G6Pase location in the endoplasmic reticulum: Implications on compartmental analysis of FDG uptake in cancer cells.

abstract：:The Thoroughbred horse has played an important role in both sporting and economic aspects of society since the establishment of the breed in the 1700s. The extensive pedigree and phenotypic information available for the Thoroughbred horse population provides a unique opportunity to examine the effects of 300 years of ...

journal_title：Scientific reports

authors： Todd ET,Ho SYW,Thomson PC,Ang RA,Velie BD,Hamilton NA

更新日期：2018-04-18 00:00:00

abstract：:Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained co...

journal_title：Scientific reports

authors： Supervie V,Barrett M,Kahn JS,Musuka G,Moeti TL,Busang L,Blower S

更新日期：2011-01-01 00:00:00

abstract：:Inflammatory processes have been implicated in the pathogenesis of Parkinson's disease (PD), including the development of PD-associated cognitive impairment. Whether genetic variants of inflammatory cytokine genes influence the risk of cognitive impairment in PD is unknown. In this study, we investigated single nucleo...

journal_title：Scientific reports

authors： Liu Z,Guo J,Wang Y,Li K,Kang J,Wei Y,Sun Q,Xu Q,Xu C,Yan X,Tang B

更新日期：2016-02-02 00:00:00

abstract：:The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis c...

journal_title：Scientific reports

authors： Chang HH,Chang YK,Lu CW,Huang CT,Chien CT,Hung KY,Huang KC,Hsu CC

更新日期：2016-02-23 00:00:00

abstract：:Maximal rate of heart rate (HR) increase (rHRI) as a measure of HR acceleration during the transition from rest to exercise, or during an increase in workload, tracks exercise performance. rHRI assessed at relative rather than absolute workloads may track performance better, and a field test would increase applicabili...

journal_title：Scientific reports

authors： Bellenger CR,Thomson RL,Robertson EY,Davison K,Nelson MJ,Karavirta L,Buckley JD

更新日期：2020-09-03 00:00:00

abstract：:Based on the electric rotating magnetoresistance method, the shape anisotropy of a Co microstrip has been systematically investigated. We find that the shape anisotropy is dependent not only on the shape itself, but also on the magnetization distribution controlled by an applied magnetic field. Together with micro-mag...

journal_title：Scientific reports

authors： Fan X,Zhou H,Rao J,Zhao X,Zhao J,Zhang F,Xue D

更新日期：2015-11-13 00:00:00

abstract：:Male infertility is a worldwide medical problem. Asthenozoospermia is a common cause of infertility. Epigenetic modifications of DNA and histones have been shown to influence human infertility, but no research has explored whether N(6)-methyladenosine (m(6)A) level in RNA is associated with asthenozoospermia. Here, we...

journal_title：Scientific reports

authors： Yang Y,Huang W,Huang JT,Shen F,Xiong J,Yuan EF,Qin SS,Zhang M,Feng YQ,Yuan BF,Liu SM

更新日期：2016-04-13 00:00:00

abstract：:Biological armors such as mollusk shells have long been recognized and studied for their values in inspiring novel designs of engineering materials with higher toughness and strength. However, no material is invincible and biological armors also have their rivals. In this paper, our attention is focused on the teeth o...

journal_title：Scientific reports

authors： Fu J,He C,Xia B,Li Y,Feng Q,Yin Q,Shi X,Feng X,Wang H,Yao H

更新日期：2016-03-22 00:00:00

abstract：:Mechanical function of the heart during open-chest cardiac surgery is exclusively monitored by echocardiographic techniques. However, little is known about local kinematics, particularly for the reperfused regions after ischemic events. We report a novel imaging modality, which extracts local and global kinematic para...

journal_title：Scientific reports

authors： Fassina L,Rozzi G,Rossi S,Scacchi S,Galetti M,Lo Muzio FP,Del Bianco F,Colli Franzone P,Petrilli G,Faggian G,Miragoli M

更新日期：2017-04-11 00:00:00

abstract：:Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLC...

journal_title：Scientific reports

authors： Dinh TA,Vitucci EC,Wauthier E,Graham RP,Pitman WA,Oikawa T,Chen M,Silva GO,Greene KG,Torbenson MS,Reid LM,Sethupathy P

更新日期：2017-03-17 00:00:00

abstract：:In this article, the interaction between bovine serum albumin (BSA) and the cationic 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) at the air-buffer interface was investigated at different subphase's pH values (pH = 3, 5 and 10). Surface pressure measurements (π - A) and penetration kinetics process (π - t) were ca...

