Abstract:
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journal_name
Sci Repjournal_title
Scientific reportsauthors
Crollen V,Albouy G,Lepore F,Collignon Odoi
10.1038/s41598-017-16992-0subject
Has Abstractpub_date
2017-12-04 00:00:00pages
17152issue
1issn
2045-2322pii
10.1038/s41598-017-16992-0journal_volume
7pub_type
杂志文章,已发布勘误abstract::The function of most long noncoding RNAs (lncRNAs) is unknown. However, recent studies reveal important roles of lncRNAs in regulating cancer-related pathways. Human antisense lncRNA-NKX2-1-AS1 partially overlaps the NKX2-1/TTF1 gene within chromosomal region 14q13.3. Amplification of this region and/or differential e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32793-5
更新日期:2018-09-26 00:00:00
abstract::The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin α3 (ITGα3) in malignant cancers. Here, we determined the functional role of ITGα3 in pancreatic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39628-x
更新日期:2019-02-26 00:00:00
abstract::Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of cells adjacent to the tumor and metastasis. Thus, this study analyzed the effect of tumor cell-free DNA, isolated from the blood of prostate cancer patients, o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78766-5
更新日期:2020-12-10 00:00:00
abstract::Determining the success of eradication of an invasive species requires a way to decide when its risk of reoccurrence has become acceptably low. In Japan, the area populated by the Argentine ant, Linepithema humile (Mayr), is expanding, and eradication via chemical treatment is ongoing at various locations. One such pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03516-z
更新日期:2017-06-13 00:00:00
abstract::Anthropogenic inputs into coastal ecosystems are causing more frequent environmental fluctuations and reducing seawater pH. One such ecosystem is Florida Bay, an important nursery for the Caribbean spiny lobster, Panulirus argus. Although adult crustaceans are often resilient to reduced seawater pH, earlier ontogeneti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75021-9
更新日期:2020-10-22 00:00:00
abstract::Previous reports on epigenetic mechanisms involved in alcohol abuse have focus on hepatic and neuronal regions, leaving the immune system and specifically monocyte-derived dendritic cells (MDDCs) understudied. Our lab has previously shown histone deacetylases are modulated in cells derived from alcohol users and after...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11172-6
更新日期:2017-09-11 00:00:00
abstract::Dorso-ventral (DV) countershading is a highly-conserved pigmentary adaptation in vertebrates. In mammals, spatially regulated expression of agouti-signaling protein (ASIP) generates the difference in shading by driving a switch between the production of chemically-distinct melanins in melanocytes in dorsal and ventral...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40251-z
更新日期:2019-03-05 00:00:00
abstract::Diabetes mellitus accelerates vascular calcification (VC) and increases the risk of end-stage renal disease (ESRD). Nevertheless, the impact of VC in renal disease progression in type 2 diabetes mellitus (T2DM) is poorly understood. We addressed the effect of VC and mechanisms involved in renal dysfunction in a murine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55501-3
更新日期:2020-01-09 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60510-8
更新日期:2020-02-20 00:00:00
abstract::Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while secondary MIBC presumes that non-muscle invasive disease later progressed to MIB...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-018-26002-6
更新日期:2018-05-15 00:00:00
abstract::Circulating miRNAs have attracted attention as serum biomarkers for several diseases. In this study, we aimed to evaluate the diagnostic value of circulating miRNA-21 (miR-21) as a novel biomarker for elderly patients with type 2 cardiorenal syndrome (CRS-2). A total of 157 elderly patients with chronic heart failure ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61836-z
更新日期:2020-03-17 00:00:00
abstract::To understand the ecosystem dynamics that underpin the year-round presence of a large generalist consumer, the Bryde's whale (Balaenoptera edeni brydei), we use a DNA metabarcoding approach and systematic zooplankton surveys to investigate seasonal and regional changes in zooplankton communities and if whale diet refl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36478-x
更新日期:2019-01-22 00:00:00
abstract::Axolotls have the amazing ability to regenerate. When compared to humans, axolotls display a very fast wound closure, no scarring and are capable to replace lost appendages perfectly. Understanding the signaling mechanism leading to this perfect healing is a key step to help develop regenerative treatments for humans....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38171-5
更新日期:2019-02-04 00:00:00
abstract::African swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09948-x
更新日期:2017-09-04 00:00:00
abstract::We have studied differentially regulated nuclear proteome of the clinical tissue specimens of glioblastoma (GBM, WHO Grade IV) and lower grades of gliomas (Grade II and III) using high resolution mass spectrometry- based quantitative proteomics approach. The results showed altered expression of many regulatory protein...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47360-9
