Abstract：
:Diagnostic test accuracy of the loop-mediated isothermal amplification (LAMP) assay for culture proven tuberculosis is unclear. We searched electronic databases for both cohort and case-control studies that provided data to calculate sensitivity and specificity. The index test was any LAMP assay including both commercialized kits and in-house assays. Culture-proven M. tuberculosis was considered a positive reference test. We included 26 studies on 9330 sputum samples and one study on 315 extra-pulmonary specimens. For sputum samples, 26 studies yielded the summary estimates of sensitivity of 89.6% (95% CI 85.6-92.6%), specificity of 94.0% (95% CI 91.0-96.1%), and a diagnostic odds ratio of 145 (95% CI 93-226). Nine studies focusing on Loopamp MTBC yielded the summary estimates of sensitivity of 80.9% (95% CI 76.0-85.1%) and specificity of 96.5% (95% CI 94.7-97.7%). Loopamp MTBC had higher sensitivity and lower specificity for smear-positive sputa compared to smear-negative sputa. In-house assays showed higher sensitivity and lower specificity compared to Loopamp MTBC. LAMP promises to be a useful test for the diagnosis of TB, however there is still need to improve the assay to make it simpler, cheaper and more efficient to make it competitive against other PCR methods already available.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nagai K,Horita N,Yamamoto M,Tsukahara T,Nagakura H,Tashiro K,Shibata Y,Watanabe H,Nakashima K,Ushio R,Ikeda M,Narita A,Kanai A,Sato T,Kaneko Tdoi
10.1038/srep39090subject
Has Abstractpub_date
2016-12-13 00:00:00pages
39090issn
2045-2322pii
srep39090journal_volume
6pub_type
杂志文章,meta分析,评审abstract：:Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair. Recent studies suggested the key role of CD8+T lymphocytes for mediating immune response in vitiligo through melanocyte differentiation antigens, including tyrosinase, gp100 and Mela...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36360
更新日期：2016-11-08 00:00:00
abstract：:In the gastrointestinal (GI) epithelium, enterochromaffin (EC) cells are enteroendocrine cells responsible for producing >90% of the body's serotonin (5-hydroxytryptamine, 5-HT). However, the molecular mechanisms of EC cell function are poorly understood. Here, we found that EC cells in mouse primary cultures fired sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15834-3
更新日期：2017-11-15 00:00:00
abstract：:Genetic epidemiological studies show that genetic factors contribute significantly to cervical cancer carcinogenesis. Several genome-wide association studies (GWAS) have revealed novel genetic variants associated with cervical cancer susceptibility. We aim to replicate 4 GWAS-identified single nucleotide polymorphisms...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33430-x
更新日期：2018-10-17 00:00:00
abstract：:Although the rapid urease test (RUT) is a simple method for detecting Helicobacter pylori (H. pylori) infection, it requires sufficient biopsy samples and its sensitivity varies depending on the site and condition of H. pylori infection. We compared the diagnostic performance of a "sweeping method" for H. pylori detec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75528-1
更新日期：2020-10-28 00:00:00
abstract：:Motor symptoms are defining traits in the diagnosis of Parkinson's disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive affere...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39204-3
更新日期：2019-02-22 00:00:00
abstract：:Although the demand for high-speed telecommunications has increased in recent years, the performance of transistors fabricated with traditional semiconductors such as silicon, gallium arsenide, and gallium nitride have reached their physical performance limits. Therefore, new materials with high carrier velocities sho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03951
更新日期：2014-02-04 00:00:00
abstract：:Host-genetic control of influenza virus infection has been the object of little attention. In this study we determined that two inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectively relatively resistant and susceptible to infection with the low pathogenicity influenza vir...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26787
更新日期：2016-06-09 00:00:00
abstract：:The 28,000-year-old remains of a woolly mammoth, named 'Yuka', were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40546-1
更新日期：2019-03-11 00:00:00
abstract：:In absence of soil erosion plots for determination of erodibility index (K) for erosion models like Universal Soil Loss Equation (USLE) or Revised Universal Soil Loss Equation (RUSLE) to estimate soil erosion, empirical relations are used. In the present study, soil erodibility index was determined for entire Ri-bhoi ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72070-y
更新日期：2020-09-11 00:00:00
abstract：:A common philosophy in control theory is the control of disorder by order. Control of decoherence is no exception; strategies aimed at suppressing quantum decoherence adopt this point of view. Here we predict an anomalous phenomenon in open quantum systems-control of disorder by (even more) disorder. It is shown that ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02746
更新日期：2013-09-25 00:00:00
abstract：:Recent studies have shown that ionic direct current (iDC) can modulate the vestibular system in-vivo, with potential benefits over conventional pulsed stimulation. In this study, the effects of iDC stimulation on vestibular nerve fiber firing rate was investigated using loose-patch nerve fiber recordings in the acutel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55045-6
更新日期：2019-12-12 00:00:00
abstract：:Quantification of stillbirth risk has potential to support clinical decision-making. Studies that have attempted to quantify stillbirth risk have been hampered by small event rates, a limited range of predictors that typically exclude obstetric history, lack of validation, and restriction to a single classifier (logis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62210-9
更新日期：2020-03-24 00:00:00
abstract：:An increase in adipose tissue is caused by the increased size and number of adipocytes. Lipids accumulate in intracellular stores, known as lipid droplets (LDs). Recent studies suggest that parameters such as LD size, shape and dynamics are closely related to the development of obesity. Berberine (BBR), a natural plan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47060-4
