Abstract:
:For many malignancies, inflammation-based scores correlate with survival. The neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are immunonutritional indices associated with postoperative outcomes in patients with hepatocellular carcinoma (HCC). We evaluated whether a combined preoperative NLR and PNI score was prognostically superior to either index alone in 793 patients with unresectable HCC after transarterial chemoembolization. Patient demographic, clinical, and pathological data were also collected and analysed. A receiver-operating characteristic (ROC) analysis was used to classify patients as follows: NLR-PNI 0 group (NLR ≤ 2.2 and PNI > 46), NLR-PNI 1 group (NLR > 2.2 or PNI ≤ 46) and NLR-PNI 2 group (NLR > 2.2 and PNI ≤ 46). Regarding 1-, 3-, and 5-year survival, the NLR-PNI score had superior discriminative abilities (i.e., higher area under the ROC curve), compared with either the NLR or PNI alone, and patients in the NLR-PNI 0, 1, and 2 groups had median survival times of 33 (95% confidence interval: 22.8-43.2), 14 (10.9-17.1), and 6 (9.9-14.1) months, respectively. In multivariate analyses, the Barcelona Clinic Liver Cancer, total bilirubin, vascular invasion, and NLR-PNI score adversely affected overall survival. In conclusion, the NLR-PNI score can improve the accuracy of prognoses for patients with unresectable HCC.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu C,Li L,Lu WS,Du H,Yan LN,Yang JY,Wen TF,Zeng GJ,Jiang L,Yang Jdoi
10.1038/s41598-017-13239-wsubject
Has Abstractpub_date
2017-10-24 00:00:00pages
13873issue
1issn
2045-2322pii
10.1038/s41598-017-13239-wjournal_volume
7pub_type
杂志文章abstract::Hepatitis C virus (HCV) infection of hepatocytes promotes liver fibrosis by activation of hepatic stellate cells (HSCs) and excessive deposition of extracellular matrix in liver tissue. Whether or not host factors released from the HCV-infected hepatocytes play role in HSCs activation is unclear. In this study, HSCs w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04259-7
更新日期:2017-06-30 00:00:00
abstract::Activated coke (AC) has great potential in the field of low-temperature NO removal (DeNOx), especially the branch prepared by blending modification. In this study, the AC-based pyrolusite and/or titanium ore blended catalysts were prepared and applied for DeNOx. The results show blending pyrolusite and titanium ore pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76592-3
更新日期:2020-11-10 00:00:00
abstract::Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23984-1
更新日期:2018-04-04 00:00:00
abstract::The traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF). A fundamentally different approach, abbreviated "mcDESPOT", uses a more efficient steady-state acquisition to generate an eq...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80585-7
更新日期:2021-01-14 00:00:00
abstract::Lipid droplet (LD)-associated hydrolase (LDAH) is a newly identified LD protein abundantly expressed in tissues that predominantly store triacylglycerol (TAG). However, how LDAH regulates TAG metabolism remains unknown. We found that upon oleic acid loading LDAH translocalizes from the ER to newly formed LDs, and indu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02963-y
更新日期:2017-06-02 00:00:00
abstract::Cell-based assays are growing in importance for screening drugs and investigating their mechanisms of action. Most of the assays use so-called "normal" cell strain because it is difficult to produce cell lines in which the disease conditions are reproduced. In this study, we used a cell-resealing technique, which reve...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15443-0
更新日期:2017-11-09 00:00:00
abstract::When faced with adverse environmental conditions, the marsupial Dromiciops gliroides uses either daily or seasonal torpor to support survival and is the only known hibernating mammal in South America. As the sole living representative of the ancient Order Microbiotheria, this species can provide crucial information ab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24627
更新日期:2016-04-19 00:00:00
abstract::Hyperlipidemia, a very common disease throughout the world, usually gives rise to severe liver damages. The current experiment was to investigate the antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable Dictyophora indusiata polysaccharides (Al-DPS and En-DPS) on the hyperlipidemic mice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50717-9
更新日期:2019-10-03 00:00:00
abstract::The combination of biomaterials and stem cells for clinical applications constitute a great challenge in bone tissue engineering. Hence, cellular networks derived from cells-biomaterials crosstalk have a profound influence on cell behaviour and communication, preceding proliferation and differentiation. The purpose of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73428-y
更新日期:2020-10-05 00:00:00
abstract::Emergence of drug-resistant strains of the pathogen Mycobacterium tuberculosis (Mtb) and the ineffectiveness of BCG in curtailing Mtb infection makes vaccine development for tuberculosis an important objective. Identifying immunogenic CD8+ T cell peptide epitopes is necessary for peptide-based vaccine strategies. We p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04632
更新日期:2014-04-23 00:00:00
abstract::Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated. Makorin-2 (Mkrn2) is an evolutionarily conserved gene whose biological functions are not fully known. We developed an Mrkn2 knockout mouse model to study t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39318
更新日期:2016-12-23 00:00:00
abstract::The study of mechanisms that govern feeding behaviour and its related disorders is a matter of global health interest. The roundworm Caenorhabditis elegans is becoming a model organism of choice to study these conserved pathways. C. elegans feeding depends on the contraction of the pharynx (pumping). Thanks to the wor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21964-z
更新日期:2018-02-26 00:00:00
abstract::One of the factors that has increased the incidence and worse prognosis of breast cancer is obesity. In this condition, high amounts of leptin are secreted, which have proliferative, mitogenic, antiapoptotic, and proinflammatory activity that may be antagonistic to treatment with tamoxifen, considered the first choice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55674-x
更新日期:2019-12-16 00:00:00
