Abstract：
:The purpose of this study was to evaluate the efficacy of intravitreal aflibercept for active polypoidal choroidal vasculopathy (PCV) without active polyps and to identify prognostic factors. We enrolled 40 eyes from 40 patients who manifested PCV with exudation but without active polyps after prior treatment with photodynamic therapy (PDT) and/or anti-vascular endothelial growth factor (VEGF) other than aflibercept. Participants were initially given three consecutive intravitreal injections of aflibercept at 1-month intervals, followed by injections every 2 months in the maintenance phase. Spectral-domain optical coherence tomographic and indocyanine green angiographic features were assessed to determine associations between anatomical parameters and visual outcomes 14 months later. Mean visual acuity improved from 61.5 ± 11.1 letters at baseline to 68.1 ± 13.6 letters at 14 months (P = 0.001). Better vision and a smaller branching vascular network at baseline and 1 month after three monthly injections (visit 4) were associated with better final vision (P < 0.001). The presence of an inner retinal cyst at visit 4 was significantly related to worse final vision (P = 0.011). Intravitreal aflibercept improved the visual and anatomical outcomes of PCV with exudation from BVN after pre-treatment with PDT and/or anti-VEGF other than aflibercept. Better vision, smaller lesion size, and absence of an inner retinal cyst after induction therapy may predict better visual outcome.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee SE,Jang JW,Kang SW,Park KH,Lee DW,Kim JH,Bae Kdoi
10.1038/s41598-018-37523-5subject
Has Abstractpub_date
2019-02-06 00:00:00pages
1487issue
1issn
2045-2322pii
10.1038/s41598-018-37523-5journal_volume
9pub_type
杂志文章abstract：:Tom40 is an integral protein of the mitochondrial outer membrane, which as the central component of the Translocase of the Outer Membrane (TOM) complex forms a channel for protein import. We characterize the diffusion properties of individual Tom40 molecules fused to the photoconvertable fluorescent protein Dendra2 wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00195
更新日期：2011-01-01 00:00:00
abstract：:Interaction between the epithelium and mesenchyme coordinates patterning and differentiation of oral cavity structures including teeth, palatal rugae and tongue papillae. SHH is one of the key signaling molecules for this interaction. Epithelial expression of Shh in the tooth buds and tongue papillae is regulated by a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12532-y
更新日期：2017-10-11 00:00:00
abstract：:Species-centric approaches to biodiversity in ecological research are limited in their ability to reflect the evolutionary history and functional diversity of community assembly. Recently, the introduction of alternative facets of biodiversity, such as phylogenetic and functional diversity, has shed light on this prob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21266-4
更新日期：2018-02-12 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-57947-2
更新日期：2020-01-30 00:00:00
abstract：:Ferritin has gained significant attention as a potential reporter gene for in vivo imaging by magnetic resonance imaging (MRI). However, due to the ferritin ferrihydrite core, the relaxivity and sensitivity for detection of native ferritin is relatively low. We report here on a novel chimeric magneto-ferritin reporter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26550
更新日期：2016-05-23 00:00:00
abstract：:Biological samples are frequently stained with heavy metals in preparation for examining the macro, micro and ultra-structure using X-ray microtomography and electron microscopy. A single X-ray microtomography scan reveals detailed 3D structure based on staining density, yet it lacks both material composition and func...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25099-z
更新日期：2018-05-15 00:00:00
abstract：:Loss of miR-200c is correlated to advanced cancer-subtypes due to increased EMT and decreased treatment efficacy by chemotherapeutics. As miRNAs regulate a multitude of targets, the analysis of differentially expressed proteins upon a genomic knock-out (KO) is of interest. In this study, we generated a TALENs KO of mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25240-y
更新日期：2018-05-02 00:00:00
abstract：:Nanomaterials are extensively studied in electrochemical energy storage and conversion systems because of their structural advantages. However, their volumetric energy density still needs improvement due to the high surface area, especially the carbon based nanocomposites. Constructing hierarchical micro-scaled materi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33682
更新日期：2016-09-21 00:00:00
abstract：:The macular ellipsoid zone intensity (mEZi) is a known marker of disease severity in a number of diverse ocular diseases. The purpose of this study was to establish an automated method (AM) for mEZi quantification and to compare the method's performance with that of a manual method (MM) for glaucoma patients and healt...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-56337-7
更新日期：2019-12-24 00:00:00
abstract：:Ion mobility mass spectrometry (IM-MS) is a technique capable of investigating structural changes of biomolecules based on their collision cross section (CCS). Recent advances in IM-MS allow us to separate carbohydrate isomers with subtle conformational differences, but the relationship between CCS and atomic structur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20012-0
更新日期：2018-01-26 00:00:00
abstract：:The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its progression from the preoperative MR radiomics. 57 newly diagnosed cerebral glioblastoma patients were ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66691-6
更新日期：2020-06-16 00:00:00
abstract：:Competing phenomena in low dimensional systems can generate exotic electronic phases, either through symmetry breaking or a non-trivial topology. In two-dimensional (2D) systems, the interplay between superfluidity, disorder and repulsive interactions is especially fruitful in this respect although both the exact natu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35834
更新日期：2016-10-27 00:00:00
abstract：:Nano-flowers reported so far were mostly constituted of inorganic or hybrid materials. We have synthesized and crystallized a new organic compound, 1, 2-bis(tritylthio)ethane forming an organic nano-flower consisting of single crystalline petals. Crystal structure at nano and micro level indicates that π-π stacking in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17538-0
更新日期：2017-12-11 00:00:00
abstract：:To determine levels of change in risk factors for cardiovascular disease among people with and without a previous diagnosis of diabetes from 2007 to 2016 in Iran. Data were obtained from five rounds of the World Health Organization STEPwise approach to Surveillance (STEPS) cross-sectional surveys. Participants were 76...
