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An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model.

Abstract：

:The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV's neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in preclinical models, particularly T cell responses, remain sparse. We deployed RNA nanoparticle technology to create a vaccine candidate that elicited ZIKV E protein-specific IgG responses in C57BL/6 mice as assayed by ELISA. Using this tool, we identified a unique H-2Db-restricted epitope to which there was a CD8+ T cell response in mice immunized with our modified dendrimer-based RNA nanoparticle vaccine. These results demonstrate that this approach can be used to evaluate new candidate antigens and identify immune correlates without the use of live virus.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Chahal JS,Fang T,Woodham AW,Khan OF,Ling J,Anderson DG,Ploegh HL

doi

10.1038/s41598-017-00193-w

subject

Has Abstract

pub_date

2017-03-21 00:00:00

pages

252

issue

1

issn

2045-2322

pii

10.1038/s41598-017-00193-w

journal_volume

7

pub_type

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