Event- and time-dependent decline of outcome information in the primate prefrontal cortex.

Abstract:

:The prefrontal cortex (PF) is involved in outcome-based flexible adaptation in a dynamically changing environment. The outcome signal dissipates gradually over time, but the temporal dynamics of this dissipation remains unknown. To examine this issue, we analyzed the outcome-related activity of PF neurons in 2 monkeys in a distance discrimination task. The initial prestimulus period of this task varied in duration, allowing us to dissociate the effects of time and event on the decline in previous outcome-related activity -previous correct versus previous error. We observed 2 types of decline in previous outcome representation: PF neurons that ceased to encode the previous outcome as time passed (time-dependent) and neurons that maintained their signal but it decreased rapidly after the occurrence of a new external event (event-dependent). Although the time-dependent dynamics explained the decline in a greater proportion of neurons, the event-dependent decline was also observed in a significant population of neurons.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Marcos E,Tsujimoto S,Genovesio A

doi

10.1038/srep25622

subject

Has Abstract

pub_date

2016-05-10 00:00:00

pages

25622

issn

2045-2322

pii

srep25622

journal_volume

6

pub_type

杂志文章
  • Reactive saccade adaptation boosts orienting of visuospatial attention.

    abstract::Attention and saccadic eye movements are critical components of visual perception. Recent studies proposed the hypothesis of a tight coupling between saccadic adaptation (SA) and attention: SA increases the processing speed of unpredictable stimuli, while increased attentional load boosts SA. Moreover, their cortical ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70120-z

    authors: Nicolas J,Bidet-Caulet A,Pélisson D

    更新日期:2020-08-10 00:00:00

  • Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection.

    abstract::Antiretroviral therapy-naive HIV-1 infected infants experience poor viral containment and rapid disease progression compared to adults. Viral factors (e.g. transmitted cytotoxic T- lymphocyte (CTL) escape mutations) or infant factors (e.g. reduced CTL functional capacity) may explain this observation. We assessed CTL ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29536

    authors: Garcia-Knight MA,Slyker J,Payne BL,Pond SL,de Silva TI,Chohan B,Khasimwa B,Mbori-Ngacha D,John-Stewart G,Rowland-Jones SL,Esbjörnsson J

    更新日期:2016-07-12 00:00:00

  • Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications.

    abstract::Metal-organic frameworks (MOFs) formed from metals and organic ligands, are crystalline materials that are degradable in aqueous medium, and capable of releasing Ca and Sr ions. In this manuscript, the ability of MOFs to degrade and release osteogenic Ca and Sr ions was investigated. MOFs were generated by choosing os...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49536-9

    authors: Joseph N,Lawson HD,Overholt KJ,Damodaran K,Gottardi R,Acharya AP,Little SR

    更新日期:2019-09-10 00:00:00

  • A novel design to screen chlorogenic acid-producing microbial strains from the environment.

    abstract::The present study aimed to develop a plate-screening method, based on the specific color development of complexes formed between chlorogenic acid, a valuable plant-derived compound, and aluminum (III), to detect chlorogenic acid-producing microbial strains. Modified media with 0.75 mM aluminum chloride were developed ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32968-0

    authors: Wang X,Qin L,Zhou J,Li Y,Fan X

    更新日期:2018-10-03 00:00:00

  • FeCr₂S₄ in magnetic fields: possible evidence for a multiferroic ground state.

    abstract::We report on neutron diffraction, thermal expansion, magnetostriction, dielectric, and specific heat measurements on polycrystalline FeCr2S4 in external magnetic fields. The ferrimagnetic ordering temperatures TC ≈ 170 K and the transition at TOO ≈ 10 K, which has been associated with orbital ordering, are only weakly...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06079

    authors: Bertinshaw J,Ulrich C,Günther A,Schrettle F,Wohlauer M,Krohns S,Reehuis M,Studer AJ,Avdeev M,Quach DV,Groza JR,Tsurkan V,Loidl A,Deisenhofer J

    更新日期:2014-08-15 00:00:00

  • WeiBI (web-based platform): Enriching integrated interaction network with increased coverage and functional proteins from genome-wide experimental OMICS data.

