Abstract:
:One of the greatest challenges in the field of biofabrication remains the discovery of suitable bioinks that satisfy physicochemical and biological requirements. Despite recent advances in tissue engineering and biofabrication, progress has been limited to the development of technologies using polymer-based materials. Here, we show that a nucleotide lipid-based hydrogel resulting from the self-assembly of nucleotide lipids can be used as a bioink for soft tissue reconstruction using injection or extrusion-based systems. To the best of our knowledge, the use of a low molecular weight hydrogel as an alternative to polymeric bioinks is a novel concept in biofabrication and 3D bioprinting. Rheological studies revealed that nucleotide lipid-based hydrogels exhibit suitable mechanical properties for biofabrication and 3D bioprinting, including i) fast gelation kinetics in a cell culture medium and ii) shear moduli and thixotropy compatible with extruded oral cell survival (human gingival fibroblasts and stem cells from the apical papilla). This polymer-free soft material is a promising candidate for a new bioink design.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dessane B,Smirani R,Bouguéon G,Kauss T,Ribot E,Devillard R,Barthélémy P,Naveau A,Crauste-Manciet Sdoi
10.1038/s41598-020-59632-wsubject
Has Abstractpub_date
2020-02-18 00:00:00pages
2850issue
1issn
2045-2322pii
10.1038/s41598-020-59632-wjournal_volume
10pub_type
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