Abstract:
:Electronic cigarettes (ECs) are nicotine delivery devices that are proposed as tobacco harm reduction products to smokers. Nicotine delivery from ECs is potentially important in their efficacy as smoking substitutes. Herein, nicotine delivery from using a new-generation EC device (variable-wattage, set at 9 W) was evaluated, comparing experienced (vapers) with naïve users (smokers). Twenty-four vapers and 23 smokers participated to the study. They were asked to obtain 10 puffs in 5 minutes and then use the EC ad lib for 60 more minutes (total duration of use: 65 minutes). An 18 mg/mL nicotine-containing liquid was used. Blood samples were obtained at baseline, 5-minutes and every 15 minutes thereafter, while number of puffs and average puff duration were recorded. Although at baseline both groups had similar plasma nicotine levels, smokers consistently exhibited lower levels at all time-periods; at 5-minutes the levels were lower by 46%, while during the subsequent period they were lower by 43% (at 65-minutes) to 54% (at 20-minutes). Both groups took similar number of puffs, but smokers had average puff duration of 2.3 s compared to 3.5 s in vapers. Even in vapers, plasma nicotine levels at 5 minutes were lower than those observed after smoking 1 tobacco cigarette.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Farsalinos KE,Spyrou A,Stefopoulos C,Tsimopoulou K,Kourkoveli P,Tsiapras D,Kyrzopoulos S,Poulas K,Voudris Vdoi
10.1038/srep11269subject
Has Abstractpub_date
2015-06-17 00:00:00pages
11269issn
2045-2322pii
srep11269journal_volume
5pub_type
杂志文章abstract::Breast cancer is a heterogeneous disease consisting of several subtypes. Among these subtypes, triple negative breast cancer is particularly difficult to treat. This is due to a lack of understanding of the mechanisms behind the disease, and consequently a lack of druggable targets. PAK4 plays critical roles in cell s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42555
更新日期:2017-02-15 00:00:00
abstract::Yeast Cdc48 is a well-conserved, essential chaperone of ATPases associated with diverse cellular activity (AAA) proteins, which recognizes substrate proteins and modulates their conformations to carry out many cellular processes. However, the fundamental mechanisms underlying the diverse pivotal roles of Cdc48 remain ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05806-y
更新日期:2017-07-14 00:00:00
abstract::Thymocyte and T cell trafficking relies on signals initiated by G-protein coupled receptors. To address the importance of the G-proteins Gαi2 and Gαi3 in thymocyte and T cell function, we developed several mouse models. Gαi2 deficiency in hematopoietic progenitors led to a small thymus, a double negative (DN)1/DN2 thy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04537-4
更新日期:2017-06-23 00:00:00
abstract::Dietary exposure of insects to a feeding deterrent substance for hours to days can induce habituation and concomitant desensitization of the response of peripheral gustatory neurons to such a substance. In the present study, larvae of the herbivore Helicoverpa armigera were fed on diets containing either a high, mediu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39358
更新日期:2016-12-14 00:00:00
abstract::The ovules and egg cells are well developed to be fertilized at anthesis in many flowering plants. However, ovule development is triggered by pollination in most orchids. In this study, we characterized the function of a Bsister gene, named PeMADS28, isolated from Phalaenopsis equestris, the genome-sequenced orchid. S...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79877-9
更新日期:2021-01-13 00:00:00
abstract::A better understanding of the seroprevalence and specificity of influenza HA stem-directed broadly neutralizing antibodies (bNAbs) in the human population could significantly inform influenza vaccine design efforts. Here, we utilized probes comprising headless, HA stabilized stem (SS) to determine the prevalence, bind...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26538-7
更新日期:2018-06-05 00:00:00
abstract::As fine particle (FP) pollution is harmful to humans, previous studies have focused on the mechanisms of FP removal by forests. The current study aims to compare the FP removal capacities of urban forests and wetlands on the leaf, canopy, and landscape scales. Water washing and scanning electron microscopy are used to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46214
更新日期:2017-04-10 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-28914-9
更新日期:2018-08-10 00:00:00
abstract::Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77013-1
更新日期:2020-11-18 00:00:00
abstract::Solvent-free, nonvolatile, room-temperature alkylated-π functional molecular liquids (FMLs) are rapidly emerging as a new generation of fluid matter. However, precision design to tune their physicochemical properties remains a serious challenge because the properties are governed by subtle π-π interactions among funct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03584-1
更新日期:2017-06-13 00:00:00
abstract::We have developed sensitive detection of cancer biomarker vascular endothelial growth factor (VEGF) using the p-n heterojunction comprised of p-type BiOI nanoflakes (NFs) array and n-type TiO2 nanotubes (NTs) array. Due to the unique arrayed structure and the synergy effect of photoelectrochemistry in the formed p-n j...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04426
更新日期:2014-03-21 00:00:00
abstract::Worldwide, Bartonella infections are known to inflict a wide range of mammals and, within rodents alone, more than 20 Bartonella species have been detected. There is, however, a lack of studies on the presence of Bartonella spp. in rodents in the Baltic region. We analysed 580 individuals belonging to eight small rode...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48715-y
更新日期:2019-08-26 00:00:00
