Repurposing a platelet aggregation inhibitor ticagrelor as an antimicrobial against Clostridioides difficile.

abstract：:This was a nine-year retrospective cohort study to investigate obstetric and perinatal outcomes in a cohort of adolescent girls with twin pregnancies from a major Australian tertiary centre in Brisbane, Australia. The adolescent cohort was aged <19 years and the control group was aged 20-24 years. The total study coho...

journal_title：Scientific reports

authors： Robson D,Daniels S,Flatley C,Kumar S

更新日期：2018-12-24 00:00:00

abstract：:Unlike individual, free-floating planktonic bacteria, biofilms are surface-attached communities of slow- or non-replicating bacteria encased within a protective extracellular polymeric matrix enabling persistent bacterial populations to tolerate high concentrations of antimicrobials. Our current antibacterial arsenal ...

journal_title：Scientific reports

authors： Yang H,Abouelhassan Y,Burch GM,Kallifidas D,Huang G,Yousaf H,Jin S,Luesch H,Huigens RW

更新日期：2017-05-17 00:00:00

abstract：:In recent years many monoclonal antibodies (mAb) have entered the biotherapeutics market, offering new treatments for chronic and life-threatening diseases. Protein A resin captures monoclonal antibody (mAb) effectively, but the binding capacity decays over repeated purification cycles. On an industrial scale, replaci...

journal_title：Scientific reports

authors： Boulet-Audet M,Kazarian SG,Byrne B

更新日期：2016-07-29 00:00:00

abstract：:The precision prediction of peptide retention time (RT) plays an increasingly important role in liquid chromatography-tandem mass spectrometry (LC-MS/MS) based proteomics. Owing to the high reproducibility of liquid chromatography, RT prediction provides promising information for both identification and quantification...

journal_title：Scientific reports

authors： Lu W,Liu X,Liu S,Cao W,Zhang Y,Yang P

更新日期：2017-03-17 00:00:00

abstract：:We aimed to establish a highly sensitive method for measuring visual function using spatial-sweep steady-state pattern electroretinography (swpPERG). Overall, 35 eyes of 35 healthy adults (18 men; mean age, 32.3 years) were examined using swpPERG, and the data were recorded using spatial-patterned and contrast-reverse...

journal_title：Scientific reports

authors： Minami S,Nagai N,Suzuki M,Kurihara T,Sonobe H,Watanabe K,Shinoda H,Takagi H,Tsubota K,Ozawa Y

更新日期：2019-12-02 00:00:00

abstract：:Dissolved organic carbon (DOC) concentrations and water colour are increasing in many inland waters across northern Europe and northeastern North America. This inland-water "browning" has profound physical, chemical and biological repercussions for aquatic ecosystems affecting water quality, biological community struc...

journal_title：Scientific reports

authors： Meyer-Jacob C,Michelutti N,Paterson AM,Cumming BF,Keller WB,Smol JP

更新日期：2019-11-13 00:00:00

abstract：:E-cadherin is a key Ca-dependent cell adhesion molecule, which is expressed on many cell surfaces and involved in cell morphogenesis, embryonic development, EMT, etc. The fusion protein E-cad-Fc consists of the extracellular domain of E-cadherin and the IgG Fc domain. On plates coated with this chimeric protein, ES/iP...

journal_title：Scientific reports

authors： Shibata-Seki T,Nagaoka M,Goto M,Kobatake E,Akaike T

更新日期：2020-10-12 00:00:00

abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...

journal_title：Scientific reports

authors： Melli M,West M,Hickman S,Dhuey S,Lin D,Khorasaninejad M,Chang C,Jolly S,Tae H,Poliakov E,St Hilaire P,Cabrini S,Peroz C,Klug M

更新日期：2020-11-26 00:00:00

abstract：:The fungal microbiota is an important component of the human gut microbiome and may be linked to gastrointestinal disease. In this study, the fungal microbiota of biopsy samples from adenomas and adjacent tissues was characterized by deep sequencing. Ascomycota, Glomeromycota and Basidiomycota were identified as the d...

journal_title：Scientific reports

authors： Luan C,Xie L,Yang X,Miao H,Lv N,Zhang R,Xiao X,Hu Y,Liu Y,Wu N,Zhu Y,Zhu B

更新日期：2015-01-23 00:00:00

abstract：:Src family of kinases (SFKs) has been found to play an important role in the regulation of nociception. However, how each member of this family acts in the central nervous system (CNS) structures involved in the relay and/or modulation of nociceptive signals, and thereby contributes to the formation and maintenance of...

