Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex.

abstract：:The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear condit...

journal_title：Scientific reports

authors： Hoang Trung H,Yoshihara T,Nakao A,Hayashida K,Hirata Y,Shirasuna K,Kuwamura M,Nakagawa Y,Kaneko T,Mori Y,Asano M,Kuramoto T

更新日期：2021-01-21 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy of intravitreal aflibercept for active polypoidal choroidal vasculopathy (PCV) without active polyps and to identify prognostic factors. We enrolled 40 eyes from 40 patients who manifested PCV with exudation but without active polyps after prior treatment with pho...

journal_title：Scientific reports

authors： Lee SE,Jang JW,Kang SW,Park KH,Lee DW,Kim JH,Bae K

更新日期：2019-02-06 00:00:00

abstract：:The biogeographic history of lichenized fungi remains unrevealed because those organisms rarely fossilize due to their delicate, often tiny and quickly rotting thalli. Also the ecology and factors limiting occurrence of numerous taxa, especially those restricted in their distribution to tropical areas are poorly recog...

journal_title：Scientific reports

authors： Kukwa M,Kolanowska M

更新日期：2016-12-08 00:00:00

abstract：:What is intuitive: pro-social or anti-social behaviour? To answer this fundamental question, recent studies analyse decision times in game theory experiments under the assumption that intuitive decisions are fast and that deliberation is slow. These analyses keep track of the average time taken to make decisions under...

journal_title：Scientific reports

authors： Gallotti R,Grujić J

更新日期：2019-11-19 00:00:00

abstract：:Map3k8 has been proposed as a useful target for the treatment of inflammatory diseases. We show here that during lipopolysaccharide-induced emergency granulopoiesis, Map3k8 deficiency strongly impairs the increase in circulating mature (Ly6GhighCD11b+) and immature (Ly6GlowCD11b+) neutrophils. After chimaeric bone mar...

journal_title：Scientific reports

authors： Sánchez Á,Relaño C,Carrasco A,Contreras-Jurado C,Martín-Duce A,Aranda A,Alemany S

更新日期：2017-07-10 00:00:00

abstract：:Pachychoroid spectrum diseases have attracted increasing attention, though their pathophysiology has yet to be fully elucidated. In this study, we assessed the vascular diameters of vortex veins in pachychoroid spectrum diseases such as central serous chorioretinopathy (CSC), pachychoroid neovasculopathy without polyp...

journal_title：Scientific reports

authors： Matsumoto H,Hoshino J,Arai Y,Mukai R,Nakamura K,Kikuchi Y,Kishi S,Akiyama H

更新日期：2020-11-11 00:00:00

abstract：:Dinosaurs thrived and reproduced in various regions worldwide, including the Arctic. In order to understand their nesting in diverse or extreme environments, the relationships between nests, nesting environments, and incubation methods in extant archosaurs were investigated. Statistical analyses reveal that species of...

journal_title：Scientific reports

authors： Tanaka K,Zelenitsky DK,Therrien F,Kobayashi Y

更新日期：2018-03-15 00:00:00

abstract：:A panel of 32 candidate reference genes was used to identify the most stable genes for gene normalisation in quantitative RT-PCR studies using endometrial biopsies obtained from women with endometrial cancer (type 1 or type 2) and without cancer (controls). RNA from the biopsies was isolated, examined for purity and q...

journal_title：Scientific reports

authors： Ayakannu T,Taylor AH,Konje JC

更新日期：2020-05-21 00:00:00

abstract：:The synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating that graphene might be an embryo of protocell membrane. Firstly, we found that the highly oxidized graphene and phospholipid-graphene oxide ...

journal_title：Scientific reports

authors： Li Z,Wang C,Tian L,Bai J,Yao H,Zhao Y,Zhang X,Cao S,Qi W,Wang S,Shi K,Xu Y,Mingliang Z,Liu B,Qiu H,Liu J,Wu W,Wang X,Wenzhen A

更新日期：2015-05-19 00:00:00

abstract：:CLE peptide hormones are critical regulators of many cell proliferation and differentiation mechanisms in plants. These 12-13 amino acid glycosylated peptides play vital roles in a diverse range of plant tissues, including the shoot, root and vasculature. CLE peptides are also involved in controlling legume nodulation...

journal_title：Scientific reports

authors： Hastwell AH,de Bang TC,Gresshoff PM,Ferguson BJ

更新日期：2017-08-24 00:00:00

abstract：:Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity m...

