Evaluation of reference genes for real-time quantitative PCR analysis in southern corn rootworm, Diabrotica undecimpunctata howardi (Barber).

abstract：:NK cell adoptive therapy is a promising cancer therapeutic approach, but there are significant challenges that limiting its feasibility and clinical efficacy. One difficulty is the paucity of clinical grade manufacturing platforms to support the large scale expansion of highly active NK cells. We created an NK cell fe...

journal_title：Scientific reports

authors： Ojo EO,Sharma AA,Liu R,Moreton S,Checkley-Luttge MA,Gupta K,Lee G,Lee DA,Otegbeye F,Sekaly RP,de Lima M,Wald DN

更新日期：2019-10-17 00:00:00

abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are desirable for diabetes, especially in patients with overweight/obesity. We aimed to determine whether GLP-1RAs exhibit different glucose-lowering efficacies between Asian type 2 diabetes (T2D) patients with and without overweight/obesity. Randomized controlled t...

journal_title：Scientific reports

authors： Zhang F,Tang L,Zhang Y,Lü Q,Tong N

更新日期：2017-11-22 00:00:00

abstract：:Astaxanthin is a ketocarotenoid produced by photosynthetic microalgae. It is a pigment of high industrial interest in acquaculture, cosmetics, and nutraceutics due to its strong antioxidant power. Haematococcus pluvialis, a fresh-water microalga, accumulates high levels of astaxanthin upon oxidative stress, reaching v...

journal_title：Scientific reports

authors： Mascia F,Girolomoni L,Alcocer MJP,Bargigia I,Perozeni F,Cazzaniga S,Cerullo G,D'Andrea C,Ballottari M

更新日期：2017-11-24 00:00:00

abstract：:Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Wi...

journal_title：Scientific reports

authors： Scherer K,Yaroshenko A,Bölükbas DA,Gromann LB,Hellbach K,Meinel FG,Braunagel M,Berg JV,Eickelberg O,Reiser MF,Pfeiffer F,Meiners S,Herzen J

更新日期：2017-03-24 00:00:00

abstract：:Genome editing via CRISPR/Cas9 has become an efficient and reliable way to make precise, targeted changes to the genome of living cells. CXCR4 is a co-receptor for the human immunodeficiency virus type 1 (HIV-1) infection and has been considered as an important therapeutic target for AIDS. CXCR4 mediates viral entry i...

journal_title：Scientific reports

authors： Hou P,Chen S,Wang S,Yu X,Chen Y,Jiang M,Zhuang K,Ho W,Hou W,Huang J,Guo D

更新日期：2015-10-20 00:00:00

abstract：:Autophagy is a major regulator of pancreatic beta cell homeostasis. Altered autophagic activity has been implicated in the beta cells of patients with type 2 diabetes, and in the beta cells of obese diabetic rodents. Here, we show that autophagy was induced in beta cells by either a high-fat diet or a combined high-fa...

journal_title：Scientific reports

authors： Sheng Q,Xiao X,Prasadan K,Chen C,Ming Y,Fusco J,Gangopadhyay NN,Ricks D,Gittes GK

更新日期：2017-11-27 00:00:00

abstract：:The purpose of this study is to investigate whether implementing a myofascial release (MFR) protocol designed to restore the myofascial properties of the diaphragm has any effect on the symptoms, quality of life, and consumption of proton pump inhibitors (PPI) drugs by patients with non-erosive gastroesophageal reflux...

journal_title：Scientific reports

authors： Martínez-Hurtado I,Arguisuelas MD,Almela-Notari P,Cortés X,Barrasa-Shaw A,Campos-González JC,Lisón JF

更新日期：2019-05-13 00:00:00

abstract：:Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because of their wide variety of potential functionalizations and coordination modes. Herein, we report three copper complexes 1-3 with ...

journal_title：Scientific reports

authors： Hussain A,AlAjmi MF,Rehman MT,Amir S,Husain FM,Alsalme A,Siddiqui MA,AlKhedhairy AA,Khan RA

更新日期：2019-03-27 00:00:00

abstract：:The arrival of infected travelers from endemic regions can trigger sustained autochthonous transmission of mosquito-borne pathogens in Europe. In 2007 a Chikungunya outbreak was observed in central Italy, mostly affecting two villages characterised by a high density of Aedes albopictus. The outbreak was mitigated thro...

journal_title：Scientific reports

authors： Trentini F,Poletti P,Baldacchino F,Drago A,Montarsi F,Capelli G,Rizzoli A,Rosà R,Rizzo C,Merler S,Melegaro A

更新日期：2018-06-13 00:00:00

abstract：:Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to...

