A high-resolution history of the South American Monsoon from Last Glacial Maximum to the Holocene.

abstract：:Hepatocellular carcinoma (HCC) is the most common liver cancer, with a very poor prognosis. There is an urgent need for an effective therapy for HCC. Ginsenoside Rh2 (GRh2) has been shown to significantly inhibit growth of some types of cancer, whereas its effects on HCC have not been examined. Here, we treated human ...

journal_title：Scientific reports

authors： Yang Z,Zhao T,Liu H,Zhang L

更新日期：2016-01-19 00:00:00

abstract：:Transmission electron microscopy and related analytical techniques have been widely used to study the microstructure of different materials. However, few research works have been performed in the field of glasses, possibly due to the electron-beam irradiation damage. In this paper, we have developed a method based on ...

journal_title：Scientific reports

authors： Cheng S,Yang G,Zhao Y,Peng M,Skibsted J,Yue Y

更新日期：2015-12-08 00:00:00

abstract：:The brain is organized into large scale spatial networks that can be detected during periods of rest using fMRI. The brain is also a dynamic organ with activity that changes over time. We developed a method and investigated properties where the connections as a function of time are derived and quantified. The point ba...

journal_title：Scientific reports

authors： Thompson WH,Fransson P

更新日期：2016-12-19 00:00:00

abstract：:Developing optically transparent magnets at room temperature is an important challenge. They would bring many innovations to various industries, not only for electronic and magnetic devices but also for optical applications. Here we introduce FeCo-(Al-fluoride) nanogranular films exhibiting ferromagnetic properties wi...

journal_title：Scientific reports

authors： Kobayashi N,Masumoto H,Takahashi S,Maekawa S

更新日期：2016-09-28 00:00:00

abstract：:The freshwater crustacean Daphnia is known for its ability to develop inducible morphological defences that thwart predators. These defences are developed only in the presence of predators and are realized as morphological shape alterations e.g. 'neckteeth' in D. pulex and 'crests' in D. longicephala. Both are discuss...

journal_title：Scientific reports

authors： Kruppert S,Horstmann M,Weiss LC,Witzel U,Schaber CF,Gorb SN,Tollrian R

更新日期：2017-08-29 00:00:00

abstract：:Parasites exhibiting a high degree of host specificity are expected to be intimately associated with their hosts. Therefore, the evolution of host-specific parasites is at least partially shaped by the evolutionary history and distribution of such hosts. Gill ectoparasites of Dactylogyrus (Monogenea) are specific to c...

journal_title：Scientific reports

authors： Benovics M,Desdevises Y,Vukić J,Šanda R,Šimková A

更新日期：2018-08-29 00:00:00

abstract：:Traumatic brain injury (TBI) causes brain edema that induces increased intracranial pressure and decreased cerebral perfusion. Decompressive craniectomy has been recommended as a surgical procedure for the management of swollen brain and intracranial hypertension. Proper location and size of a decompressive craniectom...

journal_title：Scientific reports

authors： Lambride C,Christodoulou N,Michail A,Vavourakis V,Stylianopoulos T

更新日期：2020-10-29 00:00:00

abstract：:Surface plasmon resonators can drastically redistribute incident light over different output wave vectors and polarizations. This can lead for instance to sub-diffraction sized nanoapertures in metal films that beam and to nanoparticle antennas that enable efficient conversion of photons between spatial modes, or heli...

journal_title：Scientific reports

authors： Osorio CI,Mohtashami A,Koenderink AF

更新日期：2015-04-30 00:00:00

abstract：:Diseases and toxins may lead to death of active liver tissue, resulting in a loss of total clearance capacity at the whole-body level. However, it remains difficult to study, whether the loss of metabolizing tissue is sufficient to explain loss of metabolic capacity of the liver or whether the surviving tissue undergo...

journal_title：Scientific reports

authors： Schenk A,Ghallab A,Hofmann U,Hassan R,Schwarz M,Schuppert A,Schwen LO,Braeuning A,Teutonico D,Hengstler JG,Kuepfer L

更新日期：2017-07-24 00:00:00

abstract：:Chinese sturgeon (Acipenser sinensis) has been listed as a critically endangered species on the IUCN Red List and is an endemic fish of China. Five sets of duplex polymerase chain reactions (PCR) assays were developed with 10 tetranucleotide microsatellites for Chinese sturgeon. The size of CS57, ZHX43, ZHX69, AS105, ...