abstract::Ichthyoarchaeological evidence is uncommon at ancient hunter-gatherer sites from various regions and timeframes. This research contributes to the development of microarchaeological techniques useful for identifying fishing economies in situations where classifiable bones are unavailable. Specifically, traces of heat a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03737-2
更新日期:2017-06-15 00:00:00
abstract::Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis. We sought to assess to which extent HIV exposure of neonates is associated with GBS neonatal disease. Furthermore, we assessed to which extent HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-13218-1
更新日期:2017-10-23 00:00:00
abstract::Dysfunction of cortical GABAergic interneurons are involved in numerous neurological disorders including epilepsy, schizophrenia and autism; and replenishment of these cells by transplantation strategy has proven to be a feasible and effective method to help revert the symptoms in several animal models. To develop met...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19003
更新日期:2016-01-11 00:00:00
abstract::During skin healing, periostin facilitates myofibroblast differentiation through a β1 integrin/FAK dependent mechanism and continued expression is associated with scarring. In contrast to skin, gingival tissue does not typically scar upon injury, but the role of periostin in gingival healing has never been investigate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35805-6
更新日期:2019-02-25 00:00:00
abstract::We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11205
更新日期:2015-07-02 00:00:00
abstract::The neural bases of the inter-trial validity/invalidity sequential effects in a visuo-auditory modified version of the Central Cue Posner's Paradigm (CCPP) are analyzed by means of Early Directing Attention Negativity (EDAN), Contingent Negative Variation (CNV) and Lateralized Readiness Potential (LRP). ERPs results i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04526
更新日期:2014-03-31 00:00:00
abstract::Viral capsids are metastable structures that perform many essential processes; they also act as robust cages during the extracellular phase. Viruses can use multifunctional proteins to optimize resources (e.g., VP3 in avian infectious bursal disease virus, IBDV). The IBDV genome is organized as ribonucleoproteins (RNP...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13486
更新日期:2015-09-04 00:00:00
abstract::The molecular mechanisms underlying viral pathogenesis are yet poorly understood owed to the large number of factors involved and the complexity of their interactions. Could we identify a minimal set of host transcription factors (TF) whose misregulation would result in the transcriptional profile characteristic of in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01006
更新日期:2012-01-01 00:00:00
abstract::In this paper, we investigate the possibility of improving efficiency in non-radiative wireless power transfer (WPT) using metasurfaces embedded between two current varying coils and present a complete theoretical analysis of this system. We use a point-dipole approximation to calculate the fields of the coils. Based ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33174-8
更新日期:2018-10-05 00:00:00
abstract::Bacillus megaterium is a microorganism widely used in industrial biotechnology for production of enzymes and recombinant proteins, as well as in bioleaching processes. Precise understanding of its metabolism is essential for designing engineering strategies to further optimize B. megaterium for biotechnology applicati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55041-w
更新日期:2019-12-10 00:00:00
abstract::The development of scalable synthesis techniques for optically transparent, electrically conductive coatings is in great demand due to the constantly increasing market price and limited resources of indium for indium tin oxide (ITO) materials currently applied in most of the optoelectronic devices. This work pioneers ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13710
更新日期:2015-09-03 00:00:00
abstract::The proteins AtSEOR1 and AtSEOR2 occur as conjugates in the form of filaments in sieve elements of Arabidopsis thaliana. A reduced phytoplasma titre found in infected defective-mutant Atseor1ko plants in previous work raised the speculation that non-conjugated SEOR2 is involved in the phytohormone-mediated suppression...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71660-0
更新日期:2020-09-08 00:00:00
abstract::Solid oxide fuel cells (SOFCs) are promising electrochemical devices that enable the highest fuel-to-electricity conversion efficiencies under high operating temperatures. The concept of multi-stage electrochemical oxidation using SOFCs has been proposed and studied over the past several decades for further improving ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12640
更新日期:2015-07-28 00:00:00
abstract::The advantages of the digital PCR technology are already well documented until now. One way to achieve better cost efficiency of the technique is to use it in a multiplexing strategy. Droplet digital PCR platforms, which include two fluorescence filters, support at least duplex reactions and with some developments and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35451
更新日期:2016-10-14 00:00:00
abstract::Brain µ-opioid receptors (MOR) mediate reward and help coping with pain, social rejection, anxiety and depression. The dorsal midline thalamus (dMT) integrates visceral/emotional signals and biases behavior towards aversive or defensive states through projections to the amygdala. While a dense MOR expression in the dM...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54128-8
更新日期:2019-11-28 00:00:00
abstract::Good mechanical properties and large adiabatic temperature change render Heusler-type Ni2FeGa-based magnetic shape memory alloys as a promising candidate material for solid-state mechanical cooling application at ambient conditions. Superelastic behavior and associated elastocaloric effect strongly reply on deformatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25500
更新日期:2016-05-03 00:00:00
abstract::Despite efforts during the past decades, loop modeling remains a difficult part of protein structure modeling. Several approaches have been developed in the framework of crystal structures. However, for homology models, the modeling of loops is still far from being solved. We propose DaReUS-Loop, a data-based approach...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32079-w
更新日期:2018-09-12 00:00:00