journal_title：Scientific reports

authors： Dvorak AV,Swift-LaPointe T,Vavasour IM,Lee LE,Abel S,Russell-Schulz B,Graf C,Wurl A,Liu H,Laule C,Li DKB,Traboulsee A,Tam R,Boyd LA,MacKay AL,Kolind SH

更新日期：2021-01-11 00:00:00

abstract：:Alveolar type II epithelial cells (ATII) are instrumental in early wound healing in response to lung injury, restoring epithelial integrity through spreading and migration. We previously reported in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor CXCR4 promote epithelial repair mechanism...

journal_title：Scientific reports

authors： Ghosh MC,Makena PS,Kennedy J,Teng B,Luellen C,Sinclair SE,Waters CM

更新日期：2017-05-19 00:00:00

abstract：:Accumulated evidence suggests that activated pancreatic stellate cells (PSCs) serve as the main source of the extracellular matrix proteins accumulated under the pathological conditions leading to pancreatic fibrosis in chronic pancreatitis (CP). However, little is known about the mechanisms of PSC activation. PSCs ha...

journal_title：Scientific reports

authors： Gao L,Lei XF,Miyauchi A,Noguchi M,Omoto T,Haraguchi S,Miyazaki T,Miyazaki A,Kim-Kaneyama JR

更新日期：2020-11-05 00:00:00

abstract：:The structural and magnetic properties of seven CeMn2Ge(2-x)Six compounds with x = 0.0-2.0 have been investigated in detail. Substitution of Ge with Si leads to a monotonic decrease of both a and c along with concomitant contraction of the unit cell volume and significant modifications of the magnetic states - a cross...

journal_title：Scientific reports

authors： Md Din MF,Wang JL,Cheng ZX,Dou SX,Kennedy SJ,Avdeev M,Campbell SJ

更新日期：2015-06-19 00:00:00

abstract：:Multiplexed error-robust fluorescence in situ hybridization (MERFISH) allows simultaneous imaging of numerous RNA species in their native cellular environment and hence spatially resolved single-cell transcriptomic measurements. However, the relatively modest brightness of signals from single RNA molecules can become ...

journal_title：Scientific reports

authors： Xia C,Babcock HP,Moffitt JR,Zhuang X

更新日期：2019-05-22 00:00:00

abstract：:Estrogen receptor-α (ERα) plays an important role in normal and abnormal physiology of the human reproductive system by interacting with the endogenous ligand estradiol (E2). However, other ligands, either analogous or dissimilar to E2, also bind to ERα. This may create unintentional activation of ER signaling in repr...

journal_title：Scientific reports

authors： Sekar TV,Foygel K,Massoud TF,Gambhir SS,Paulmurugan R

更新日期：2016-10-10 00:00:00

abstract：:Increasing population has posed insurmountable challenges to agriculture in the provision of future food security, particularly in the Middle East and North Africa (MENA) region where biophysical conditions are not well-suited for agriculture. Iran, as a major agricultural country in the MENA region, has long been in ...

journal_title：Scientific reports

authors： Mesgaran MB,Madani K,Hashemi H,Azadi P

更新日期：2017-08-09 00:00:00

abstract：:It is now well established that invasive plants may induce drifts in the quantity and/or quality of floral resources. They are then often pointed out as a potential driver of bee decline. However, their impact on bee population remains quite unclear and still controversial, as bee responses are highly variable among s...

journal_title：Scientific reports

authors： Drossart M,Michez D,Vanderplanck M

更新日期：2017-11-24 00:00:00

abstract：:Although rare in the U.S., outbreaks due to Neisseria meningitidis do occur. Rapid, early outbreak detection is important for timely public health response. In this study, we characterized U.S. meningococcal isolates (N = 201) from 15 epidemiologically defined outbreaks (2009-2015) along with temporally and geographic...

journal_title：Scientific reports

authors： Whaley MJ,Joseph SJ,Retchless AC,Kretz CB,Blain A,Hu F,Chang HY,Mbaeyi SA,MacNeil JR,Read TD,Wang X

更新日期：2018-10-25 00:00:00

abstract：:Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 60...

journal_title：Scientific reports

authors： Di Giglio MG,Muttenthaler M,Harpsøe K,Liutkeviciute Z,Keov P,Eder T,Rattei T,Arrowsmith S,Wray S,Marek A,Elbert T,Alewood PF,Gloriam DE,Gruber CW

更新日期：2017-02-01 00:00:00

abstract：:This study was to evaluate the prognostic value of pretreatment inflammatory indexes including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) in colorectal cancer (CRC) patients receiving neoadjuvant chemoradiot...

