Gene network analysis identifies rumen epithelial cell proliferation, differentiation and metabolic pathways perturbed by diet and correlated with methane production.

abstract：:Protein aggregation is a process by which misfolded proteins polymerizes into aggregates and forms fibrous structures with a β-sheet conformation, known as amyloids. It is an undesired outcome, as it not only causes numerous neurodegenerative diseases, but is also a major deterrent in the development of protein biopha...

journal_title：Scientific reports

authors： Rajan R,Matsumura K

更新日期：2017-04-04 00:00:00

abstract：:Ionic currents, whether measured as conductance amplitude or as ion channel transcript numbers, can vary many-fold within a population of identified neurons. In invertebrate neuronal types multiple currents can be seen to vary while at the same time their magnitudes are correlated. These conductance amplitude correlat...

journal_title：Scientific reports

authors： Tran T,Unal CT,Severin D,Zaborszky L,Rotstein HG,Kirkwood A,Golowasch J

更新日期：2019-02-08 00:00:00

abstract：:This study aimed to explore the development of mental rotation ability throughout life by comparing different kinds of stimuli. Thirty-six children (6-9 years-old), 30 young (20-28 years-old) and 30 elderly people (60-82 years-old) performed mental rotation tasks with abstract (i.e. two-dimensional lines) and concrete...

journal_title：Scientific reports

authors： Iachini T,Ruggiero G,Bartolo A,Rapuano M,Ruotolo F

更新日期：2019-02-04 00:00:00

abstract：:The favourable kinetics of 18F-fluoro-2-deoxyglucose (FDG) permits to depict cancer glucose consumption by a single evaluation of late tracer uptake. This standard procedure relies on the slow radioactivity loss, usually attributed to the limited tumour expression of G6P-phosphatase (G6Pase). However, this classical i...

journal_title：Scientific reports

authors： Scussolini M,Bauckneht M,Cossu V,Bruno S,Orengo AM,Piccioli P,Capitanio S,Yosifov N,Ravera S,Morbelli S,Piana M,Sambuceti G,Caviglia G,Marini C

更新日期：2019-02-26 00:00:00

abstract：:Extracellular vesicles (EVs) are an important class of membrane-bound structures that have been widely investigated for their roles in intercellular communication in the contexts of tumor progression, vascular function, immunity and regenerative medicine. Much of the current knowledge on the functions of EVs pertains ...

journal_title：Scientific reports

authors： Baxter AA,Phan TK,Hanssen E,Liem M,Hulett MD,Mathivanan S,Poon IKH

更新日期：2019-05-17 00:00:00

abstract：:Rice is the most important crop in the world, acting as the staple food for over half of the world's population. The evolutionary relationships of cultivated rice and its wild relatives have remained contentious and inconclusive. Here we report on the use of whole chloroplast sequences to elucidate the evolutionary an...

journal_title：Scientific reports

authors： Wambugu PW,Brozynska M,Furtado A,Waters DL,Henry RJ

更新日期：2015-09-10 00:00:00

abstract：:Adaptive responses to hypoxia regulate hepatic lipid metabolism, but their consequences in nonalcoholic fatty liver disease (NAFLD) are largely unknown. Here, we show that hypoxia inducible factor-1 (HIF-1), a key determinant of hypoxic adaptations, prevents excessive hepatic lipid accumulation in the progression of N...

journal_title：Scientific reports

authors： Arai T,Tanaka M,Goda N

更新日期：2018-09-21 00:00:00

abstract：:Although genetically modified mice can be generated with high efficiency by using CRISPR/Cas9-mediated genome editing in mouse zygotes, only the loci with a protospacer-adjacent motif (PAM) sequence are targetable. The present study investigated the usability of engineered Streptococcus pyogenes Cas9 (SpCas9-NG) in mo...

journal_title：Scientific reports

authors： Fujii W,Ito H,Kanke T,Ikeda A,Sugiura K,Naito K

更新日期：2019-09-09 00:00:00

abstract：:Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked...

journal_title：Scientific reports

authors： Cisneros E,di Marco F,Rueda-Carrasco J,Lillo C,Pereyra G,Martín-Bermejo MJ,Vargas A,Sanchez R,Sandonís Á,Esteve P,Bovolenta P

更新日期：2020-03-20 00:00:00

abstract：:Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic targets for asthma treatment. We previously showed ...

journal_title：Scientific reports

authors： Teoh CM,Tan SSL,Langenbach SY,Wong AH,Cheong DHJ,Tam JKC,New CS,Tran T

更新日期：2019-07-09 00:00:00

abstract：:Many real networks feature the property of nestedness, i.e. the neighbours of nodes with a few connections are hierarchically nested within the neighbours of nodes with more connections. Despite the abstract simplicity of this notion, various mathematical definitions of nestedness have been proposed, sometimes giving ...