更新日期：2019-07-19 00:00:00
abstract：:In this study, we categorize the microbial community in mangrove sediment samples from four different locations within a vast mangrove system in Kerala, India. We compared this data to other samples taken from the other known mangrove data, a tropical rainforest, and ocean sediment. An examination of the microbial com...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09254-6
更新日期：2017-08-18 00:00:00
abstract：:Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a novel immunomodulatory sulf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05969-8
更新日期：2017-07-24 00:00:00
abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38928
更新日期：2016-12-13 00:00:00
abstract：:The interaction of a mechanical oscillator with the operation actions and environment fields will give rise to the splitting of normal modes. In this study, we investigate the normal mode splitting behaviour of a moving-particles-pumped single-span clamped-hinged elastic homogeneous beam based on the proposed multi-oc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27989-8
更新日期：2018-06-28 00:00:00
abstract：:The carrier transport characteristics of Sb2Se2Te topological insulators were investigated, after exposure to different levels of nitrogen gas. The magnetoresistance (MR) slope for the Sb2Se2Te crystal increased by approximately 100% at 10 K after 2-days of exposure. The Shubnikov-de Haas (SdH) oscillation amplitude i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05369-y
更新日期：2017-07-11 00:00:00
abstract：:The evolution to bipedalism forced humans to develop suitable strategies for dynamically controlling their balance, ensuring stability, and preventing falling. The natural aging process and traumatic events such as lower-limb loss can alter the human ability to control stability significantly increasing the risk of fa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46721
更新日期：2017-05-11 00:00:00
abstract：:Many basic properties of the T-cell receptor (TCR) repertoire require clarification, and the changes occurring in the TCR repertoire during carcinogenesis, especially during precancerous stages, remain unclear. This study used deep sequencing analyses to examine 41 gastric tissue samples at different pathological stag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08289-z
更新日期：2017-08-10 00:00:00
abstract：:This study was intended to determine the efficacy of nivolumab, we evaluated treatment response with respect to PD-1/PD-L1 SNPs among patients with NSCLC. A total of 50 patients with NSCLC were treated with nivolumab and were also evaluated for PD-1/PD-L1 single nucleotide polymorphisms (SNPs) from plasma DNA. We inve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45124
更新日期：2017-03-23 00:00:00
abstract：:Nitric oxide synthase like enzyme (NOS-like enzyme), which produces nitric oxide, participates in many biological processes. However it remains unidentified and highly controversial that plants do possess a NOS-like enzyme. In this paper, a novel arginine analogue NP1 was designed and developed for the direct identifi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32630
更新日期：2016-09-02 00:00:00
abstract：:Present study focuses on rainfall over Western Ghats (WG), a complex topographic region (elevation > 500 m) of India to evaluate and to better understand the satellite behavior in contrast with a flat region (FR) (elevation < 500 m) of central India from 1998 to 2016 using the combinatory data sets of TMPA and IMERG (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52075-y
更新日期：2019-10-30 00:00:00
abstract：:The changes of balance control mechanism caused by lumbar disc herniation (LDH) has not been well understood. This study aimed to investigate the effects of LDH on the balance control during standing on sloped surfaces. Ten patients with LDH and 10 gender- and age-matched healthy subjects were instructed to stand quie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58455-z
更新日期：2020-02-03 00:00:00
abstract：:Multiferroic BiFeO3 exhibits excellent magnetoelectric coupling critical for magnetic information processing with minimal power consumption. However, the degenerate nature of the easy spin axis in the (111) plane presents roadblocks for real world applications. Here, we explore the stabilization and switchability of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12969
更新日期：2015-08-06 00:00:00
abstract：:Major overturn within a magma chamber can bring together felsic and mafic magmas, prompting de-volatilisation and acting as the driver for Plinian eruptions. Until now identification of mixing has been limited to analysis of lavas or individual crystals ejected during eruptions. We have recovered partially developed c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00731
更新日期：2012-01-01 00:00:00
abstract：:Burley tobacco (Nicotiana Tabacum) is a chlorophyll-deficiency mutant. Nitrate is one precursor of tobacco-specific nitrosamines (TSNAs) and is largely accumulated in burley tobacco. To decrease nitrate accumulation in burley tobacco, glycerol, a polyhydric alcohol compound and physiological regulating material, was s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31432-3
更新日期：2018-09-05 00:00:00
abstract：:The outbreak of multidrug-resistant pathogenic bacteria made the discovery of novel control strategies necessary. Phages have regained attention for their specific lytic activity against pathogenic bacterium. A newly isolated phage infecting the clinical Escherichia coli isolates, including several multidrug-resistant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26004-4
更新日期：2018-05-24 00:00:00
abstract：:The sustainable use of common pool resources has become a significant global challenge. It is now widely accepted that specific mechanisms such as community-based management strategies, institutional responses such as resource privatization, information availability and emergent social norms can be used to constrain i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02151-y
更新日期：2017-05-23 00:00:00
abstract：:Subsolid pulmonary nodules are commonly encountered in lung cancer screening and clinical routine. Compared to other nodule types, subsolid nodules are associated with a higher malignancy probability for which the size and mass of the nodule and solid core are important indicators. However, reliably measuring these ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19101-3
更新日期：2018-01-12 00:00:00
