao L,Zhang J,Dong J,Yao B,Wang H,Zhou H,Gao Y,Peng R

    更新日期：2017-09-07 00:00:00

  • Postprandial metabolic response of breast-fed infants and infants fed lactose-free vs regular infant formula: A randomized controlled trial.

    abstract：:Lactose intolerance is a major concern driving the growth of lactose-free foods including lactose-free infant formula. It is unknown what the metabolic consequence is of consumption of a formula where lactose has been replaced with corn syrup solids (CSS). Here, a randomized double-blinded intervention study was condu...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-017-03975-4

    authors： Slupsky CM,He X,Hernell O,Andersson Y,Rudolph C,Lönnerdal B,West CE

    更新日期：2017-06-16 00:00:00

  • Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform.

    abstract：:A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly acidic conditions. PTX...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23489

    authors： Mo J,Eggers PK,Yuan ZX,Raston CL,Lim LY

    更新日期：2016-03-24 00:00:00

  • Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis.

    abstract：:With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22626-w

    authors： Pastorino R,Puggina A,Carreras-Torres R,Lagiou P,Holcátová I,Richiardi L,Kjaerheim K,Agudo A,Castellsagué X,Macfarlane TV,Barzan L,Canova C,Thakker NS,Conway DI,Znaor A,Healy CM,Ahrens W,Zaridze D,Szeszenia-Dabrowska

    更新日期：2018-03-14 00:00:00

  • HLA genotypes and cold medicine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis.

    abstract：:Serious cutaneous adverse drug reactions [i.e., SJS/TEN with severe ocular complications (SOC)] associated with cold medicine (CM) were reported in several studies. To assess the risks of CM-induced SJS/TEN with SOC, systematic review and meta-analysis were employed. Studies investigating associations between HLA geno...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-020-67610-5

    authors： Tangamornsuksan W,Chanprasert S,Nadee P,Rungruang S,Meesilsat N,Ueta M,Lohitnavy M

    更新日期：2020-06-29 00:00:00

  • Genetic structure in the paternal lineages of South East Spain revealed by the analysis of 17 Y-STRs.

    abstract：:The genetic data of 17 Y chromosome short tandem repeats in 146 unrelated donor residents in the provinces of Granada, Málaga, and Almería (GMA) were analyzed to determine the genetic legacy of the male inhabitants of the former Kingdom of Granada. A total of 139 unique haplotypes were identified. Observed allele freq...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41580-9

    authors： Saiz M,Alvarez-Cubero MJ,Lorente JA,Alvarez JC,Martinez-Gonzalez LJ

    更新日期：2019-03-26 00:00:00

  • Bloodstain Pattern Analysis: implementation of a fluid dynamic model for position determination of victims.

    abstract：:Bloodstain Pattern Analysis is a forensic discipline in which, among others, the position of victims can be determined at crime scenes on which blood has been shed. To determine where the blood source was investigators use a straight-line approximation for the trajectory, ignoring effects of gravity and drag and thus ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11461

    authors： Laan N,de Bruin KG,Slenter D,Wilhelm J,Jermy M,Bonn D

    更新日期：2015-06-22 00:00:00

  • A cryogenic spin-torque memory element with precessional magnetization dynamics.

    abstract：:We present a study of precessional magnetization switching in orthogonal spin-torque spin-valve devices at low temperatures. The samples consist of a spin-polarizing layer that is magnetized out-of-the film plane and an in-plane magnetized free and reference magnetic layer separated by non-magnetic metallic layers. We...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37204-3

    authors： Rowlands GE,Ryan CA,Ye L,Rehm L,Pinna D,Kent AD,Ohki TA

    更新日期：2019-01-28 00:00:00

  • Discrimination of three Ephedra species and their geographical origins based on multi-element fingerprinting by inductively coupled plasma mass spectrometry.

    abstract：:Discrimination of species and geographical origins of traditional Chinese medicine (TCM) is essential to prevent adulteration and inferior problems. We studied Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A.Mey. and Ephedra przewalskii Bge. to investigate the relationship between inorganic element content and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28558-9

    authors： Ma X,Fan L,Mao F,Zhao Y,Yan Y,Tian H,Xu R,Peng Y,Sui H

    更新日期：2018-07-06 00:00:00

  • The first evidence for Late Pleistocene dogs in Italy.

    abstract：:The identification of the earliest dogs is challenging because of the absence and/or mosaic pattern of morphological diagnostic features in the initial phases of the domestication process. Furthermore, the natural occurrence of some of these characters in Late Pleistocene wolf populations and the time it took from the...

    journal_title：Scientific reports

    pub_type： 历史文章,杂志文章

    doi：10.1038/s41598-020-69940-w

    authors： Boschin F,Bernardini F,Pilli E,Vai S,Zanolli C,Tagliacozzo A,Fico R,Fedi M,Corny J,Dreossi D,Lari M,Modi A,Vergata C,Tuniz C,Moroni A,Boscato P,Caramelli D,Ronchitelli A

    更新日期：2020-08-07 00:00:00

  • Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication.

    abstract：:Hepatitis B Virus (HBV) replication in hepatocytes is restricted by the host innate immune system and related intracellular signaling pathways. Transforming growth factor β-activated kinase 1 (TAK1) is a key mediator of toll-like receptors and pro-inflammatory cytokine signaling pathways. Here, we report that silencin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39901

    authors： Pang J,Zhang G,Lin Y,Xie Z,Liu H,Tang L,Lu M,Yan R,Guo H,Sun J,Hou J,Zhang X

    更新日期：2017-01-03 00:00:00

  • Ghrelin inhibits autonomic response to gastric distension in rats by acting on vagal pathway.

    abstract：:Ghrelin is the only orexigenic peptide currently known and a potent prokinetic by promoting gastric motility but novel insights suggest that its role extends beyond satiety regulation. Whereas ghrelin was shown to provide somatic and colonic antinociception, its impact on gastric sensitivity is unknown even though sto...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67053-y

    authors： Meleine M,Mounien L,Atmani K,Ouelaa W,Bôle-Feysot C,Guérin C,Depoortere I,Gourcerol G

    更新日期：2020-06-19 00:00:00

  • First evidence for an association between joint hypermobility and excitability in a non-human species, the domestic dog.

    abstract：:There is a well-established relationship between joint hypermobility and anxiety in humans, that has not previously been investigated in other species. A population of 5575 assistance dogs were scored for both hip hypermobility and 13 behaviour characteristics using previously validated methods. Our results suggest a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45096-0

    authors： Bowen J,Fatjó J,Serpell JA,Bulbena-Cabré A,Leighton E,Bulbena A

    更新日期：2019-06-13 00:00:00