Abstract：
:The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons, and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level, and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Guo D,Wu S,Chen M,Perc M,Zhang Y,Ma J,Cui Y,Xu P,Xia Y,Yao Ddoi
10.1038/srep26096subject
Has Abstractpub_date
2016-05-17 00:00:00pages
26096issn
2045-2322pii
srep26096journal_volume
6pub_type
杂志文章abstract：:Awarding CO2 offset credits may incentivize seagrass restoration projects and help reverse greenhouse gas (GHG) emissions from global seagrass loss. However, no study has quantified net GHG removal from the atmosphere from a seagrass restoration project, which would require coupled Corg stock and GHG flux enhancement ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64094-1
更新日期：2020-04-30 00:00:00
abstract：:Advances in lab-on-a-chip (LOC) devices have led to significant improvements in the on-chip manipulation, separation, sorting, and isolation of particles and cells. Among various LOC-based approaches such as inertia-based methods, acoustophoresis, and magnetophoresis, the planar-slanted-electrode dielectrophoresis (DE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68699-4
更新日期：2020-07-16 00:00:00
abstract：:Plant microbiota is a key determinant of plant health and productivity. The composition and structure of plant microbiota varies according to plant tissue and compartment, which are specific habitats for microbial colonization. To investigate the structural composition of the microbiome associated with tomato roots un...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45660-8
更新日期：2019-06-26 00:00:00
abstract：:Predicting the hosts of newly discovered viruses is important for pandemic surveillance of infectious diseases. We investigated the use of alignment-based and alignment-free methods and support vector machine using mononucleotide frequency and dinucleotide bias to predict the hosts of viruses, and applied these approa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28308-x
更新日期：2018-07-03 00:00:00
abstract：:Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical impr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13931
更新日期：2015-09-10 00:00:00
abstract：:Surfaces with reversible wettability have broad applications but remain challenging since the switching process is usually energy intensive and complex. In this paper, a pyramid shaped Cu2S film with hierarchical micro/nanostructures is formed on a commercial copper mesh. This film is formed by a spontaneous redox sul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48952-1
更新日期：2019-08-28 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62901-3
更新日期：2020-04-20 00:00:00
abstract：:When estimating national PM2.5 concentrations, the results of traditional interpolation algorithms are unreliable due to a lack of monitoring sites and heterogeneous spatial distributions. PM2.5 spatial distribution is strongly correlated to elevation, and the information diffusion algorithm has been shown to be highl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14197-z
更新日期：2017-11-14 00:00:00
abstract：:We formulate uncertainty relations for arbitrary N observables. Two uncertainty inequalities are presented in terms of the sum of variances and standard deviations, respectively. The lower bounds of the corresponding sum uncertainty relations are explicitly derived. These bounds are shown to be tighter than the ones s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14238
更新日期：2015-09-15 00:00:00
abstract：:The recent rise of multidrug resistant microbial strains requires development of new and novel therapeutic alternatives. In this study, we present a novel antibacterial system that comprises of modified naturally abundant antimicrobial peptides in conjugation with silver nanoparticles. Further, we propose a simple rou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41005-7
更新日期：2019-03-14 00:00:00
abstract：:Gastroenteritis is common among children. Campylobacter jejuni is one of the main causative bacterial pathogens, together with Shigella, Salmonella and invasive Escherichia coli. Campylobacteriosis is a zoonotic, usually self-limited disease that does not always require antibiotic treatment. In cases of protracted dia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62744-y
更新日期：2020-04-02 00:00:00
abstract：:Habitat fragmentation is considered as major threat to biodiversity worldwide. Biodiversity can be described as taxonomic, functional and phylogenetic diversity. However, the effect of forest fragmentation on taxonomic, phylogenetic and functional diversity is barely understood. We compare the response of taxonomic (s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76917-2
更新日期：2020-11-23 00:00:00
abstract：:In this study, a design methodology for a multi-optical probe confocal imaging system was developed. To develop an imaging system that has the required resolving power and imaging area, this study focused on a design methodology to create a scalable and easy-to-implement confocal imaging system. This system overcomes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33278
更新日期：2016-09-12 00:00:00
abstract：:Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor function for the early diagnosis and monitoring of these diseases is either subjective, as in visual field testing, requires contact with the eye, like in electroretinography, o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50057-8
更新日期：2019-09-20 00:00:00
abstract：:Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a novel immunomodulatory sulf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05969-8
更新日期：2017-07-24 00:00:00
