Abstract：
:Different anti-PD-1 and anti-PD-L1 antibodies bind different epitopes. However, whether the results from the SP142 and 22C3 immunochemistry (IHC) assays can be interchanged to determine patient eligibility for immunotherapy remains largely unknown. Histologic sections from 135 tumor samples were probed with both 22C3 and SP142 antibodies. The concordance of PD-L1 expression determined by the two assays was assessed. Additionally, we evaluated the association of PD-L1 expression detected by different assays with clinicopathological features and prognosis. In total, 105 (77.78%) of 135 samples evaluated by the 22C3-IHC platform produced the same results with the SP142-IHC platform (Kappa value: 0.481, p < 0.001). In addition, 69 (51.11%) of 135 samples evaluated by the SP142-IHC platform produced the same results with the 22C3-IHC platform (Kappa value: 0.324, p < 0.001). PD-L1 expression based on the 22C3-IHC assay was significantly correlated with smoking status, whereas that based on the SP142-IHC assay was correlated with smoking status, sex, and histology. Compared to the SP142-IHC assay, the 22C3-IHC assay usually resulted in an underestimation of PD-L1 expression in tumor cells and immune cells. Thus, the results from the two assays cannot be interchanged. Our data also suggest that the use of different reagents may account for inconsistencies in the literature regarding the association between PD-L1 expression and clinicopathological features.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu H,Lin G,Huang C,Zhu W,Miao Q,Fan X,Wu B,Zheng X,Lin X,Jiang K,Hu D,Li Cdoi
10.1038/s41598-017-17034-5subject
Has Abstractpub_date
2017-12-05 00:00:00pages
16956issue
1issn
2045-2322pii
10.1038/s41598-017-17034-5journal_volume
7pub_type
杂志文章abstract：:The dispersion of organic N-benzyl-2-methyl-4-nitroaniline (BNA) in nematic liquid crystals (LCs) is studied. BNA doping decreases the threshold voltage of cell because of the reduced splay elastic constant and increased dielectric anisotropy of the LC mixture. When operated in the high voltage difference condition, t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71306-1
更新日期：2020-08-31 00:00:00
abstract：:Cytochrome P450 monooxygenases are present in almost all organisms and can play vital roles in hormone regulation, metabolism of xenobiotics and in biosynthesis or inactivation of endogenous compounds. In the present study, a genome-wide approach was used to identify and analyze the P450 gene family of diamondback mot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08952
更新日期：2015-03-10 00:00:00
abstract：:The development of well-organized structures with high luminescent properties in the solid and aggregated states is of both scientific and technological interest due to their applications in nanotechnology. In this paper we described the synthesis of amphiphilic and dumbbell shaped AIE-active tetraphenylethylene (TPE)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42898
更新日期：2017-02-23 00:00:00
abstract：:Multisensory integration is a powerful mechanism for constructing body awareness and key for the sense of selfhood. Recent evidence has shown that the specialised C tactile modality that gives rise to feelings of pleasant, affective touch, can enhance the experience of body ownership during multisensory integration. N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13345-9
更新日期：2017-10-10 00:00:00
abstract：:We present the first complete, closed genome sequences of Streptococcus pyogenes strains NCTC 8198T and CCUG 4207T, the type strain of the type species of the genus Streptococcus and an important human pathogen that causes a wide range of infectious diseases. S. pyogenes NCTC 8198T and CCUG 4207T are derived from depo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68249-y
更新日期：2020-07-15 00:00:00
abstract：:The effect of resistin (RETN) on the response to anti-HCV therapy remains unclear. A prospective cohort study was performed using 655 consecutive HCV patients, of whom 513 had completed a course of interferon-based therapy. Multivariate and GEE analyses revealed four RETN single-nucleotide polymorphisms (SNPs), rs3486...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30799
更新日期：2016-08-01 00:00:00
abstract：:The housefly (Musca domestica L.) lives in close association with its microbiota and its symbionts are suggested to have pivotal roles in processes such as metabolism and immune response, but it is unclear how the profound physiological changes during ontogeny affect the housefly's associated microbiota and their meta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64704-y
更新日期：2020-05-12 00:00:00
abstract：:Petunia × hybrida cv 'Mitchell Diploid' floral volatile benzenoid/phenylpropanoid (FVBP) biosynthesis ultimately produces floral volatiles derived sequentially from phenylalanine, cinnamic acid, and p-coumaric acid. In an attempt to better understand biochemical steps after p-coumaric acid production, we cloned and ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45183-2
更新日期：2019-06-20 00:00:00
abstract：:This work aimed to investigate the co-grinding effects of β-cyclodextrin (β-CD) and cucurbit[7]uril (CB[7]) on crystalline zaltoprofen (ZPF) in tablet formulation. Crystalline ZPF was prepared through anti-solvent recrystallization and fully analyzed through single-crystal X-ray diffraction. Co-ground dispersions and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45984
更新日期：2017-04-03 00:00:00
abstract：:Tipping point dynamics are fundamental drivers for sustainable transition pathways of social-ecological systems (SES). Current research predominantly analyzes how crossing tipping points causes regime shifts, however, the analysis of potential transition pathways from these social and ecological tipping points is ofte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59713-w
更新日期：2020-03-05 00:00:00
abstract：:Antigen-presenting cells including dendritic cells (DCs) express mannan receptors (MR) on their surface, which can be exploited in cancer therapy by designing immune-stimulatory viruses coated with mannan-modified capsids that then bind to DCs and initiate a potent immune response. Although the combination of anti-ang...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11275
更新日期：2015-06-18 00:00:00
abstract：:Hydrogen sulfide (H2S) signaling has been considered a key regulator of plant developmental processes and defenses. In this study, we demonstrate that high levels of H2S inhibit auxin transport and lead to alterations in root system development. H2S inhibits auxin transport by altering the polar subcellular distributi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08251