journal_title：Scientific reports

authors： Bruno M,Saracco F,Garlaschelli D,Tessone CJ,Caldarelli G

更新日期：2020-11-16 00:00:00

abstract：:Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA2 activity and mass by genotyping multiple polymorphisms in PLA2G7, the gene encoding Lp-PLA2, among 1258 participants from the Chinese Multi-provincial ...

journal_title：Scientific reports

authors： Qi Y,Zhao D,Jia Z,Wang W,Wang M,Sun J,Liu J,Li Y,Xie W,Liu J

更新日期：2016-12-01 00:00:00

abstract：:Dopamine is an important neurotransmitter that plays a key role in a wide range of both locomotive and cognitive functions in humans. Disturbances on the dopaminergic system cause, among others, psychosis, Parkinson's disease and Huntington's disease. Antipsychotics are drugs that interact primarily with the dopamine ...

journal_title：Scientific reports

authors： Goode-Romero G,Winnberg U,Domínguez L,Ibarra IA,Vargas R,Winnberg E,Martínez A

更新日期：2020-12-09 00:00:00

abstract：:Bacterial environmental and surgical site infection (SSI) surveillance was implemented from 2011-2016 in a UK Equine Referral Veterinary Hospital and identified 81 methicillin-resistant Staphylococcus aureus (MRSA) isolates. A cluster of MRSA SSIs occurred in early 2016 with the isolates confirmed as ST398 by multiloc...

journal_title：Scientific reports

authors： Bortolami A,Williams NJ,McGowan CM,Kelly PG,Archer DC,Corrò M,Pinchbeck G,Saunders CJ,Timofte D

更新日期：2017-07-14 00:00:00

abstract：:Several studies have shown that the human gaze, but not the robot gaze, has significant effects on infant social cognition and facilitate social engagement. The present study investigates early understanding of the referential nature of gaze by comparing-through the eye-tracking technique-infants' response to human an...

journal_title：Scientific reports

authors： Manzi F,Ishikawa M,Di Dio C,Itakura S,Kanda T,Ishiguro H,Massaro D,Marchetti A

更新日期：2020-07-17 00:00:00

abstract：:Functional reactivation of p53 pathway, although arduous, can potentially provide a broad-based strategy for cancer therapy owing to frequent p53 inactivation in human cancer. Using a phosphoprotein-screening array, we found that Benzyl Isothiocynate, (BITC) increases p53 phosphorylation in breast cancer cells and rev...

journal_title：Scientific reports

authors： Xie B,Nagalingam A,Kuppusamy P,Muniraj N,Langford P,Győrffy B,Saxena NK,Sharma D

更新日期：2017-01-10 00:00:00

abstract：:Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellul...

journal_title：Scientific reports

authors： Bomfim LM,de Araujo FA,Dias RB,Sales CBS,Rocha CAG,Correa RS,Soares MBP,Batista AA,Bezerra DP

更新日期：2019-08-07 00:00:00

abstract：:Heterotrimeric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPCRs. However, some non-receptor proteins are also GEFs. GIV (a.k.a Girdin) was the first non-receptor protein for which the GEF activity was ascribed to a well-defined protein sequence that directly binds Gαi....

journal_title：Scientific reports

authors： DiGiacomo V,de Opakua AI,Papakonstantinou MP,Nguyen LT,Merino N,Blanco-Canosa JB,Blanco FJ,Garcia-Marcos M

更新日期：2017-08-17 00:00:00

abstract：:Piwi-like proteins are essential for stem-cell maintenance and self-renewal in multicellular organisms. We analyzed the expression of Piwi-like 1 and Piwi-like 2 by immunohistochemistry (IHC) in 95 muscle invasive bladder cancer (MIBC) samples using tissue microarray. Application of an immunoreactive score (IRS) revea...

journal_title：Scientific reports

authors： Eckstein M,Jung R,Weigelt K,Sikic D,Stöhr R,Geppert C,Agaimy A,Lieb V,Hartmann A,Wullich B,Wach S,Taubert H

更新日期：2018-12-06 00:00:00

abstract：:Layered Li2RuO3 is an important candidate cathode material in rechargeable lithium ion batteries because of its novel anionic redox process and high reversible capacity. Atomistic scale simulations are used to calculate the intrinsic defect process, favourable dopants and migration energies of lithium ion diffusions t...

journal_title：Scientific reports

authors： Kuganathan N,Kordatos A,Chroneos A

更新日期：2019-01-24 00:00:00

abstract：:The incidence and mortality of primary liver cancer are very high and resection of tumor is the most crucial treatment for it. We aimed to assess the efficacy and safety of combined use of transversus abdominis plane (TAP) block and laryngeal mask airway (LMA) during implementing Enhanced Recovery After Surgery (ERAS)...

