HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.

Abstract:

:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encouraging preclinical and clinical results in solid tumors. Here we describe the efficacy of a HIF-1α inhibitor, Acriflavine, and demonstrate its potency against brain cancer. This safe antibacterial dye induces cell death and apoptosis in several glioma cell lines, targets HIF-1α-mediated pathways, and decreases the level of PGK1, VEGF and HIF-1α in vitro and in vivo. Administered locally via biodegradable polymers, Acriflavine provides significant benefits in survival resulting in nearly 100% long term survival, confirmed by MRI and histological analyses. This study reports preclinical evidence that this safe, small molecule can contribute to brain tumor therapy and highlights the significance of HIF-1α-targeting molecules.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B

doi

10.1038/s41598-017-14990-w

subject

Has Abstract

pub_date

2017-11-02 00:00:00

pages

14978

issue

1

issn

2045-2322

pii

10.1038/s41598-017-14990-w

journal_volume

7

pub_type

杂志文章
  • Risk Factors for Progression of Barrett's Esophagus to High Grade Dysplasia and Esophageal Adenocarcinoma.

    abstract::Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC). Methods of identifying BE patients at high risk for progression to high-grade dysplasia (HGD) or EAC are needed to improve outcomes and identify who will benefit most from intensive surveillance or ablative therapy. Clinical predi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61874-7

    authors: Kambhampati S,Tieu AH,Luber B,Wang H,Meltzer SJ

    更新日期:2020-03-17 00:00:00

  • Robust high-Q filter with complete transmission by conjugated topological photonic crystals.

    abstract::High quality factor (High-Q) and transmission optical devices are required for various applications in the fields of physics and engineering. Critical for these applications is the realization of a structure with high-Q, complete transmission and small volume. A robust high-Q filter with complete transmission by conju...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64076-3

    authors: Lin YC,Chou SH,Hsueh WJ

    更新日期:2020-04-27 00:00:00

  • A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors.

    abstract::Anterior-posterior body axis in all bilaterians is determined by the Hox gene clusters that are activated in a spatio-temporal order. This expression pattern of Hox genes is established and maintained by regulatory mechanisms that involve higher order chromatin structure and Polycomb group (PcG) and trithorax group (t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03011

    authors: Vasanthi D,Nagabhushan A,Matharu NK,Mishra RK

    更新日期:2013-10-22 00:00:00

  • Neandertal cannibalism and Neandertal bones used as tools in Northern Europe.

    abstract::Almost 150 years after the first identification of Neandertal skeletal material, the cognitive and symbolic abilities of these populations remain a subject of intense debate. We present 99 new Neandertal remains from the Troisième caverne of Goyet (Belgium) dated to 40,500-45,500 calBP. The remains were identified thr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29005

    authors: Rougier H,Crevecoeur I,Beauval C,Posth C,Flas D,Wißing C,Furtwängler A,Germonpré M,Gómez-Olivencia A,Semal P,van der Plicht J,Bocherens H,Krause J

    更新日期:2016-07-06 00:00:00

  • Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release.

    abstract::Miscarriage affects ~20% of pregnancies and maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires endometrial stromal cell (ESC) decidualisation. Maintenance of pregnancy re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02223-z

    authors: Giakoumelou S,Wheelhouse N,Brown J,Wade J,Simitsidellis I,Gibson D,Saunders PTK,Horner P,Entrican G,Howie SEM,Horne AW

    更新日期:2017-05-17 00:00:00

  • Accuracy of Two Point-of-Care Tests for Rapid Diagnosis of Bovine Tuberculosis at Animal Level using Non-Invasive Specimens.

    abstract::Bovine tuberculosis (BTB) testing in cattle requires a significant investment of time, equipment, and labor. Novel, rapid, cheaper and accurate methods are needed. The Alere Determine TB lipoarabinomannan antigen (LAM-test) is a World Health Organization-endorsed point-of-care urine test designed to detect active TB d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62314-2

    authors: Kelley HV,Waibel SM,Sidiki S,Tomatis-Souverbielle C,Scordo JM,Hunt WG,Barr N,Smith R,Silwani SN,Averill JJ,Baer S,Hengesbach J,Yildiz VO,Pan X,Gebreyes WA,Balada-Llasat JM,Wang SH,Torrelles JB