journal_title：Scientific reports

authors： Wang X,Cui H,Gong G,Fu Z,Zhou J,Gu J,Yin Y,Feng D

更新日期：2018-07-13 00:00:00

abstract：:Advanced structural characterisation techniques which are rapid to use, non-destructive and structurally definitive on the nanoscale are in demand, especially for a detailed understanding of extended-defects and their influence on the properties of materials. We have applied the electron backscatter diffraction (EBSD)...

journal_title：Scientific reports

authors： Naresh-Kumar G,Vilalta-Clemente A,Jussila H,Winkelmann A,Nolze G,Vespucci S,Nagarajan S,Wilkinson AJ,Trager-Cowan C

更新日期：2017-09-07 00:00:00

abstract：:The three-dimensional construction of arrays of functional molecules on an electrode surface, such as organic semiconductors and redox-active molecules, is a considerable challenge in the fabrication of sophisticated junctions for molecular devices. In particular, well-defined organic layers with precise molecular gra...

journal_title：Scientific reports

authors： Kawauchi T,Oguchi Y,Nagai K,Iyoda T

更新日期：2015-06-09 00:00:00

abstract：:The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the self-produced extracellular biofilm matrix confer high resistance to antibiotics, triggering infec...

journal_title：Scientific reports

authors： Matilla-Cuenca L,Gil C,Cuesta S,Rapún-Araiz B,Žiemytė M,Mira A,Lasa I,Valle J

更新日期：2020-11-03 00:00:00

abstract：:We have assembled the complete sequence of the Durio zibethinus chloroplast genome using long PacBio reads. Durian is a valuable commercial tree that produces durian fruit, which is popular in Southeast Asia. The chloroplast genome assembled into a single 143 kb cyclic contig that contained 111 genes. There were 46 sh...

journal_title：Scientific reports

authors： Shearman JR,Sonthirod C,Naktang C,Sangsrakru D,Yoocha T,Chatbanyong R,Vorakuldumrongchai S,Chusri O,Tangphatsornruang S,Pootakham W

更新日期：2020-10-07 00:00:00

abstract：:Nociceptive neurons play an essential role in pain sensation by transmitting painful stimuli to the central nervous system. However, investigations of nociceptive neuron biology have been hampered by the lack of accessibility of human nociceptive neurons. Here, we describe a system for efficiently guiding human embryo...

journal_title：Scientific reports

authors： Boisvert EM,Engle SJ,Hallowell SE,Liu P,Wang ZW,Li XJ

更新日期：2015-11-19 00:00:00

abstract：:Antibiotics in feed select for resistant strains and is thus a threat to human health. In this study, the effect of a multi-strain probiotic and antibiotics on the growth and health of broilers was studied. Equal numbers of broilers received on a daily basis either a multi-strain probiotic or a combination of sulphadi...

journal_title：Scientific reports

authors： Neveling DP,van Emmenes L,Ahire JJ,Pieterse E,Smith C,Dicks LMT

更新日期：2017-10-16 00:00:00

abstract：:Receipt of broad-spectrum antibiotics enhances Candida albicans colonization of the GI tract, a risk factor for haematogenously-disseminated candidiasis. To understand how antibiotics influence C. albicans colonization, we treated mice orally with vancomycin or a combination of penicillin, streptomycin, and gentamicin...

journal_title：Scientific reports

authors： Shankar J,Solis NV,Mounaud S,Szpakowski S,Liu H,Losada L,Nierman WC,Filler SG

更新日期：2015-02-03 00:00:00

abstract：:Plants are constantly exposed to pathogens and environmental stresses. To minimize damage caused by these potentially harmful factors, plants respond by massive transcriptional reprogramming of various stress-related genes via major transcription factor families. One of the transcription factor families, WRKY, plays a...

journal_title：Scientific reports

authors： Huh SU,Lee GJ,Jung JH,Kim Y,Kim YJ,Paek KH

更新日期：2015-01-23 00:00:00

abstract：:The marine bacterial strain Desulfovibrio ferrophilus IS5, known for its lithotrophic growth ability to use metallic iron as a sole electron donor and for causing corrosion of steel, was used in the current study. Four commonly used biocides in the oil and gas industry, namely tetrakis(hydroxymethyl) phosphonium sulfa...

journal_title：Scientific reports

authors： Sharma M,Liu H,Chen S,Cheng F,Voordouw G,Gieg L

更新日期：2018-11-09 00:00:00

abstract：:Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are determined by complex host-parasite interactions. It has been difficult to study the effects of parasite strains on disease severity in human infections, but the mechanisms leading to specific disease phenotypes can be investigated...

