Abstract：
:Memristive systems have gained considerable attention in the field of neuromorphic engineering, because they allow the emulation of synaptic functionality in solid state nano-physical systems. In this study, we show that memristive behavior provides a broad working framework for the phenomenological modelling of cellular synaptic mechanisms. In particular, we seek to understand how close a memristive system can account for the biological realism. The basic characteristics of memristive systems, i.e. voltage and memory behavior, are used to derive a voltage-based plasticity rule. We show that this model is suitable to account for a variety of electrophysiology plasticity data. Furthermore, we incorporate the plasticity model into an all-to-all connecting network scheme. Motivated by the auto-associative CA3 network of the hippocampus, we show that the implemented network allows the discrimination and processing of mnemonic pattern information, i.e. the formation of functional bidirectional connections resulting in the formation of local receptive fields. Since the presented plasticity model can be applied to real memristive devices as well, the presented theoretical framework can support both, the design of appropriate memristive devices for neuromorphic computing and the development of complex neuromorphic networks, which account for the specific advantage of memristive devices.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Diederich N,Bartsch T,Kohlstedt H,Ziegler Mdoi
10.1038/s41598-018-27616-6subject
Has Abstractpub_date
2018-06-19 00:00:00pages
9367issue
1issn
2045-2322pii
10.1038/s41598-018-27616-6journal_volume
8pub_type
杂志文章abstract：:Chronic alcohol feeding causes lipid accumulation and apoptosis in the liver. This study investigated the role of bioactive lipid metabolites in alcohol-induced liver damage and tested the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver disease (ALD). Results showed that chroni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02759-0
更新日期：2017-08-21 00:00:00
abstract：:No study to date has prospectively evaluated the association between pre-diagnostic cruciferous vegetables intake and lung cancer survival among women. This analysis included 547 incident lung cancer cases identified from the Shanghai Women's Health Study (SWHS) during the follow-up period of 1997-2011. Dietary intake...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10306
更新日期：2015-05-19 00:00:00
abstract：:In all organisms, salts produce either appetitive or aversive responses depending on the concentration. While low-salt concentration in food elicits positive responses to ingest, high-salt triggers aversion. Still the mechanisms involved in this dual behavior have just started to be uncovered in some organisms. In Rho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15861-0
更新日期：2017-11-14 00:00:00
abstract：:Cancer hallmarks are evolutionary traits required by a tumour to develop. While extensively characterised, the way these traits are achieved through the accumulation of somatic mutations in key biological pathways is not fully understood. To shed light on this subject, we characterised the landscape of pathway alterat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25076-6
更新日期：2018-04-30 00:00:00
abstract：:Evaluation of facial asymmetry generally involves landmark-based analyses that cannot intuitively assess differences in three-dimensional (3D) stereoscopic structures between deviation and non-deviation sides. This study tested a newly developed similarity index that uses a mirroring technique to intuitively evaluate ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47477-x
更新日期：2019-07-29 00:00:00
abstract：:The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22197
更新日期：2016-02-23 00:00:00
abstract：:Dorso-ventral (DV) countershading is a highly-conserved pigmentary adaptation in vertebrates. In mammals, spatially regulated expression of agouti-signaling protein (ASIP) generates the difference in shading by driving a switch between the production of chemically-distinct melanins in melanocytes in dorsal and ventral...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40251-z
更新日期：2019-03-05 00:00:00
abstract：:The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22464
更新日期：2016-03-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-63162-w
更新日期：2020-04-15 00:00:00
abstract：:The major human pathogen Streptococcus pneumoniae is a leading cause of disease and death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term colonization and persistence within the host. We have previously demonstrated that the capsular surface-associated pneumococcal serine rich repea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32371
更新日期：2016-09-01 00:00:00
abstract：:Magnetic skyrmions are hailed as a potential technology for data storage and other data processing devices. However, their stability against thermal fluctuations is an open question that must be answered before skyrmion-based devices can be designed. In this work, we study paths in the energy landscape via which the t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03391-8
更新日期：2017-06-22 00:00:00
abstract：:Polycrystalline CeGe is investigated by means of DC and AC susceptibility, non-linear DC susceptibility, electrical transport and heat capacity measurements in the low temperature regime. This compound shows two peaks at low magnetic field around TI ~ 10.7 and TII ~ 7.3 K due to antiferromagnetic ordering and subseque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41565-8
更新日期：2019-03-26 00:00:00
abstract：:The spectral distribution of light emitted from a scanning tunnelling microscope junction not only bears its intrinsic plasmonic signature but is also imprinted with the characteristics of optical frequency fluc- tuations of the tunnel current. Experimental spectra from gold-gold tunnel junctions are presented that sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03766-x