    更新日期:2020-03-25 00:00:00

  • Author Correction: Carbon nanotubes promote cell migration in hydrogels.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-62443-8

    authors: Ravanbakhsh H,Bao G,Mongeau L

    更新日期:2020-03-24 00:00:00

  • Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family.

    abstract::Triterpenic acids (TAs), a large group of natural compounds with diverse biological activity, are produced by several plant taxa. Betulinic, oleanolic, and ursolic acids are the most medicinally important TAs and are mainly found in plants of the mint family. Metabolic engineering is strongly dependent on identifying ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52090-z

    authors: Aminfar Z,Rabiei B,Tohidfar M,Mirjalili MH

    更新日期:2019-11-01 00:00:00

  • Single-molecule real-time detection of telomerase extension activity.

    abstract::The ends of eukaryotic chromosomes are capped by telomeres which consist of tandem G-rich DNA repeats stabilized by the shelterin protein complex. Telomeres shorten progressively in most normal cells due to the end replication problem. In more than 85% of cancers however, the telomere length is maintained by telomeras...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06391

    authors: Hwang H,Opresko P,Myong S

    更新日期:2014-09-29 00:00:00

  • Impact of Sub-Retinal Fluid on the Long-Term Incidence of Macular Atrophy in Neovascular Age-related Macular Degeneration under Treat & Extend Anti-Vascular Endothelial Growth Factor Inhibitors.

    abstract::Sub-retinal fluid (SRF) has been discussed as a protective factor against macular atrophy in eyes with neovascular age-related macular degeneration (nAMD).To gauge the impact of SRF on macular atrophy, a database of 310 nAMD eyes was screened for eyes manifesting an SRF-only phenotype under treat & extend anti-VEGF tr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64901-9

    authors: Siedlecki J,Fischer C,Schworm B,Kreutzer TC,Luft N,Kortuem KU,Schumann RG,Wolf A,Priglinger SG

    更新日期:2020-05-15 00:00:00

  • Exploration of miRNA families for hypotheses generation.

    abstract::Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhanc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02940

    authors: Kamanu TK,Radovanovic A,Archer JA,Bajic VB

    更新日期:2013-10-15 00:00:00

  • Investigating a new neuromodulation treatment for brain disorders using synchronized activation of multimodal pathways.

    abstract::Neuromodulation is an increasingly accepted treatment for neurological and psychiatric disorders but is limited by its invasiveness or its inability to target deep brain structures using noninvasive techniques. We propose a new concept called Multimodal Synchronization Therapy (mSync) for achieving targeted activation...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09462

    authors: Markovitz CD,Smith BT,Gloeckner CD,Lim HH

    更新日期:2015-03-25 00:00:00

  • A pilot-scale forward osmosis membrane system for concentrating low-strength municipal wastewater: performance and implications.

    abstract::Recovery of nutrients and energy from municipal wastewater has attracted much attention in recent years; however, its efficiency is significantly limited by the low-strength properties of municipal wastewater. Herein, we report a pilot-scale forward osmosis (FO) system using a spiral-wound membrane module to concentra...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21653

    authors: Wang Z,Zheng J,Tang J,Wang X,Wu Z

    更新日期:2016-02-22 00:00:00

  • Light absorption enhancement in ultrathin film solar cell with embedded dielectric nanowires.

    abstract::A novel design of thin-film crystalline silicon solar cell (TF C-Si-SC) is proposed and numerically analyzed. The reported SC has 1.0 µm thickness of C-Si with embedded dielectric silicon dioxide nanowires (NWs). The introduced NWs increase the light scattering in the active layer which improves the optical path lengt...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74453-7

    authors: Elrabiaey MA,Hussein M,Hameed MFO,Obayya SSA

    更新日期:2020-10-16 00:00:00

  • High-performance asymmetric optical transmission based on coupled complementary subwavelength gratings.

