Abstract：
:Current knowledge about the overall and site-specific risk of malignancy associated with ankylosing spondylitis (AS) is inconsistent. We conducted a systematic review and meta-analysis to address this knowledge gap. Five databases (PubMed, EMBASE, Web of Science, the Cochrane library and the virtual health library) were systematically searched. A manual search of publications within the last 2 years in key journals in the field (Annals of the Rheumatic Diseases, Rheumatology and Arthritis &rheumatology) was also performed. STATA 11.2 software was used to conduct the meta-analysis. After screening, twenty-three studies, of different designs, were eligible for meta-analysis. AS is associated with a 14% (pooled RR 1.14; 95% CI 1.03-1.25) increase in the overall risk for malignancy. Compared to controls, patients with AS are at a specific increased risk for malignancy of the digestive system (pooled RR 1.20; 95% CI 1.01 to 1.42), multiple myelomas (pooled RR 1.92; 95% CI 1.37 to 3.69) and lymphomas (pooled RR 1.32; 95% CI 1.11 to 1.57). On subgroup analysis, evidence from high quality cohort studies indicated that AS patients from Asia are at highest risk for malignancy overall. Confirmation of findings from large-scale longitudinal studies is needed to identify specific risk factors and to evaluate treatment effects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Deng C,Li W,Fei Y,Li Y,Zhang Fdoi
10.1038/srep32063subject
Has Abstractpub_date
2016-08-18 00:00:00pages
32063issn
2045-2322pii
srep32063journal_volume
6pub_type
杂志文章,meta分析,评审abstract：:The Gulf of California, Mexico is home to many cetacean species, including a presumed resident population of fin whales, Balaenoptera physalus. Past studies reported very low levels of genetic diversity among Gulf of California fin whales and a significant level of genetic differentiation from con-specifics in the eas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48700-5
更新日期：2019-08-27 00:00:00
abstract：:The visual magnocellular system is thought to play a crucial role in learning to read. Here therefore, we examined whether magnocellular based training could improve reading in children with visual reading problems. The participants were 24 male primary school students aged between 9-11 (Mean = 9.76, SD = 0.59) with s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37753-7
更新日期：2019-02-04 00:00:00
abstract：:Lactose intolerance is a major concern driving the growth of lactose-free foods including lactose-free infant formula. It is unknown what the metabolic consequence is of consumption of a formula where lactose has been replaced with corn syrup solids (CSS). Here, a randomized double-blinded intervention study was condu...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-017-03975-4
更新日期：2017-06-16 00:00:00
abstract：:Sampling various compartments within the lower airways to examine human bronchial epithelial cells (HBEC) is essential for understanding numerous lung diseases. Conventional methods to identify HBEC in bronchoalveolar lavage (BAL) and wash (BW) have throughput limitations in terms of efficiency and ensuring adequate c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42214
更新日期：2017-02-06 00:00:00
abstract：:Pot experiments were carried out to study the effects of rice straw (RS) and rice straw ash (RSA) on the growth of early rice and α-diversity of bacterial community in soils around rare earth mining areas of Xunwu and Xinfeng counties in South Jiangxi of China. The results showed that the exploitation of rare earth re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67160-w
更新日期：2020-06-25 00:00:00
abstract：:The studies investigating the effects of green tea on blood pressure (BP) have generated inconsistent results. The aim of this study is to quantitatively evaluate the effects of green tea on BP control. PubMed, Embase, and the Cochrane Library (updated to March 2014) were searched for randomized controlled trials eval...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep06251
更新日期：2014-09-01 00:00:00
abstract：:It is well established that topographical features modulate cell behaviour, including cell morphology, proliferation and differentiation. To define the effects of topography on human induced pluripotent stem cells (iPSC), we plated cells on a topographical library containing over 1000 different features in medium lack...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18948
更新日期：2016-01-13 00:00:00
abstract：:Unlike the constant nature of elastic coefficients of isotropic bulk materials, the Young's (E) and shear (μ) moduli of nano-structured (NS) gyroid metamaterials change with relative density (ρ), but at different rates depending on the cell size of the structure. These elastic behaviors displayed by E and μ cause cros...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10978-8
更新日期：2017-09-05 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-65654-1
更新日期：2020-05-26 00:00:00
abstract：:Digital phase shifters have been applied in traditional phased array antennas to realize beam steering. However, the phase shifter deals with the phase of the induced current; hence, it has to be in the path of each element of the antenna array, making the phased array antennas very expensive. Metamaterials and/or met...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20663
更新日期：2016-02-10 00:00:00
abstract：:Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We conducted a cross-sectional anal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78493-x
更新日期：2020-12-09 00:00:00
abstract：:The killer toxin K1 is a virally encoded fungal A/B toxin acting by disrupting plasma membrane integrity. The connection of α and β constitutes a critical feature for toxin biology and for decades the formation of three disulphide bonds linking the major toxin subunits was accepted as status quo. Due to the absence of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49621-z
更新日期：2019-09-11 00:00:00
abstract：:This present paper was focused on the manufacture of activated carbon (AC) and its application in the electrokinetic remediation (EKR) technology on removal of the heavy metals (HMs) from the municipal solid waste incineration fly ash. AC was produced from Neosinocalamus affinis (NF) by chemical activation with H3PO4 ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39312
更新日期：2016-12-21 00:00:00
