Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H.

abstract：:Flattening of a carbon nanotube results in the formation of a carbon nanoribbon with well-defined edges. In addition, a switching of the flattening direction by about a right angle yields a carbon nanotetrahedron at the switching point in a nanoribbon. Here, we report that chains of carbon nanotetrahedra/nanoribbons a...

journal_title：Scientific reports

authors： Kohno H,Hasegawa T

更新日期：2015-02-12 00:00:00

abstract：:Effective treatment of osteomyelitis remains a formidable clinical challenge. The rapid emergence of multidrug-resistant bacteria has renewed interest in developing antimicrobial biomaterials using antiseptic silver ions to treat osteomyelitis. However, inadequate local retention and severe cytotoxic effects have limi...

journal_title：Scientific reports

authors： Lu M,Liao J,Dong J,Wu J,Qiu H,Zhou X,Li J,Jiang D,He TC,Quan Z

更新日期：2016-12-16 00:00:00

abstract：:Despite advances in renovascular disease (RVD) research, gaps remain between experimental and clinical outcomes, translation of results, and the understanding of pathophysiological mechanisms. A predictive tool to indicate support (or lack of) for biological findings may aid clinical translation of therapies. We creat...

journal_title：Scientific reports

authors： Williams E,Chade AR

更新日期：2020-01-16 00:00:00

abstract：:Natural killer (NK) cells are essential for immunosurveillance against transformed cells. Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel gated by ADP-ribose (ADPR). However, the role of TRPM2-mediated Ca(2+) signaling in the antitumor response of NK cells has not been explored. ...

journal_title：Scientific reports

authors： Rah SY,Kwak JY,Chung YJ,Kim UH

更新日期：2015-03-25 00:00:00

abstract：:An intact cell wall is critical for cellular interactions with the environment and protecting the cell from environmental challenges. Signaling mechanisms are necessary to monitor cell wall integrity and to regulate cell wall production and remodeling during growth and division cycles. The green alga, Chlamydomonas, h...

journal_title：Scientific reports

authors： Cronmiller E,Toor D,Shao NC,Kariyawasam T,Wang MH,Lee JH

更新日期：2019-08-21 00:00:00

abstract：:Coral reefs all over the Indo-Pacific suffer from substantial damage caused by the crown-of-thorns seastar Acanthaster planci, a voracious predator that moves on and between reefs to seek out its coral prey. Chemoreception is thought to guide A. planci. As vision was recently introduced as another sense involved in se...

journal_title：Scientific reports

authors： Sigl R,Steibl S,Laforsch C

更新日期：2016-08-01 00:00:00

abstract：:WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H d...

journal_title：Scientific reports

authors： Zhu J,Vasilopoulou M,Davazoglou D,Kennou S,Chroneos A,Schwingenschlögl U

更新日期：2017-01-18 00:00:00

abstract：:Quantum cryptography is set to become a key technology for future secure communications. However, to get maximum benefit in communication networks, transmission links will need to be shared among several quantum keys for several independent users. Such links will enable switching in quantum network nodes of the quantu...

journal_title：Scientific reports

authors： Bacco D,Ding Y,Dalgaard K,Rottwitt K,Oxenløwe LK

更新日期：2017-09-29 00:00:00

abstract：:Protein synthesis is traditionally associated with specific cytoplasmic compartments. We now show that OFD1, a centrosomal/basal body protein, interacts with components of the Preinitiation complex of translation (PIC) and of the eukaryotic Initiation Factor (eIF)4F complex and modulates the translation of specific mR...

journal_title：Scientific reports

authors： Iaconis D,Monti M,Renda M,van Koppen A,Tammaro R,Chiaravalli M,Cozzolino F,Pignata P,Crina C,Pucci P,Boletta A,Belcastro V,Giles RH,Surace EM,Gallo S,Pende M,Franco B

更新日期：2017-04-27 00:00:00

abstract：:Nine new bicyclic cembranoids, sarcophytrols M-U(1-9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of t...

journal_title：Scientific reports

authors： Liang LF,Chen WT,Li XW,Wang HY,Guo YW

更新日期：2017-04-21 00:00:00

abstract：:Aggregates of corundum crystals with skeletal to hopper morphology occur in pyroclastic rocks erupted from Cretaceous basaltic volcanoes on Mt Carmel, N. Israel. The rapid growth of the crystals trapped volumes of the parental Al2O3-supersaturated melt; phenocrysts of tistarite (Ti2O3) in the trapped melts indicate cr...

