Abstract：
:MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 siRNA can accelerate mitotic exit. MCM7 depletion leads to CDK1 inactivation and promotes subsequent cohesin/RAD21 cleavage, which eventually leads to sister chromatin segregation. Moreover, MCM7 is co-localized with tubulin in the mitotic cells and MCM7 depletion results in aberrant mitosis. Our results indicate that MCM7 may exert certain functions on spindle formation to prevent cytokinesis during early mitosis by regulating CDK1 activity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zheng D,Ye S,Wang X,Zhang Y,Yan D,Cai X,Gao W,Shan H,Gao Y,Chen J,Hu Z,Li H,Li Jdoi
10.1038/s41598-017-03148-3subject
Has Abstractpub_date
2017-06-06 00:00:00pages
2854issue
1issn
2045-2322pii
10.1038/s41598-017-03148-3journal_volume
7pub_type
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