Abstract:
:Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical improvement. On 30(th) day after onset, there was significantly higher frequency of axonal degeneration in the corticosteroids-treated rabbits than saline-treated rabbits. Corticosteroids may reduce the scavengers that play a crucial role for nerve regeneration, thus delay the recovery of this disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang YZ,Lv H,Shi QG,Fan XT,Li L,Yi Wong AH,Hao YL,Si CP,Li CL,Yuki Ndoi
10.1038/srep13931subject
Has Abstractpub_date
2015-09-10 00:00:00pages
13931issn
2045-2322pii
srep13931journal_volume
5pub_type
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