Abstract：
:Atropa acuminata Royle Ex Lindl (Atropa acuminata) under tremendous threat of extinction in its natural habitat. However, the antimicrobial, antileishmanial and anticancer effects of the plant's extracts have not been reported yet. In the current study, an attempt has been made to evaluate the pharmacological potential of this plant's extracts against microbes, Leishmania and cancer. The roots, stems and leaves of Atropa acuminata were ground; then, seven different solvents were used alone and in different ratios to prepare crude extracts, which were screened for pharmacological effects. The aqueous, methanolic and ethanolic extracts of all parts carried a broad spectrum of anti-bacterial activities, while no significant activity was observed with combined solvents. Three types of cytotoxicity assays were performed, i.e., haemolytic, brine shrimp and protein kinase assays. The aqueous extract of all the parts showed significant haemolytic activity while n-hexane extracts of roots showed significant activity against brine shrimp. The acetone extracts strongly inhibited protein kinase while the methanolic extracts exhibited significant cytotoxic activity of roots and stem. The anti-leishmanial assays revealed that the methanolic extract of leaves and roots showed significant activity. These findings suggest that this plant could be a potential source of natural product based drugs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rahman K,Khan SU,Fahad S,Shinwari ZK,Khan D,Kamal S,Ullah I,Anjum SI,Man S,Khan AJ,Khan WU,Khan MHU,Jan M,Adnan M,Noor Mdoi
10.1038/s41598-018-29231-xsubject
Has Abstractpub_date
2018-07-23 00:00:00pages
11028issue
1issn
2045-2322pii
10.1038/s41598-018-29231-xjournal_volume
8pub_type
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