Abstract：
:The activation and growth of tumour-initiating cells with stem-like properties in distant organs characterize colorectal cancer (CRC) growth and metastasis. Thus, inhibition of colon cancer stem cell (CCSC) growth holds promise for CRC growth and metastasis prevention. We and others have shown that farnesyl dimethyl chromanol (FDMC) inhibits cancer cell growth and induces apoptosis in vitro and in vivo. We provide the first demonstration that FDMC inhibits CCSC viability, survival, self-renewal (spheroid formation), pluripotent transcription factors (Nanog, Oct4, and Sox2) expression, organoids formation, and Wnt/β-catenin signalling, as evidenced by comparisons with vehicle-treated controls. In addition, FDMC inhibits CCSC migration, invasion, inflammation (NF-kB), angiogenesis (vascular endothelial growth factor, VEGF), and metastasis (MMP9), which are critical tumour metastasis processes. Moreover, FDMC induced apoptosis (TUNEL, Annexin V, cleaved caspase 3, and cleaved PARP) in CCSCs and CCSC-derived spheroids and organoids. Finally, in an orthotopic (cecum-injected CCSCs) xenograft metastasis model, we show that FDMC significantly retards CCSC-derived tumour growth (Ki-67); inhibits inflammation (NF-kB), angiogenesis (VEGF and CD31), and β-catenin signalling; and induces apoptosis (cleaved PARP) in tumour tissues and inhibits liver metastasis. In summary, our results demonstrate that FDMC inhibits the CCSC metastatic phenotype and thereby supports investigating its ability to prevent CRC metastases.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Husain K,Coppola D,Yang CS,Malafa MPdoi
10.1038/s41598-020-80911-zsubject
Has Abstractpub_date
2021-01-26 00:00:00pages
2185issue
1issn
2045-2322pii
10.1038/s41598-020-80911-zjournal_volume
11pub_type
杂志文章abstract：:Hot days in summer (involving a few hours at particularly high temperatures) are expected to become more common under climate change. How such events at different life stages affect survival and reproduction remains unclear in most organisms. Here, we investigated how an exposure to 40 °C at different life stages in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10436
更新日期：2015-05-22 00:00:00
abstract：:An image fiber-based miniature suspended solid sensor has been demonstrated. The diameter of the sensor is only a few millimeters. A superhydrophobic material is coated on the end of the image fiber to avoid the adsorption of suspended solids and bubbles. Multiple parameters, including mass concentration, morphology a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17003-y
更新日期：2017-12-01 00:00:00
abstract：:Chronic physiological stress impacts animal fitness by catabolizing metabolic stores and suppressing reproduction. This can be especially deleterious for capital breeding carnivores such as marine mammals, with potential for ecosystem-wide effects. However, the impacts and indicators of chronic stress in animals are c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39089-2
更新日期：2019-02-25 00:00:00
abstract：:Near-surface ozone is enhanced under particular chemical reactions and physical processes. This study showed the seasonal variation of near-surface ozone in Nicosia, Cyprus and focused in summers when the highest ozone levels were noted using a seven year hourly dataset from 2007 to 2014. The originality of this study...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27590-z
更新日期：2018-06-15 00:00:00
abstract：:Stress-induced viscous flow is the characteristic of atomic movements during plastic deformation of metallic glasses in the absence of substantial temperature increase, which suggests that stress state plays an important role in mechanically induced crystallization in a metallic glass. However, it is poorly understood...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19358
更新日期：2016-01-13 00:00:00
abstract：:Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodontal ligament tissue...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23670
更新日期：2016-03-31 00:00:00
abstract：:The quantification of hepatitis C virus (HCV) is essential for the management of chronic hepatitis C therapy. We have developed a fully automated microfluidic RT-qPCR system for rapid quantitative detection of HCV RNA in human EDTA-plasma and serum, and the performance of the method was assessed. The platform for the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64169-z
更新日期：2020-04-30 00:00:00
abstract：:Acrolein, a highly toxic α, β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. One of the most promising methods for detecting acrolein involves the use of antibodies that can recognize the acrolein-lysine conjugate, 3-formyl-3, 4-dehydropi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35872
更新日期：2016-10-26 00:00:00
abstract：:In the Brown et al. study 'Increased food supply mitigates ocean acidification effects on calcification but exacerbates effects on growth' they show disagreement with the tested hypothesis and data analysis methodology used in our 2016 study. We acknowledge careful criticism and a constructive dialogue are necessary t...
