Abstract：
:8p22-23-rs2254546 was firstly discovered to be associated with Kawasaki disease (KD) susceptibility by a genome-wide association study. However, only one Chinese replication study has been performed so far. To verify this association in another Chinese population, a hospital-based case-control study in Zhejiang province was conducted followed by an integrated meta-analysis, comprising five case-control studies of 1958 cases, 5615 controls and four transmission disequilibrium tests of 503 trios. In our case-control study, significant associations were observed between GG genotype or GG/GA genotypes of rs2254546 and increased KD risk (OR = 1.86, 95% CI = 1.01-3.41, P = 0.045; OR = 1.83, 95% CI = 1.01-3.33, P = 0.048), compared with AA genotype; however, no significant association was found in allelic model (OR = 1.20, 95% CI = 0.96-1.50, P = 0.117). The meta-analysis further revealed that the G allele was significantly associated with the increased KD risk without evidence of heterogeneity (OR = 1.55, 95% CI = 1.42-1.70, P < 0.001). In conclusion, rs2254546 polymorphism might significantly contribute to the risk of KD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang W,Lou J,Lu XZ,Qi YQ,Shen N,Zhong R,Wang YJ,Zou L,Zhang Q,Duan JY,Ke JT,Miao XP,Gong FQdoi
10.1038/srep04247subject
Has Abstractpub_date
2014-02-28 00:00:00pages
4247issn
2045-2322pii
srep04247journal_volume
4pub_type
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