journal_title：Scientific reports

authors： Xu G,Hao C,Zhang L,Sun R

更新日期：2018-01-10 00:00:00

abstract：:The implementation of HTS (high-throughput sequencing) approaches is rapidly changing our understanding of the lichen symbiosis, by uncovering high bacterial and fungal diversity, which is often host-specific. Recently, HTS methods revealed the presence of multiple photobionts inside a single thallus in several lichen...

journal_title：Scientific reports

authors： Paul F,Otte J,Schmitt I,Dal Grande F

更新日期：2018-06-05 00:00:00

abstract：:Many basic properties of the T-cell receptor (TCR) repertoire require clarification, and the changes occurring in the TCR repertoire during carcinogenesis, especially during precancerous stages, remain unclear. This study used deep sequencing analyses to examine 41 gastric tissue samples at different pathological stag...

journal_title：Scientific reports

authors： Kuang M,Cheng J,Zhang C,Feng L,Xu X,Zhang Y,Zu M,Cui J,Yu H,Zhang K,Yang A,Cheng S

更新日期：2017-08-10 00:00:00

abstract：:While implicated in therapeutic resistance, malignant progenitor cell cycle kinetics have been difficult to quantify in real-time. We developed an efficient lentiviral bicistronic fluorescent, ubiquitination-based cell cycle indicator reporter (Fucci2BL) to image live single progenitors on a defined niche coupled with...

journal_title：Scientific reports

authors： Pineda G,Lennon KM,Delos Santos NP,Lambert-Fliszar F,Riso GL,Lazzari E,Marra MA,Morris S,Sakaue-Sawano A,Miyawaki A,Jamieson CH

更新日期：2016-04-04 00:00:00

abstract：:The salmon louse is an ectoparasitic copepod of salmonids in the marine environment, and represents a global challenge to salmon aquaculture. A major issue is the reliance of the industry on a limited number of chemicals to delouse salmonids on farms, and the high levels of resistance that lice have developed to all o...

journal_title：Scientific reports

authors： Kaur K,Besnier F,Glover KA,Nilsen F,Aspehaug VT,Fjørtoft HB,Horsberg TE

更新日期：2017-09-27 00:00:00

abstract：:The current research on cellular heat stress management focuses on the roles of heat shock proteins (HSPs) and the proteostasis network under severe stress conditions. The mild, fever-type stress and the maintenance of membrane homeostasis are less well understood. Herein, we characterized the acute effect of mild, fe...

journal_title：Scientific reports

authors： Peksel B,Gombos I,Péter M,Vigh L Jr,Tiszlavicz Á,Brameshuber M,Balogh G,Schütz GJ,Horváth I,Vigh L,Török Z

更新日期：2017-11-15 00:00:00

abstract：:III-nitride materials have been linked with a vast number of exciting applications from power electronics to solar cells. Herein, polycrystalline InN, GaN and systematically controlled InxGa1-xN composite thin films are fabricated on FTO glass by a facile, low-cost and scalable aerosol assisted chemical vapor depositi...

journal_title：Scientific reports

authors： McInnes A,Sagu JS,Mehta D,Wijayantha KGU

更新日期：2019-02-19 00:00:00

abstract：:Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of these lines with their other properties. The analysis revealed a r...

journal_title：Scientific reports

authors： Zielinski DC,Jamshidi N,Corbett AJ,Bordbar A,Thomas A,Palsson BO

更新日期：2017-01-25 00:00:00

abstract：:Duck Tembusu virus (DTMUV), a mosquito-borne Flavivirus, has caused serious economic losses for the Chinese poultry industry. The genome is translated into a polyprotein that is cleaved to mature protein by host and viral proteases in the host cell, and this proteolytic process is important for the viral life cycle. H...

journal_title：Scientific reports

authors： Jiang B,Zhang W,Wu Y,Wang T,Wang M,Jia R,Zhu D,Liu M,Zhao X,Yang Q,Wu Y,Zhang S,Liu Y,Zhang L,Yu Y,Pan L,Chen S,Cheng A

更新日期：2020-07-24 00:00:00

abstract：:Sunitinib (ST), a multitargeted receptor tyrosine kinase inhibitor, has been demonstrated to be effective for the treatment of renal carcinoma. It has been reported that ST is involved in the mediation of autophagy; however, its regulatory role in the autophagic process remains controversial. Furthermore, the mechanis...

journal_title：Scientific reports

authors： Hou B,Wang G,Gao Q,Wei Y,Zhang C,Wang Y,Huo Y,Yang H,Jiang X,Xi Z

更新日期：2019-07-31 00:00:00

abstract：:We introduce a polarization-resolved terahertz time-domain spectrometer with a broadband (0.3-2.5 THz), rotatable THz polarization state, and which exhibits minimal change in the electric field amplitude and polarization state upon rotation. This was achieved by rotating an interdigitated photoconductive emitter, and ...