    abstract::Many molecular system biology approaches recognize various interactions and functional associations of proteins that occur in cellular processing. Further understanding of the characterization technique reveals noteworthy information. These types of known and predicted interactions, gained through multiple resources, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62508-8

    authors: Kaushik AC,Mehmood A,Dai X,Wei DQ

    更新日期:2020-03-27 00:00:00

  • Full use of factors promoting catalytic performance of chitosan supported manganese porphyrin.

    abstract::In order to make full use of the impact of internal and external factors on the performance of title catalyst for ethyl benzene oxidation, the key internal influencing factors on the catalytic performance were modulated by coordinating and grafting manganese porphyrin to mesoporous and macroporous chitosan, and the im...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70210-y

    authors: Mo LQ,Huang XF,Wang GC,Huang G,Liu P

    更新日期:2020-08-24 00:00:00

  • The effect of high glucose on lipid metabolism in the human placenta.

    abstract::Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to placental dysfunction, which has health consequences for the infant. Here we test our prediction from previous work using a placental cell line that high glucose concentrations affect placental lipid metabolism. Placentas from women ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50626-x

    authors: Hulme CH,Nicolaou A,Murphy SA,Heazell AEP,Myers JE,Westwood M

    更新日期:2019-10-01 00:00:00

  • Sensations from a single M-cone depend on the activity of surrounding S-cones.

    abstract::Color vision requires the activity of cone photoreceptors to be compared in post-receptoral circuitry. Decades of psychophysical measurements have quantified the nature of these comparative interactions on a coarse scale. How such findings generalize to a cellular scale remains unclear. To answer that question, we qua...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26754-1

    authors: Schmidt BP,Sabesan R,Tuten WS,Neitz J,Roorda A

    更新日期:2018-06-04 00:00:00

  • Ultrasonography of wallaby prenatal development shows that the climb to the pouch begins in utero.

    abstract::Marsupials have a functional placenta for a shorter period of time compared to that of eutherian species, and their altricial young reach the teats without any help from the mother. We have monitored the short intrauterine development of one marsupial, the tammar wallaby, with high-resolution ultrasound from reactivat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01458

    authors: Drews B,Roellig K,Menzies BR,Shaw G,Buentjen I,Herbert CA,Hildebrandt TB,Renfree MB

    更新日期:2013-01-01 00:00:00

  • A clinicohaematological prognostic model for nasal-type natural killer/T-cell lymphoma: A multicenter study.

    abstract::Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with N...

    journal_title:Scientific reports

    pub_type: 杂志文章,多中心研究

    doi:10.1038/s41598-019-51522-0

    authors: Tan KM,Chia B,Lim JQ,Khoo LP,Cheng CL,Tan L,Poon E,Somasundaram N,Farid M,Tang TPL,Tao M,Cheah DMZ,Laurensia Y,Pang JWL,Song T,Tan J,Huang D,Kim SJ,Kim WS,Ong CK,Lim ST,Chan JY

    更新日期:2019-10-18 00:00:00

  • Improved therapeutic potential of tapentadol employing cationic exchange resins as carriers in neuropathic pain: evidence from pharmacokinetic and pharmacodynamics study.

    abstract::Current investigation was endeavoured to overcome problem of poor palatability and bioavailability of centrally acting analgesic, tapentadol (TAP) by formulating controlled release drug-resin complexes (DRCs). The technology encompassed in preparation of DRCs involved chemisorption of TAP to weak cationic resins (Kyro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21214-2

    authors: Sharma M,Soni R

    更新日期:2018-02-12 00:00:00

  • High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis.

    abstract::Maternal obesity is associated with lower basal plasma cortisol levels and increased risk of postpartum psychiatric disorders. Given that both obesity and the peripartum period are characterized by an imbalance between adrenocorticotropic hormone (ACTH) and cortisol, we hypothesized that the adrenal glands undergo per...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14821

    authors: Perani CV,Neumann ID,Reber SO,Slattery DA

    更新日期:2015-10-07 00:00:00

  • Ethnicity and anticoagulation management of hospitalized patients with atrial fibrillation in northwest China.

    abstract::The therapeutic management and health challenges caused by atrial fibrillation (AF) differ between different groups. The purpose of this study was to investigate the clinical features of patients hospitalized with AF and to explore the use of anticoagulation treatments in Han and Uygur patients in Xinjiang, northwest ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45884

    authors: Cheng X,Zhou X,Song S,Wu M,Baolatejiang R,Lu Y,Li Y,Zhang W,Lv W,Ye Y,Zhou Q,Wang H,Zhang J,Xing Q,Tang B

