ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.

abstract：:Cancer cells accumulate somatic mutations as result of DNA damage, inaccurate repair and other mechanisms. Different genetic instability processes result in characteristic non-random patterns of DNA mutations, also known as mutational signatures. We developed mutSignatures, an integrated R-based computational framewor...

journal_title：Scientific reports

authors： Fantini D,Vidimar V,Yu Y,Condello S,Meeks JJ

更新日期：2020-10-26 00:00:00

abstract：:During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here show that next to vasa vasorum, also the adventitial lymphatic capillary bed is expanding during plaque development in humans and mouse models of atherosclerosis....

journal_title：Scientific reports

authors： Rademakers T,van der Vorst EP,Daissormont IT,Otten JJ,Theodorou K,Theelen TL,Gijbels M,Anisimov A,Nurmi H,Lindeman JH,Schober A,Heeneman S,Alitalo K,Biessen EA

更新日期：2017-03-28 00:00:00

abstract：:C4.4A is a modular glycolipid-anchored Ly6/uPAR/α-neurotoxin multidomain protein that exhibits a prominent membrane-associated expression in stratified squamous epithelia. C4.4A is also expressed in various solid cancer lesions, where high expression levels often are correlated to poor prognosis. Circumstantial eviden...

journal_title：Scientific reports

authors： Kriegbaum MC,Jacobsen B,Füchtbauer A,Hansen GH,Christensen IJ,Rundsten CF,Persson M,Engelholm LH,Madsen AN,Di Meo I,Lund IK,Holst B,Kjaer A,Lærum OD,Füchtbauer EM,Ploug M

更新日期：2016-05-12 00:00:00

abstract：:The use of misidentified cell lines contaminated by other cell lines and/or microorganisms has generated much confusion in the scientific literature. Detailed characterization of such contaminations is therefore crucial to avoid misinterpretation and ensure robustness and reproducibility of research. Here we use DNA-s...

journal_title：Scientific reports

authors： Loiseau V,Cordaux R,Giraud I,Beby-Defaux A,Lévêque N,Gilbert C

更新日期：2020-09-29 00:00:00

abstract：:Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found that in utero DBP exposure was associated with an increase of adipose tissue weight and serum lipids in offspring, but the precise mechanism is unknown. Here we aim...

journal_title：Scientific reports

authors： Li H,Li J,Qu Z,Qian H,Zhang J,Wang H,Xu X,Liu S

更新日期：2020-10-01 00:00:00

abstract：:The architecture of the genome influences the functions of DNA from bacteria to eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have pivotal roles in various processes of gene expression. IDR is rare in bacteria, but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that...

journal_title：Scientific reports

authors： Savitskaya A,Nishiyama A,Yamaguchi T,Tateishi Y,Ozeki Y,Nameta M,Kon T,Kaboso SA,Ohara N,Peryanova OV,Matsumoto S

更新日期：2018-05-29 00:00:00

abstract：:Macro-fungi play important roles in the soil elemental cycle in terrestrial ecosystems. Many researchers have focused on the interactions between mycorrhizal fungi and host plants, whilst comparatively few studies aim to characterise the relationships between macro-fungi and bacteria in situ. In this study, we detecte...

journal_title：Scientific reports

authors： Liu Y,Sun Q,Li J,Lian B

更新日期：2018-08-03 00:00:00

abstract：:We report the structural, magnetoelectric (ME), magnetic and electric control of magnetic properties in Co4Nb2O9 (CNO) single crystal. A detailed ME measurement reveals a nonlinear ME effect instead of a linear ME effect in CNO single crystal. By fitting the magnetization-electric field (M-E) curve, it can be found th...

journal_title：Scientific reports

authors： Cao Y,Deng G,Beran P,Feng Z,Kang B,Zhang J,Guiblin N,Dkhil B,Ren W,Cao S

更新日期：2017-10-26 00:00:00

abstract：:Ancestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome transgenerational programming. Here we report that prenatal stress in rats generates a transgenerat...

journal_title：Scientific reports

authors： McCreary JK,Erickson ZT,Hao Y,Ilnytskyy Y,Kovalchuk I,Metz GA

更新日期：2016-11-24 00:00:00

abstract：:Complex Semi-Definite Programming (SDP) is introduced as a novel approach to phase retrieval enabled control of monochromatic light transmission through highly scattering media. In a simple optical setup, a spatial light modulator is used to generate a random sequence of phase-modulated wavefronts, and the resulting i...

