当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Yinchenhao Decoction Alleviates Liver Fibrosis by Regulating Bile Acid Metabolism and TGF-β/Smad/ERK Signalling Pathway.

Yinchenhao Decoction Alleviates Liver Fibrosis by Regulating Bile Acid Metabolism and TGF-β/Smad/ERK Signalling Pathway.

Abstract：

:Yinchenhao decoction (YCHD), comprising Yinchenhao (Artemisiae Scopariae Herba), Zhizi (Gardeniae Fructus) and Dahuang (Radix Rhei et Rhizoma), is widely used for treating various diseases. We aimed to investigate the bile acid metabolic mechanism of YCHD in dimethylnitrosamine (DMN)-induced liver fibrosis model. Rats received DMN (10 mg/kg, intraperitoneally) for four successive weeks for liver fibrosis induction and were treated with YCHD for the last 2 weeks. Histopathological analysis showed that YCHD prevented DMN-induced histopathological changes in liver tissues. Serum liver function in YCHD group improved. Ultraperformance liquid chromatography-mass spectrometry analysis showed that YCHD significantly restored both free and conjugated bile acid levels increased by DMN, to normal levels. RT-qPCR results showed that YCHD treatment upregulated the expression of genes related to bile acid synthesis, reabsorption, and excretion. Western blotting analysis showed that YCHD downregulated α-SMA, TGF-β1, p-Smad3, and p-ERK1/2 expression in chenodeoxycholic acid (CDCA)-activated hepatic stellate cells (HSCs). The viability of CDCA-activated HSCs significantly increased after treatment with YCHD and PD98059 (an ERK inhibitor) compared to YCHD treatment alone. Our findings suggest that YCHD alleviated DMN-induced liver fibrosis by regulating enzymes responsible for bile acid metabolism. Additionally, it inhibits CDCA-induced HSC proliferation and activation via TGF-β1/Smad/ERK signalling pathway.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Cai FF,Wu R,Song YN,Xiong AZ,Chen XL,Yang MD,Yang L,Hu Y,Sun MY,Su SB

doi

10.1038/s41598-018-33669-4

subject

Has Abstract

pub_date

2018-10-18 00:00:00

pages

15367

issue

1

issn

2045-2322

pii

10.1038/s41598-018-33669-4

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Optimization and standardization of the culturomics technique for human microbiome exploration.

    abstract：:Culturomics is a high-throughput culture approach that has dramatically contributed to the recent renewal of culture. While metagenomics enabled substantial advances in exploring the microbiota, culturomics significantly expanded our knowledge regarding the bacterial gut repertoire through the discovery and the descri...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66738-8

    authors： Diakite A,Dubourg G,Dione N,Afouda P,Bellali S,Ngom II,Valles C,Tall ML,Lagier JC,Raoult D

    更新日期：2020-06-15 00:00:00

  • A temporal proteome dynamics study reveals the molecular basis of induced phenotypic resistance in Mycobacterium smegmatis at sub-lethal rifampicin concentrations.

    abstract：:In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectrometry-based proteomics...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43858

    authors： Giddey AD,de Kock E,Nakedi KC,Garnett S,Nel AJ,Soares NC,Blackburn JM

    更新日期：2017-03-06 00:00:00

  • Terahertz spectroscopy of anisotropic materials using beams with rotatable polarization.

    abstract：:We introduce a polarization-resolved terahertz time-domain spectrometer with a broadband (0.3-2.5 THz), rotatable THz polarization state, and which exhibits minimal change in the electric field amplitude and polarization state upon rotation. This was achieved by rotating an interdigitated photoconductive emitter, and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12568-0

    authors： Mosley CDW,Failla M,Prabhakaran D,Lloyd-Hughes J

    更新日期：2017-09-26 00:00:00

  • Author Correction: Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-55022-z

    authors： Montalvo-Ortiz JL,Cheng Z,Kranzler HR,Zhang H,Gelernter J

    更新日期：2019-12-05 00:00:00

  • Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.

    abstract：:Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12511

    authors： Malvaez M,Greenfield VY,Wang AS,Yorita AM,Feng L,Linker KE,Monbouquette HG,Wassum KM