journal_title：Scientific reports
pub_type： 评论,杂志文章
doi：10.1038/s41598-018-27670-0
更新日期：2018-06-28 00:00:00
abstract：:FcRn mediates recycling and transcytosis of IgG and albumin in various cell types. The MHC-class-I-like protein of the FcRn heterodimer is encoded by FCGRT. Few determinants of variable FCGRT expression in humans have been identified so far. In this study, we investigated the presence of DNA methylation in regulatory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45203-1
更新日期：2019-06-17 00:00:00
abstract：:Soil fauna play an essential role in the soil ecosystem, but they may be influenced by insecticidal Cry proteins derived from Bacillus thuringiensis (Bt) maize. In this study, a 2-year field trial was conducted to study the effects of transgenic cry1Ie maize, a type of Bt maize (Event IE09S034), on soil fauna, with th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46851-z
更新日期：2019-07-17 00:00:00
abstract：:The ability to avoid predators is crucial to wild prey animals' survival. Potential danger is signalled, among others, by the presence of predator scents. These odors are used in research both to trigger and to study fear reactions in laboratory animals; they are also employed as repellents against pest rodent species...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27054-4
更新日期：2018-06-21 00:00:00
abstract：:College students, as a large part of young adults, are a vulnerable group to several risky behaviors including smoking and drug abuse. This study aimed to utilize and to compare count regression models to identify correlates of cigarette smoking among college students. This was a cross-sectional study conducted on stu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65813-4
更新日期：2020-06-01 00:00:00
abstract：:Porous materials display enhanced scattering mechanisms that greatly influence their transport properties. Metal-assisted chemical etching (MACE) enables fabrication of porous silicon nanowires starting from a doped Si wafer by using a metal template that catalyzes the etching process. Here, we report on the low therm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30223-0
更新日期：2018-08-24 00:00:00
abstract：:Spectra-structure interrelationship is still the weakness of NIR spectral assignment. In this paper, a comprehensive investigation from chemical structural property to natural chemical compounds was carried out for NIR spectral assignment. Surprisingly, we discovered that NIR absorption frequency of the skeleton struc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45945-y
更新日期：2019-07-01 00:00:00
abstract：:The therapeutic effects of iron, zinc and magnesium trace elements, as well as rifaximin were investigated and compared in HE rats. In this study, HE rats were treated with either ferrous sulfate (HE-Fe, 30 mg/kg/day), zinc sulfate (HE-Zn, 30 mg/kg/day), magnesium sulfate (HE-Mg, 50 mg/kg/day) or rifaximin (HE-Rf, 50 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02101-8
更新日期：2017-05-12 00:00:00
abstract：:Current image processing methods for dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) do not capture complex dynamic information of time-signal intensity curves. We investigated whether an autoencoder-based pattern analysis of DSC MRI captured representative temporal features that improves tissue...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78485-x
更新日期：2020-12-08 00:00:00
abstract：:Sapphirinid copepods, which are marine zooplankton, exhibit tunable structural colors originating from a layered structure of guanine crystal plates. In the present study, the coloring portion of adult male of a sapphirinid copepod, Sapphirina nigromaculata, under the dorsal body surface was characterized to clarify t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59090-4
更新日期：2020-02-10 00:00:00
abstract：:The Early Cretaceous Greater Ontong Java Event in the Pacific Ocean may have covered ca. 1% of the Earth's surface with volcanism. It has puzzled scientists trying to explain its origin by several mechanisms possible on Earth, leading others to propose an extraterrestrial trigger to explain this event. A large oceanic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00268
更新日期：2012-01-01 00:00:00
