Effect of drug metabolizing enzymes and transporters in Thai colorectal cancer patients treated with irinotecan-based chemotherapy.

abstract：:The lack of a precisely-dated, unequivocal climate proxy from northern China, where precipitation variability is traditionally considered as an East Asian summer monsoon (EASM) indicator, impedes our understanding of the behaviour and dynamics of the EASM. Here we present a well-dated, pollen-based, ~20-yr-resolution ...

journal_title：Scientific reports

authors： Chen F,Xu Q,Chen J,Birks HJ,Liu J,Zhang S,Jin L,An C,Telford RJ,Cao X,Wang Z,Zhang X,Selvaraj K,Lu H,Li Y,Zheng Z,Wang H,Zhou A,Dong G,Zhang J,Huang X,Bloemendal J,Rao Z

更新日期：2015-06-18 00:00:00

abstract：:In this work, photoacoustic eigen-spectrum analysis was proposed for noninvasively characterizing the mechanical properties of materials. We theoretically predicted the relationship between the photoacoustic eigen-spectra of cylindrical optical absorbers and their mechanical properties. Experimental measurements of ei...

journal_title：Scientific reports

authors： Gao X,Tao C,Zhu R,Liu X

更新日期：2018-05-17 00:00:00

abstract：:Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painful syndromes TRPM8 a...

journal_title：Scientific reports

authors： Beccari AR,Gemei M,Lo Monte M,Menegatti N,Fanton M,Pedretti A,Bovolenta S,Nucci C,Molteni A,Rossignoli A,Brandolini L,Taddei A,Za L,Liberati C,Vistoli G

更新日期：2017-09-08 00:00:00

abstract：:The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than ERα under similar ...

journal_title：Scientific reports

authors： Souza PCT,Textor LC,Melo DC,Nascimento AS,Skaf MS,Polikarpov I

更新日期：2017-06-14 00:00:00

abstract：:Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of ~100 nm. Here, the vascular distribution of spherical particles, from 10 to 1,000 nm in diameter, is studied using intravital microscopy and com...

journal_title：Scientific reports

authors： Lee TR,Choi M,Kopacz AM,Yun SH,Liu WK,Decuzzi P

更新日期：2013-01-01 00:00:00

abstract：:Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day...

journal_title：Scientific reports

authors： Ojha A,Nandi D,Batra H,Singhal R,Annarapu GK,Bhattacharyya S,Seth T,Dar L,Medigeshi GR,Vrati S,Vikram NK,Guchhait P

更新日期：2017-01-31 00:00:00

abstract：:The function of Latexin (LXN) in inflammation has attracted attention. However, no data are available regarding its role in colitis. We report that LXN is a suppressor of colitis. LXN deficiency leads to the severity of colitis in DSS-induced mice, and LXN is required for the therapeutic effect of retinoic acid on col...

journal_title：Scientific reports

authors： Li Y,Huang B,Yang H,Kan S,Yao Y,Liu X,Pu S,He G,Khan TM,Qi G,Zhou Z,Shu W,Chen M

更新日期：2020-06-17 00:00:00

abstract：:The Longwangzhuang pluton is a typical example of Paleoproterozoic A-type granite intrusions at the southern margin of the North China Craton. This pluton is composed of arfvedsonite granite and minor aegirine-augite granites. Samples from both granite types display similar zircon U-Pb ages with 207U-206Pb ages of 161...

journal_title：Scientific reports

authors： Wang Y,Yang YZ,Siebel W,Zhang H,Zhang YS,Chen F

更新日期：2020-01-09 00:00:00

abstract：:Glioblastoma (grade IV glioma) is the most common and aggressive adult brain tumor. A better understanding of the biology of glioblastoma cells is crucial to identify molecular targets stimulating cell death. NPM1 (nucleophosmin) is a multifunctional chaperone that plays an important role in cancer development. Herein...

journal_title：Scientific reports

authors： Holmberg Olausson K,Elsir T,Moazemi Goudarzi K,Nistér M,Lindström MS

更新日期：2015-11-12 00:00:00

abstract：:The modifier protein, ubiquitin (Ub) regulates various cellular pathways by controlling the fate of substrates to which it is conjugated. Ub moieties are also conjugated to each other, forming chains of various topologies. In cells, poly-Ub is attached to proteins and also exists in unanchored form. Accumulation of un...

journal_title：Scientific reports

authors： Blount JR,Libohova K,Marsh GB,Sutton JR,Todi SV

更新日期：2018-05-31 00:00:00

abstract：:It is unclear whether N-acetylaspartate (NAA) depletions documented in schizophrenia patients might be due to the disease progression or medications. Here we investigated longitudinal NAA changes in drug-naïve first-episode patients (FEP) who are relatively free from chronicity. Forty-two drug-naïve FEP and 38 control...

