Nucleotide lipid-based hydrogel as a new biomaterial ink for biofabrication.

Abstract:

:One of the greatest challenges in the field of biofabrication remains the discovery of suitable bioinks that satisfy physicochemical and biological requirements. Despite recent advances in tissue engineering and biofabrication, progress has been limited to the development of technologies using polymer-based materials. Here, we show that a nucleotide lipid-based hydrogel resulting from the self-assembly of nucleotide lipids can be used as a bioink for soft tissue reconstruction using injection or extrusion-based systems. To the best of our knowledge, the use of a low molecular weight hydrogel as an alternative to polymeric bioinks is a novel concept in biofabrication and 3D bioprinting. Rheological studies revealed that nucleotide lipid-based hydrogels exhibit suitable mechanical properties for biofabrication and 3D bioprinting, including i) fast gelation kinetics in a cell culture medium and ii) shear moduli and thixotropy compatible with extruded oral cell survival (human gingival fibroblasts and stem cells from the apical papilla). This polymer-free soft material is a promising candidate for a new bioink design.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dessane B,Smirani R,Bouguéon G,Kauss T,Ribot E,Devillard R,Barthélémy P,Naveau A,Crauste-Manciet S

doi

10.1038/s41598-020-59632-w

subject

Has Abstract

pub_date

2020-02-18 00:00:00

pages

2850

issue

1

issn

2045-2322

pii

10.1038/s41598-020-59632-w

journal_volume

10

pub_type

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