    更新日期:2017-04-10 00:00:00

  • Intratumor heterogeneity inferred from targeted deep sequencing as a prognostic indicator.

    abstract::Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has been used widely as a diagnostic tool to identify actionable mutations in cancer patients. In this study, we evaluated the clinical utility o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41098-0

    authors: Oh BY,Shin HT,Yun JW,Kim KT,Kim J,Bae JS,Cho YB,Lee WY,Yun SH,Park YA,Park YH,Im YH,Lee J,Joung JG,Kim HC,Park WY

    更新日期:2019-03-14 00:00:00

  • Cathepsin D regulates lipid metabolism in murine steatohepatitis.

    abstract::Due to the obesity epidemic, non-alcoholic steatohepatitis (NASH) is a prevalent liver disease, characterized by fat accumulation and inflammation of the liver. However, due to a lack of mechanistic insight, diagnostic and therapeutic options for NASH are poor. Recent evidence has indicated cathepsin D (CTSD), a lysos...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03796-5

    authors: Houben T,Oligschlaeger Y,Hendrikx T,Bitorina AV,Walenbergh SMA,van Gorp PJ,Gijbels MJJ,Friedrichs S,Plat J,Schaap FG,Lütjohann D,Hofker MH,Shiri-Sverdlov R

    更新日期:2017-06-14 00:00:00

  • Sleep problems and depression among 237 023 community-dwelling adults in 46 low- and middle-income countries.

    abstract::Sleep problems are considered a core symptom of depression. However, there is little information about the comorbidity of sleep problems and depression in low- and middle-income countries (LMICs), and whether sleep problems with depression confer additional risk for decrements in health compared to sleep problems alon...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48334-7

    authors: Stickley A,Leinsalu M,DeVylder JE,Inoue Y,Koyanagi A

    更新日期:2019-08-19 00:00:00

  • Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries.

    abstract::Broadly neutralizing antibodies developed from the IGHV1-69 germline gene are known to bind to the stem region of hemagglutinin in diverse influenza viruses but the sequence determinants for the antigen recognition, including neutralization potency and binding affinity, are not clearly understood. Such understanding c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15053

    authors: Tung CP,Chen IC,Yu CM,Peng HP,Jian JW,Ma SH,Lee YC,Jan JT,Yang AS

    更新日期:2015-10-12 00:00:00

  • A practical method for multimodal registration and assessment of whole-brain disease burden using PET, MRI, and optical imaging.

    abstract::Many neurological diseases present with substantial genetic and phenotypic heterogeneity, making assessment of these diseases challenging. This has led to ineffective treatments, significant morbidity, and high mortality rates for patients with neurological diseases, including brain cancers and neurodegenerative disor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74459-1

    authors: Scarpelli ML,Healey DR,Mehta S,Kodibagkar VD,Quarles CC

    更新日期:2020-10-14 00:00:00

  • Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A.

    abstract::Hepatitis C virus (HCV) uses components of the very-low-density lipoprotein (VLDL) pathway for assembly/release. We previously reported that hepatocyte nuclear factor 4α (HNF4α) participates in HCV assembly/release through downstream factors those participate in VLDL assembly/secretion. Cell-death-inducing DFFA-like e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27778

    authors: Cai H,Yao W,Li L,Li X,Hu L,Mai R,Peng T

    更新日期:2016-06-10 00:00:00

  • Genome-wide identification and co-expression network analysis provide insights into the roles of auxin response factor gene family in chickpea.

    abstract::Auxin response factors (ARFs) are the transcription factors that regulate auxin responses in various aspects of plant growth and development. Although genome-wide analysis of ARF gene family has been done in some species, no information is available regarding ARF genes in chickpea. In this study, we identified 28 ARF ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11327-5

    authors: Singh VK,Rajkumar MS,Garg R,Jain M

    更新日期:2017-09-07 00:00:00

  • A Research on Preparation and Application of the Monolithic Catalyst with Interconnecting Pore Structure.

    abstract::In recent years, the monolithic material has been developed increasingly in the high performance liquid phase field, and it could also be applied in the field of catalyst, as a monolithic catalyst carrier, since it has a large specific surface area, and could be customized based on the mould. The monolithic catalyst i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35021-2

    authors: Tsai SB,Ma H

    更新日期:2018-11-09 00:00:00

  • A novel proton transfer mechanism in the SLC11 family of divalent metal ion transporters.