abstract：:The biochemical abnormalities and oxidative stress during pathogenesis of hepatic fibrosis could lead to alteration of trace elements. We studied the alteration of major trace elements during the pathogenesis of N-nitrosodimethylamine (NDMA)-induced hepatic fibrosis in rats. The biochemical and pathological indices of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37516-4
更新日期：2019-01-24 00:00:00
abstract：:Routers, switches, and repeaters are essential components of modern information-processing systems. Similar devices will be needed in future superconducting quantum computers. In this work we investigate experimentally the time evolution of Autler-Townes splitting in a superconducting phase qubit under the application...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00645
更新日期：2012-01-01 00:00:00
abstract：:Dietary modulation of the gut microbiota impacts human health. Here we investigated the hitherto unknown effects of resistant starch type 4 (RS4) enriched diet on gut microbiota composition and short-chain fatty acid (SCFA) concentrations in parallel with host immunometabolic functions in twenty individuals with signs...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28797
更新日期：2016-06-30 00:00:00
abstract：:The synthesis of ordered monolayers of gold nano-urchin (Au-NU) nanostructures with controlled size, directly on thin films using a simple electrochemical method is reported in this study. In order to demonstrate one of the vast potential applications, the developed Au-NUs were formed on the electrodes of transducers ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24625
更新日期：2016-04-19 00:00:00
abstract：:Phase modulators are one of the key components of many applications in electromagnetic and opto-electric wave propagations. Phase-shifters play an integral role in communications, imaging and in coherent material excitations. In order to realize the terahertz (THz) electromagnetic spectrum as a fully-functional bandwi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38041
更新日期：2016-11-30 00:00:00
abstract：:Traditionally, dynamic atomic force microscopy (AFM) techniques are based on the analysis of the quasi-steady state response of the cantilever deflection in terms of Fourier analysis. Here we describe a technique that instead exploits the often disregarded transient response of the cantilever through a relatively mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49104-1
更新日期：2019-09-03 00:00:00
abstract：:In 2010, a new rabbit hemorrhagic disease virus (RHDV) variant, designated RHDV2, was identified for the first time in Italy. Studies have shown that RHDV2 differs from RHDV1 (traditional RHDV) in terms of its antigenic profile and genetic characteristics. The VP60 protein of RHDV is a structural protein that plays im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20857
更新日期：2016-02-16 00:00:00
abstract：:Tissue damage induces rapid recruitment of leukocytes and changes in the transcriptional landscape that influence wound healing. However, the cell-type specific transcriptional changes that influence leukocyte function and tissue repair have not been well characterized. Here, we employed translating ribosome affinity ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72750-9
更新日期：2020-09-24 00:00:00
abstract：:Hybrid cells of Nicotiana suaveolens x N. tabacum grow normally at 36 °C, but immediately express lethality due to probable autoimmune response when transferred from 36 to 28 °C. Our recent study showed that the temperature-sensitive lethality of these hybrid cells occurs through autolytic programmed cell death (PCD)....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46619-5
更新日期：2019-07-15 00:00:00
abstract：:The human hepatoma-derived growth factor (HDGF), containing the chromatin-associated N-terminal PWWP domain capable of binding the SMYD1 promoter, participates in various cellular processes and is involved in human cancers. We report the first crystal structures of the human HDGF PWWP domain (residues 1-100) in a comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18510-8
更新日期：2018-01-10 00:00:00
abstract：:Rs1042522 (Arg72Pro) is a functional polymorphism of TP53. Pro72 has been associated with lower all-cause mortality and lower mortality after cancer. We hypothesized that TP53 Pro72 is associated with lower mortality after cancer, lower all-cause mortality, and with increased cancer incidence in the general population...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00427-x
更新日期：2017-03-23 00:00:00
