Environment- and eye-centered inhibitory cueing effects are both observed after a methodological confound is eliminated.

abstract：:Among the 146 patients enrolled in the Korean FH registry, 83 patients who had undergone appropriate LLT escalation and were followed-up for ≥ 6 months were analyzed for pathogenic variants (PVs). The achieved percentage of expected low-density lipoprotein-cholesterol (LDL-C) reduction (primary variable) and achieveme...

journal_title：Scientific reports

authors： Kim H,Lee CJ,Pak H,Kim DI,Rhee MY,Lee BK,Ahn Y,Cho BR,Woo JT,Hur SH,Jeong JO,Lee JH,Lee SH

更新日期：2020-11-09 00:00:00

abstract：:A series of novel dioxin-containing pyrazoline derivatives with thiourea skeleton have been designed, synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities. A majority of them displayed selective HER-2 inhibitory activity against EGFR inhibitory activity. Compound C20 displayed th...

journal_title：Scientific reports

authors： Yang B,Yang YS,Yang N,Li G,Zhu HL

更新日期：2016-06-08 00:00:00

abstract：:This retrospective cohort study investigated the association between in-hospital survival and two-dimensional (2D) echocardiography within 24 hours after the return of spontaneous circulation (ROSC) in patients who underwent in-hospital cardiopulmonary resuscitation (ICPR) after in-hospital cardiopulmonary arrest (IHC...

journal_title：Scientific reports

authors： Song IA,Cha JK,Oh TK,Jo YH,Yoon YE

更新日期：2020-01-08 00:00:00

abstract：:Objectum-sexuality (OS) is a sexual orientation which has received little attention in the academic literature. Individuals who identify as OS experience emotional, romantic and/or sexual feelings towards inanimate objects (e.g. a bridge, a statue). We tested 34 OS individuals and 88 controls, and provide the first em...

journal_title：Scientific reports

authors： Simner J,Hughes JEA,Sagiv N

更新日期：2019-12-27 00:00:00

abstract：:The interplay between the quasi 1-dimensional CuO-chains and the 2-dimensional CuO2 planes of YBa(2)Cu(3)O(6+x) (YBCO) has been in focus for a long time. Although the CuO-chains are known to be important as charge reservoirs that enable superconductivity for a range of oxygen doping levels in YBCO, the understanding o...

journal_title：Scientific reports

authors： Magnuson M,Schmitt T,Strocov VN,Schlappa J,Kalabukhov AS,Duda LC

更新日期：2014-11-12 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induced blockade of neuromuscular transmission. While aminopyridines have ...

journal_title：Scientific reports

authors： Beske PH,Hoffman KM,Machamer JB,Eisen MR,McNutt PM

更新日期：2017-11-20 00:00:00

abstract：:Predicting the occurrence of ventricular tachyarrhythmia (VTA) in advance is a matter of utmost importance for saving the lives of cardiac arrhythmia patients. Machine learning algorithms have been used to predict the occurrence of imminent VTA. In this study, we used a one-dimensional convolutional neural network (1-...

journal_title：Scientific reports

authors： Taye GT,Hwang HJ,Lim KM

更新日期：2020-04-21 00:00:00

abstract：:Laminotomy and transforaminal lumbar interbody fusion (TLIF) is usually used to treat unstable spinal stenosis. Minimally invasive surgery (MIS) can cause less muscle injury than conventional open surgery (COS). The purpose of this study was to compare the degree of postoperative fatty degeneration in the paraspinal m...

journal_title：Scientific reports

authors： Fu CJ,Chen WC,Lu ML,Cheng CH,Niu CC

更新日期：2020-09-03 00:00:00

abstract：:Magnetic resonance imaging (MRI) is a widely used non-invasive methodology for both preclinical and clinical studies. However, MRI lacks molecular specificity. Molecular contrast agents for MRI would be highly beneficial for detecting specific pathological lesions and quantitatively evaluating therapeutic efficacy in ...

journal_title：Scientific reports

authors： Kim JH,Dodd S,Ye FQ,Knutsen AK,Nguyen D,Wu H,Su S,Mastrogiacomo S,Esparza TJ,Swenson RE,Brody DL

更新日期：2021-01-08 00:00:00

abstract：:The formation of proper sensory afferent connections during development is essential for brain function. Activity-based competition is believed to drive ocular dominance columns (ODC) in mammals and in experimentally-generated three-eyed frogs. ODC formation is thus a compromise of activity differences between two eye...