abstract：:Materials and construction methods of nests vary between bird species and at present, very little is known about the relationships between architecture and function in these structures. This study combines computational and experimental techniques to study the structural biology of nests fabricated by the edible nest ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41245-7
更新日期：2019-03-18 00:00:00
abstract：:The pine wood nematode, Bursaphelenchus xylophilus, is the causal agent of pine wilt disease that has devastated pine forests in Asia. Parasitic nematodes are known to have evolved antioxidant stress responses that defend against host plant defenses. In this study, the infestation of whitebark pine, Pinus bungean, wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27438
更新日期：2016-06-07 00:00:00
abstract：:Global ocean acidification is expected to chronically lower the pH to 7.3 (>2200 µatm seawater pCO2) by the year 2300. Acute hypercapnia already occurs along the South African west and south coasts due to upwelling- and low-oxygen events, with increasing frequency. In the present project we investigated the impact of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54795-7
更新日期：2019-12-19 00:00:00
abstract：:SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood. Overexpression of Myc often correlates with more aggressive tumour forms, supporting its involvement in carcinogenesis. Yes-associated prot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17701
更新日期：2015-12-04 00:00:00
abstract：:Alzheimer's disease is characterized by neuronal loss and cerebral accumulation of amyloid-β protein (Aβ) and lowering the generation of Aβ is a pivotal approach in the strategy of Alzheimer's disease treatment. Midlife hypertension is a major risk factor for the future onset of sporadic Alzheimer's disease and the us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12059
更新日期：2015-07-08 00:00:00
abstract：:Gaze-following behaviour is considered crucial for social interactions which are influenced by social similarity. We investigated whether the degree of similarity, as indicated by the perceived age of another person, can modulate gaze following. Participants of three different age-groups (18-25; 35-45; over 65) perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04746
更新日期：2014-04-22 00:00:00
abstract：:The ability of wild animals to respond flexibly to anthropogenic environmental changes, including agriculture, is critical to survival in human-impacted habitats. Understanding use of human foods by wildlife can shed light on the acquisition of novel feeding habits and how animals respond to human-driven land-use chan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05956
更新日期：2014-08-05 00:00:00
abstract：:Carbon coated TiO2 (TiO2@C) is fabricated by a convenient and green one-pot solvothermal method, in which ethylene glycol serve as both the reaction medium and carbon source without the addition of any other carbon additives. During the solvothermal process, ethylene glycol polymerize and coordinate with Ti4+ to form ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43895
更新日期：2017-03-03 00:00:00
abstract：:The ability to extract the direction of the other's gaze allows us to shift our attention to an object of interest to the other and to establish joint attention. By mapping one's own intentions on the object of joint attention, humans develop a Theory of (the other's) Mind (TOM), a functional sequence possibly disrupt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51783-9
更新日期：2019-10-25 00:00:00
abstract：:Host-generalist pathogens sporadically infect naive hosts, potentially triggering epizootics. The waterborne fungus Batrachochytrium dendrobatidis (Bd) is linked to declines of hundreds of amphibian species with aquatic larvae. Although several population declines and extinctions attributed to Bd have been reported am...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16425-y
更新日期：2017-11-30 00:00:00
abstract：:Circular Dichroism data are often decomposed into their constituent spectra to quantify the secondary structure of peptides or proteins but the estimation of the secondary structure content fails when light scattering leads to spectral distortion. If peptide-induced liposome self-association occurs, subtracting contro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39450
更新日期：2016-12-22 00:00:00
abstract：:This study is to investigate the frequencies of T-helper (Th)22, Th17 and Th1 cells and the levels of related cytokines in subchondral bone marrow in patients with rheumatoid arthritis (RA). Bone marrow and peripheral blood samples were collected from RA, osteoarthritis (OA) patients and healthy controls. The frequenc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05014-8
更新日期：2017-07-06 00:00:00
abstract：:Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer and has a high survival rate when properly managed. Prognosis is correlated with many factors such as age, gender, white blood cell (WBC) count, CD10, French-American-British (FAB) classification, and many others. Many of these factors are include...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63528-0
更新日期：2020-04-21 00:00:00
abstract：:Fundamental life history processes of mycorrhizal fungi with inconspicuous fruiting bodies can be difficult to elucidate. In this study we investigated the species identities and life history of the orchid mycorrhizal Tulasnella fungi, which associate with the south eastern Australia orchid genus Chiloglottis. Tulasne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05855-3
更新日期：2017-07-17 00:00:00
abstract：:Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial. Optical intrinsic signal (OIS) imaging can be used to study brain activity by simultaneously recording hemodynamic signals at diff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21627
更新日期：2016-02-10 00:00:00
