Methanolic extract of Potentilla fulgens root and its ethyl-acetate fraction delays the process of carcinogenesis in mice.

abstract：:Segmentation of the vertebrate hindbrain is an evolutionarily conserved process. Here, we identify the transcription factor early growth response 4 (egr4) as a novel regulator of posterior hindbrain development in Xenopus. egr4 is specifically and transiently expressed in rhombomeres 5 and 6 (r5/r6), and Egr4 knockdow...

journal_title：Scientific reports

authors： Bae CJ,Jeong J,Saint-Jeannet JP

更新日期：2015-01-13 00:00:00

abstract：:Carbon nanofibers were widely utilized to improve microwave absorption properties since they are a promising lightweight candidate. Adjustable conductive nanostructures of carbon nanofibers were synthesized by electrospinning technique. The conductive network is controlled by the polyvinyl pyrrolidone (PVP) content du...

journal_title：Scientific reports

authors： Lv J,Gu W,Cui X,Dai S,Zhang B,Ji G

更新日期：2019-03-12 00:00:00

abstract：:Junctophilin-2 (JPH2) is a part of the junctional membrane complex that facilitates calcium-handling in the cardiomyocyte. Previously, missense variants in JPH2 have been linked to hypertrophic cardiomyopathy; however, pathogenic "loss of function" (LOF) variants have not been described. Family-based genetic analysis ...

journal_title：Scientific reports

authors： Jones EG,Mazaheri N,Maroofian R,Zamani M,Seifi T,Sedaghat A,Shariati G,Jamshidi Y,Allen HD,Wehrens XHT,Galehdari H,Landstrom AP

更新日期：2019-06-21 00:00:00

abstract：:The SELEX (Systematic Evolution of Ligands by EXponential enrichment) method has been used successfully since 1990, but work is still required to obtain highly specific aptamers. Here, we present a novel approach called 'Competitive non-SELEX' (and termed as 'SELCOS' (Systematic Evolution of Ligands by COmpetitive Sel...

journal_title：Scientific reports

authors： Kushwaha A,Takamura Y,Nishigaki K,Biyani M

更新日期：2019-04-30 00:00:00

abstract：:Quantum key agreement is an important topic that the shared key must be negotiated equally by all participants, and any nontrivial subset of participants cannot fully determine the shared key. To date, the embed modes of subkey in all the previously proposed quantum key agreement protocols are based on either BB84 or ...

journal_title：Scientific reports

authors： Cao H,Ma W

更新日期：2017-03-23 00:00:00

abstract：:Accurate cancer diagnosis often requires extraction and purification of genetic materials from cells, and sophisticated instrumentations that follow. Otherwise in order to directly treat the diagnostic materials to cells, multiple steps to optimize dose concentration and treatment time are necessary due to diversity i...

journal_title：Scientific reports

authors： Park KS,Shin SW,Jang MS,Shin W,Yang K,Min J,Cho SW,Oh BK,Bae JW,Jung S,Choi JW,Um SH

更新日期：2015-12-18 00:00:00

abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...

journal_title：Scientific reports

authors： Utsunomia R,Silva DMZA,Ruiz-Ruano FJ,Goes CAG,Melo S,Ramos LP,Oliveira C,Porto-Foresti F,Foresti F,Hashimoto DT

更新日期：2019-04-10 00:00:00

abstract：:E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer. The immobilization is expected to take place through the coordination between Ni(II) and His-tag. The bFGF-immobiliz...

journal_title：Scientific reports

authors： Shakya A,Imado E,Nguyen PK,Matsuyama T,Horimoto K,Hirata I,Kato K

更新日期：2020-05-29 00:00:00

abstract：:VCF2CNA is a tool (Linux commandline or web-interface) for copy-number alteration (CNA) analysis and tumor purity estimation of paired tumor-normal VCF variant file formats. It operates on whole genome and whole exome datasets. To benchmark its performance, we applied it to 46 adult glioblastoma and 146 pediatric neur...

journal_title：Scientific reports

authors： Putnam DK,Ma X,Rice SV,Liu Y,Newman S,Zhang J,Chen X

更新日期：2019-07-17 00:00:00

abstract：:Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...

journal_title：Scientific reports

authors： Gharooi Ahangar O,Javanrouh N,Daneshpour MS,Barzin M,Valizadeh M,Azizi F,Hosseinpanah F

更新日期：2020-08-12 00:00:00

abstract：:The conformation of the German shepherd dog (GSD) varies considerably within the breed. These differences may result in large variation in the movement and limb loading and undesirable consequences to their musculoskeletal health. This study aimed to investigate the relationship between conformation and biomechanical ...

