Abstract:
:Bilirubin neurotoxicity has been studied for decades and has been shown to affect various mechanisms via significant modulation of gene expression. This suggests that vital regulatory mechanisms of gene expression, such as epigenetic mechanisms, could play a role in bilirubin neurotoxicity. Histone acetylation has recently received attention in the CNS due to its role in gene modulation for numerous biological processes, such as synaptic plasticity, learning, memory, development and differentiation. Aberrant epigenetic regulation of gene expression in psychiatric and neurodegenerative disorders has also been described. In this work, we followed the levels of histone 3 lysine 14 acetylation (H3K14Ac) in the cerebellum (Cll) of the developing (2, 9, 17 days after the birth) and adult Gunn rat, the natural model for neonatal hyperbilirubinemia and kernicterus. We observed an age-specific alteration of the H3K14Ac in the hyperbilirubinemic animals. The GeneOntology analysis of the H3K14Ac linked chromatin revealed that almost 45% of H3K14Ac ChiP-Seq TSS-promoter genes were involved in CNS development including maturation and differentiation, morphogenesis, dendritogenesis, and migration. These data suggest that the hallmark Cll hypoplasia in the Gunn rat occurs also via epigenetically controlled mechanisms during the maturation of this brain structure, unraveling a novel aspect of the bilirubin-induced neurotoxicity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Vianello E,Zampieri S,Marcuzzo T,Tordini F,Bottin C,Dardis A,Zanconati F,Tiribelli C,Gazzin Sdoi
10.1038/s41598-018-32106-wsubject
Has Abstractpub_date
2018-09-12 00:00:00pages
13690issue
1issn
2045-2322pii
10.1038/s41598-018-32106-wjournal_volume
8pub_type
杂志文章abstract::Mixed species biofilms are shaped and influenced by interactions between species. In the oral cavity, dysbiosis of the microbiome leads to diseases such as periodontitis. Porphyromonas gingivalis is a keystone pathogen of periodontitis. In this study, we showed that polymicrobial biofilm formation promoted the toleran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41467-9
更新日期:2019-03-20 00:00:00
abstract::Dating the start of intensive anthropogenic influence on ecosystems is important for identifying the conditions necessary for ecosystem recovery. However, few studies have focused on determining when anthropogenic influences on wetland began through sedimentary archives. To fill this critical gap in our knowledge, com...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22153
更新日期:2016-02-24 00:00:00
abstract::CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form of CD74 (soluble CD74, sCD74) was recently discovered in autoimmune liver disease. Using two murine ALI models and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30067
更新日期:2016-07-22 00:00:00
abstract::The human genome is persistently exposed to damage caused by xenobiotics, therefore the assessment of genotoxicity of substances having a direct contact with humans is of importance. Phthalates are commonly used in industrial applications. Widespread exposure to phthalates has been evidenced by their presence in human...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79932-5
更新日期:2021-01-18 00:00:00
abstract::Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density parasitemia on re-infection. Previous studies using the P. chabaudi (Pch) mouse model to understand the reason for chronic malaria, found that mice with a deletion o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26210
更新日期:2016-05-24 00:00:00
abstract::Lonicera japonica Thunb, rich in chlorogenic acid (CHA), is used for viral upper respiratory tract infection treatment caused by influenza virus, parainfluenza virus, and respiratory syncytial virus, ect in China. It was reported that CHA reduced serum hepatitis B virus level and death rate of influenza virus-infected...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45723
更新日期:2017-04-10 00:00:00
abstract::In social interactions, including cooperation and conflict, individuals can adjust their behaviour over the shorter term through learning within a generation, and natural selection can change behaviour over the longer term of many generations. Here we investigate the evolution of cognitive bias by individuals investin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52781-7
更新日期:2019-11-08 00:00:00
abstract::The high-speed liquid-jet velocity achieved using an injector strongly depends on the piston motion, physical property of the liquid, and container shape of the injector. Herein, we investigate the liquid ejection mechanism and a technique for estimating the ejection velocity of a high-speed liquid jet using a pyro je...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56511-x
更新日期:2019-12-27 00:00:00
abstract::Neurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes. However, the effects of NKB administration on hot f...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/srep08466
更新日期:2015-02-16 00:00:00
abstract::Selective removal of lignin and other recalcitrant compounds, collectively registered as acid-unhyrolyzable residue (AUR), results in bleaching of leaf litter, but the importance of bleaching in decomposition processes on forest soil has not been fully evaluated. The aims of this study were to elucidate the occurrence...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81206-7
更新日期:2021-01-19 00:00:00
abstract::Hydrostatic pressure is an important environmental factor affecting the vertical distribution of marine organisms. Laboratory-based studies have shown that many extant shallow-water marine benthic invertebrates can tolerate hydrostatic pressure outside their known natural distributions. However, only a few studies hav...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39716-y
更新日期:2019-03-05 00:00:00
abstract::The hepatitis C virus (HCV) is one of the leading causes of chronic hepatitis, liver cirrhosis and hepatocellular carcinomas and infects approximately 170 million people worldwide. Although several reporter systems have been developed, many shortcomings limit their use in the assessment of HCV infections. Here, we rep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08865
更新日期:2015-03-09 00:00:00
abstract::Heavy metals are environmental pollutants affect the integrity and distribution of living organisms in the ecosystem and also humans across the food chain. The study targeted the removal of copper (Cu2+) from aqueous solutions, depending on the biosorption process. The bacterial candidate was identified using 16S rRNA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66101-x
更新日期:2020-06-11 00:00:00