    abstract::Asymmetric transmission (AT) devices are fundamental elements for optical computing and information processing. We here propose an AT device consisting of a pair of coupled complementary subwavelength gratings. Different from previous works, asymmetric dielectric environment is employed for unidirectional excitation o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53586-4

    authors: Li S,Huang LR,Ling YH,Liu WB,Ba CF,Li HH

    更新日期:2019-11-19 00:00:00

  • The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function.

    abstract::Despite strong evidence for NMDA receptor (NMDAR) hypofunction as an underlying factor for cognitive disorders, the precise roles of various NMDAR subtypes remains unknown. The GluN2C-containing NMDARs exhibit unique biophysical properties and expression pattern, and lower expression of GluN2C subunit has been reporte...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38321

    authors: Gupta SC,Ravikrishnan A,Liu J,Mao Z,Pavuluri R,Hillman BG,Gandhi PJ,Stairs DJ,Li M,Ugale RR,Monaghan DT,Dravid SM

    更新日期:2016-12-06 00:00:00

  • Isolation, characterization and antifungal docking studies of wortmannin isolated from Penicillium radicum.

    abstract::During the search for a potent antifungal drug, a cell-permeable metabolite was isolated from a soil isolate taxonomically identified as Penicillium radicum. The strain was found to be a potent antifungal agent. Production conditions of the active compound were optimized and the active compound was isolated, purified,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11948

    authors: Singh V,Praveen V,Tripathi D,Haque S,Somvanshi P,Katti SB,Tripathi CK

    更新日期:2015-07-10 00:00:00

  • Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS).

    abstract::Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultrasound (CEUS) to diag...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77801-9

    authors: Chang J,Dumitrache A,Böhling N,Abu-Omar J,Meyer C,Strobel D,Luetkens J,Luu AM,Rockstroh J,Strassburg CP,Trebicka J,Gonzalez-Carmona MA,Marinova M,Praktiknjo M

    更新日期:2020-11-26 00:00:00

  • Study of the lithium diffusion properties and high rate performance of TiNb6O17 as an anode in lithium secondary battery.

    abstract::TiNb6O17 and TiNb2O7 were synthesized using a solid-state method. The techniques were used to assess the electrochemical performance and lithium diffusion kinetics of TiNb6O17 related to the unit cell volume with TiNb2O7. The charge-discharge curves and cyclic voltammetry revealed TiNb6O17 to have a similar redox pote...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16711-9

    authors: Lee YS,Ryu KS

    更新日期:2017-11-30 00:00:00

  • Accuracy assessment of a novel semiautomatic method evaluating bone grafts around the dental implant: an in vitro and ex vivo study.

    abstract::The present study aimed to evaluate the accuracy and repeatability of morphological contour interpolation (MCI)-based semiautomatic segmentation method for volumetric measurements of bone grafts around dental implants. Three in vitro (one with a cylinder and two with a geometrically complex form) and four ex vivo mode...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71651-1

    authors: Shi JY,Li Y,Zhuang LF,Zhang X,Fan LF,Lai HC

    更新日期:2020-09-10 00:00:00

  • Ultra-high Photoresponsivity in Suspended Metal-Semiconductor-Metal Mesoscopic Multilayer MoS2 Broadband Detector from UV-to-IR with Low Schottky Barrier Contacts.

    abstract::The design, fabrication, and characterization of ultra-high responsivity photodetectors based on mesoscopic multilayer MoS2 is presented, which is a less explored system compared to direct band gap monolayer MoS2 that has received increasing attention in recent years. The device architecture is comprised of a metal-se...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19367-1

    authors: Saenz GA,Karapetrov G,Curtis J,Kaul AB

    更新日期:2018-01-19 00:00:00

  • Randomized Trial of Mindfulness-Based Stress Reduction in Cardiac Patients Eligible for Cardiac Rehabilitation.