journal_title：Scientific reports

authors： N'Gom M,Lien MB,Estakhri NM,Norris TB,Michielssen E,Nadakuditi RR

更新日期：2017-05-31 00:00:00

abstract：:First-generation adenovirus vectors (FG AdVs) are widely used in basic studies and gene therapy. However, virus-associated (VA) RNAs that act as small-interference RNAs are indeed transcribed from the vector genome. These VA RNAs can trigger the innate immune response. Moreover, VA RNAs are processed to functional vir...

journal_title：Scientific reports

authors： Maekawa A,Pei Z,Suzuki M,Fukuda H,Ono Y,Kondo S,Saito I,Kanegae Y

更新日期：2013-01-01 00:00:00

abstract：:Microbubble contrast agents are widely used in ultrasound imaging and therapy, typically with transmission center frequencies in the MHz range. Currently, an ultrasound center frequency near 250 kHz is proposed for clinical trials in which ultrasound combined with microbubble contrast agents is applied to open the blo...

journal_title：Scientific reports

authors： Ilovitsh T,Ilovitsh A,Foiret J,Caskey CF,Kusunose J,Fite BZ,Zhang H,Mahakian LM,Tam S,Butts-Pauly K,Qin S,Ferrara KW

更新日期：2018-11-05 00:00:00

abstract：:Structural characteristics of the active layers in organic photovoltaic (OPV) devices play a critical role in charge generation, separation and transport. Here we report on morphology and structural control of p-DTS(FBTTh2)2:PC71BM films by means of thermal annealing and 1,8-diiodooctane (DIO) solvent additive process...

journal_title：Scientific reports

authors： Herath N,Das S,Keum JK,Zhu J,Kumar R,Ivanov IN,Sumpter BG,Browning JF,Xiao K,Gu G,Joshi P,Smith S,Lauter V

更新日期：2015-08-28 00:00:00

abstract：:Continuous and non-invasive monitoring of hemodynamic parameters through unobtrusive wearable sensors can potentially aid in early detection of cardiac abnormalities, and provides a viable solution for long-term follow-up of patients with chronic cardiovascular diseases without disrupting the daily life activities. El...

journal_title：Scientific reports

authors： Shafiq G,Tatinati S,Ang WT,Veluvolu KC

更新日期：2016-11-22 00:00:00

abstract：:Mid-infrared quantum cascade lasers operating under external optical feedback and external periodic bias forcing are shown to exhibit a deterministic chaotic pattern composed of frequencies which are linked to the one of the forcing. Results also show that both the amplitude and the frequency of the forcing play a key...

journal_title：Scientific reports

authors： Spitz O,Wu J,Carras M,Wong CW,Grillot F

更新日期：2019-03-14 00:00:00

abstract：:Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen tensions, hemodynamics, and cell proliferation to sustain development. Here, we tested the hypothesis that proliferating neonatal cardiomyocytes are dependent on high oxidative energy metabolism. We show that energy-related gene expressi...

journal_title：Scientific reports

authors： de Carvalho AETS,Bassaneze V,Forni MF,Keusseyan AA,Kowaltowski AJ,Krieger JE

更新日期：2017-11-13 00:00:00

abstract：:Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(ω-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the ...

journal_title：Scientific reports

authors： Nikolajski M,Adams GG,Gillis RB,Besong DT,Rowe AJ,Heinze T,Harding SE

更新日期：2014-01-24 00:00:00

abstract：:Photocatalysis is a promising strategy to address the global environmental and energy challenges. However, the studies on the application of the photocatalytically degraded dye-polluted water and the multi-purpose use of one type of catalyst have remained sparse. In this report, we try to demonstrate a concept of mult...

journal_title：Scientific reports

authors： Zhang Q,Zhang Y,Meng Z,Tong W,Yu X,An Q

更新日期：2017-09-25 00:00:00

abstract：:The considerable range of genetic variation in human populations may partly reflect distinctive processes of adaptation to variable environmental conditions. However, the adaptive genomic signatures remain to be completely elucidated. This research explores candidate loci under selection at the population level by cha...

journal_title：Scientific reports

authors： Fujikura K

更新日期：2016-03-02 00:00:00

abstract：:Microwave absorbers have important applications in various areas including stealth, camouflage, and antenna. Here, we have designed an ultra-broadband light absorber by integrating two different-sized tapered hyperbolic metamaterial (HMM) waveguides, each of which has wide but different absorption bands due to broadba...

journal_title：Scientific reports

authors： Yin X,Long C,Li J,Zhu H,Chen L,Guan J,Li X

更新日期：2015-10-19 00:00:00

abstract：:Bacterial blight and bacterial leaf streak are serious, economically damaging, diseases of rice caused by the bacteria Xanthomonas oryzae pv. oryzae and X. oryzae pv. oryzicola. Bacillus amyloliquefaciens FZB42 was shown to possess biocontrol activity against these Xanthomonas strains by producing the antibiotic compo...