    更新日期：2015-07-27 00:00:00

  • Spontaneous Parametric Down-Conversion Induced by Non-Degenerate Three-Wave Mixing in a Scanning MEMS Micro Mirror.

    abstract：:Scanning micro-mirror actuators are silicon-based oscillatory micro-electro-mechanical systems (MEMS). They enable laser distance measurements for automotive LIDAR applications as well as projection modules for the consumer market. For MEMS applications, the geometric structure is typically designed to serve a number ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40377-0

    authors： Nabholz U,Schatz F,Mehner JE,Degenfeld-Schonburg P

    更新日期：2019-03-08 00:00:00

  • Quorum sensing in Pseudomonas aeruginosa mediated by RhlR is regulated by a small RNA PhrD.

    abstract：:Pseudomonas aeruginosa is a highly invasive human pathogen in spite of the absence of classical host specific virulence factors. Virulence factors regulated by quorum sensing (QS) in P. aeruginosa cause acute infections to shift to chronic diseases. Several small regulatory RNAs (sRNAs) mediate fine-tuning of bacteria...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36488-9

    authors： Malgaonkar A,Nair M

    更新日期：2019-01-23 00:00:00

  • The substrate matters in the Raman spectroscopy analysis of cells.

    abstract：:Raman spectroscopy is a powerful analytical method that allows deposited and/or immobilized cells to be evaluated without complex sample preparation or labeling. However, a main limitation of Raman spectroscopy in cell analysis is the extremely weak Raman intensity that results in low signal to noise ratios. Therefore...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13150

    authors： Mikoliunaite L,Rodriguez RD,Sheremet E,Kolchuzhin V,Mehner J,Ramanavicius A,Zahn DR

    更新日期：2015-08-27 00:00:00

  • Phantom vortices: hidden angular momentum in ultracold dilute Bose-Einstein condensates.

    abstract：:Vortices are essential to angular momentum in quantum systems such as ultracold atomic gases. The existence of quantized vorticity in bosonic systems stimulated the development of the Gross-Pitaevskii mean-field approximation. However, the true dynamics of angular momentum in finite, interacting many-body systems like...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40122

    authors： Weiner SE,Tsatsos MC,Cederbaum LS,Lode AU

    更新日期：2017-01-16 00:00:00

  • A chronology of landsliding based on archaeological and documentary data: Pavlovské vrchy Hills, Western Carpathian Flysch Belt.

    abstract：:Pavlovské vrchy Hills represent a distinctive elevation near the Czech-Austrian border where the active, dormant and relict landslides cover 12% of the area. Here we focused on the chronology of landsliding in this area using geological, archaeological and historical evidence. The earliest records of landsliding were ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-57551-4

    authors： Bíl M,Krejčí O,Dolák L,Krejčí V,Martínek J,Svoboda J

    更新日期：2020-01-22 00:00:00

  • Greenhouse gas emissions and carbon sequestration by agroforestry systems in southeastern Brazil.

    abstract：:Agrosilvopastoral and silvopastoral systems can increase carbon sequestration, offset greenhouse gas (GHG) emissions and reduce the carbon footprint generated by animal production. The objective of this study was to estimate GHG emissions, the tree and grass aboveground biomass production and carbon storage in differe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16821-4

    authors： Torres CMME,Jacovine LAG,Nolasco de Olivera Neto S,Fraisse CW,Soares CPB,de Castro Neto F,Ferreira LR,Zanuncio JC,Lemes PG

    更新日期：2017-12-01 00:00:00

  • Stem cells catalyze cartilage formation by neonatal articular chondrocytes in 3D biomimetic hydrogels.

    abstract：:Cartilage loss is a leading cause of disability among adults and effective therapy remains elusive. Neonatal chondrocytes (NChons) are an attractive allogeneic cell source for cartilage repair, but their clinical translation has been hindered by scarce donor availability. Here we examine the potential for catalyzing c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03553

    authors： Lai JH,Kajiyama G,Smith RL,Maloney W,Yang F

    更新日期：2013-12-19 00:00:00

  • Shape analysis of the basioccipital bone in Pax7-deficient mice.