journal_title：Scientific reports
pub_type： 历史文章,杂志文章
doi：10.1038/s41598-020-68640-9
更新日期：2020-07-16 00:00:00
abstract：:Although cochlear venous insufficiency has been considered to cause sudden sensorineural hearing loss (SSHL), there is insufficient clinical evidence to support this hypothesis. We sought to determine whether there is a correlation between draining patterns of the dural venous sinuses and the side of the affected ear ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62946-4
更新日期：2020-04-07 00:00:00
abstract：:The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26096
更新日期：2016-05-17 00:00:00
abstract：:Epilepsy, that comprises a wide spectrum of neuronal disorders and accounts for about one percent of global disease burden affecting people of all age groups, is recognised as apasmara in the traditional medicinal system of Indian antiquity commonly known as Ayurveda. Towards exploring the molecular level complex regu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46715-6
更新日期：2019-07-22 00:00:00
abstract：:Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The enzyme histone deacetylase 3 (HDAC3) appears to be important in HD pathology by negatively regula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05125-2
更新日期：2017-07-20 00:00:00
abstract：:Alveolar β2-receptor blockade worsens lung diffusion in heart failure (HF). This effect could be mitigated by stimulating alveolar β2-receptors. We investigated the safety and the effects of indacaterol on lung diffusion, lung mechanics, sleep respiratory behavior, cardiac rhythm, welfare, and exercise performance in ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-62644-1
更新日期：2020-04-28 00:00:00
abstract：:Tea plant is a typical fluorine (F) accumulator. F concentration in mature tea leaves is several hundred times higher than that in normal field crops. Long-term consumption of teas with high level F will increase the risks of dental and skeletal fluorosis. The mechanism of F accumulation in tea stands unclear. RNA-Seq...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08587-6
更新日期：2017-08-29 00:00:00
abstract：:We experimentally perform the simulation of open quantum dynamics in single-qudit systems. Using a spatial light modulator as a dissipative optical device, we implement dissipative-dynamical maps onto qudits encoded in the transverse momentum of spontaneous parametric down-converted photon pairs. We show a well-contro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16049
更新日期：2015-11-03 00:00:00
abstract：:Ocimum is one of the most revered medicinally useful plants which have various species. Each of the species is distinct in terms of metabolite composition as well as the medicinal property. Some basil types are used more often as an aromatic and flavoring ingredient. It would be informative to know relatedness among t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61957-5
更新日期：2020-03-23 00:00:00
abstract：:O antigen (O-Ag) in many bacteria is synthesized via the Wzx/Wzy-dependent pathway in which Wzy polymerizes lipid-linked O-Ag subunits to modal lengths regulated by Wzz. Characterization of 83 site-directed mutants of Wzy from Pseudomonas aeruginosa PAO1 (WzyPa) in topologically-mapped periplasmic (PL) and cytoplasmic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03441
更新日期：2013-12-06 00:00:00
abstract：:In comparison to genome-wide association studies (GWAS), there has been poor replication of gene expression studies in chronic obstructive pulmonary disease (COPD). We performed microarray gene expression profiling on a large sample of resected lung tissues from subjects with severe COPD. Comparing 111 COPD cases and ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/srep44232
更新日期：2017-03-13 00:00:00
abstract：:The widespread use of electric light and electronic devices has resulted in an excessive exposure to light during the late-evening and at night. This late light exposure acutely suppresses melatonin and sleepiness and delays the circadian clock. Here we investigate whether the acute effects of late-evening light expos...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-52352-w
更新日期：2019-11-05 00:00:00
abstract：:We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24425-9
更新日期：2018-04-18 00:00:00
abstract：:The prognosis of malignancies has improved in recent years, subsequent primary cancers (SPCs) have become more frequent. This study investigates the patterns of lung cancer involved multiple primary cancers. We enrolled 206,619 primary lung cancer patients and 2,071,922 patients with other primary malignancies from Su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06763-2
更新日期：2017-07-25 00:00:00
abstract：:Changes in climate extremes pose far-reaching consequences to ecological processes and hydrologic cycles in alpine ecosystems of the arid mountain regions. Therefore, regional assessments in various climates and mountain regions are needed for understanding the uncertainties of the change trends for extreme climate ev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02345-4
更新日期：2017-05-22 00:00:00
abstract：:Revisiting threat-related scenes elicits fear and activates a brain network related to cognitive-affective processing. Prior experience may contribute to the present fearful experience. We aimed to investigate (a) patterns of brain activation associated with individual differences in past fearful experiences (pFear) a...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-22805-9
更新日期：2018-03-23 00:00:00
abstract：:It has been an old unsolved puzzle to evolutionary theorists on which mechanisms would increase large-scale cooperation in human societies. Thus, how such mechanisms operate in a biological network is still not well understood. This study addresses these questions with empirical evidence from agent-based models design...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17481-0
更新日期：2017-12-11 00:00:00