abstract::The 'brain regionalization genes' Six3/6, Otx, Pax2/5/8, Gbx, and Hox1 are expressed in a similar fashion in the deuterostome, ecdysozoan, and the cephalopod brain, questioning whether this holds also true for the remaining Mollusca. We investigated developmental Gbx-expression in representatives of both molluscan sis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05605-5
更新日期:2017-07-14 00:00:00
abstract::The effects of dairy products on human health have been studied for years. However, the relationship between dairy products as well as calcium intake and the risk of lung cancer is still inconclusive. A total of 32 studies regarding this association were identified from the PubMed and Web of Science databases through ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep20624
更新日期:2016-02-15 00:00:00
abstract::NiFe nanoparticles-decorated & N-doped graphene is introduced as an effective and stable non-precious electrocatalyst for ORR in the acid medium. Compared to conventional Pt/C electrodes under the same conditions, the proposed nanocatalyst shows closer onset potential and current density. Typically, the observed onset...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22114-1
更新日期:2018-02-28 00:00:00
abstract::Soybean cyst nematode (SCN) Heterodera glycines is an obligate parasite that relies on the secretion of effector proteins to manipulate host cellular processes that favor the formation of a feeding site within host roots to ensure its survival. The sequence complexity and co-evolutionary forces acting upon these effec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20536-5
更新日期:2018-02-06 00:00:00
abstract::Focusing on the chemical basis of dietary selection while investigating the nutritional ecology of animals helps understand their feeding biology. It is also important to consider food abundance/biomass while studying the mechanism of animal food selection. We studied leaf selection in two Bornean folivorous primates ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01873
更新日期:2013-01-01 00:00:00
abstract::The aperture stop of the iris is subject to refraction by the cornea, and thus an outside observer sees a virtual image: the "entrance pupil" of the eye. When viewed off-axis, the entrance pupil has an elliptical form. The precise appearance of the entrance pupil is a consequence of the anatomical and optical properti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45827-3
更新日期:2019-06-27 00:00:00
abstract::We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40247-9
更新日期:2019-03-06 00:00:00
abstract::Bisphenol A (BPA), a member of the environmental endocrine disruptors (EDCs), has recently received increased attention because of its effects on brain insulin resistance. Available data have indicated that brain insulin resistance may contribute to neurodegenerative diseases. However, the associated mechanisms that u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07544-7
更新日期:2017-08-08 00:00:00
abstract::Polymorphisms contribute to inter-individual differences and show a promising predictive role for chemotherapy-related toxicity in colon cancer (CC). TOSCA is a multicentre, randomized, non-inferiority, phase III study conducted in high-risk stage II/stage III CC patients treated with 6 vs 3 months of FOLFOX-4 or XELO...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-47627-1
更新日期:2019-08-08 00:00:00
abstract::Pituitary adenylate cyclase activating polypeptide (PACAP) is a regulatory and cytoprotective neuropeptide, its deficiency implies accelerated aging in mice. It is present in the auditory system having antiapoptotic effects. Expression of Ca2+-binding proteins and its PAC1 receptor differs in the inner ear of PACAP-de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50775-z
更新日期:2019-10-10 00:00:00
abstract::For isotropic fluids, classical nucleation theory predicts the nucleation rate, barrier height and critical droplet size by ac- counting for the competition between bulk energy and interfacial tension. The nucleation process in liquid crystals is less understood. We numerically investigate nucleation in monolayered ne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40059
更新日期:2017-01-05 00:00:00
abstract::The rapid increase in the number of genetically modified (GM) varieties has led to a demand for high-throughput methods to detect genetically modified organisms (GMOs). We describe a new dynamic array-based high throughput method to simultaneously detect 48 targets in 48 samples on a Fludigm system. The test targets i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07616
更新日期:2015-01-05 00:00:00
abstract::A new synchrotron-based technique for elemental imaging that combines radiography and fluorescence spectroscopy has been developed and applied to study the spatial distribution of Ag, Zr and Mo in an Al alloy during heating and melting to 700, and then re-soldification. For the first time, multi-element distributions ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15988
更新日期:2015-11-02 00:00:00
abstract::The goal of this study was to develop a cheap and simple medium and to optimize fermentation parameters for fibrinolytic enzyme production by Bacillus subtilis WR350. A low-cost medium containing 35 g/L sucrose, 20 g/L corn steep powder and 2 g/L MgSO4·7H2O was developed via single-factor and orthogonal experiments. A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43371-8
更新日期:2019-05-02 00:00:00
abstract::Human societies greatly depend on tools, which spare us considerable time and effort. Humans might have evolved a bias to employ tools, using them even when they are unnecessary. This study aimed to investigate whether adult humans and a distantly related habitually tool-using vertebrate species, the New Caledonian cr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16984-0
更新日期:2017-12-06 00:00:00
abstract::Global ocean acidification is expected to chronically lower the pH to 7.3 (>2200 µatm seawater pCO2) by the year 2300. Acute hypercapnia already occurs along the South African west and south coasts due to upwelling- and low-oxygen events, with increasing frequency. In the present project we investigated the impact of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54795-7
更新日期:2019-12-19 00:00:00
abstract::Acute chest syndrome (ACS) is a major complication of sickle cell anaemia (SCA) and a leading cause for hospital admissions and death. We aimed to study the spectrum of clinical and laboratory features of ACS and to assess the predisposing factors and predictors of severity. A retrospective case-control cohort was stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59258-y
更新日期:2020-02-12 00:00:00