    abstract：:We compared the cranial base of newborn Pax7-deficient and wildtype mice using a computational shape modeling technology called particle-based modeling (PBM). We found systematic differences in the morphology of the basiooccipital bone, including a broadening of the basioccipital bone and an antero-inferior inflection...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18199-9

    authors： Cates J,Nevell L,Prajapati SI,Nelon LD,Chang JY,Randolph ME,Wood B,Keller C,Whitaker RT

    更新日期：2017-12-20 00:00:00

  • Neutralization of Acidic Intracellular Vesicles by Niclosamide Inhibits Multiple Steps of the Dengue Virus Life Cycle In Vitro.

    abstract：:Dengue fever is one of the most important mosquito-borne viral infections in large parts of tropical and subtropical countries and is a significant public health concern and socioeconomic burden. There is an urgent need to develop antivirals that can effectively reduce dengue virus (DENV) replication and decrease vira...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45095-1

    authors： Jung E,Nam S,Oh H,Jun S,Ro HJ,Kim B,Kim M,Go YY

    更新日期：2019-06-18 00:00:00

  • Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system.

    abstract：:Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made relatively easily. Technologies that facilitate specific and precise genome editing, such as knock-in, are critica...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24360

    authors： Wu M,Wei C,Lian Z,Liu R,Zhu C,Wang H,Cao J,Shen Y,Zhao F,Zhang L,Mu Z,Wang Y,Wang X,Du L,Wang C

    更新日期：2016-04-11 00:00:00

  • Experimental interference of uncorrelated photons.

    abstract：:The distinguishing of the multiphoton quantum interference effect from the classical one forms one of the most important issues in modern quantum mechanics and experimental quantum optics. For a long time, the two-photon interference (TPI) of correlated photons has been recognized as a pure quantum effect that cannot ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54504-4

    authors： Kim H,Kwon O,Moon HS

    更新日期：2019-12-05 00:00:00

  • ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.

    abstract：:The lipid mediator lysophosphatidic acid (LPA) signals via six distinct G protein-coupled receptors to mediate both unique and overlapping biological effects, including cell migration, proliferation and survival. LPA is produced extracellularly by autotaxin (ATX), a secreted lysophospholipase D, from lysophosphatidylc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23433

    authors： Nishioka T,Arima N,Kano K,Hama K,Itai E,Yukiura H,Kise R,Inoue A,Kim SH,Solnica-Krezel L,Moolenaar WH,Chun J,Aoki J

    更新日期：2016-03-23 00:00:00

  • MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.

    abstract：:Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28281

    authors： Yan L,Cao R,Liu Y,Wang L,Pan B,Lv X,Jiao H,Zhuang Q,Sun X,Xiao R

    更新日期：2016-09-06 00:00:00

  • Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study.

    abstract：:Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This st...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34461-0

    authors： Chong KC,Zhang C,Jia KM,Zee BCY,Luo T,Wang L,Tam GCH,Sun R,Wang MH,Guan X

    更新日期：2018-10-31 00:00:00

  • Charge disproportionation and nano phase separation in [Formula: see text].

    abstract：:We have successfully grown centimeter-sized layered [Formula: see text] single crystals under high oxygen pressures of 120-150 bar by the floating zone technique. This enabled us to perform neutron scattering experiments where we observe close to quarter-integer magnetic peaks below [Formula: see text] that are accomp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74884-2

    authors： Guo H,Li ZW,Chang CF,Hu Z,Kuo CY,Perring TG,Schmidt W,Piovano A,Schmalzl K,Walker HC,Lin HJ,Chen CT,Blanco-Canosa S,Schlappa J,Schüßler-Langeheine C,Hansmann P,Khomskii DI,Tjeng LH,Komarek AC

    更新日期：2020-10-22 00:00:00

  • Fitting mathematical models of biochemical pathways to steady state perturbation response data without simulating perturbation experiments.

    abstract：:Fitting Ordinary Differential Equation (ODE) models of signal transduction networks (STNs) to experimental data is a challenging problem. Computational parameter fitting algorithms simulate a model many times with different sets of parameter values until the simulated STN behaviour match closely with experimental data...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30118-0

    authors： Santra T

    更新日期：2018-08-03 00:00:00

  • Assessment of Concordance between 22C3 and SP142 Immunohistochemistry Assays regarding PD-L1 Expression in Non-Small Cell Lung Cancer.