journal_title：Scientific reports

authors： Hu Y,Liu X,Yang J,Xiao K,Wang B,Du H

更新日期：2020-02-26 00:00:00

abstract：:Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39(+) Treg were isolated from normal donors' peripheral blood and co-incubated with TEX or exosomes iso...

journal_title：Scientific reports

authors： Muller L,Mitsuhashi M,Simms P,Gooding WE,Whiteside TL

更新日期：2016-02-04 00:00:00

abstract：:Recent studies have demonstrated functions of miR-145 in vascular smooth muscle cells (VSMCs) phenotypes and vascular diseases. In this study, we aim to determine whether CD40 is involved in miR-145 mediated switch of VSMC phenotypes. In cultured VSMCs, the effects of miR-145 and CD40 on TNF-α, TGF-β, and Homocysteine...

journal_title：Scientific reports

authors： Guo X,Li D,Chen M,Chen L,Zhang B,Wu T,Guo R

更新日期：2016-10-12 00:00:00

abstract：:The ability to harvest thermal energy and manipulate heat fluxes has recently attracted a great deal of research interest because this is critical to achieve efficient solar-to-thermal energy conversion in the technology of concentrated solar thermal collectors. Thermal metamaterials with engineered thermal conduction...

journal_title：Scientific reports

authors： Chen F,Lei DY

更新日期：2015-06-25 00:00:00

abstract：:The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabe...

journal_title：Scientific reports

authors： Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HS

更新日期：2016-07-06 00:00:00

abstract：:After spinal cord injury (SCI) chronic inflammation hampers regeneration. Influencing the local microenvironment after SCI may provide a strategy to modulate inflammation and the immune response. The objectives of this work were to determine whether bone or spinal cord derived ECM hydrogels can deliver human mesenchym...

journal_title：Scientific reports

authors： Tatic N,Rose FRAJ,des Rieux A,White LJ

更新日期：2019-09-30 00:00:00

abstract：:Recent decades have experienced the discovery of numerous complex materials. At the root of the complexity underlying many of these materials lies a large number of contending atomic- and largerscale configurations. In order to obtain a more detailed understanding of such systems, we need tools that enable the detecti...

journal_title：Scientific reports

authors： Ronhovde P,Chakrabarty S,Hu D,Sahu M,Sahu KK,Kelton KF,Mauro NA,Nussinov Z

更新日期：2012-01-01 00:00:00

abstract：:Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and expense of animal testing often makes it unfeasible to examine this large number of nanoparticles in vivo. This often leads to the investigation...

journal_title：Scientific reports

authors： Elias A,Crayton SH,Warden-Rothman R,Tsourkas A

更新日期：2014-07-28 00:00:00

abstract：:Positron emission tomography (PET) imaging is used to localize recurrent disease in prostate cancer (PCa). The tracer 68Ga-PSMA-11 visualizes lesions overexpressing prostate-specific membrane antigen (PSMA), while 11C-acetate visualizes lesions with increased anabolic metabolism. The aim of this study was to compare t...

journal_title：Scientific reports

authors： Regula N,Kostaras V,Johansson S,Trampal C,Lindström E,Lubberink M,Velikyan I,Sörensen J

更新日期：2020-03-19 00:00:00

abstract：:CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic modifications. Typically, sgRNA is constitutively expressed relying on RNA polymerase III promoters. Polymerase II promoters initiate transcription in a flexible manner, but sgRNAs generated by RNA polymerase II promoter lost their nuclease ...

journal_title：Scientific reports

authors： Xie C,Chen YL,Wang DF,Wang YL,Zhang TP,Li H,Liang F,Zhao Y,Zhang GY

更新日期：2017-07-19 00:00:00

abstract：:The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear condit...

journal_title：Scientific reports

authors： Hoang Trung H,Yoshihara T,Nakao A,Hayashida K,Hirata Y,Shirasuna K,Kuwamura M,Nakagawa Y,Kaneko T,Mori Y,Asano M,Kuramoto T

