Abstract：
:The graft-versus-leukemia effect reminds us to observe the allogeneic cell elicited anti-tumor immune responses. Here we immunized recipient B6 mice with different types of allogenic leukocytes and found that vaccination with allogenic dendritic cells (alloDC) elicited the most efficient protection against broad-spectrum tumors. The recipient lymphocytes were analyzed and the data showed that CD8 T cells increased significantly after immunization and expressed effector memory T cell marker KLRG1. Functional evaluation demonstrated that these KLRG1+CD8 T cells could kill tumor cells in vitro and in vivo in Granzyme B- and Fas/FasL-dependent manners with no tumor antigen specificity, and tend to migrate into tumor sites by high expression of heparanase. Adoptive transfer of these cells could provide antitumor protection against tumors. AlloDC could also treat mice with residual tumors and combination of anti-PD1 antibody could enhance this effects. Together, our study showed that alloDC-immunization could induce potent antitumor effect through the expansion of KLRG1+CD8 T cells, which can work as both preventive and therapeutic tumor vaccines.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang C,Li Z,Zhu Z,Chai Y,Wu Y,Yuan Z,Chang Z,Wang Z,Zhang Mdoi
10.1038/s41598-019-52151-3subject
Has Abstractpub_date
2019-10-29 00:00:00pages
15527issue
1issn
2045-2322pii
10.1038/s41598-019-52151-3journal_volume
9pub_type
杂志文章abstract：:Sensitivity to sounds is one frequent symptom of a sport-related concussion, but its assessment rarely goes beyond a single question. Here we examined sensitivity to sounds using psychoacoustic and psychometric outcomes in athletes beyond the acute phase of injury. Fifty-eight college athletes with normal hearing who ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28312-1
更新日期：2018-07-02 00:00:00
abstract：:Non-classical crystallisation (NCC) pathways are widely accepted, however there is conflicting evidence regarding the intermediate stages of crystallisation, how they manifest and further develop into crystals. Evidence from direct observations is especially lacking for small organic molecules, as distinguishing these...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75937-2
更新日期：2020-11-05 00:00:00
abstract：:Vertical vergence is generally associated with one of three mechanisms: vestibular activation during a head tilt, induced by vertical visual disparity, or as a by-product of ocular torsion. However, vertical vergence can also be induced by seemingly unrelated visual conditions, such as optokinetic rotations. This stud...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72646-8
更新日期：2020-09-23 00:00:00
abstract：:In this paper, we demonstrate the fabrication of conductive porous polymers based on foaming of an aqueous dispersion of polymeric particles and multi-walled carbon nanotubes (CNT). By tuning the surface energy of the constituents, we direct their preferential adsorption at the air-liquid (bubble) interface or within ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01770-9
更新日期：2017-05-11 00:00:00
abstract：:Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a central role in iron metabolism regulation. Emerging evidence suggests that disordered iron metabolism is a risk factor for various types of diseases including cancers. However, it remains challenging to apply current mass spectrometry (M...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43756-9
更新日期：2019-05-13 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-49306-7
更新日期：2019-09-03 00:00:00
abstract：:The addition of a small amount of dopant impurities to crystals is a common method to tune the properties of materials. Usually the doping grade is restricted by the low solubility of the dopants; increasing the doping concentration beyond this solubility limit leads to supersaturated solutions in which dopant cluster...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12730-8
更新日期：2017-10-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40530-9
更新日期：2019-03-08 00:00:00
abstract：:Trastuzumab combined with chemotherapy is standard of care for HER2 positive advanced gastro-esophageal cancers. The reported prevalence of HER2 discordance between primary tumors and corresponding metastases varies, hampering uniform patient selection for HER2 targeted therapy. This meta-analysis explores the influen...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-03304-9
更新日期：2017-06-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14283-2
更新日期：2017-10-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17869-y
更新日期：2017-12-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57865-3
更新日期：2020-01-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43620-w
更新日期：2019-05-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70389-0
更新日期：2020-08-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33415-w
更新日期：2018-10-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75747-6
更新日期：2020-10-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13080-1
更新日期：2017-10-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00900
更新日期：2012-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32091
更新日期：2016-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79852-4
更新日期：2021-01-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52775-5
更新日期：2019-11-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43207-5
更新日期：2019-05-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35394-4
更新日期：2018-11-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19719
更新日期：2016-01-29 00:00:00
abstract：:Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08237-x
更新日期：2017-08-11 00:00:00
abstract：:Brain µ-opioid receptors (MOR) mediate reward and help coping with pain, social rejection, anxiety and depression. The dorsal midline thalamus (dMT) integrates visceral/emotional signals and biases behavior towards aversive or defensive states through projections to the amygdala. While a dense MOR expression in the dM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54128-8
更新日期：2019-11-28 00:00:00
abstract：:Upper urinary tract urothelial carcinoma (UT-UC) is rare and treatment options or prognostic markers are limited. There is increasing evidence indicating that urothelial carcinoma may be an endocrine-related cancer. The aim of this study was to analyze the prognostic effect of estrogen receptor beta (ERβ) on the outco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24263
更新日期：2016-04-07 00:00:00
abstract：:Komagataeibacter nataicola is an acetic acid bacterium (AAB) that can produce abundant bacterial cellulose and tolerate high concentrations of acetic acid. To globally understand its fermentation characteristics, we present a high-quality complete genome sequence of K. nataicola RZS01. The genome consists of a 3,485,1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04589-6
更新日期：2017-06-30 00:00:00
abstract：:Neuroimaging studies in social neuroscience have largely relied on functional connectivity (FC) methods to characterize the functional integration between different brain regions. However, these methods have limited utility in social-cognitive studies that aim to understand the directed information flow among brain ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38801-6
更新日期：2019-02-22 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep46290. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46823
更新日期：2017-05-22 00:00:00