    abstract::Currently, exercise-based cardiac rehabilitation (CR) is the only recommended secondary prevention strategy for cardiac patients that attempts to tackle stress and psychosocial wellbeing, but it is under-utilized and lacks a comprehensive curriculum for this purpose; hence there is a critical gap to address psychosoci...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-019-54932-2

    authors: Nijjar PS,Connett JE,Lindquist R,Brown R,Burt M,Pergolski A,Wolfe A,Balaji P,Chandiramani N,Yu X,Kreitzer MJ,Everson-Rose SA

    更新日期:2019-12-05 00:00:00

  • Constructing Smaller Pauli Twirling Sets for Arbitrary Error Channels.

    abstract::Twirling is a technique widely used for converting arbitrary noise channels into Pauli channels in error threshold estimations of quantum error correction codes. It is vitally useful both in real experiments and in classical quantum simulations. Minimising the size of the twirling gate set increases the efficiency of ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46722-7

    authors: Cai Z,Benjamin SC

    更新日期:2019-08-02 00:00:00

  • Quasisolitons in self-diffusive excitable systems, or Why asymmetric diffusivity obeys the Second Law.

    abstract::Solitons, defined as nonlinear waves which can reflect from boundaries or transmit through each other, are found in conservative, fully integrable systems. Similar phenomena, dubbed quasi-solitons, have been observed also in dissipative, "excitable" systems, either at finely tuned parameters (near a bifurcation) or in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30879

    authors: Biktashev VN,Tsyganov MA

    更新日期:2016-08-05 00:00:00

  • Suppression of chorismate synthase, which is localized in chloroplasts and peroxisomes, results in abnormal flower development and anthocyanin reduction in petunia.

    abstract::In plants, the shikimate pathway generally occurs in plastids and leads to the biosynthesis of aromatic amino acids. Chorismate synthase (CS) catalyses the last step of the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to chorismate, but the role of CS in the metabolism of higher plants has not been reported...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67671-6

    authors: Zhong S,Chen Z,Han J,Zhao H,Liu J,Yu Y

    更新日期:2020-07-02 00:00:00

  • Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium.

    abstract::For augmentation or reconstruction of urinary bladder after cystectomy, bladder urothelium derived from human induced pluripotent stem cells (hiPSCs) has recently received focus. However, previous studies have only shown the emergence of cells expressing some urothelial markers among derivatives of hiPSCs, and no repo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46848-8

    authors: Suzuki K,Koyanagi-Aoi M,Uehara K,Hinata N,Fujisawa M,Aoi T

    更新日期:2019-07-19 00:00:00

  • In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector.

    abstract::RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REVec for in vivo gene delivery...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62630-7

    authors: Komatsu Y,Tanaka C,Komorizono R,Tomonaga K

    更新日期:2020-04-03 00:00:00

  • Expression regulation of myo-inositol 3-phosphate synthase 1 (INO1) in determination of phytic acid accumulation in rice grain.

    abstract::Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51485-2

    authors: Perera I,Fukushima A,Akabane T,Horiguchi G,Seneweera S,Hirotsu N

    更新日期:2019-10-16 00:00:00

  • Experimental study on mandibular length and facial symmetry of low estrogen level and anterior disc displacement of temporomandibular joint.

    abstract::This study was aimed at elucidating the changes of mandible symmetry in a rabbit model with low estrogen levels induced by ovariectomy (OVX) combined with temporomandibular joint (TMJ) anterior disc displacement without reduction (ADDWoR). 32 growing rabbits were randomly allocated into 4 groups; OVX group, ADDWoR gro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34023-4

    authors: Jiao Z,Wang X,Zhang X,Yang C

    更新日期:2018-10-23 00:00:00

  • Extensive fragmentation and re-organization of transcription in Systemic Lupus Erythematosus.

    abstract::Systemic Lupus Erythematosus (SLE) is the prototype of autoimmune diseases, characterized by extensive gene expression perturbations in peripheral blood immune cells. Circumstantial evidence suggests that these perturbations may be due to altered epigenetic profiles and chromatin accessibility but the relationship bet...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73654-4

    authors: Ntasis VF,Panousis NI,Tektonidou MG,Dermitzakis ET,Boumpas DT,Bertsias GK,Nikolaou C

    更新日期:2020-10-06 00:00:00