journal_title：Scientific reports

authors： Wu L,Wu H,Chen L,Yu X,Borriss R,Gao X

更新日期：2015-08-13 00:00:00

abstract：:Despite recent advances in cancer management and therapy, resistance to cytotoxic medications remains a major clinical challenge; hence, combination-based anti-cancer treatment regimens are currently gaining momentum. PTC-209 reduced BMI1 protein expression, while palbociclib inhibited CDK4, Rb, and pRbSer795 protein ...

journal_title：Scientific reports

authors： Elango R,Vishnubalaji R,Manikandan M,Binhamdan SI,Siyal AA,Alshawakir YA,Alfayez M,Aldahmash A,Alajez NM

更新日期：2019-09-23 00:00:00

abstract：:In the era of precision medicine the treatment options for cancer patients and subsequent outcomes are expected to improve. We present a review of patients enrolled in first-in-human Phase1 trials at University of Alabama at Birmingham. Between 1/2015-6/2017, 162 cancer patients (whole cohort, WC) were enrolled on pha...

journal_title：Scientific reports

authors： Paluri RK,Li P,Anderson A,Nandagopal L,McArdle T,Young M,Robert F,Naik G,Saleh M

更新日期：2020-05-13 00:00:00

abstract：:Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabo...

journal_title：Scientific reports

authors： Maidana P,Fritzler A,Mocarbel Y,Perez Lana MB,González D,Rosales M,González de Chazal F,Sternberg K,Lamas Majek E,Mallea-Gil S,Genovesi E,Pelayo M,Fabre B,Mesch V

更新日期：2019-03-08 00:00:00

abstract：:Cellular reprogramming involves profound alterations in genome-wide gene expression that is precisely controlled by a hypothetical epigenetic code. Small molecules have been shown to artificially induce epigenetic modifications in a sequence independent manner. Recently, we showed that specific DNA binding hairpin pyr...

journal_title：Scientific reports

authors： Pandian GN,Nakano Y,Sato S,Morinaga H,Bando T,Nagase H,Sugiyama H

更新日期：2012-01-01 00:00:00

abstract：:Rs1042522 (Arg72Pro) is a functional polymorphism of TP53. Pro72 has been associated with lower all-cause mortality and lower mortality after cancer. We hypothesized that TP53 Pro72 is associated with lower mortality after cancer, lower all-cause mortality, and with increased cancer incidence in the general population...

journal_title：Scientific reports

authors： Kodal JB,Vedel-Krogh S,Kobylecki CJ,Nordestgaard BG,Bojesen SE

更新日期：2017-03-23 00:00:00

abstract：:Among its other biological roles, acetylcholinesterase (AChE, EC 3.1.1.7), encoded by two ace in most insects, catalyses the breakdown of acetylcholine, thereby terminating synaptic transmission. ace1 encodes the synaptic enzyme and ace2 has other essential actions in many insect species, such as Chilo suppressalis an...

journal_title：Scientific reports

authors： Ye X,Yang L,Stanley D,Li F,Fang Q

更新日期：2017-07-10 00:00:00

abstract：:Angiogenesis is essential in tumor biology and is regulated by vascular endothelial growth factor (VEGF) ligands and receptors. Here we aimed to discover genetic variants associated with levels of circulating angiogenic proteins in cancer patients. Plasma was collected at baseline in 216 pancreatic and 114 colorectal ...

journal_title：Scientific reports

authors： Innocenti F,Jiang C,Sibley AB,Etheridge AS,Hatch AJ,Denning S,Niedzwiecki D,Shterev ID,Lin J,Furukawa Y,Kubo M,Kindler HL,Auman JT,Venook AP,Hurwitz HI,McLeod HL,Ratain MJ,Gordan R,Nixon AB,Owzar K

更新日期：2018-11-05 00:00:00

abstract：:In recent years, the topic of noise in the sea and its effects on marine mammals has attracted considerable attention from both the scientific community and the general public. Since marine mammals rely heavily on acoustics as a primary means of communicating, navigating, and foraging in the ocean, any change in their...

journal_title：Scientific reports

authors： Frisk GV

更新日期：2012-01-01 00:00:00

abstract：:For the past 30 years, oocytes from Xenopus laevis have been extensively used to express and characterise ion channels in an easily controlled environment. Here we report the first use of oocytes from the closely related species Xenopus borealis as an alternative expression system for neuronal ion channels. Using the ...

journal_title：Scientific reports

authors： Cristofori-Armstrong B,Soh MS,Talwar S,Brown DL,Griffin JD,Dekan Z,Stow JL,King GF,Lynch JW,Rash LD

更新日期：2015-10-06 00:00:00