journal_title：Scientific reports

authors： Yang J,Xu H,Guo X,Zhang J,Ye X,Yang Y,Ma X

更新日期：2018-02-14 00:00:00

abstract：:GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the functional connectivity between abDGCs and local interneurons is required to understand their development and integration into the hippocampal circuit. We recorded from birthdated abDGCs in mice and photoactivated parvalbumin ...

journal_title：Scientific reports

authors： Remmers CL,Castillon CCM,Armstrong JN,Contractor A

更新日期：2020-10-16 00:00:00

abstract：:Recent studies have shown that the representation of an item in visual working memory (VWM) can bias the deployment of attention to stimuli in the visual scene possessing the same features. When multiple item representations are simultaneously held in VWM, whether these representations, especially those held in a non-...

journal_title：Scientific reports

authors： Zhang B,Liu S,Doro M,Galfano G

更新日期：2018-09-17 00:00:00

abstract：:Identification of epitopes for integrin-blocking monoclonal antibodies (mAbs) has aided our understanding of structure-function relationship of integrins. We mapped epitopes of chicken anti-integrin-α8-subunit-blocking mAbs by mutational analyses, examining regions that harboured all mapped epitopes recognized by mAbs...

journal_title：Scientific reports

authors： Nishimichi N,Kawashima N,Yokosaki Y

更新日期：2015-09-09 00:00:00

abstract：:Treatment of decompensated heart failure often includes administration of levosimendan. Myeloperoxidase (MPO) is released during polymorphonuclear neutrophil (PMN) degranulation, and mediates dysregulation of vascular tone in heart failure. We evaluated the effects of levosimendan-treatment on MPO in patients with acu...

journal_title：Scientific reports

authors： Adam M,Meyer S,Knors H,Klinke A,Radunski UK,Rudolph TK,Rudolph V,Spin JM,Tsao PS,Costard-Jäckle A,Baldus S

更新日期：2015-04-13 00:00:00

abstract：:Spermatogenesis in the mouse has been extensively studied for decades. Previous methods, such as histological staining or bulk transcriptome analysis, either lacked resolution at the single-cell level or were focused on a very narrowly defined set of factors. Here, we present the first comprehensive, unbiased single-c...

journal_title：Scientific reports

authors： Lukassen S,Bosch E,Ekici AB,Winterpacht A

更新日期：2018-04-25 00:00:00

abstract：:Alternate bearing (AB) refers to the tendency of trees to have an irregular crop load from 1 year (ON) to the next year (OFF). Despite its economic importance, it is not fully understood how gene networks and their related metabolic pathways may influence the irregular bearing in olive trees. To unravel molecular mech...

journal_title：Scientific reports

authors： Dastkar E,Soleimani A,Jafary H,de Dios Alche J,Bahari A,Zeinalabedini M,Salami SA

更新日期：2020-09-25 00:00:00

abstract：:Rhodophiala bifida (R. bifida) is a representative of the Amaryllidaceae plant family and is rich in montanine, an alkaloid with high pharmaceutical potential. Despite the interest in these compounds, many steps of the biosynthetic pathway have not been elucidated. In this study, we identified the alkaloids produced i...

journal_title：Scientific reports

authors： Reis A,Magne K,Massot S,Tallini LR,Scopel M,Bastida J,Ratet P,Zuanazzi JAS

更新日期：2019-06-11 00:00:00

abstract：:The pathways of protein post-translational modifications (PTMs) have been shown to play particularly important roles for almost any biological process. Identification of PTM substrates along with information on the exact sites is fundamental for fully understanding or controlling biological processes. Alternative comp...

journal_title：Scientific reports

authors： Chen X,Shi SP,Xu HD,Suo SB,Qiu JD

更新日期：2016-05-13 00:00:00

abstract：:To demonstrate the identification of corneal diseases using a novel deep learning algorithm. A novel hierarchical deep learning network, which is composed of a family of multi-task multi-label learning classifiers representing different levels of eye diseases derived from a predefined hierarchical eye disease taxonomy...

journal_title：Scientific reports

authors： Gu H,Guo Y,Gu L,Wei A,Xie S,Ye Z,Xu J,Zhou X,Lu Y,Liu X,Hong J

更新日期：2020-10-20 00:00:00

abstract：:Multi-drug resistant efflux transporters found in Blood-Brain Barrier (BBB) acts as a functional barrier, by pumping out most of the drugs into the blood. Previous studies showed focused ultrasound (FUS) induced microbubble oscillation can disrupt the BBB by loosening the tight junctions in the brain endothelial cells...

journal_title：Scientific reports

authors： Cho H,Lee HY,Han M,Choi JR,Ahn S,Lee T,Chang Y,Park J

更新日期：2016-08-11 00:00:00