Abstract：
:Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a novel immunomodulatory sulfolipid named β-SQDG18 that prototypes a class of natural-derived glycolipids able to prime human DCs by a TLR2/TLR4-independent mechanism and trigger an efficient immune response in vivo. β-SQDG18 induces maturation of DC with the upregulation of MHC II molecules and co-stimulatory proteins (CD83, CD86), as well as pro-inflammatory cytokines (IL-12 and INF-γ). Mice immunized with OVA associated to β-SQDG18 (1:500) produced a titer of anti-OVA Ig comparable to traditional adjuvants. In an experimental model of melanoma, vaccination of C57BL/6 mice with β-SQDG18-adjuvanted hgp10 peptide elicited a protective response with a reduction in tumour growth and increase in survival.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Manzo E,Cutignano A,Pagano D,Gallo C,Barra G,Nuzzo G,Sansone C,Ianora A,Urbanek K,Fenoglio D,Ferrera F,Bernardi C,Parodi A,Pasquale G,Leonardi A,Filaci G,De Palma R,Fontana Adoi
10.1038/s41598-017-05969-8subject
Has Abstractpub_date
2017-07-24 00:00:00pages
6286issue
1issn
2045-2322pii
10.1038/s41598-017-05969-8journal_volume
7pub_type
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