Abstract：
:Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A diabetic patient has lower cavernous VASH1 expression than in the potent man. VASH1 was mainly expressed in endothelial cells. There were significant decreases in cavernous endothelial cell and pericyte contents in VASH1 knockout mice compared with those in wild-type mice, which resulted in impairments in erectile function. Intracavernous injection of VASH1 protein successfully restored erectile function in the diabetic mice (~ 90% of control values). VASH1 protein reinstated endothelial cells, pericytes, and endothelial cell-cell junction proteins and induced phosphorylation of eNOS (Ser1177) in the diabetic mice. The induction of angiogenic factors, such as angiopoietin-1 and vascular endothelial growth factor, is responsible for cavernous angiogenesis and the restoration of erectile function mediated by VASH1. Altogether, these findings suggest that VASH1 is proangiogenic in diabetic penis and is a new potential target for diabetic ED.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Song KM,Kim WJ,Choi MJ,Kwon KD,Limanjaya A,Ghatak K,Ock J,Yin GN,Sato Y,Hong SS,Ryu JK,Suh JKdoi
10.1038/s41598-020-80925-7subject
Has Abstractpub_date
2021-01-13 00:00:00pages
1114issue
1issn
2045-2322pii
10.1038/s41598-020-80925-7journal_volume
11pub_type
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