journal_title：Scientific reports

authors： Huang HM,Chen RX,Zhu LM,Zhao WS,Ye XJ,Luo JW,Lu FD,Zhang L,Yang XY,Yuan Y,Cao J

更新日期：2020-09-10 00:00:00

abstract：:The geometry of metal nanoparticles greatly affects the properties of the localized surface plasmon resonance and surface-enhanced Raman scattering. The synthesis of metal nanoparticles with controllable geometry has thus attracted extensive attentions. In this work, we report a modified polyol synthesis approach of s...

journal_title：Scientific reports

authors： Wu F,Wang W,Xu Z,Li F

更新日期：2015-06-09 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression...

journal_title：Scientific reports

authors： Fu XL,Liu DJ,Yan TT,Yang JY,Yang MW,Li J,Huo YM,Liu W,Zhang JF,Hong J,Hua R,Chen HY,Sun YW

更新日期：2016-09-15 00:00:00

abstract：:It is well known that tumour-associated macrophages (TAMs) play an important role in tumour development by modulating the tumour microenvironment, and targeting of protumour activation or the M2 polarization of TAMs is expected to be an effective therapy for cancer patients. We previously demonstrated that onionin A (...

journal_title：Scientific reports

authors： Tsuboki J,Fujiwara Y,Horlad H,Shiraishi D,Nohara T,Tayama S,Motohara T,Saito Y,Ikeda T,Takaishi K,Tashiro H,Yonemoto Y,Katabuchi H,Takeya M,Komohara Y

更新日期：2016-07-12 00:00:00

abstract：:Porcine reproductive and respiratory syndrome virus (PRRSV) activates NF-κB during infection. We examined the ability of all 22 PRRSV genes for NF-κB regulation and determined the nucleocapsid (N) protein as the NF-κB activator. Protein inhibitor of activated STAT1 (signal transducer and activator of transcription 1) ...

journal_title：Scientific reports

authors： Ke H,Lee S,Kim J,Liu HC,Yoo D

更新日期：2019-07-30 00:00:00

abstract：:Knowledge of the ecology of N2-fixing (diazotrophic) plankton is mainly limited to oligotrophic (sub)tropical oceans. However, diazotrophs are widely distributed and active throughout the global ocean. Likewise, relatively little is known about the temporal dynamics of diazotrophs in productive areas. Between February...

journal_title：Scientific reports

authors： Moreira-Coello V,Mouriño-Carballido B,Marañón E,Fernández-Carrera A,Bode A,Sintes E,Zehr JP,Turk-Kubo K,Varela MM

更新日期：2019-03-06 00:00:00

abstract：:This study investigates the immune responses induced by metal-filled single-walled carbon nanotubes (SWCNT) under in vitro, ex vivo and in vivo settings. Either empty amino-functionalized CNTs [SWCNT-NH2 (1)] or samarium chloride-filled amino-functionalized CNTs with [SmCl3@SWCNT-mAb (3)] or without [SmCl3@SWCNT-NH2 (...

journal_title：Scientific reports

authors： Perez Ruiz de Garibay A,Spinato C,Klippstein R,Bourgognon M,Martincic M,Pach E,Ballesteros B,Ménard-Moyon C,Al-Jamal KT,Tobias G,Bianco A

更新日期：2017-02-15 00:00:00

abstract：:This study proposes a new method of visualizing the ambient dose rate distribution using artificial neural networks (ANNs) from airborne radiation monitoring results. The method was applied to the results of the airborne radiation monitoring which was conducted around the Fukushima Daiichi Nuclear Power Plant by an un...

journal_title：Scientific reports

authors： Sasaki M,Sanada Y,Katengeza EW,Yamamoto A

更新日期：2021-01-20 00:00:00

abstract：:Although large populations feel fatigue, the standardized medicinal therapy is currently absent. In this study, we determined whether 5-aminolevulinic acid (5-ALA) supplementation alleviates the feeling of fatigue in healthy subjects who feel chronic physical tiredness. Males and females between ages of 20 and 64 who ...

journal_title：Scientific reports

authors： Higashikawa F,Kanno K,Ogata A,Sugiyama M

更新日期：2020-09-29 00:00:00

abstract：:Irreversible electroporation (IRE) is a non-thermal ablation modality that has been shown to be safe and effective in its application to tumors that are close to risky areas. This study aims to assess the safety and efficacy of IRE for unresectable hilar cholangiocarcinoma. Nine patients from two medical centers in As...

journal_title：Scientific reports

authors： Hsiao CY,Yang PC,Li X,Huang KW

更新日期：2020-07-02 00:00:00