Abstract：
:Autophagy is a major regulator of pancreatic beta cell homeostasis. Altered autophagic activity has been implicated in the beta cells of patients with type 2 diabetes, and in the beta cells of obese diabetic rodents. Here, we show that autophagy was induced in beta cells by either a high-fat diet or a combined high-fat and high-glucose diet, but not by high-glucose alone. However, a high-glucose intake alone did increase beta cell mass and insulin secretion moderately. Depletion of Atg7, a necessary component of the autophagy pathway, in beta cells by pancreatic intra-ductal AAV8-shAtg7 infusion in C57BL/6 mice, resulted in decreased beta cell mass, impaired glucose tolerance, defective insulin secretion, and increased apoptosis when a combined high-fat and high-glucose diet was given, seemingly due to suppression of autophagy. Taken together, our findings suggest that the autophagy pathway may act as a protective mechanism in pancreatic beta cells during a high-calorie diet.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sheng Q,Xiao X,Prasadan K,Chen C,Ming Y,Fusco J,Gangopadhyay NN,Ricks D,Gittes GKdoi
10.1038/s41598-017-16485-0subject
Has Abstractpub_date
2017-11-27 00:00:00pages
16348issue
1issn
2045-2322pii
10.1038/s41598-017-16485-0journal_volume
7pub_type
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