Abstract:
:The aims of this study were, firstly, to assess the effect of concurrent peripheral artery disease (PAD) on the health-related quality of life (QOL) of people diagnosed with a small abdominal aortic aneurysm (AAA); and secondly, to test whether the peroxisome proliferator-activated receptor α agonist fenofibrate improved QOL of people diagnosed with a small AAA, including those diagnosed with concurrent PAD. The study included both a cross-sectional observational study and a randomized placebo-controlled clinical trial. 140 people diagnosed with a 35-49 mm diameter AAA, 56 (40%) of whom had concurrent PAD, and 25 healthy controls were prospectively recruited. QOL was assessed with the short form (SF) 36. Findings in participants that were diagnosed with both AAA and PAD were compared separately with those of participants that had a diagnosis of AAA alone or who had neither AAA nor PAD diagnosed (healthy controls). All participants diagnosed with an AAA were then randomly allocated to 145 mg of fenofibrate per day or identical placebo. Outcomes were assessed by changes in the domains of the SF-36 and ankle brachial pressure Index (ABPI) from randomization to 24 weeks. Data were analyzed using Mann-Whitney U tests. Participants diagnosed with both AAA and PAD had significantly worse QOL than participants diagnosed with AAA alone or healthy controls. Fenofibrate did not significantly alter SF-36 scores or ABPI over 24 weeks. Fenofibrate does not improve QOL of people diagnosed with small AAA, irrespective of whether they have concurrent PAD.Trial registration: ACTN12613001039774 Australian New Zealand Clinical Trials Registry.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Golledge J,Pinchbeck J,Rowbotham SE,Yip L,Jenkins JS,Quigley F,Moxon JVdoi
10.1038/s41598-020-71454-4subject
Has Abstractpub_date
2020-09-03 00:00:00pages
14583issue
1issn
2045-2322pii
10.1038/s41598-020-71454-4journal_volume
10pub_type
杂志文章abstract::Radopholus similis is an important migratory endoparasitic nematode, severely harms banana, citrus and many other commercial crops. Little is known about the molecular mechanism of infection and pathogenesis of R. similis. In this study, 64761 unigenes were generated from eggs, juveniles, females and males of R. simil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42724-7
更新日期:2019-04-18 00:00:00
abstract::Every day we are exposed to different ideas, or memes, competing with each other for our attention. Previous research explained popularity and persistence heterogeneity of memes by assuming them in competition for limited attention resources, distributed in a heterogeneous social network. Little has been said about wh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06477
更新日期:2014-09-26 00:00:00
abstract::Ce(3+)-doped yttrium aluminum garnet (YAG:Ce) nanocrystals were successfully synthesized via a facile sol-gel method. Multiple characterization techniques were employed to study the structure, morphology, composition and photoluminescence properties of YAG:Ce nanophosphors. The YAG:Ce0.0055 sintered at 1030 °C exhibit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22238
更新日期:2016-03-03 00:00:00
abstract::Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and non-functioning organelles. We recently demonstrated that exercise activates autophagy and re-establishe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30365-1
更新日期:2018-08-07 00:00:00
abstract::Angiogenin (hANG), a member of the Ribonuclease A superfamily has angiogenic, neurotrophic and neuroprotective activities. Mutations in hANG have been found in patients with Amyotrophic lateral sclerosis (ALS). The zebrafish (Danio rerio) rnasel-1, 2 and 3 are orthologues of hANG and of these only Rnasel-1 and Rnasel-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37140-2
更新日期:2019-02-01 00:00:00
abstract::No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leishmania vaccines such as centrin deleted Leishmania donovani parasites (LdCen -...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05088-4
更新日期:2017-07-05 00:00:00
abstract::Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31198
更新日期:2016-08-09 00:00:00
abstract::Agriculture provides livelihood for 65% of Nepal's population contributing for 27% of its GDP. Smallholder farms constitute 60% of farming segment. Distress farming, with inadequate minimum support price, subsidies and inadequate revenue generation force 29% of the general population to be malnourished. Farming system...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67657-4
更新日期:2020-06-29 00:00:00
abstract::Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy skin microbial populations, and tried to establish global patterns of skin-phage evolution. However, the detail associated with the phages that potentially play a role in skin health has not been invest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30705-1
更新日期:2018-08-16 00:00:00
abstract::Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40760
更新日期:2017-01-17 00:00:00
abstract::The gist of natural scenes can be extracted very rapidly and even without focal attention. However, it is unclear whether and to what extent the gist of natural scenes can break through the bottleneck of crowding, a phenomenon in which object recognition will be immensely impaired. In the first two experiments, a targ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32455-6
更新日期:2018-09-19 00:00:00
abstract::The arrival of the Longobards in Northern Italy in 568 CE marked a period of renewed political stability in the Peninsula after the collapse of the Western Roman Empire. The trajectory of the spread of Longobards in Italy across the Alps and into the South is known from many literary sources. However, their mobility a...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-67480-x
更新日期:2020-07-15 00:00:00
abstract::We show that widely used approaches in statistical physics incorrectly indicate the existence of power-law cross-correlations between financial stock market fluctuations measured over several years and the neuronal activity of the human brain lasting for only a few minutes. While such cross-correlations are nonsensica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27089
更新日期:2016-06-02 00:00:00
abstract::Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strateg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17070
更新日期:2015-11-23 00:00:00