abstract：:Human African trypanosomiasis (sleeping sickness) is a neglected tropical disease caused by Trypanosoma brucei spp. The parasites are transmitted by tsetse flies and adapt to their different hosts and environments by undergoing a series of developmental changes. During differentiation, the trypanosome alters its prote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22451
更新日期：2016-03-02 00:00:00
abstract：:Patients with end stage renal disease (ESRD) suffer high mortality from arrhythmias linked to fibrosis, but are contraindicated to late gadolinium enhancement magnetic resonance imaging (MRI). We present a quantitative method for gadolinium-free cardiac fibrosis imaging using magnetization transfer (MT) weighted MRI, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35394-4
更新日期：2018-11-19 00:00:00
abstract：:The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35809
更新日期：2016-11-02 00:00:00
abstract：:To evaluate crop rotation effects on maize seedling performance and its associated microbiome, maize plants were grown in the greenhouse in soils preceded by either maize, pea, soybean or sunflower. Soils originated from a replicated field experiment evaluating different four-year rotation combinations. In the greenho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15955-9
更新日期：2017-11-16 00:00:00
abstract：:Fungal pathogens represent a significant threat to immunocompromised patients or individuals with traumatic injury. Strategies to efficiently remove fungal spores from hospital surfaces and, ideally, patient skin thus offer the prospect of dramatically reducing infections in at-risk patients. Photodynamic inactivation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05000-0
更新日期：2017-07-04 00:00:00
abstract：:The pine wood nematode, Bursaphelenchus xylophilus, is the causal agent of pine wilt disease that has devastated pine forests in Asia. Parasitic nematodes are known to have evolved antioxidant stress responses that defend against host plant defenses. In this study, the infestation of whitebark pine, Pinus bungean, wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27438
更新日期：2016-06-07 00:00:00
abstract：:Metal-silicon junctions are crucial to the operation of semiconductor devices: aggressive scaling demands low-resistive metallic terminals to replace high-doped silicon in transistors. It suggests an efficient charge injection through a low Schottky barrier between a metal and Si. Tremendous efforts invested into engi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25980
更新日期：2016-05-23 00:00:00
abstract：:The therapeutic potential of targeting CD4+Foxp3+ regulatory T cells (Tregs) remains controversial under the condition of neuroinflammation. This study aims to explore the neuroprotective role of Tregs in optic nerve ischemia (ONI) and evaluate the therapeutic strategy of Tregs transfer with a focus on targeting the m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37805
更新日期：2016-11-25 00:00:00
abstract：:Axonal injury is a common feature of central nervous system insults that culminates with the death of the affected neurons, and an irreversible loss of function. Inflammation is an important component of the neurodegenerative process, where the microglia plays an important role by releasing proinflammatory factors as ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38499
更新日期：2016-12-08 00:00:00
abstract：:Approximately 75% of melanomas have known driver oncogenic mutations in BRAF, NRAS, GNA11 or GNAQ, while the mutations providing constitutive oncogenic signaling in the remaining melanomas are not known. We established a melanoma cell line from a tumor with none of the common driver mutations. This cell line demonstra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27454
更新日期：2016-06-08 00:00:00
abstract：:The Plasmodium life cycle within the mosquito involves the gamete, zygote, motile ookinete, and the oocyst stage that supports sporogony and sporozoite formation. We mapped the P. falciparum transcriptome as the parasite progresses through the oocyst stage of development on days 2, 4, 6, and 8 post-P. falciparum infec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29969-4
更新日期：2018-08-01 00:00:00
abstract：:We consider the finite-temperature properties of the extended Bose-Hubbard model realized recently in an ETH experiment [Nature 532, 476 (2016)]. Competing short- and global-range interactions accommodate fascinating collective phenomena. We formulate a self-consistent mean-field theory to describe the behaviors of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66054-1
更新日期：2020-06-03 00:00:00
abstract：:Social information use has well-known fitness benefits. However, causes underlying the apparent inter-individual variability in the propensity to use social information are poorly studied. Melanins are pigments responsible for most of intra-specific color variation in vertebrates and their variation is often associate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58826-6
更新日期：2020-02-05 00:00:00
abstract：:Norfloxacin (NOF) is an environmentally harmful and ubiquitous aquatic pollutant with extensive production and application. In this study, a novel composition named carbon-based composite photocatalytic material of zinc oxide and zinc sulphide (ZnO/ZnS@BC) was successfully obtained by the impregnation-roasting method ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68517-x
更新日期：2020-07-17 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermetia illucens were firstly expressed in Pichia pastoris, with the yields of 873.5 and 801.3 mg/l, respectively...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10839-4
更新日期：2017-09-21 00:00:00
abstract：:Spontaneous activity found in neural networks usually results in a reduction of computational performance. As a consequence, artificial neural networks are often operated at the edge of chaos, where the network is stable yet highly susceptible to input information. Surprisingly, regular spontaneous dynamics in Neural ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21624-2
更新日期：2018-02-20 00:00:00
abstract：:The ability to extract the direction of the other's gaze allows us to shift our attention to an object of interest to the other and to establish joint attention. By mapping one's own intentions on the object of joint attention, humans develop a Theory of (the other's) Mind (TOM), a functional sequence possibly disrupt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51783-9
更新日期：2019-10-25 00:00:00