abstract::The concentration of CO2 in many aquatic systems is variable, often lower than the KM of the primary carboxylating enzyme Rubisco, and in order to photosynthesize efficiently, many algae operate a facultative CO2 concentrating mechanism (CCM). Here we measured the responses of a marine diatom, Thalassiosira pseudonana...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42333
更新日期:2017-02-09 00:00:00
abstract::Islet transplantation is a novel promising strategy to cure type 1 diabetes. However, the long-term outcome is still poor, because both function and survival of the transplant decline over-time. Non-invasive imaging methods have the potential to enable monitoring of islet survival after transplantation and the effects...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15521
更新日期:2015-10-22 00:00:00
abstract::A series of novel dioxin-containing pyrazoline derivatives with thiourea skeleton have been designed, synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities. A majority of them displayed selective HER-2 inhibitory activity against EGFR inhibitory activity. Compound C20 displayed th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27571
更新日期:2016-06-08 00:00:00
abstract::This study aims to examine the long-term effect of adjuvant treatment in Korean Medicine (KM) clinics in ischemic stroke patients, using a national sample cohort from the National Health Insurance Service in Korea between 2010 and 2013. The National Health Insurance Service - National Sample Cohort database from 2002 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19841-w
更新日期:2018-01-26 00:00:00
abstract::Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess effects of altered salt intake on plasma and urine UA levels and the relationship between UA levels and salt sensitivity in humans. Ninety subjects (18-65 years old) were ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-20048-2
更新日期:2018-01-23 00:00:00
abstract::Ruminants obtain nutrients from microbial fermentation of plant material, primarily in their rumen, a multilayered forestomach. How the different layers of the rumen wall respond to diet and influence microbial fermentation, and how these process are regulated, is not well understood. Gene expression correlation netwo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39022
更新日期:2016-12-14 00:00:00
abstract::Amazonian wildfires in 2019 have raised awareness about rainforest burning due to increased emissions of particulate matter and carbon. In the context of these emissions, by-products of lignin thermal degradation (i.e. methoxyphenols) are often neglected. Methoxyphenols entering the atmosphere may form intermediates w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81789-1
更新日期:2021-01-28 00:00:00
abstract::Full-endoscopic transforaminal lumbar discectomy (FETD) is increasingly used in patients with lumbar disc herniation (LDH). There is little knowledge on the related factors, including the straight leg raising test (SLR), that influence the operation. Consecutive patients with LDH who came to our hospital from August 2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73357-w
更新日期:2020-10-05 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24098-4
更新日期:2018-04-12 00:00:00
abstract::Next generation sequencing (NGS) of DNAs amplified by rolling circle amplification from 6 tomato (Solanum lycopersicum) plants with leaf curl symptoms identified a number of monopartite begomoviruses, including Tomato yellow leaf curl virus (TYLCV), and a betasatellite (Tomato leaf curl betasatellite [ToLCB]). Both TY...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53106-4
更新日期:2019-11-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-72744-7
更新日期:2020-09-21 00:00:00
abstract::Orientation controllable DNA biosensors hold great application potentials in recognizing small molecules and detecting DNA hybridization. Though electric field is usually used to control the orientation of DNA molecules, it is also of great importance and significance to seek for other triggered methods to control the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14415
更新日期:2015-09-24 00:00:00
abstract::There is a significant need to develop antibacterial materials that could be applied locally and directly to the places surrounded by large amount of bacteria, in order to address the problems of bacterial antibiotic-resistance or irreversible biofilm formation. Hydrogels are thought to be suitable candidates due to t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07753
更新日期:2015-01-13 00:00:00
abstract::The phylogenetic diversity of marine bacteria belonged to the Bacillus cereus group has not been well investigated. Here, we present the genetic diversity and population structure of 71 bacteria from diverse marine environments, using a multilocus sequence typing (MLST) approach and the analyses of digital DNA-DNA hyb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00817-1
更新日期:2017-04-06 00:00:00
abstract::Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A diabetic patient has lower ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80925-7
更新日期:2021-01-13 00:00:00
abstract::Colon cancer stem cells have been attributed to poor prognosis, therapeutic resistance and aggressive nature of the malignancy. Recent reports associated CD44v6 expression with relapse, metastasis and reduced 5-year survival of colon cancer patients, thereby making it a potential therapeutic target. Thus, in this stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35069-0
更新日期:2018-11-19 00:00:00
abstract::Alpha melanocyte stimulating hormone (α-MSH) and Forkhead box C2 protein (Foxc2) enhance lipolysis in multiple tissues. However, their relationship in adipose fatty acid oxidation (FAO) remains unclear. Here, we demonstrated that α-MSH and Foxc2 increased palmitate oxidation to CO2 in white (WAT) and brown adipose tis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36661
更新日期:2016-11-07 00:00:00
abstract::Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the interleukin-18 (IL18) signaling pathway, and pharmacologic inhibition...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45747-2
更新日期:2019-06-28 00:00:00