journal_title：Scientific reports

authors： Ma H,Yao C,Ma P,Zhou J,Gong S,Tao J,Yu XM,Jiang X

更新日期：2019-03-07 00:00:00

abstract：:Elastic waves are guided along finite structures such as cylinders, plates, or rods through reflection, refraction, and mode conversion at the interfaces. Such wave propagation is ubiquitous in the world around us, and studies of elastic waveguides first emerged in the later part of the 19(th) century. Early work on e...

journal_title：Scientific reports

authors： Philippe FD,Murray TW,Prada C

更新日期：2015-06-08 00:00:00

abstract：:Biological hydrogen production is based on activity of specific enzymes called hydrogenases. Hydrogenases are oxygen sensitive metalloenzymes containing Ni and/or Fe atoms at the active site, catalyzing reversible reduction of protons. Generally, [Fe-Fe] hydrogenases prefer proton reduction to molecular hydrogen, a po...

journal_title：Scientific reports

authors： Mangayil R,Karp M,Lamminmäki U,Santala V

更新日期：2016-10-27 00:00:00

abstract：:Soil microorganisms have important influences on plant growth and health. In this study, four black pepper fields consecutively monocultured for 12, 18, 28 and 38 years were selected for investigating the effect of planting age on rhizosphere and non-rhizosphere soil microbial communities and soil physicochemical prop...

journal_title：Scientific reports

authors： Li Z,Zu C,Wang C,Yang J,Yu H,Wu H

更新日期：2016-10-24 00:00:00

abstract：:The early life stages represent a crucial period that can strongly influence population dynamics. We studied the development of foraging behaviour in the red-footed booby, a tropical seabird with an extensive post-fledging care period (3 to 6 months). Adults and juveniles were observed from shore and tracked at sea us...

journal_title：Scientific reports

authors： Mendez L,Prudor A,Weimerskirch H

更新日期：2017-10-24 00:00:00

abstract：:X-ray free-electron lasers (XFELs) provide extremely bright and highly spatially coherent x-ray radiation with femtosecond pulse duration. Currently, they are widely used in biology and material science. Knowledge of the XFEL statistical properties during an experiment may be vitally important for the accurate interpr...

journal_title：Scientific reports

authors： Gorobtsov OY,Mukharamova N,Lazarev S,Chollet M,Zhu D,Feng Y,Kurta RP,Meijer JM,Williams G,Sikorski M,Song S,Dzhigaev D,Serkez S,Singer A,Petukhov AV,Vartanyants IA

更新日期：2018-02-02 00:00:00

abstract：:Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected cells and eradication of the virus. Here we report the design, gener...

journal_title：Scientific reports

authors： Li W,Wu Y,Kong D,Yang H,Wang Y,Shao J,Feng Y,Chen W,Ma L,Ying T,Dimitrov DS

更新日期：2017-08-22 00:00:00

abstract：:Attention and saccadic eye movements are critical components of visual perception. Recent studies proposed the hypothesis of a tight coupling between saccadic adaptation (SA) and attention: SA increases the processing speed of unpredictable stimuli, while increased attentional load boosts SA. Moreover, their cortical ...

journal_title：Scientific reports

authors： Nicolas J,Bidet-Caulet A,Pélisson D

更新日期：2020-08-10 00:00:00

abstract：:The effective differentiation between multiple primary lung tumors (MPs) and intrapulmonary metastases (IMs) in patients is imperative to discover the exact disease stage and to select the most appropriate treatment. In this study, the authors was to evaluate the efficacy and validity of large-scale targeted sequencin...

journal_title：Scientific reports

authors： Duan J,Ge M,Peng J,Zhang Y,Yang L,Wang T,Qin T,Yuan R,Zhang Y,Cheng W

更新日期：2020-11-02 00:00:00

abstract：:Influenza's propensity for antigenic drift and shift, and to elicit predominantly strain specific antibodies (Abs) leaves humanity susceptible to waves of new strains with pandemic potential for which limited or no immunity may exist. Subsequently new clinical interventions are needed. To identify hemagglutinin (HA) e...

journal_title：Scientific reports

authors： Nogales A,Piepenbrink MS,Wang J,Ortega S,Basu M,Fucile CF,Treanor JJ,Rosenberg AF,Zand MS,Keefer MC,Martinez-Sobrido L,Kobie JJ

更新日期：2018-03-12 00:00:00

abstract：:Methylation of histone H3 lysine 4 (H3K4) is catalyzed by the multi-component COMPASS or COMPASS-like complex, which is highly conserved from yeast to human, and plays essential roles in gene expression and transcription, cell cycle progression, and DNA repair. Here we present a cryo-EM map of the complete S. cerevisi...