journal_title：Scientific reports

authors： Zong X,Hu M,Li Z,Cao H,He Y,Liao Y,Zhou J,Sang D,Zhao H,Tang J,Lv L,Chen X

更新日期：2015-03-16 00:00:00

abstract：:Two novel species of the fungal genus Ochroconis, O. lascauxensis and O. anomala have been isolated from the walls of the Lascaux Cave, France. The interest in these fungi and their melanins lies in the formation of black stains on the walls and rock art which threatens the integrity of the paintings. Here we report s...

journal_title：Scientific reports

authors： De la Rosa JM,Martin-Sanchez PM,Sanchez-Cortes S,Hermosin B,Knicker H,Saiz-Jimenez C

更新日期：2017-10-18 00:00:00

abstract：:The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 200...

journal_title：Scientific reports

authors： Yi SW,Park S,Lee YH,Park HJ,Balkau B,Yi JJ

更新日期：2017-08-15 00:00:00

abstract：:A two-dimensional (2D) material placed on an atomically flat substrate can lead to the formation of surface nanobubbles trapping different types of substances. In this paper graphene nanobubbles of the radius of 7-34 nm with argon atoms inside are studied using molecular dynamics (MD). All modeled graphene nanobubbles...

journal_title：Scientific reports

authors： Iakovlev E,Zhilyaev P,Akhatov I

更新日期：2017-12-20 00:00:00

abstract：:The P2X receptor family of ATP-gated cation channels are attractive drug targets for pain and inflammatory disease, but no subtype-selective agonists, and few partially selective agonists have been described to date. As proof-of-concept for the discovery of novel P2X receptor agonists, here we demonstrate the use of D...

journal_title：Scientific reports

authors： Grimes L,Griffiths J,Pasqualetto G,Brancale A,Kemp PJ,Young MT,van der Goes van Naters W

更新日期：2020-05-19 00:00:00

abstract：:The corneal endothelium is essential for maintaining corneal transparency; therefore, corneal endothelial dysfunction causes serious vision loss. Tissue engineering-based therapy is potentially a less invasive and more effective therapeutic modality. We recently started a first-in-man clinical trial of cell-based ther...

journal_title：Scientific reports

authors： Okumura N,Kusakabe A,Hirano H,Inoue R,Okazaki Y,Nakano S,Kinoshita S,Koizumi N

更新日期：2015-10-07 00:00:00

abstract：:Globally breast cancer is the leading cause of cancer death among women. The breast consists of epithelium, stroma and a mucosal immune system that make up a complex microenvironment. Growing awareness of the role of microbes in the microenvironment recently has led to a series of findings important for human health. ...

journal_title：Scientific reports

authors： Hieken TJ,Chen J,Hoskin TL,Walther-Antonio M,Johnson S,Ramaker S,Xiao J,Radisky DC,Knutson KL,Kalari KR,Yao JZ,Baddour LM,Chia N,Degnim AC

更新日期：2016-08-03 00:00:00

abstract：:Natural sensory signals have nonlinear structures dynamically composed of the carrier frequencies and the variation of the amplitude (i.e., envelope). How the human brain processes the envelope information is still poorly understood, largely due to the conventional analysis failing to quantify it directly. Here, we us...

journal_title：Scientific reports

authors： Nguyen KT,Liang WK,Lee V,Chang WS,Muggleton NG,Yeh JR,Huang NE,Juan CH

更新日期：2019-11-15 00:00:00

abstract：:In order to design a painless and mechanically durable micro syringe-needle system for biomedical applications, the study of insect stingers is of interest because of their elegant structures and functionalities. In the present work, the structure, mechanical properties and the mechanical behavior during insertion of ...

journal_title：Scientific reports

authors： Das R,Yadav RN,Sihota P,Uniyal P,Kumar N,Bhushan B

更新日期：2018-10-08 00:00:00

abstract：:Soil respiration (Rs) is an important source of atmospheric CO2 flux and is sensitive to changes in soil nutrient and water contents. Despite extensive studies on the effects of enhanced atmospheric nitrogen (N) deposition and changes in precipitation (P) on Rs, few studies have taken into account the effects of inter...

