Abstract：
:The Thoroughbred horse has played an important role in both sporting and economic aspects of society since the establishment of the breed in the 1700s. The extensive pedigree and phenotypic information available for the Thoroughbred horse population provides a unique opportunity to examine the effects of 300 years of selective breeding on genetic load. By analysing the relationship between inbreeding and racing performance of 135,572 individuals, we found that selective breeding has not efficiently alleviated the Australian Thoroughbred population of its genetic load. However, we found evidence for purging in the population that might have improved racing performance over time. Over 80% of inbreeding in the contemporary population is accounted for by a small number of ancestors from the foundation of the breed. Inbreeding to these ancestors has variable effects on fitness, demonstrating that an understanding of the distribution of genetic load is important in improving the phenotypic value of a population in the future. Our findings hold value not only for Thoroughbred and other domestic breeds, but also for small and endangered populations where such comprehensive information is not available.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Todd ET,Ho SYW,Thomson PC,Ang RA,Velie BD,Hamilton NAdoi
10.1038/s41598-018-24663-xsubject
Has Abstractpub_date
2018-04-18 00:00:00pages
6167issue
1issn
2045-2322pii
10.1038/s41598-018-24663-xjournal_volume
8pub_type
杂志文章abstract：:Stochastic surface patterns form an important requirement to facilitate digital image correlation and to subsequently quantify material properties of various tissues when loaded and deformed without artefacts arising from material slippage. Depending on the samples' natural colour, a surface pattern is created by spec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77299-1
更新日期：2020-11-27 00:00:00
abstract：:We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26217-7
更新日期：2018-05-21 00:00:00
abstract：:Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents a significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed as a novel approach for human vocal cords oxidative metabolism detection and a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16807-2
更新日期：2017-12-05 00:00:00
abstract：:Understanding the rhizodeposited carbon (C) dynamics of winter wheat (Triticum aestivum L.), is crucial for soil fertility and C sequestration. Pot-grown winter wheat was pulse labelled with 14CO2 at the key growth stages. 14C in the shoots, roots and soil was measured at 5 or 2 days after 14C-labelling (DAL 5/2) at e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21547-y
更新日期：2018-02-16 00:00:00
abstract：:Heart rate variability (HRV) analyses can be performed using group or individual changes. Individual changes could be of potential interest during training camps for national soccer teams. The purpose of this study was to compare whether analysis of individual daily HRV could detect changes in cardiac autonomic respon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68698-5
更新日期：2020-07-16 00:00:00
abstract：:Information spreading in complex networks is often modeled as diffusing information with certain probability from nodes that possess it to their neighbors that do not. Information cascades are triggered when the activation of a set of initial nodes - seeds - results in diffusion to large number of nodes. Here, several...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00937-8
更新日期：2017-04-18 00:00:00
abstract：:Studies in mice suggest that early life represents a critical time window, where antibiotics may exert profound and lasting effects on the gut microbiota and metabolism. We aimed to test the hypothesis that prenatal antibiotic exposure is associated with increased risk of childhood overweight in a population-based coh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48065-9
更新日期：2019-08-08 00:00:00
abstract：:Exposure to silica can cause lung fibrosis and cancer. Identification of molecular targets is important for the intervention and/or prevention of silica-induced lung diseases. Telomeres consist of tandem repeats of DNA sequences at the end of chromosomes, preventing chromosomal fusion and degradation. Regulator of tel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17645-y
更新日期：2017-12-11 00:00:00
abstract：:Changes in immune and coagulation systems and possible viral spread through the blood-brain barrier have been described in SARS-CoV-2 infection. In this study, we evaluated the possible retinal involvement and ocular findings in severe COVID-19 pneumonia patients. A cross-sectional study was conducted on 46 patients a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74446-6
更新日期：2020-10-15 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep44888. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46881
更新日期：2017-08-29 00:00:00
abstract：:Low intensity transcranial focused ultrasound (LIFU) is a promising method of non-invasive neuromodulation that uses mechanical energy to affect neuronal excitability. LIFU confers high spatial resolution and adjustable focal lengths for precise neuromodulation of discrete regions in the human brain. Before the full p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62265-8
更新日期：2020-03-27 00:00:00
abstract：:The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV's neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in preclinical models, particular...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00193-w
更新日期：2017-03-21 00:00:00
abstract：:Coordination polymerization leads to various metal-organic frameworks (MOFs) with unique physical properties and chemical functionalities. One of the challenges towards their applications as porous materials is to make MOFs optimally conductive to be used as electronic components. Here, it is demonstrated that Co-MOF-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02618-y