journal_title：Scientific reports

authors： Humphries A,Shaheen AF,Gómez Álvarez CB

更新日期：2020-10-15 00:00:00

abstract：:The factors regulating phytoplankton community composition play a crucial role in structuring aquatic food webs. However, consensus is still lacking about the mechanisms underlying the observed biogeographical differences in cell size composition of phytoplankton communities. Here we use a trait-based model to disenta...

journal_title：Scientific reports

authors： Acevedo-Trejos E,Brandt G,Bruggeman J,Merico A

更新日期：2015-03-09 00:00:00

abstract：:Dynamic Nuclear Polarization (DNP) has been introduced to overcome the sensitivity limitations of nuclear magnetic resonance (NMR) spectroscopy also of supported lipid bilayers. When investigated by solid-state NMR techniques the approach typically involves doping the samples with biradicals and their investigation at...

journal_title：Scientific reports

authors： Salnikov ES,Aisenbrey C,Aussenac F,Ouari O,Sarrouj H,Reiter C,Tordo P,Engelke F,Bechinger B

更新日期：2016-02-15 00:00:00

abstract：:Viral hepatitis leads to immune-mediated liver injury. The rate of disease progression varies between individuals. We aimed to phenotype immune cells associated with preservation of normal liver function during hepatitis C virus (HCV) infection. Clinical data and specimens were obtained from 19 HCV-infected patients u...

journal_title：Scientific reports

authors： Doyle EH,Aloman C,El-Shamy A,Eng F,Rahman A,Klepper AL,Haydel B,Florman SS,Fiel MI,Schiano T,Branch AD

更新日期：2021-01-15 00:00:00

abstract：:Historical records indicate that extensive cultural, commercial and technological interaction occurred between European and Asian populations. What have been the biological consequences of these contacts in terms of gene flow? We systematically estimated gene flow between Eurasian groups using genome-wide polymorphism...

journal_title：Scientific reports

authors： Qin P,Zhou Y,Lou H,Lu D,Yang X,Wang Y,Jin L,Chung YJ,Xu S

更新日期：2015-04-02 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodontal ligament tissue...

journal_title：Scientific reports

authors： Liu J,Saito K,Maruya Y,Nakamura T,Yamada A,Fukumoto E,Ishikawa M,Iwamoto T,Miyazaki K,Yoshizaki K,Ge L,Fukumoto S

更新日期：2016-03-31 00:00:00

abstract：:The Klein tunneling of optical waves near the Dirac points in the metal-dielectric multilayer metamaterials is theoretically investigated and demonstrated through the coupled-mode theory under the tight-binding approximation and the rigorous band structure analysis based on the transfer-matrix method. The optical anal...

journal_title：Scientific reports

authors： Sun L,Gao J,Yang X

更新日期：2017-08-29 00:00:00

abstract：:Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...

journal_title：Scientific reports

authors： Perera I,Fukushima A,Akabane T,Horiguchi G,Seneweera S,Hirotsu N

更新日期：2019-10-16 00:00:00

abstract：:Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent naive and primed pluripotency states, respectively, and are maintained in vitro by specific signalling pathways. Furthermore, ESCs cultured in serum-free medium with two kinase inhibitors (2i-ESCs) are thought to be the ground naïve pluripote...

journal_title：Scientific reports

authors： Tosolini M,Brochard V,Adenot P,Chebrout M,Grillo G,Navia V,Beaujean N,Francastel C,Bonnet-Garnier A,Jouneau A

更新日期：2018-04-10 00:00:00

abstract：:Photobiomodulation-based (LLLT) therapies show tantalizing promise for treatment of skin diseases. Confidence in this approach is blighted however by lamentable inconsistency in published experimental designs, and so complicates interpretation. Here we interrogate the appropriateness of a range of previously-reported ...

journal_title：Scientific reports

authors： Mignon C,Uzunbajakava NE,Raafs B,Botchkareva NV,Tobin DJ

更新日期：2017-06-05 00:00:00

abstract：:Working memory capacity is incredibly limited and thus it is important to use this resource wisely. Prior knowledge in long-term memory can aid in efficient encoding of information by allowing for the prioritization of novel stimuli over familiar ones. Here we used a full-report procedure in a visual working memory pa...