journal_title：Scientific reports

authors： Wang Y,Ding Z,Liu X,Bao Y,Huang M,Wong CCL,Hong X,Cong Y

更新日期：2018-11-27 00:00:00

abstract：:Wet-chemistry methods have crucial advantages for the synthesis of nanostructures, including simple, low-cost, large-area, and low-temperature deposition on almost arbitrary substrates. Nevertheless, the rational design of improved wet-chemistry procedures is extremely difficult because, in practice, only post-synthes...

journal_title：Scientific reports

authors： Orsini A,Falconi C

更新日期：2014-09-05 00:00:00

abstract：:Biomarkers of Huntington's disease (HD) in cerebrospinal fluid (CSF) could be of value in elucidating the biology of this genetic neurodegenerative disease, as well as in the development of novel therapeutics. Deranged synaptic and immune function have been reported in HD, and concentrations of the synaptic protein ne...

journal_title：Scientific reports

authors： Byrne LM,Rodrigues FB,Johnson EB,De Vita E,Blennow K,Scahill R,Zetterberg H,Heslegrave A,Wild EJ

更新日期：2018-03-09 00:00:00

abstract：:Laser-driven ultrafast electron emission offers the possibility of manipulation and control of coherent electron motion in ultrashort spatiotemporal scales. Here, an analytical solution is constructed for the highly nonlinear electron emission from a dc biased metal surface illuminated by a single frequency laser, by ...

journal_title：Scientific reports

authors： Zhang P,Lau YY

更新日期：2016-01-28 00:00:00

abstract：:The pathophysiology of stress cardiomyopathy (SCM), also known as takotsubo syndrome, is poorly understood. SCM usually occurs sporadically, often in association with a stressful event, but clusters of cases are reported after major natural disasters. There is some evidence that this is a familial condition. We have e...

journal_title：Scientific reports

authors： Lacey CJ,Doudney K,Bridgman PG,George PM,Mulder RT,Zarifeh JJ,Kimber B,Cadzow MJ,Black MA,Merriman TR,Lehnert K,Bickley VM,Pearson JF,Cameron VA,Kennedy MA

更新日期：2018-05-15 00:00:00

abstract：:Transcriptional enhancers are non-coding segments of DNA that play a central role in the spatiotemporal regulation of gene expression programs. However, systematically and precisely predicting enhancers remain a major challenge. Although existing methods have achieved some success in enhancer prediction, they still su...

journal_title：Scientific reports

authors： Liu F,Li H,Ren C,Bo X,Shu W

更新日期：2016-06-22 00:00:00

abstract：:Drought is one of the major impediments in wheat productivity. Traditional breeding and marker assisted QTL introgression had limited success. Available wheat genomic and RNA-seq data can decipher novel drought tolerance mechanisms with putative candidate gene and marker discovery. Drought is first sensed by root tiss...

journal_title：Scientific reports

authors： Iquebal MA,Sharma P,Jasrotia RS,Jaiswal S,Kaur A,Saroha M,Angadi UB,Sheoran S,Singh R,Singh GP,Rai A,Tiwari R,Kumar D

更新日期：2019-09-26 00:00:00

abstract：:The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to e...

journal_title：Scientific reports

authors： Bernegger A,Kienesberger K,Carlberg L,Swoboda P,Ludwig B,Koller R,Inaner M,Zotter M,Kapusta N,Aigner M,Haslacher H,Kasper S,Schosser A

更新日期：2018-01-12 00:00:00

abstract：:Autophagy is a crucial and physiological process for cell survival from yeast to mammals, including protozoan parasites. Toxoplasma gondii, an intracellular parasite, typically exploits autophagic machinery of host cell; however host cell upregulates autophagy to combat the infection. Herein we tested the efficacy of ...

journal_title：Scientific reports

authors： Ietta F,Maioli E,Daveri E,Gonzaga Oliveira J,da Silva RJ,Romagnoli R,Cresti L,Maria Avanzati A,Paulesu L,Barbosa BF,Gomes AO,Roberto Mineo J,Ferro EAV

更新日期：2017-04-28 00:00:00

abstract：:Around 350 million tonnes of plastics are annually produced worldwide. A remarkable percentage of these products is dispersed in the environment, finally reaching and dispersed in the marine environment. Recent field surveys detected microplastics' concentrations in the Mediterranean Sea. The most commonly polymers fo...

journal_title：Scientific reports

authors： Corbari L,Maltese A,Capodici F,Mangano MC,Sarà G,Ciraolo G

更新日期：2020-11-16 00:00:00

abstract：:Current deep tissue microscopy techniques are mostly restricted to intensity mapping of fluorophores, which significantly limit their applications in investigating biochemical processes in vivo. We present a deep tissue multiplexed functional imaging method that probes multiple Förster resonant energy transfer (FRET) ...

journal_title：Scientific reports

authors： Zhao M,Wan X,Li Y,Zhou W,Peng L

更新日期：2015-09-21 00:00:00