更新日期：2017-05-26 00:00:00
abstract：:The sweetpotato whitefly Bemisia tabaci (Gennadius) was challenged with different combinations of matrine (insecticide) and Lecanicillium muscarium (entomopathogenic fungus). Our results revealed a synergistic relationship between matrine and L. muscarium on mortality and enzyme activities of B. tabaci. To illustrate ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46558
更新日期：2017-04-20 00:00:00
abstract：:Loss of anorectal resting pressure due to internal anal sphincter (IAS) dysfunctionality causes uncontrolled fecal soiling and leads to passive fecal incontinence (FI). The study is focused on immediate and long-term safety and potential efficacy of bioengineered IAS BioSphincters to treat passive FI in a clinically r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54440-3
更新日期：2019-12-02 00:00:00
abstract：:MicroRNAs can promote translation of specific mRNAs in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes. We report that microRNA-mediated upregulation of target mRNAs in oocytes is dependent on nuclear entry of the microRNA; cytoplasmically-injected microRNA repress target mRNAs. Components of the ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00842
更新日期：2012-01-01 00:00:00
abstract：:We theoretically investigate the problem of finding optimal characteristics of photon pairs, produced in the spontaneous parametric down-conversion (SPDC) process, for fiber-based quantum communication protocols. By using the accessible setup parameters, the pump pulse duration and the extended phase-matching function...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77662-2
更新日期：2020-11-30 00:00:00
abstract：:The graft-versus-leukemia effect reminds us to observe the allogeneic cell elicited anti-tumor immune responses. Here we immunized recipient B6 mice with different types of allogenic leukocytes and found that vaccination with allogenic dendritic cells (alloDC) elicited the most efficient protection against broad-spect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52151-3
更新日期：2019-10-29 00:00:00
abstract：:Genetic polymorphisms in drug metabolizing enzymes and drug transporters may affect irinotecan toxicity. Although genetic polymorphisms have been shown to influence the irinotecan toxicity, data are limited in Thai population. Thus, the aim of this study was to assess the allele and genotype frequencies and the relati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70351-0
更新日期：2020-08-10 00:00:00
abstract：:We have developed a framework to convert an arbitrary integer factorization problem to an executable Ising model by first writing it as an optimization function then transforming the k-bit coupling (k ≥ 3) terms to quadratic terms using ancillary variables. Our resource-efficient method uses [Formula: see text] binary...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36058-z
更新日期：2018-12-05 00:00:00
abstract：:The 1111-type iron-based superconductor LnFeAsO(1-x)Fx (Ln stands for lanthanide) is the first material with a Tc above 50 K, other than cuprate superconductors. Electron doping into LaFeAsO by H, rather than F, revealed a double-dome-shaped Tc-x diagram, with a first dome (SC1, 0.05 journal_title：Scientific reports pub_type： 杂志文章 doi：10.1038/srep07829 更新日期：2015-01-16 00:00:00
abstract：:The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for the therapy of different malignant conditions, but not yet for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated the expression of PD-1 and PD-L1...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-018-36129-1
更新日期：2018-12-13 00:00:00
abstract：:Sixty-six million years ago, an asteroid approximately 9 km in diameter hit the hydrocarbon- and sulfur-rich sedimentary rocks in what is now Mexico. Recent studies have shown that this impact at the Yucatan Peninsula heated the hydrocarbon and sulfur in these rocks, forming stratospheric soot and sulfate aerosols and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14199-x
更新日期：2017-11-09 00:00:00
abstract：:A classic example of solid-state topochemical reactions is the ultraviolet-light induced photodimerization of α-trans-cinnamic acid (CA). Here, we report the first observation of an X-ray-induced dimerization of CA and monitor it in situ using nonresonant inelastic X-ray scattering spectroscopy (NRIXS). The time-evolu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15851
更新日期：2015-11-16 00:00:00
abstract：:PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28890
更新日期：2016-07-04 00:00:00
abstract：:Scrapie is a lethal neurodegenerative disease of sheep and goats caused by the misfolding of the prion protein. Variants such as M142, D145, S146, H154, Q211, and K222 were experimentally found to increase resistance or extend scrapie incubation period in goats. We aimed to identify polymorphisms in the Afar and Arsi-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63874-z
更新日期：2020-04-24 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42527-w
更新日期：2019-04-12 00:00:00
abstract：:The Synlestidae (Odonata: Zygoptera) of southern Africa comprise some highly localized species. All but one species are endemic to South Africa, and many to the Cape Floristic Region. Here we present the first phylogenetic reconstruction of the southern African Synlestidae using nuclear and mitochondrial molecular dat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72001-x
更新日期：2020-09-15 00:00:00
abstract：:Current knowledge about the overall and site-specific risk of malignancy associated with ankylosing spondylitis (AS) is inconsistent. We conducted a systematic review and meta-analysis to address this knowledge gap. Five databases (PubMed, EMBASE, Web of Science, the Cochrane library and the virtual health library) we...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep32063
更新日期：2016-08-18 00:00:00
abstract：:MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03148-3
更新日期：2017-06-06 00:00:00
