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The hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns.

Abstract：

:When faced with adverse environmental conditions, the marsupial Dromiciops gliroides uses either daily or seasonal torpor to support survival and is the only known hibernating mammal in South America. As the sole living representative of the ancient Order Microbiotheria, this species can provide crucial information about the evolutionary origins and biochemical mechanisms of hibernation. Hibernation is a complex energy-saving strategy that involves changes in gene expression that are elicited in part by microRNAs. To better elucidate the role of microRNAs in orchestrating hypometabolism, a modified stem-loop technique and quantitative PCR were used to characterize the relative expression levels of 85 microRNAs in liver and skeletal muscle of control and torpid D. gliroides. Thirty-nine microRNAs were differentially regulated during torpor; of these, 35 were downregulated in liver and 11 were differentially expressed in skeletal muscle. Bioinformatic analysis predicted that the downregulated liver microRNAs were associated with activation of MAPK, PI3K-Akt and mTOR pathways, suggesting their importance in facilitating marsupial torpor. In skeletal muscle, hibernation-responsive microRNAs were predicted to regulate focal adhesion, ErbB, and mTOR pathways, indicating a promotion of muscle maintenance mechanisms. These tissue-specific responses suggest that microRNAs regulate key molecular pathways that facilitate hibernation, thermoregulation, and prevention of muscle disuse atrophy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hadj-Moussa H,Moggridge JA,Luu BE,Quintero-Galvis JF,Gaitán-Espitia JD,Nespolo RF,Storey KB

doi

10.1038/srep24627

subject

Has Abstract

pub_date

2016-04-19 00:00:00

pages

24627

issn

2045-2322

pii

srep24627

journal_volume

6

pub_type

杂志文章

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