更新日期：2021-01-21 00:00:00

abstract：:The distinction between primary and secondary volcaniclastic deposits, which are currently defined as the "direct" products of volcanic eruptions and the "reworked" products of the former, respectively, is the first step to interpreting volcaniclastic deposits, particularly the genetic connection with active volcanism...

journal_title：Scientific reports

authors： Sohn C,Sohn YK

更新日期：2019-08-27 00:00:00

abstract：:Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous multi-trait GWAS methods that exploit either summary statistics or individual-level data have been developed, but their relative performance...

journal_title：Scientific reports

authors： Porter HF,O'Reilly PF

更新日期：2017-03-13 00:00:00

abstract：:The gene PFKFB3 encodes for inducible 6-phosphofructo-2-kinase, a glycolysis-regulatory enzyme that protects against diet-induced intestine inflammation. However, it is unclear how nutrient overload regulates PFKFB3 expression and inflammatory responses in intestinal epithelial cells (IECs). In the present study, prim...

journal_title：Scientific reports

authors： Botchlett R,Li H,Guo X,Qi T,Zhao J,Zheng J,Woo SL,Pei Y,Liu M,Hu X,Chen G,Guo T,Yang S,Li Q,Xiao X,Huo Y,Wu C

更新日期：2016-07-08 00:00:00

abstract：:Multisensory integration provides continuous and stable perception from separate sensory inputs. Here, we investigated the functional role of temporal binding between the visual and the tactile senses. To this end we used the paradigm of compression that induces shifts in time when probe stimuli are degraded, e.g., by...

journal_title：Scientific reports

authors： Zimmermann E,Derichs C,Fink GR

更新日期：2016-05-16 00:00:00

abstract：:Emergency granulopoiesis occurs in response to severe microbial infection. However, whether and how other blood components, particularly monocytes/macrophages and their progenitors, including hematopoietic stem/progenitor cells (HSPCs), participate in the process and the underlying molecular mechanisms remain unknown....

journal_title：Scientific reports

authors： Hou Y,Sheng Z,Mao X,Li C,Chen J,Zhang J,Huang H,Ruan H,Luo L,Li L

更新日期：2016-11-11 00:00:00

abstract：:An effective method, involving time and frequency domains was developed to interpret seismic precursors by comparing groundwater-level fluctuations recorded immediately and long before the occurrence of a known earthquake. The proposed method, consisting of the pre-processing (3-point filtering, band-pass filtering, a...

journal_title：Scientific reports

authors： Hwang HS,Hamm SY,Cheong JY,Lee SH,Ha K,Lee C,Woo NC,Yun SM,Kim KH

更新日期：2020-05-12 00:00:00

abstract：:CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing several B- and T-cell epitopes. However, immunization of mice wit...

journal_title：Scientific reports

authors： Qi X,Xiong S

更新日期：2017-02-02 00:00:00

abstract：:We report a small molecule tandem organic photovoltaic (OPV) cell with a high power conversion efficiency (PCE) of 7.27%. This cell contains two subcells with an identical mixed active layer of C70:5 wt%TAPC (1,1-bis-(4-bis(4-methyl-phenyl)-amino-phenyl)-cyclohexane). The performance was dramatically improved by simpl...

journal_title：Scientific reports

authors： Gao Y,Jin F,Li W,Su Z,Chu B,Wang J,Zhao H,Wu H,Liu C,Hou F,Lin T,Song Q

更新日期：2016-04-01 00:00:00

abstract：:Sublingual immunization is emerging as an alternative to nasal immunization and induction of mucosal IgA responses. Using Bacillus anthracis edema toxin (EdTx) as an adjuvant, we previously showed that innate responses triggered after sublingual immunization could limit generation of IgA responses. We tested whether c...

journal_title：Scientific reports

authors： Rowe JC,Attia Z,Kim E,Cormet-Boyaka E,Boyaka PN

更新日期：2019-01-24 00:00:00

abstract：:Prostate-specific antigen (PSA) kinetics predicts survival in castration-resistant prostate cancer (CRPC); however, the influence of prior treatment on this relationship is unclear. Patients with CRPC were stratified according to time to PSA nadir and time to CRPC progression to investigate their prognostic significan...

journal_title：Scientific reports

authors： Hah YS,Lee JS,Rha KH,Hong SJ,Chung BH,Koo KC

更新日期：2019-08-15 00:00:00