Abstract:
:Brain µ-opioid receptors (MOR) mediate reward and help coping with pain, social rejection, anxiety and depression. The dorsal midline thalamus (dMT) integrates visceral/emotional signals and biases behavior towards aversive or defensive states through projections to the amygdala. While a dense MOR expression in the dMT has been described, the exact cellular and synaptic mechanisms of µ-opioidergic modulation in the dMT-amygdala circuitry remain unresolved. Here, we hypothesized that MORs are important negative modulators of dMT-amygdala excitatory networks. Using retrograde tracers and targeted channelrhodopsin expression in combination with patch-clamp electrophysiology, we found that projections of dMT neurons onto both basal amygdala principal neurons (BA PN) and central amygdala (CeL) neurons are attenuated by stimulation of somatic or synaptic MORs. Importantly, dMT efferents to the amygdala drive feedforward excitation of centromedial amygdala neurons (CeM), which is dampened by MOR activation. This downregulation of excitatory activity in dMT-amygdala networks puts the µ-opioid system in a position to ameliorate aversive or defensive behavioral states associated with stress, withdrawal, physical pain or social rejection.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Goedecke L,Bengoetxea X,Blaesse P,Pape HC,Jüngling Kdoi
10.1038/s41598-019-54128-8subject
Has Abstractpub_date
2019-11-28 00:00:00pages
17837issue
1issn
2045-2322pii
10.1038/s41598-019-54128-8journal_volume
9pub_type
杂志文章abstract::The prefrontal cortex (PF) is involved in outcome-based flexible adaptation in a dynamically changing environment. The outcome signal dissipates gradually over time, but the temporal dynamics of this dissipation remains unknown. To examine this issue, we analyzed the outcome-related activity of PF neurons in 2 monkeys...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25622
更新日期:2016-05-10 00:00:00
abstract::Since its recent foundation, phase-coherent caloritronics has sparkled continuous interest giving rise to numerous concrete applications. This research field deals with the coherent manipulation of heat currents in mesoscopic superconducting devices by mastering the Josephson phase difference. Here, we introduce a new...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30268-1
更新日期:2018-08-16 00:00:00
abstract::The use of impedance-based label free cell analysis is increasingly popular and has many different applications. Here, we report that a real-time cell analyzer (RTCA) can be used to study the stimulation of Natural Killer (NK) cells. Engagement of NK cells via plate-bound antibodies directed against different activati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23368-5
更新日期:2018-03-21 00:00:00
abstract::Phototherapy was introduced in the early 1950's, and is the primary treatment of severe neonatal jaundice or Crigler-Najjar syndrome. Nevertheless, the potential biological effects of the products generated from the photodegradation of bilirubin during phototherapy remain unknown. This is very relevant in light of rec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25684-2
更新日期:2018-05-10 00:00:00
abstract::Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and proteasome activities in frozen postmortem OFC tissue from 76 (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38490-1
更新日期:2019-02-19 00:00:00
abstract::Low-dimensional behavior of large systems of globally coupled oscillators has been intensively investigated since the introduction of the Ott-Antonsen ansatz. In this report, we generalize the Ott-Antonsen ansatz to second-order Kuramoto models in complex networks. With an additional inertia term, we find a low-dimens...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04783
更新日期:2014-05-02 00:00:00
abstract::The exact extent, by which the hydrologic cycle in the Neotropics was affected by external forcing during the last deglaciation, remains poorly understood. Here we present a new paleo-rainfall reconstruction based on high-resolution speleothem δ18O records from the core region of the South American Monsoon System (SAM...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44267
更新日期:2017-03-10 00:00:00
abstract::The accurate prediction of the impact of an amino acid substitution on the thermal stability of a protein is a central issue in protein science, and is of key relevance for the rational optimization of various bioprocesses that use enzymes in unusual conditions. Here we present one of the first computational tools to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23257
更新日期:2016-03-18 00:00:00
abstract::The double-slit experiment strikingly demonstrates the wave-particle duality of quantum objects. In this famous experiment, particles pass one-by-one through a pair of slits and are detected on a distant screen. A distinct wave-like pattern emerges after many discrete particle impacts as if each particle is passing th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04685
更新日期:2014-04-28 00:00:00
abstract::Parthenocarpy is the development of an ovary into a seedless fruit without pollination. The ubiquitous downregulation of SlIAA9 induces not only parthenocarpic fruit formation but also an abnormal vegetative phenotype. To make parthenocarpic transgenic tomato plants without unwanted phenotypes, we found two genes, nam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55400-7
更新日期:2019-12-11 00:00:00
abstract::Many behaviors of cancer, such as progression, metastasis and drug resistance etc., cannot be fully understood by genetic mutations or intracellular signaling alone. Instead, they are emergent properties of the cell community which forms a tumor. Studies of tumor heterogeneity reveal that many cancer behaviors critica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09307-w
更新日期:2017-08-18 00:00:00
abstract::Study aimed to assess long-term bowel function in patients who underwent low anterior resection for cancer five and more years ago. Patients who underwent low anterior resection for rectal cancer from 2010 to 2015 at National Cancer Institute were prospectively included in our study. They were interviewed using low an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68900-8
更新日期:2020-07-17 00:00:00
abstract::Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21552-1