更新日期：2017-06-14 00:00:00
abstract：:InPBi was predicted to be the most robust infrared optoelectronic material but also the most difficult to synthesize within In-VBi (V = P, As and Sb) 25 years ago. We report the first successful growth of InPBi single crystals with Bi concentration far beyond the doping level by gas source molecular beam epitaxy. The ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05449
更新日期：2014-06-26 00:00:00
abstract：:Web search tools are widely used by the general public to obtain health-related information, and analysis of search data is often suggested for public health monitoring. We analyzed popularity of searches related to smell loss and taste loss, recently listed as symptoms of COVID-19. Searches on sight loss and hearing ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77316-3
更新日期：2020-11-25 00:00:00
abstract：:Acute kidney injury (AKI) in patients with septic shock is associated with high mortality, but the appropriate timing for initiating continuous renal replacement therapy (CRRT) is controversial. We retrospectively enrolled 158 septic shock patients with AKI in the medical intensive care unit (ICU) from July 2016 to Ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48418-4
更新日期：2019-08-19 00:00:00
abstract：:Selective serotonin reuptake inhibitors are among the most prescribed antidepressants. Fluoxetine is the lead molecule which exerts its therapeutic effects, at least in part, by promoting neuroplasticity through increased brain-derived neurotrophic factor (BDNF)/tropomyosin-related receptor kinase B (TrkB) signalling....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42775-w
更新日期：2019-04-19 00:00:00
abstract：:Lightweight, simple and flexible self-powered photodetectors are urgently required for the development and application of advanced optical systems for the future of wearable electronic technology. Here, using a low-temperature reduction process, we report a chemical approach for producing freestanding monolithic reduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33525
更新日期：2016-09-16 00:00:00
abstract：:Unlike the constant nature of elastic coefficients of isotropic bulk materials, the Young's (E) and shear (μ) moduli of nano-structured (NS) gyroid metamaterials change with relative density (ρ), but at different rates depending on the cell size of the structure. These elastic behaviors displayed by E and μ cause cros...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10978-8
更新日期：2017-09-05 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-54236-5
更新日期：2019-11-22 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep16188. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46909
更新日期：2017-12-22 00:00:00
abstract：:The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32350
更新日期：2016-08-30 00:00:00
abstract：:The numerous species that make up the oral microbiome are now understood to play a key role in establishment and maintenance of oral health. The ability to taxonomically identify community members at the species level is important to elucidating its diversity and association to health and disease. We report the overal...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/srep43344
更新日期：2017-02-27 00:00:00
abstract：:Due to the different craniocervical structures in humans and cetaceans, a standardised method assessing the normal craniocervical relationship in cetaceans is lacking, causing difficulties in defining the presence of atlanto-occipital dissociation (AOD) in cetaceans. The present study aimed to 1) describe a novel stan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26866-8
更新日期：2018-05-31 00:00:00
abstract：:We evaluated surgical outcomes of bilateral rectus (BLR) recession in patients with intermittent exotropia who underwent diagnostic monocular occlusion. Records of patients with intermittent exotropia who were preoperatively examined one-hour monocular occlusion and underwent BLR recession were reviewed retrospectivel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64642-9
更新日期：2020-05-08 00:00:00
abstract：:We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00931-0
更新日期：2017-04-11 00:00:00
abstract：:Tumour growth and metastatic colonization is strongly influenced by the tumour stroma, including cancer-associated fibroblasts (CAF). Multipotent mesenchymal stromal cells (MSC) are a possible source of CAF following myofibroblastic differentiation, and we have previously shown that MSC support tumour growth. Triggere...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48142-z
更新日期：2019-08-13 00:00:00
abstract：:We have developed a framework to convert an arbitrary integer factorization problem to an executable Ising model by first writing it as an optimization function then transforming the k-bit coupling (k ≥ 3) terms to quadratic terms using ancillary variables. Our resource-efficient method uses [Formula: see text] binary...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36058-z
更新日期：2018-12-05 00:00:00
abstract：:HIV-1 Tat protein is released from HIV-1-infected cells and can enter non-permissive cells including neurons. Tat disrupts neuronal homeostasis and may contribute to the neuropathogenesis in people living with HIV (PLWH). The use of cocaine by PLWH exacerbates neuronal dysfunction. Here, we examined the mechanisms by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34539-9
更新日期：2018-11-02 00:00:00
abstract：:Fabric-based personal heating patches have small geometric profiles and can be attached to selected areas of garments for personal thermal management to enable significant energy savings in built environments. Scalable fabrication of such patches with high thermal performance at low applied voltage, high durability an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35650-7
更新日期：2018-11-21 00:00:00
