Abstract：
:The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for the therapy of different malignant conditions, but not yet for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated the expression of PD-1 and PD-L1 in GEP-NETs and its potential correlations with clinical outcomes. Expression of PD-1/PD-L1 was analyzed by immunohistochemistry in 116 GEP-NETs and 48 samples of peritumoral tissue. In addition, the expression of these molecules was assessed by flow cytometry in peripheral blood mononuclear cells (PBMC) from patients with GEP-NETs (n = 32) and healthy controls (n = 32) and in intratumoral mononuclear cells (TMCs) (n = 3). Expression of PD-L1 and PD-1 was detected by immunohistochemistry in 6% and 1% of tumor tissue samples, respectively, and in 8% of peritumoral tissue samples, for both markers. We also observed that PD-1 expression by TMCs was associated with metastatic disease at diagnosis, and the levels of circulating PD-1+ PBMCs were associated with progressive disease upon follow-ups. In addition, circulating PD-1+ PBMCs were significantly correlated with PD-L1 expression by tumor cells. Our data suggest that PD-1/PD-L1 is expressed in 1 to 8% of GEP-NETs, and that this feature is significantly associated with disease evolution (p < 0.01).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sampedro-Núñez M,Serrano-Somavilla A,Adrados M,Cameselle-Teijeiro JM,Blanco-Carrera C,Cabezas-Agricola JM,Martínez-Hernández R,Martín-Pérez E,Muñoz de Nova JL,Díaz JÁ,García-Centeno R,Caneiro-Gómez J,Abdulkader I,González-Amarodoi
10.1038/s41598-018-36129-1subject
Has Abstractpub_date
2018-12-13 00:00:00pages
17812issue
1issn
2045-2322pii
10.1038/s41598-018-36129-1journal_volume
8pub_type
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