Abstract：
:Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to create an optimized anatomical brain template and accompanying MWF and IET2 atlases. We then used the MWF atlas to characterize how myelin content relates to demographic factors. In most brain regions, myelin content followed a quadratic pattern of increase during the third decade of life, plateau at a maximum around the fifth decade, then decrease during later decades. The ranking of mean myelin content between brain regions remained consistent across age groups. These openly available normative atlases can facilitate evaluation of myelin imaging results on an individual basis and elucidate the distribution of myelin content between brain regions and in the context of aging.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dvorak AV,Swift-LaPointe T,Vavasour IM,Lee LE,Abel S,Russell-Schulz B,Graf C,Wurl A,Liu H,Laule C,Li DKB,Traboulsee A,Tam R,Boyd LA,MacKay AL,Kolind SHdoi
10.1038/s41598-020-79540-3subject
Has Abstractpub_date
2021-01-11 00:00:00pages
269issue
1issn
2045-2322pii
10.1038/s41598-020-79540-3journal_volume
11pub_type
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