Abstract:
:The dependences of spreading and differentiation of stem cells plated on hydrogel and silicone gel substrates on the rigidity and porosity of the substrates have recently been a subject of some controversy. In experiments on human mesenchymal stem cells plated on soft, medium rigidity, and hard silicone gels we show that harder gels are more osteogenic, softer gels are more adipogenic, and cell spreading areas increase with the silicone gel substrate rigidity. The results of our study indicate that substrate rigidity induces some universal cellular responses independently of the porosity or topography of the substrate.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Vertelov G,Gutierrez E,Lee SA,Ronan E,Groisman A,Tkachenko Edoi
10.1038/srep33411subject
Has Abstractpub_date
2016-09-21 00:00:00pages
33411issn
2045-2322pii
srep33411journal_volume
6pub_type
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