    abstract：:Different anti-PD-1 and anti-PD-L1 antibodies bind different epitopes. However, whether the results from the SP142 and 22C3 immunochemistry (IHC) assays can be interchanged to determine patient eligibility for immunotherapy remains largely unknown. Histologic sections from 135 tumor samples were probed with both 22C3 ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17034-5

    authors： Xu H,Lin G,Huang C,Zhu W,Miao Q,Fan X,Wu B,Zheng X,Lin X,Jiang K,Hu D,Li C

    更新日期：2017-12-05 00:00:00

  • Controlling the Polarity of the Molecular Beam Epitaxy Grown In-Bi Atomic Film on the Si(111) Surface.

    abstract：:Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37051-2

    authors： Lin CY,Hsu CH,Huang YZ,Hsieh SC,Chen HD,Huang L,Huang ZQ,Chuang FC,Lin DS

    更新日期：2019-01-24 00:00:00

  • Publisher Correction: Femtosecond laser fabrication of silver nanostructures on glass for surface enhanced Raman spectroscopy.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59779-6

    authors： MacKenzie M,Chi H,Varma M,Pal P,Kar A,Paterson L

    更新日期：2020-03-16 00:00:00

  • Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation.

    abstract：:Magnesium has been shown to effectively prevent vascular calcification associated with chronic kidney disease. Magnesium has been hypothesized to prevent the upregulation of osteoblastic genes that potentially drives calcification. However, extracellular effects of magnesium on hydroxyapatite formation are largely neg...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20241-3

    authors： Ter Braake AD,Tinnemans PT,Shanahan CM,Hoenderop JGJ,de Baaij JHF

    更新日期：2018-02-01 00:00:00

  • Identification of candidate aberrantly methylated and differentially expressed genes in Esophageal squamous cell carcinoma.

    abstract：:Aberrant methylated genes (DMGs) play an important role in the etiology and pathogenesis of esophageal squamous cell carcinoma (ESCC). In this study, we aimed to integrate three cohorts profile datasets to ascertain aberrant methylated-differentially expressed genes and pathways associated with ESCC by comprehensive b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66847-4

    authors： Han BA,Yang XP,Hosseini DK,Zhang P,Zhang Y,Yu JT,Chen S,Zhang F,Zhou T,Sun HY

    更新日期：2020-06-16 00:00:00

  • Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging.

    abstract：:The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared to conventional CT for pulmonary imaging. A custom-made lung phantom, including nodules of different sizes and shapes, was scanned with a preclinical SPCCT and a conventional CT in standard and high-resolu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35888-1

    authors： Kopp FK,Daerr H,Si-Mohamed S,Sauter AP,Ehn S,Fingerle AA,Brendel B,Pfeiffer F,Roessl E,Rummeny EJ,Pfeiffer D,Proksa R,Douek P,Noël PB

    更新日期：2018-11-26 00:00:00

  • Assessing of the contributions of pod photosynthesis to carbon acquisition of seed in alfalfa (Medicago sativa L.).

    abstract：:The distribution of carbon from a branch setting pod in alfalfa was investigated during the seed development of seeds to determine the relative contribution of pod and leaf photoassimilates to the total C balance and to investigate the partitioning of these photoassimilates to other plant organs. A 13Clabeling procedu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42026

    authors： Zhang W,Mao P,Li Y,Wang M,Xia F,Wang H

    更新日期：2017-02-07 00:00:00

  • Author Correction: How visual experience impacts the internal and external spatial mapping of sensorimotor functions.

    abstract：:A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41598-017-16992-0

    authors： Crollen V,Albouy G,Lepore F,Collignon O

    更新日期：2017-12-04 00:00:00

  • Differential Responses of Plasma Adropin Concentrations To Dietary Glucose or Fructose Consumption In Humans.

    abstract：:Adropin is a peptide hormone encoded by the Energy Homeostasis Associated (ENHO) gene whose physiological role in humans remains incompletely defined. Here we investigated the impact of dietary interventions that affect systemic glucose and lipid metabolism on plasma adropin concentrations in humans. Consumption of gl...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/srep14691

    authors： Butler AA,St-Onge MP,Siebert EA,Medici V,Stanhope KL,Havel PJ

    更新日期：2015-10-05 00:00:00