journal_title：Scientific reports

authors： Mosley CDW,Failla M,Prabhakaran D,Lloyd-Hughes J

更新日期：2017-09-26 00:00:00

abstract：:Isolated lung perfusion (ILP) is an ideal model to study treatment effects on a variety of pathologies. As published research mostly relies on rejected donor lungs or animal organs, this study investigates the use of surgically resected human lobes as an alternative and novel model for personalized experimental resear...

journal_title：Scientific reports

authors： Slama A,Raber C,Hedderich C,Stockhammer P,Hegedüs B,Koch A,Theegarten D,Ploenes T,Aigner C

更新日期：2019-08-21 00:00:00

abstract：:Increasing evidence indicates that static magnetic fields (SMF) reduce cortical activity in both human and animal models. The aim of this work was to investigate the effect of SMF on epileptiform cortical activity, a condition related to an abnormal increase in neuronal excitability. The first experimental block inclu...

journal_title：Scientific reports

authors： Rivadulla C,Aguilar J,Coletti M,Aguila J,Prieto S,Cudeiro J

更新日期：2018-10-30 00:00:00

abstract：:Alcohol consumption is one of the major causes of hepatic steatosis, fibrosis, cirrhosis, and superimposed hepatocellular carcinoma. Ethanol metabolism alters the NAD(+)/NADH ratio, thereby suppressing the activity of sirtuin family proteins, which may affect lipid metabolism in liver cells. However, it is not clear h...

journal_title：Scientific reports

authors： Yu JH,Song SJ,Kim A,Choi Y,Seok JW,Kim HJ,Lee YJ,Lee KS,Kim JW

更新日期：2016-07-11 00:00:00

abstract：:Vaccine platforms that can be flexibly loaded with antigens can contribute to decrease response time to emerging infections. For many pathogens and chronic infections, induction of a robust cytotoxic T lymphocytes-mediated response is desirable to control infection. Antigen delivery into the cytoplasm of antigen prese...

journal_title：Scientific reports

authors： Akhras S,Toda M,Boller K,Himmelsbach K,Elgner F,Biehl M,Scheurer S,Gratz M,Vieths S,Hildt E

更新日期：2017-08-29 00:00:00

abstract：:In the aftermath of the financial crisis of 2007-2009, the growing body of literature on financial networks has widely documented the predictive power of topological characteristics (e.g., degree centrality measures) to explain the systemic impact or systemic exposure of financial institutions. This study shows that c...

journal_title：Scientific reports

authors： Gandica Y,Béreau S,Gnabo JY

更新日期：2020-10-19 00:00:00

abstract：:Alterations in the gut microbiota play a crucial role in host physiology and metabolism; however, the molecular pathways underlying these changes in diet-induced obesity are unclear. Mechanistic target of rapamycin (mTOR) signaling pathway is associated with metabolic disorders such as obesity and type 2 diabetes (T2D...

journal_title：Scientific reports

authors： Jung MJ,Lee J,Shin NR,Kim MS,Hyun DW,Yun JH,Kim PS,Whon TW,Bae JW

更新日期：2016-07-29 00:00:00

abstract：:This study aimed to investigate the basilar artery (BA) geometric changes in a longitudinal study. 154 subjects with normal vertebrobasilar arterial systems on magnetic resonance angiography were assigned into two groups: 1) non-dominant vertebral artery (VA) and 2) VA dominance. We defined the dominant VA as either t...

journal_title：Scientific reports

authors： Ngo MT,Kwak HS,Chung GH

更新日期：2020-06-01 00:00:00

abstract：:Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle plasticity and contraction strength. These changes in the mechanical properties of the affected muscle render surgical repair of RCT highly fo...

journal_title：Scientific reports

authors： Shirasawa H,Matsumura N,Shimoda M,Oki S,Yoda M,Tohmonda T,Kanai Y,Matsumoto M,Nakamura M,Horiuchi K

更新日期：2017-01-31 00:00:00

abstract：:New vaccine production technologies can significantly shorten the timelines for availability of a strain-specific vaccine in the event of an influenza pandemic. We sought to evaluate the potential benefits of early vaccination in reducing the clinical attack rate (CAR), taking into account the timing and speed of vacc...

journal_title：Scientific reports

authors： Champredon D,Laskowski M,Charland N,Moghadas SM

更新日期：2018-04-24 00:00:00