journal_title：Scientific reports

authors： Elliott KL,Houston DW,Fritzsch B

更新日期：2015-02-09 00:00:00

abstract：:Parasite death via ion channel activations is the hallmark of anthelmintic and antiparasitic drugs. Glutamate gated chloride channel (GluCl) is a prominent targets for drug selection and design in parasitology. We report several iodine-fluorine based lead activators of GluCl by computational studies and structure-acti...

journal_title：Scientific reports

authors： Rajasekharan SK,Lee JH,Ravichandran V,Kim JC,Park JG,Lee J

更新日期：2019-02-14 00:00:00

abstract：:Long-term monitoring of host-parasite interactions is important for understanding the consequences of infection on host fitness and population dynamics. In an eight-year survey of the loggerhead sea turtle (Caretta caretta) population nesting in Cabo Verde, we determined the spatiotemporal variation of Ozobranchus mar...

journal_title：Scientific reports

authors： Lockley EC,Fouda L,Correia SM,Taxonera A,Nash LN,Fairweather K,Reischig T,Durão J,Dinis H,Roque SM,Lomba JP,Dos Passos L,Cameron SJK,Stiebens VA,Eizaguirre C

更新日期：2020-10-29 00:00:00

abstract：:Bovine milk is vital for infant nutrition and is a major component of the human diet. Bovine mastitis is a common inflammatory disease of mammary gland in cattle. It alters the immune profile of the animal and lowers the quality and yield of milk causing huge economic losses to dairy industry. The incidence of sub-cli...

journal_title：Scientific reports

authors： Bathla S,Sindhu A,Kumar S,Dubey SK,Pattnaik S,Rawat P,Chopra A,Dang A,Kaushik JK,Mohanty AK

更新日期：2020-06-09 00:00:00

abstract：:The complement system is the first line of defense against foreign intruders, and deregulation of this system has been described in multiple diseases. In age-related macular degeneration (AMD), patients have higher complement activation levels compared to controls. Recently, a combination of three single nucleotide po...

journal_title：Scientific reports

authors： Paun CC,Lechanteur YTE,Groenewoud JMM,Altay L,Schick T,Daha MR,Fauser S,Hoyng CB,den Hollander AI,de Jong EK

更新日期：2016-05-31 00:00:00

abstract：:Keyboards and smartphones allow users to express their thoughts freely via manual control. Hands-free communication can be realized with brain-computer interfaces (BCIs) based on code-modulated visual evoked potentials (c-VEPs). Various variations of such spellers have been developed: Low-target systems, multi-target ...

journal_title：Scientific reports

authors： Gembler FW,Benda M,Rezeika A,Stawicki PR,Volosyak I

更新日期：2020-10-13 00:00:00

abstract：:Mutations in the TGFβR2 gene have been associated with a life threatening risk of aortic dissection but no arrhythmic death has been previously reported. Two young females carrying a TGFβR2 mutation, initially diagnosed as Marfan syndrome or Loeys Dietz syndrome, presented sudden death with autopsy ruling out dissecti...

journal_title：Scientific reports

authors： Extramiana F,Milleron O,Elbitar S,Uccellini A,Langeois M,Spentchian M,Delorme G,Arnoult F,Denjoy I,Bouleti C,Fressart V,Iserin F,Maison-Blanche P,Abifadel M,Leenhardt A,Boileau C,Jondeau G

更新日期：2018-08-29 00:00:00

abstract：:Photonic qubits lie at the heart of quantum information technology, often encoding information in their polarization state. So far, only low-frequency optical and infrared photons have been employed as flying qubits, as the resources that are at present easiest to control. With their essentially different way of inter...

journal_title：Scientific reports

authors： Gunst J,Keitel CH,Pálffy A

更新日期：2016-04-27 00:00:00

abstract：:Colloidal quantum dots (QDs) are an emerging class of new materials due to their unique physical properties. In particular, colloidal QD based light emitting diodes (QDLEDs) have been extensively studied and developed for the next generation displays and solid-state lighting. Among a number of approaches to improve pe...

journal_title：Scientific reports

authors： Kim HH,Park S,Yi Y,Son DI,Park C,Hwang DK,Choi WK

更新日期：2015-03-10 00:00:00

abstract：:Huntington's disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the mutant form of HTT is a key aspect of d...

journal_title：Scientific reports

authors： Fodale V,Pintauro R,Daldin M,Altobelli R,Spiezia MC,Bisbocci M,Macdonald D,Bresciani A

更新日期：2020-12-17 00:00:00

abstract：:CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to...

journal_title：Scientific reports

authors： Li S,Lu H,Sella R,Zhang W,Dong H,Guo C,Afshari NA,Pan Z,Jie Y

更新日期：2018-05-22 00:00:00

abstract：:We developed a new technique to observe macroautophagy in the brain in vivo, and examined whether fasting induced macroautophagy in neurons and how the induction was different between Alzheimer's disease (AD) model and control mice. Lentivirus for EGFP-LC3 injected into the brain successfully visualized autophagosome ...