    abstract::In humans, the H+-coupled Fe2+ transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis. While X-ray diffraction has recently unveiled the structure of the bacterial homologue ScaDMT as a LeuT-fold transporter, the exact mechanism of H+-cotransport has remained elusive. Here, we used a combin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06446-y

    authors: Pujol-Giménez J,Hediger MA,Gyimesi G

    更新日期:2017-07-28 00:00:00

  • The visual geometry of a tool modulates generalization during adaptation.

    abstract::Knowledge about a tool's dynamics can be acquired from the visual configuration of the tool and through physical interaction. Here, we examine how visual information affects the generalization of dynamic learning during tool use. Subjects rotated a virtual hammer-like object while we varied the object dynamics separat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39507-5

    authors: Sadeghi M,Sheahan HR,Ingram JN,Wolpert DM

    更新日期:2019-02-25 00:00:00

  • Domestic cats (Felis catus) discriminate their names from other words.

    abstract::Two of the most common nonhuman animals that interact with humans are domestic dogs (Canis familiaris) and cats (Felis catus). In contrast to dogs, the ability of domestic cats to communicate with humans has not been explored thoroughly. We used a habituation-dishabituation method to investigate whether domestic cats ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40616-4

    authors: Saito A,Shinozuka K,Ito Y,Hasegawa T

    更新日期:2019-04-04 00:00:00

  • Elucidating the mechanisms underlying the beneficial health effects of dietary pollen on honey bees (Apis mellifera) infested by Varroa mite ectoparasites.

    abstract::Parasites and pathogens of the honey bee (Apis mellifera) are key factors underlying colony losses, which are threatening the beekeeping industry and agriculture as a whole. To control the spread and development of pathogen infections within the colony, honey bees use plant resins with antibiotic activity, but little ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06488-2

    authors: Annoscia D,Zanni V,Galbraith D,Quirici A,Grozinger C,Bortolomeazzi R,Nazzi F

    更新日期:2017-07-24 00:00:00

  • Transient unidirectional energy flow and diode-like phenomenon induced by non-Markovian environments.

    abstract::Relying on an exact time evolution scheme, we identify a novel transient energy transfer phenomenon in an exactly-solvable quantum microscopic model consisting of a three-level system coupled to two non-Markovian zero-temperature bosonic baths through two separable quantum channels. The dynamics of this model can be s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15332

    authors: Jing J,Segal D,Li B,Wu LA

    更新日期:2015-10-19 00:00:00

  • Quantum phases in circuit QED with a superconducting qubit array.

    abstract::Circuit QED on a chip has become a powerful platform for simulating complex many-body physics. In this report, we realize a Dicke-Ising model with an antiferromagnetic nearest-neighbor spin-spin interaction in circuit QED with a superconducting qubit array. We show that this system exhibits a competition between the c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04083

    authors: Zhang Y,Yu L,Liang JQ,Chen G,Jia S,Nori F

    更新日期:2014-02-13 00:00:00

  • Fermi level tuning of Ag-doped Bi2Se3 topological insulator.

    abstract::The temperature dependence of the resistivity (ρ) of Ag-doped Bi2Se3 (AgxBi2-xSe3) shows insulating behavior above 35 K, but below 35 K, ρ suddenly decreases with decreasing temperature, in contrast to the metallic behavior for non-doped Bi2Se3 at 1.5-300 K. This significant change in transport properties from metalli...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41906-7

    authors: Uesugi E,Uchiyama T,Goto H,Ota H,Ueno T,Fujiwara H,Terashima K,Yokoya T,Matsui F,Akimitsu J,Kobayashi K,Kubozono Y

    更新日期:2019-03-29 00:00:00

  • Pyrophosphate inhibits gluconeogenesis by restricting UDP-glucose formation in vivo.

    abstract::Pyrophosphate (PPi) is produced by anabolic reactions and serves as an energy donor in the cytosol of plant cells; however, its accumulation to toxic levels disrupts several common biosynthetic pathways and is lethal. Before acquiring photosynthetic capacity, young seedlings must endure a short but critical heterotrop...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32894-1

    authors: Ferjani A,Kawade K,Asaoka M,Oikawa A,Okada T,Mochizuki A,Maeshima M,Hirai MY,Saito K,Tsukaya H

    更新日期:2018-10-02 00:00:00