journal_title：Scientific reports

authors： Oliveira B,Griffin WL,Gain SEM,Saunders M,Shaw J,Toledo V,Afonso JC,O'Reilly SY

更新日期：2021-01-28 00:00:00

abstract：:Haematopoietic cells arise from endothelial cells within the dorsal aorta of the embryo via a process called the endothelial-haematopoietic transition (EHT). This process crucially depends on the transcription factor RUNX1 which rapidly activates the expression of genes essential for haematopoietic development. Using ...

journal_title：Scientific reports

authors： Gilmour J,Assi SA,Noailles L,Lichtinger M,Obier N,Bonifer C

更新日期：2018-07-10 00:00:00

abstract：:Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the major etiological agents of hand, foot and mouth disease (HFMD) and are often associated with neurological complications. Currently, several vaccine types are being developed for EV71 and CA16. In this study, we constructed a bivalent chimeric virus-lik...

journal_title：Scientific reports

authors： Xu L,He D,Yang L,Li Z,Ye X,Yu H,Zhao H,Li S,Yuan L,Qian H,Que Y,Kuo Shih JW,Zhu H,Li Y,Cheng T,Xia N

更新日期：2015-08-05 00:00:00

abstract：:Polymer-supported nanozero-valent iron composites (D001-nZVI) were fabricated for the removal of lead ions from aqueous solutions by embedding nZVI into the porous polystyrene anion exchanger D001. Humic acid (HA) was selected as a model species because of its ubiquitous existence to gain insight into the influencing ...

journal_title：Scientific reports

authors： Wang L,Wei S,Jiang Z

更新日期：2020-11-12 00:00:00

abstract：:Migraines are a common and undertreated disease and often have psychiatric comorbidities; however, the abnormal mechanism of emotional processing in migraine patients has not been well clarified. This study sought to investigate the different brain functional activation to neutral, positive and negative emotional stim...

journal_title：Scientific reports

authors： Wang M,Su J,Zhang J,Zhao Y,Yao Q,Zhang Q,Zhang H,Wang S,Li GF,Liu JR,Du X

更新日期：2017-02-09 00:00:00

abstract：:We explore the effect of temperature on the interaction of polydisperse mixtures of nonionic poly(ethylene glycol) (PEG) polymers of different average molar masses with the biological nanopore α-hemolysin. In contrast with what has been previously observed with various nanopores and analytes, we find that, for PEGs la...

journal_title：Scientific reports

authors： Piguet F,Ouldali H,Discala F,Breton MF,Behrends JC,Pelta J,Oukhaled A

更新日期：2016-12-07 00:00:00

abstract：:Desensitisation with therapeutic plasma exchange (TPE) is essential for ABO-incompatible (ABO-I) liver transplants (LTs). However, excessive citrate load and coagulation disturbances after TPE have been poorly studied, in particular in cirrhotic patients with hypocapnic alkalosis, metabolic compensation and electrolyt...

journal_title：Scientific reports

authors： Kwon HM,Jun IG,Lee J,Moon YJ,Jung KW,Jeong HW,Park YS,Song JG,Hwang GS

更新日期：2018-04-27 00:00:00

abstract：:The trade of bumble bees started in the early nineties for pollinator-dependent greenhouse plants. Nowadays, its rearing and transport have received public attention, since managed bees can transfer pathogens to wild bee populations. Therefore, guaranteeing pathogen-free bumble bees is fundamental. The major protein s...

journal_title：Scientific reports

authors： Pereira KS,Meeus I,Smagghe G

更新日期：2019-03-12 00:00:00

abstract：:Mountain glaciers form landscapes with U-shaped valleys, roche moutonées and overdeepenings through bedrock erosion. However, little evidence for active glacial carving has been provided particularly for areas above the Equilibrium Line Altitude (ELA) where glaciers originate. This is mainly due to our lack of informa...

journal_title：Scientific reports

authors： Nishiyama R,Ariga A,Ariga T,Lechmann A,Mair D,Pistillo C,Scampoli P,Valla PG,Vladymyrov M,Ereditato A,Schlunegger F

更新日期：2019-05-06 00:00:00

abstract：:In a 250-kyr transient simulation of the Community Earth System Model (CESM), we identified a precessional forced seesaw of the summer middle-upper tropospheric eddy temperature between Asia and the North Pacific as the paleo-APO (Asian-Pacific oscillation). The paleo-APO variability is out of phase with the precessio...

journal_title：Scientific reports

authors： Wang Y,Jian Z,Zhao P,Xiao D,Chen J

更新日期：2016-07-06 00:00:00

abstract：:Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinka...