journal_title：Scientific reports

authors： Chen X,Kondo K,Motoki K,Homma H,Okazawa H

更新日期：2015-07-14 00:00:00

abstract：:For many malignancies, inflammation-based scores correlate with survival. The neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are immunonutritional indices associated with postoperative outcomes in patients with hepatocellular carcinoma (HCC). We evaluated whether a combined preoperative NL...

journal_title：Scientific reports

authors： Liu C,Li L,Lu WS,Du H,Yan LN,Yang JY,Wen TF,Zeng GJ,Jiang L,Yang J

更新日期：2017-10-24 00:00:00

abstract：:Our goal was to evaluate early results of the clinical application of autologous whole bone marrow stem cell transplantation (AWBMSCT) for critical limb ischemia (CLI) in patients with Buerger's disease. We retrospectively analyzed the data of 58 limbs of 37 patients (mean age, 43.0 years; range, 28-63 years; male, 91...

journal_title：Scientific reports

authors： Heo SH,Park YS,Kang ES,Park KB,Do YS,Kang KS,Kim DI

更新日期：2016-01-21 00:00:00

abstract：:Retinitis pigmentosa (RP) is one of hereditary retinal diseases characterized by the loss of photoreceptors. Cell transplantation has been clinically applied to treat RP patients. Human retinal progenitor cells (HRPCs) and human bone marrow-derived mesenchymal stem cells (HBMSCs) are the two commonly and practically u...

journal_title：Scientific reports

authors： Qu L,Gao L,Xu H,Duan P,Zeng Y,Liu Y,Yin ZQ

更新日期：2017-03-15 00:00:00

abstract：:Elymus nutans is an herbaceous plant that can be used to restore degraded alpine and subalpine ecosystems. Here, we evaluated how sowing density affects soil reinforcement and slope stabilization properties of vegetation-concrete structures. To investigate the optimal sowing density of E. nutans in vegetation-concrete...

journal_title：Scientific reports

authors： Tan X,Huang Y,Xiong D,Lv K,Chen F

更新日期：2020-11-24 00:00:00

abstract：:Age-related macular degeneration (AMD) is a chronic degenerative disease of the retina. Recent reports have highlighted the potential role of mucosal surface microbes in the pathogenesis of AMD. In this case-control study, the composition of the nasal and oral microbiota in newly diagnosed neovascular age-related macu...

journal_title：Scientific reports

authors： Rullo J,Far PM,Quinn M,Sharma N,Bae S,Irrcher I,Sharma S

更新日期：2020-03-02 00:00:00

abstract：:Biomass waste treatment and detrimental dye adsorption are two of the crucial environmental issues nowadays. In this study, we investigate to simultaneously resolve the aforementioned issues by synthesizing chitosan sponges as adsorbents toward rose bengal (RB) dye adsorption. Through a temperature-controlled freeze-c...

journal_title：Scientific reports

authors： Wang M,Ma Y,Sun Y,Hong SY,Lee SK,Yoon B,Chen L,Ci L,Nam JD,Chen X,Suhr J

更新日期：2017-12-22 00:00:00

abstract：:Antiretroviral therapy-naive HIV-1 infected infants experience poor viral containment and rapid disease progression compared to adults. Viral factors (e.g. transmitted cytotoxic T- lymphocyte (CTL) escape mutations) or infant factors (e.g. reduced CTL functional capacity) may explain this observation. We assessed CTL ...

journal_title：Scientific reports

authors： Garcia-Knight MA,Slyker J,Payne BL,Pond SL,de Silva TI,Chohan B,Khasimwa B,Mbori-Ngacha D,John-Stewart G,Rowland-Jones SL,Esbjörnsson J

更新日期：2016-07-12 00:00:00

abstract：:The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanoprecipitation techn...

journal_title：Scientific reports

authors： Ramzy L,Metwally AA,Nasr M,Awad GAS

更新日期：2020-07-03 00:00:00

abstract：:Electrospun gelatin nanofibers attract great interest as a natural biomaterial for cartilage and tendon repair despite their high solubility in aqueous solution, which makes them also difficult to crosslink by means of chemical agents. In this work, we explore the efficiency of non-equilibrium atmospheric pressure pla...

journal_title：Scientific reports

authors： Liguori A,Bigi A,Colombo V,Focarete ML,Gherardi M,Gualandi C,Oleari MC,Panzavolta S

更新日期：2016-12-07 00:00:00