Action mechanism of corticosteroids to aggravate Guillain-Barré syndrome.

Abstract:

:Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical improvement. On 30(th) day after onset, there was significantly higher frequency of axonal degeneration in the corticosteroids-treated rabbits than saline-treated rabbits. Corticosteroids may reduce the scavengers that play a crucial role for nerve regeneration, thus delay the recovery of this disease.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang YZ,Lv H,Shi QG,Fan XT,Li L,Yi Wong AH,Hao YL,Si CP,Li CL,Yuki N

doi

10.1038/srep13931

subject

Has Abstract

pub_date

2015-09-10 00:00:00

pages

13931

issn

2045-2322

pii

srep13931

journal_volume

5

pub_type

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