journal_title：Scientific reports

authors： Wang C,Tang D,Wang Y,Zhao Z,Wang J,Pu M,Zhang Y,Yan W,Gao P,Luo X

更新日期：2015-12-18 00:00:00

abstract：:The study of animal vocal signals can either focus on the properties of distinct vocal elements or address the signal as a whole. Although some attention has been given to the continuous progression patterns of bird songs, such patterns in mammalian vocalisations have been largely overlooked. We examined temporal chan...

journal_title：Scientific reports

authors： Demartsev V,Ilany A,Kershenbaum A,Geva Y,Margalit O,Schnitzer I,Barocas A,Bar-Ziv E,Koren L,Geffen E

更新日期：2017-06-05 00:00:00

abstract：:Applications of ferroelectric materials in modern microelectronics will be greatly encouraged if the thermal incompatibility between inorganic ferroelectrics and semiconductor devices is overcome. Here, solution-processable layers of the most commercial ferroelectric compound--morphotrophic phase boundary lead zircona...

journal_title：Scientific reports

authors： Bretos I,Jiménez R,Tomczyk M,Rodríguez-Castellón E,Vilarinho PM,Calzada ML

更新日期：2016-02-03 00:00:00

abstract：:Quantitative reverse transcription PCR (RT-qPCR) is one of the most efficient, reliable and widely used techniques to quantify gene expression. In this study, we evaluated the performance of six southern corn rootworm, Diabrotica undecimpunctata howardi (Barber), housekeeping genes (HKG), β-actin (Actin), β-tubulin (T...

journal_title：Scientific reports

authors： Basu S,Pereira AE,Pinheiro DH,Wang H,Valencia-Jiménez A,Siegfried BD,Louis J,Zhou X',Vélez AM

更新日期：2019-07-24 00:00:00

abstract：:Quality assessment of protein models using no other information than the structure of the model itself has been shown to be useful for structure prediction. Here, we introduce two novel methods, ProQRosFA and ProQRosCen, inspired by the state-of-art method ProQ2, but using a completely different description of a prote...

journal_title：Scientific reports

authors： Uziela K,Shu N,Wallner B,Elofsson A

更新日期：2016-10-04 00:00:00

abstract：:The importance of metallurgy for social and economic development is indisputable. Although copper (Cu) was essential for the wealth of pre- and post-colonial societies in the Andes, the onset of extensive Cu metallurgy in South America is still debated. Comprehensive archaeological findings point to first sophisticate...

journal_title：Scientific reports

authors： Eichler A,Gramlich G,Kellerhals T,Tobler L,Rehren T,Schwikowski M

更新日期：2017-01-31 00:00:00

abstract：:Long interspersed element-1 (LINE-1, L1) is a mobile genetic element comprising about 17% of the human genome. L1 utilizes an endonuclease to insert L1 cDNA into the target genomic DNA, which induces double-strand DNA breaks in the human genome and activates the DNA damage signaling pathway, resulting in the recruitme...

journal_title：Scientific reports

authors： Ariumi Y,Kawano K,Yasuda-Inoue M,Kuroki M,Fukuda H,Siddiqui R,Turelli P,Tateishi S

更新日期：2018-10-26 00:00:00

abstract：:The studies investigating the effects of green tea on blood pressure (BP) have generated inconsistent results. The aim of this study is to quantitatively evaluate the effects of green tea on BP control. PubMed, Embase, and the Cochrane Library (updated to March 2014) were searched for randomized controlled trials eval...

journal_title：Scientific reports

authors： Peng X,Zhou R,Wang B,Yu X,Yang X,Liu K,Mi M

更新日期：2014-09-01 00:00:00

abstract：:Accurate and precise structural ensembles of proteins and macromolecular complexes can be obtained with metainference, a recently proposed Bayesian inference method that integrates experimental information with prior knowledge and deals with all sources of errors in the data as well as with sample heterogeneity. The s...

journal_title：Scientific reports

authors： Bonomi M,Camilloni C,Vendruscolo M

更新日期：2016-08-26 00:00:00

abstract：:Terahertz pulse time-domain holography is the ultimate technique allowing the evaluating a propagation of pulse broadband terahertz wavefronts and analyze their spatial, temporal and spectral evolution. We have numerically analyzed pulsed broadband terahertz Gauss-Bessel beam's both spatio-temporal and spatio-spectral...

journal_title：Scientific reports

authors： Kulya MS,Semenova VA,Bespalov VG,Petrov NV

更新日期：2018-01-23 00:00:00