abstract::Evasion of the potent tumour suppressor activity of p53 is one of the hurdles that must be overcome for cancer cells to escape normal regulation of cellular proliferation and survival. In addition to frequent loss of function mutations, p53 wild-type activity can also be suppressed post-translationally through several...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28002-y
更新日期:2018-06-26 00:00:00
abstract::The Saccharomyces cerevisiae kinesin-5 Cin8 performs essential mitotic functions in spindle assembly and anaphase B spindle elongation. Recent work has shown that Cin8 is a bi-directional motor which moves towards the minus-end of microtubules (MTs) under high ionic strength (IS) conditions and changes directionality ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25597
更新日期:2016-05-24 00:00:00
abstract::In earlier studies, we showed that ATF4 down-regulation affects post-synaptic development and dendritic spine morphology in neurons through increased turnover of the Rho GTPase Cell Division Cycle 42 (Cdc42) protein. Here, we find that ATF4 down-regulation in both hippocampal and cortical neuron cultures reduces prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36952
更新日期:2016-11-14 00:00:00
abstract::Quartz is a common phase in high-silica igneous rocks and is resistant to post-eruptive alteration, thus offering a reliable record of magmatic processes in silicic magma systems. Here we employ the 75 ka Toba super-eruption as a case study to show that quartz can resolve late-stage temporal changes in magmatic δ18O v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40624
更新日期:2017-01-25 00:00:00
abstract::Histone methylation is thought to control the regulation of genetic program and the dysregulation of it has been found to be closely associated with cancer. JMJD3 has been identified as an H3K27 demethylase and its role in cancer development is context specific. The role of JMJD3 in gastric cancer (GC) has not been ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37340-w
更新日期:2019-01-29 00:00:00
abstract::The dynamics of cell wall polysaccharides may modulate the cell wall mechanics and thus control the expansion growth of plant cells. The unique composition of type II primary cell wall characteristic of grasses suggests that they employ specific mechanisms for cell enlargement. We characterized the transcriptomes in f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67782-0
更新日期:2020-07-02 00:00:00
abstract::Neuropathic pain is a complex, chronic pain state that often accompanies tissue damage, inflammation or injury of the nervous system. However the underlying molecular mechanisms still remain unclear. Here, we showed that CXCL12 and CXCR4 were upregulated in the dorsal root ganglion (DRG) after chronic compression of D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05954-1
更新日期:2017-07-18 00:00:00
abstract::We developed a novel integrated technology for diver-operated surveying of shallow marine ecosystems. The HyperDiver system captures rich multifaceted data in each transect: hyperspectral and color imagery, topographic profiles, incident irradiance and water chemistry at a rate of 15-30 m2 per minute. From surveys in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07337-y
更新日期:2017-08-02 00:00:00
abstract::While nanowires and nanospheres have been utilized in the design of a diverse array of nanoscale devices, recent schemes frequently require nanoscale architectures of higher complexity. However, conventional techniques are largely unsatisfactory for the production of more intricate nanoscale shapes and patterns, and e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04864
更新日期:2014-05-06 00:00:00
abstract::The prognostic factors of patients who undergo radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is not fully elucidated. We aimed to investigate the role of liver stiffness (LS) and spleen stiffness (SS) measured by acoustic radiation force impulse (ARFI) elastography in determining the prognoses of pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58988-3
更新日期:2020-02-06 00:00:00
abstract::This study aimed to develop and validate a model for the preoperative prediction of the effectiveness of hysteroscopic resection of a uterine cesarean niche in patients with postmenstrual spotting. The predictive model was developed in a primary prospective cohort consisting of 208 patients with niche treated by hyste...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74622-8
更新日期:2020-10-15 00:00:00
abstract::Systemic Sclerosis (SSc) is a disease with limited therapeutic possibilities. Mesenchymal stem cells (MSCs)-therapy could be a promising therapeutic option, however the ideal MSCs source has not yet been found. To address this problem, we perform comparison between bone marrow (BM)-MSCs and adipose (A)-MSCs, by the mi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43638-0
更新日期:2019-05-09 00:00:00
abstract::Telomerase activation and telomere maintenance are critical for cellular immortalization and transformation. PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a telomerase regulator and the aberrant expression of PinX1 causes telomere shortening. Identifying PinX1-interacting proteins is important for understan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43650
更新日期:2017-03-03 00:00:00
abstract::Rubber-filler composites are a key component in the manufacture of tyres. The filler provides mechanical reinforcement and additional wear resistance to the rubber, but it in turn introduces non-linear mechanical behaviour to the material which most likely arises from interactions between the filler particles, mediate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07389
更新日期:2014-12-09 00:00:00
abstract::Biochemical remission after transsphenoidal surgery is still unsatisfied in acromegaly patients with macroadenomas, especially with invasive macroadenomas. Concerning the impact of preoperative somatostatin analogues (SSAs) on surgical outcomes, previous studies with limited cases reported conflicting results. To asse...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-019-50639-6
更新日期:2019-10-01 00:00:00
abstract::Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. One of the characteristic features of some tumour types is that their fast growth leads to deficient ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43618-4
更新日期:2019-05-08 00:00:00