journal_title：Scientific reports

authors： Lacerda-Queiroz N,Riteau N,Eastman RT,Bock KW,Orandle MS,Moore IN,Sher A,Long CA,Jankovic D,Su XZ

更新日期：2017-09-05 00:00:00

abstract：:The association between perioperative blood transfusion (PBT) with adverse oncological outcomes have been previously reported in multiple malignancies including RCC. Nevertheless, the importance of transfusion timing is still unclear. The primary purpose of this study is to appraise whether the receipt of intraoperati...

journal_title：Scientific reports

authors： Abu-Ghanem Y,Dotan Z,Zilberman DE,Kaver I,Ramon J

更新日期：2019-02-04 00:00:00

abstract：:The ATP-binding cassette transporter TAPL translocates polypeptides from the cytosol into the lysosomal lumen. TAPL can be divided into two functional units: coreTAPL, active in ATP-dependent peptide translocation, and the N-terminal membrane spanning domain, TMD0, responsible for cellular localization and interaction...

journal_title：Scientific reports

authors： Bock C,Löhr F,Tumulka F,Reichel K,Würz J,Hummer G,Schäfer L,Tampé R,Joseph B,Bernhard F,Dötsch V,Abele R

更新日期：2018-10-23 00:00:00

abstract：:Due to the potentially detrimental consequences of low performance in basic functional tasks, individuals are expected to improve performance with age and show the most marked changes during early stages of life. Soaring-gliding birds use rising-air columns (thermals) to reduce energy expenditure allocated to flight. ...

journal_title：Scientific reports

authors： Harel R,Horvitz N,Nathan R

更新日期：2016-06-13 00:00:00

abstract：:Recent studies have revealed the systematic altering of gene expression in human peripheral blood during the early stages of ischemic stroke, which suggests a new potential approach for the rapid diagnosis or prediction of stroke onset. Nevertheless, due to the difficulties of collecting human samples during proper di...

journal_title：Scientific reports

authors： Wang Y,Cai Y

更新日期：2016-07-13 00:00:00

abstract：:Directed transport of biological species across the surface of a substrate is essential for realizing lab-on-chip technologies. Approaches that utilize localized magnetic fields to manipulate magnetic particles carrying biological entities are attractive owing to their sensitivity, selectivity, and minimally disruptiv...

journal_title：Scientific reports

authors： Rapoport E,Beach GSD

更新日期：2017-08-31 00:00:00

abstract：:Efficient interventions to reduce blood triglycerides are few; newer and more tolerable intervention targets are needed. Understanding the molecular mechanisms underlying blood triglyceride levels variation is key to identifying new therapies. To explore the role of epigenetic mechanisms on triglyceride levels, a bloo...

journal_title：Scientific reports

authors： Truong V,Huang S,Dennis J,Lemire M,Zwingerman N,Aïssi D,Kassam I,Perret C,Wells P,Morange PE,Wilson M,Trégouët DA,Gagnon F

更新日期：2017-09-11 00:00:00

abstract：:Vitiligo is an acquired depigmentation disorder largely caused by defective melanocyte- or autoimmunity-induced melanocyte destruction. The aryl hydrocarbon receptor (AHR) is essential for melanocyte homeostasis and immune process, and abnormal AHR was observed in vitiligo. We previously identified the T allele of AHR...

journal_title：Scientific reports

authors： Wang X,Li K,Liu L,Shi Q,Song P,Jian Z,Guo S,Wang G,Li C,Gao T

更新日期：2015-09-15 00:00:00

abstract：:In the dominant livestock systems of Sahelian countries herds have to move across territories. Their mobility is often a source of conflict with farmers in the areas crossed, and helps spread diseases such as Rift Valley Fever. Knowledge of the routes followed by herds is therefore core to guiding the implementation o...

journal_title：Scientific reports

authors： Jahel C,Lenormand M,Seck I,Apolloni A,Toure I,Faye C,Sall B,Lo M,Diaw CS,Lancelot R,Coste C

更新日期：2020-05-20 00:00:00

abstract：:Free-living animals must make dietary choices in terms of chemical and physical properties, depending on their digestive physiology and availability of food resources. Here we comprehensively evaluated the dietary choices of proboscis monkeys (Nasalis larvatus) consuming young leaves. We analysed the data for leaf tou...

journal_title：Scientific reports

authors： Matsuda I,Clauss M,Tuuga A,Sugau J,Hanya G,Yumoto T,Bernard H,Hummel J

更新日期：2017-02-17 00:00:00