journal_title：Scientific reports

authors： Bruning AL,Lewis-Peacock JA

更新日期：2020-12-17 00:00:00

abstract：:Gold is a noble metal typically stable as a solid in a face-centered cubic (FCC) structure under ambient conditions; however, under particular circumstances aberrant allotropes have been synthesized. In this work, we document the phase transformation of 25 nm thick nanocrystalline (NC) free-standing gold thin-film via...

journal_title：Scientific reports

authors： Suri PK,Nathaniel JE 2nd,Li N,Baldwin JK,Wang Y,Hattar K,Taheri ML

更新日期：2020-10-20 00:00:00

abstract：:Millimeter wave (MMW)-induced heating represents a promising alternative for non-invasive hyperthermia of superficial skin cancer, such as melanoma. Pulsed MMW-induced heating of tumors allows for reaching high peak temperatures without overheating surrounding tissues. Herein, for the first time, we evaluate apoptotic...

journal_title：Scientific reports

authors： Orlacchio R,Le Page Y,Le Dréan Y,Le Guével R,Sauleau R,Alekseev S,Zhadobov M

更新日期：2019-10-24 00:00:00

abstract：:Among the range of complex interactions, especially at the interfaces of epitaxial oxide systems, contributing to the occurrence of intriguing effects, a predominant role is played by the local structural parameters. In this study, oxide molecular beam epitaxy grown lanthanum cuprate-based bilayers (consisting of a me...

journal_title：Scientific reports

authors： Suyolcu YE,Wang Y,Baiutti F,Al-Temimy A,Gregori G,Cristiani G,Sigle W,Maier J,van Aken PA,Logvenov G

更新日期：2017-03-28 00:00:00

abstract：:In nature Siberian hamsters utilize the decrement in day length following the summer solstice to implement physiological adaptations in anticipation of the forthcoming winter, but also exploit an intrinsic interval timer to initiate physiological recrudescence following the winter solstice. However, information is lac...

journal_title：Scientific reports

authors： Petri I,Diedrich V,Wilson D,Fernández-Calleja J,Herwig A,Steinlechner S,Barrett P

更新日期：2016-07-11 00:00:00

abstract：:CCN2/Connective tissue growth factor seems to be involved in development of cardiac hypertrophy and fibrosis, but a possible cardioprotective role in left ventricular (LV) remodelling following myocardial infarction has also been suggested. The main objectives of the study were therefore to investigate whether circula...

journal_title：Scientific reports

authors： Ritschel V,Shetelig C,Seljeflot I,Limalanathan S,Hoffmann P,Halvorsen S,Arnesen H,Eritsland J,Andersen GØ

更新日期：2017-09-20 00:00:00

abstract：:Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and abnormal iron metabolism are still unknown. Therefore, we evaluated the fatigue symptoms, classified PD patie...

journal_title：Scientific reports

authors： Zuo LJ,Yu SY,Hu Y,Wang F,Piao YS,Lian TH,Yu QJ,Wang RD,Li LX,Guo P,Du Y,Zhu RY,Jin Z,Wang YJ,Wang XM,Chan P,Chen SD,Wang YJ,Zhang W

更新日期：2016-12-21 00:00:00

abstract：:Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects...

journal_title：Scientific reports

authors： Mahbub MH,Yamaguchi N,Takahashi H,Hase R,Ishimaru Y,Sunagawa H,Amano H,Kobayashi-Miura M,Kanda H,Fujita Y,Yamamoto H,Yamamoto M,Kikuchi S,Ikeda A,Kageyama N,Nakamura M,Tanabe T

更新日期：2017-12-15 00:00:00

abstract：:The 37 currently recognized Bemisia tabaci cryptic species are economically important species and contain both primary and secondary endosymbionts, but their diversity has never been mapped systematically across the group. To achieve this, PacBio sequencing of full-length bacterial 16S rRNA gene amplicons was carried ...

journal_title：Scientific reports

authors： Wang HL,Lei T,Xia WQ,Cameron SL,Liu YQ,Zhang Z,Gowda MMN,De Barro P,Navas-Castillo J,Omongo CA,Delatte H,Lee KY,Patel MV,Krause-Sakate R,Ng J,Wu SL,Fiallo-Olivé E,Liu SS,Colvin J,Wang XW

更新日期：2019-04-25 00:00:00

abstract：:Network alignment (NA) compares networks with the goal of finding a node mapping that uncovers highly similar (conserved) network regions. Existing NA methods are homogeneous, i.e., they can deal only with networks containing nodes and edges of one type. Due to increasing amounts of heterogeneous network data with nod...

journal_title：Scientific reports

authors： Gu S,Johnson J,Faisal FE,Milenković T

更新日期：2018-08-21 00:00:00