更新日期：2015-02-05 00:00:00
abstract：:Detecting communities or clusters in a real-world, networked system is of considerable interest in various fields such as sociology, biology, physics, engineering science, and interdisciplinary subjects, with significant efforts devoted in recent years. Many existing algorithms are only designed to identify the compos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24017
更新日期：2016-04-07 00:00:00
abstract：:Exhibiting a red-shifted absorption/scattering feature compared to conventional plasmonic metals, titanium nitride nanoparticles (TiN NPs) look as very promising candidates for biomedical applications, but these applications are still underexplored despite the presence of extensive data for conventional plasmonic coun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37519-1
更新日期：2019-02-04 00:00:00
abstract：:The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing peri-implantitis. This study reports development of a non- immunotoxicity multilayered coating on a titanium surface that had sustained antimicrob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16336
更新日期：2015-11-09 00:00:00
abstract：:The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate analysis of HLA genes using ancient DNA (aDNA) data is crucial for understanding their role in human adaptation to pathogens. Here, we describe the TARGT pipeline for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64312-w
更新日期：2020-04-30 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-76567-4
更新日期：2020-11-05 00:00:00
abstract：:CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. In this study we examined the role of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45138-7
更新日期：2019-06-13 00:00:00
abstract：:The ability of deep learning architectures to identify glaucomatous optic neuropathy (GON) in fundus photographs was evaluated. A large database of fundus photographs (n = 14,822) from a racially and ethnically diverse group of individuals (over 33% of African descent) was evaluated by expert reviewers and classified ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35044-9
更新日期：2018-11-12 00:00:00
abstract：:The combustion of hydrocarbon fuels within the automotive industry results in harmful and reactive incomplete combustion byproducts. Specifically, nitric oxide emissions (NO) lead to increased smog, acid rain, climate change, and respiratory inflammation within the population [Nitrogen Dioxide | American Lung Associat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75360-7
更新日期：2020-10-30 00:00:00
abstract：:PCR-mediated chromosome splitting (PCS) was developed in the yeast Saccharomyces cerevisiae. It is based on homologous recombination and enables division of a chromosome at any point to form two derived and functional chromosomes. However, because of low homologous recombination activity, PCS is limited to a single si...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30278
更新日期：2016-08-17 00:00:00
abstract：:We investigate the impact of borders on the topology of spatially embedded networks. Indeed territorial subdivisions and geographical borders significantly hamper the geographical span of networks thus playing a key role in the formation of network communities. This is especially important in scientific and technologi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04546
更新日期：2014-04-01 00:00:00
abstract：:Thermal perception is essential for the survival and daily activities of people. Thus, it is desirable to realize thermal feedback stimulation for improving the sense of realism in virtual reality (VR) for users. For thermal stimulus, conventional systems utilize liquid circulation with bulky external sources or therm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68362-y
更新日期：2020-07-09 00:00:00
abstract：:Although copy number variation (CNV) and presence-absence variation (PAV) have been discovered in selected gene families in most crop species, the global prevalence of these polymorphisms in most complex genomes is still unclear and their influence on quantitatively inherited agronomic traits is still largely unknown....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61228-3
更新日期：2020-03-05 00:00:00
abstract：:Duckweed species have a great potential to develop into fast-growing crops for water remediation and bioenergy production. Seed production and utilization of hybrid vigour are essential steps in this process. However, even in the extensively-studied duckweed species, Lemna gibba, flower primordia were often aborted pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03240-8
更新日期：2017-06-08 00:00:00
abstract：:The knee joint center of rotation is altered in the absence of the anterior cruciate ligament, which leads to substantially higher variance in kinematic patterns. To overcome this, total knee arthroplasty (TKA) designs with a high congruency in the lateral compartment have been proposed. The purpose of this study was ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45694-y
更新日期：2019-06-24 00:00:00
abstract：:We propose a novel injection scheme for laser-driven wakefield acceleration in which controllable localized electron injection is obtained by inserting nanoparticles into a plasma medium. The nanoparticles provide a very confined electric field that triggers localized electron injection where nonlinear plasma waves ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34998-0
更新日期：2018-11-16 00:00:00
abstract：:Empirical yield estimation from satellite data has long lacked suitable combinations of spatial and temporal resolutions. Consequently, the selection of metrics, i.e., temporal descriptors that predict grain yield, has likely been driven by practicality and data availability rather than by systematic targetting of cri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51715-7
更新日期：2019-10-31 00:00:00
abstract：:Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system (CNS). Here we investigated the effects of acute and chronic ethanol exposure and withdrawal from chronic ethanol exposure on glymphatic function, which is a brain-wide metabolite clearance system connected ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20424-y
更新日期：2018-02-02 00:00:00
abstract：:Embryonic stem cell (ESC) derived tissue is a promising tool to be used in different clinical, preclinical and also scientific settings, for example as in vivo biological pacemaker, preclinical drug safety screening tool or ultimately as part of a cell replacement therapy. However, before ESC derived tissue can be use...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50557-7
更新日期：2019-10-01 00:00:00