更新日期:2018-02-23 00:00:00
abstract::The early detection of cognitive impairment or dementia is in the focus of current research as the amount of cognitively impaired individuals will rise intensely in the next decades due to aging population worldwide. Currently available diagnostic tools to detect mild cognitive impairment (MCI) or dementia are time-co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40010-0
更新日期:2019-03-05 00:00:00
abstract::Advances in single-photon sources (SPSs) and single-photon detectors (SPDs) promise unique applications in the field of quantum information technology. In this paper, we report long-distance quantum key distribution (QKD) by using state-of-the-art devices: a quantum-dot SPS (QD SPS) emitting a photon in the telecom ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14383
更新日期:2015-09-25 00:00:00
abstract::East Asian summer monsoon (EASM)-driven rapid hydroclimatic variation is a crucial factor with major socioeconomic impacts. Nevertheless, decadal- to centennial-scale EASM variability over the last two millennia is still poorly understood. Pollen-based quantitative annual precipitation (PqPann) and annual precipitatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74994-x
更新日期:2020-10-20 00:00:00
abstract::People of north-eastern states of India consume raw areca-nut (RAN) and lime which could lead to oral, esophageal and gastric cancers. However, the incidence of these cancers are significantly lesser in those who consume pieces of Potentilla fulgens root along with RAN. Since evaluation of anticancer role, if any, of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53747-5
更新日期:2019-11-18 00:00:00
abstract::Solute segregating to grain boundary can stabilize the microstructure of nanocrystalline materials, but a lot of solutes also cause embrittlement effect on interfacial strength. Therefore, uncovering the solute effect on grain boundary strength is very important for nanocrystalline alloys design. In this work, we have...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74065-1
更新日期:2020-10-08 00:00:00
abstract::The shape of fragments generated by the breakup of solids is central to a wide variety of problems ranging from the geomorphic evolution of boulders to the accumulation of space debris orbiting Earth. Although the statistics of the mass of fragments has been found to show a universal scaling behavior, the comprehensiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09147
更新日期:2015-03-16 00:00:00
abstract::Yinchenhao decoction (YCHD), comprising Yinchenhao (Artemisiae Scopariae Herba), Zhizi (Gardeniae Fructus) and Dahuang (Radix Rhei et Rhizoma), is widely used for treating various diseases. We aimed to investigate the bile acid metabolic mechanism of YCHD in dimethylnitrosamine (DMN)-induced liver fibrosis model. Rats...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33669-4
更新日期:2018-10-18 00:00:00
abstract::Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and non-functioning organelles. We recently demonstrated that exercise activates autophagy and re-establishe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30365-1
更新日期:2018-08-07 00:00:00
abstract::Emerging evidence demonstrates the importance of sufficient vitamin D (1α, 25-dihydroxyvitamin D3) levels during early life stage development with deficiencies associated with long-term effects into adulthood. While vitamin D has traditionally been associated with mineral ion homeostasis, accumulating evidence suggest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72622-2
更新日期:2020-09-29 00:00:00
abstract::Transthyretin (TTR) is a blood and cerebrospinal fluid transporter of thyroxine and retinol. Gene expression profiling revealed an elevation of Ttr expression in the dorsomedial hypothalamus (DMH) of rats with exercise-induced anorexia, implying that central TTR may also play a functional role in modulating food intak...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24238
更新日期:2016-04-07 00:00:00
abstract::Arabidopsis VIRE2-INTERACTING PROTEIN2 (VIP2) was previously described as a protein with a NOT domain, and Arabidopsis vip2 mutants are recalcitrant to Agrobacterium-mediated root transformation. Here we show that VIP2 is a transcription regulator and the C-terminal NOT2 domain of VIP2 interacts with VirE2. Interestin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49590-3
更新日期:2019-09-18 00:00:00
abstract::Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sections. Here, we expand the use of LESA-MSI beyond qualitative analysis t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37648
更新日期:2016-11-24 00:00:00
abstract::Diagnosis of sleep apnea (SA) using simple tools has the potential to improve the efficacy of cardiac implants in the prevention of cardiac arrhythmias. The aim of the present study was to validate a transthoracic impedance sensor for SA diagnosis in patients with cardiac implants. We compared the apnea-hypopnea index...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45255-3
更新日期:2019-07-03 00:00:00
abstract::Severe sepsis or septic shock is one of the rising causes for mortality worldwide representing nearly 10% of intensive care unit admissions. Susceptibility to sepsis is identified to be mediated by innate pattern recognition receptors and responsive signaling pathways of the host. The c-Jun N-terminal Kinase (JNK)-med...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07214
更新日期:2014-11-27 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24799-w
更新日期:2018-04-19 00:00:00
abstract::To evaluate the performance of computed high b value diffusion-weighted images (DWI) in prostate cancer detection. 97 consecutive patients who had undergone multiparametric MRI of the prostate followed by biopsy were reviewed. Five radiologists independently scored 138 lesions on native high b-value images (b = 1200 s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21523-6
更新日期:2018-02-21 00:00:00
abstract::The comprehension of the governing mechanism which affects device instability is one of the most important requirements for the formation of reliable oxide-thin film transistors (TFTs). However, a quantitative analysis of the dominant mechanism of device instability, which stems from charge trapping induced by defects...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12155-3
更新日期:2017-09-19 00:00:00