journal_title：Scientific reports

authors： Li C,Peng Y,Nie X,Yang Y,Yang L,Li F,Fang K,Xiao Y,Zhou G

更新日期：2018-11-08 00:00:00

abstract：:Transmembrane flux of Cs+ (a K+ congener) was measured in human red blood cells (RBCs; erythrocytes) on the 10-s time scale. This is the first report on dissolution dynamic nuclear polarization (dDNP) nuclear magnetic resonance (NMR) spectroscopy with this nuclide in mammalian cells. Four technical developments regula...

journal_title：Scientific reports

authors： Kuchel PW,Karlsson M,Lerche MH,Shishmarev D,Ardenkjaer-Larsen JH

更新日期：2019-12-23 00:00:00

abstract：:The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial in...

journal_title：Scientific reports

authors： Li L,Tang Q,Nakamura T,Suh JG,Ohshima H,Jung HS

更新日期：2016-11-28 00:00:00

abstract：:Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established. Although some preventive options are being reported, therapeutic options are still scarce and in...

journal_title：Scientific reports

authors： Nono JK,Fu K,Mpotje T,Varrone G,Aziz NA,Mosala P,Hlaka L,Kamdem SD,Xu D,Spangenberg T,Brombacher F

更新日期：2020-06-30 00:00:00

abstract：:Aluminum-based quasicrystals typically form across narrow composition ranges within binary to quaternary alloys, which makes their fabrication and characterization challenging. Here, we use combinatorial approaches together with fast characterization techniques to study a wide compositional range including known quasi...

journal_title：Scientific reports

authors： Wolf W,Kube SA,Sohn S,Xie Y,Cha JJ,Scanley BE,Kiminami CS,Bolfarini C,Botta WJ,Schroers J

更新日期：2019-05-09 00:00:00

abstract：:An antiferromagnetic topological insulator has been predicted to be preserved by breaking both time-reversal symmetry and primitive lattice translational symmetry. However, the topological surface state has often been observed to disappear in an antiferromagnetic phase because the doped magnetic impurity acts as an ex...

journal_title：Scientific reports

authors： Jun JH,Kim J,Kim SW,Jung MH

更新日期：2020-06-15 00:00:00

abstract：:Alterations in muscle milieu are suggested as important activity of peripheral drive in patients with chronic musculoskeletal pain (CMP). Microdialysis (MD) has been used in monitoring altered metabolic response pattern in muscles. However, the insertion of MD probe causes a local tissue trauma. Whether and how metabo...

journal_title：Scientific reports

authors： Sørensen LB,Gazerani P,Wåhlén K,Ghafouri N,Gerdle B,Ghafouri B

更新日期：2018-02-14 00:00:00

abstract：:Lipopolysaccharide (LPS) is a major component of the outer wall of gram negative bacteria. In high doses LPS contributes to the inflammation in gram negative sepsis, and in low doses contributes to the low grade inflammation characteristic of the metabolic syndrome. We wanted to assess the role of beta2-glycoprotein I...

journal_title：Scientific reports

authors： Zhou S,Chen G,Qi M,El-Assaad F,Wang Y,Dong S,Chen L,Yu D,Weaver JC,Beretov J,Krilis SA,Giannakopoulos B

更新日期：2016-09-27 00:00:00

abstract：:During recent military operations, eye-related injuries have risen in frequency due to increased use of explosive weaponry which often result in corneal puncture injuries. These have one of the poorest visual outcomes for wounded soldiers, often resulting in blindness due to the large variations in injury shape, size,...

journal_title：Scientific reports

authors： Snider EJ,Cornell LE,Acevedo JM,Gross B,Edsall PR,Lund BJ,Zamora DO

更新日期：2020-03-06 00:00:00

abstract：:The regulatory transcriptional factor PATZ1 is constantly downregulated in human thyroid cancer where it acts as a tumour suppressor by targeting p53-dependent genes involved in Epithelial-Mesenchymal Transition and cell migration. The aim of the present work was to elucidate the upstream signalling mechanisms regulat...

journal_title：Scientific reports

authors： Vitiello M,Valentino T,De Menna M,Crescenzi E,Francesca P,Rea D,Arra C,Fusco A,De Vita G,Cerchia L,Fedele M

更新日期：2016-04-29 00:00:00

abstract：:Clouds play a major role in the climate system, but large uncertainties remain about their decadal variations. Here we report a widespread decrease in cloud cover since the 1970 s over the Mediterranean region, in particular during the 1970 s-1980 s, especially in the central and eastern areas and during springtime. C...

journal_title：Scientific reports

authors： Sanchez-Lorenzo A,Enriquez-Alonso A,Calbó J,González JA,Wild M,Folini D,Norris JR,Vicente-Serrano SM

更新日期：2017-02-02 00:00:00