更新日期:2019-07-29 00:00:00
abstract::The Diels-Alder reaction is a useful tool for generating functionalized chiral molecules through the concerted cycloaddition of dienes and dienophiles leading to six-membered rings. Traditionally, the selective predictions of the products rely heavily on consideration of the secondary orbital interactions that stabili...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35147
更新日期:2016-10-12 00:00:00
abstract::In this work the chalcopyrite CuIn3Se5-xTex (x = 0~0.5) with space group through isoelectronic substitution of Te for Se have been prepared, and the crystal structure dilation has been observed with increasing Te content. This substitution allows the anion position displacement ∆u = 0.25-u to be zero at x ≈ 0.15. Howe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40224
更新日期:2017-01-06 00:00:00
abstract::Microfluidic channels have been implemented to detect cancer cells from blood using electrical measurement of each single cell from the sample. Every cell provided characteristic current profile based on its mechano-physical properties. Cancer cells not only showed higher translocation time and peak amplitude compared...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13031
更新日期:2015-09-16 00:00:00
abstract::How exponentially growing cells maintain size homeostasis is an important fundamental problem. Recent single-cell studies in prokaryotes have uncovered the adder principle, where cells add a fixed size (volume) from birth to division, irrespective of their size at birth. To mechanistically explain the adder principle,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30229
更新日期:2016-07-26 00:00:00
abstract::Heterostructures consisting of two-dimensional materials have shown new physical phenomena, novel electronic and optical properties, and new device concepts not observed in bulk material systems or purely three dimensional heterostructures. These new effects originated mostly from the van der Waals interaction between...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14374
更新日期:2015-09-23 00:00:00
abstract::In this paper, we propose a novel bio-compatible organic humidity sensor based on natural inner egg shell membrane (IESM) with multilayer cross linked fiber structure that can be used as a substrate as well as a sensing active layer. To fabricate the proposed sensors, two different size inter digital electrodes (IDEs)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42337-0
更新日期:2019-04-09 00:00:00
abstract::Hollow microporous organic nanorods (HMORs) with hypercrosslinked polymer (HCPs) shells were synthesized through emulsion polymerization followed by hypercrosslinking. The HMORs have tunable aspect ratios, high BET surface areas and monodispersed morphologies, showing good performance in gas adsorpion. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31359
更新日期:2016-08-10 00:00:00
abstract::This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the li...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71089-5
更新日期:2020-08-26 00:00:00
abstract::We investigated changes in the temporospatial features of hourly precipitation during the warm season over mainland China. The frequency and amount of hourly precipitation displayed latitudinal zonation, especially for light and moderate precipitation, which showed successive downward change over time in northeastern ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22543
更新日期:2016-03-02 00:00:00
abstract::To investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the secon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73747-0
更新日期:2020-10-27 00:00:00
abstract::Chiral optical response is an inherent property of molecules and nanostructures, which cannot be superimposed on their mirror images. In specific cases, optical chirality can be observed also for symmetric structures. This so-called extrinsic chirality requires that the mirror symmetry is broken by the geometry of the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41615-1
更新日期:2019-03-25 00:00:00
abstract::To assess whether the immunosuppressive effects of atorvastatin outweigh its antibacterial ones in an infection, mice were infected with Escherichia coli and administered atorvastatin; survival rates were then monitored. Mice treated with atorvastatin post-infection showed a remarkable decrease in their survival rate....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48282-2
更新日期:2019-08-12 00:00:00
abstract::Giant magnetoresistive (GMR) biosensors consisting of many rectangular stripes are being developed for high sensitivity medical diagnostics of diseases at early stages, but many aspects of the sensing mechanism remain to be clarified. Using e-beam patterned masks on the sensors, we showed that the magnetic nanoparticl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18692
更新日期:2016-01-05 00:00:00
abstract::Integrin alpha-4 (ITGA4) is a validated therapeutic target for multiple sclerosis (MS) and Natalizumab, an antibody targeting ITGA4 is currently approved for treating MS. However, there are severe side effects related to this therapy. In this study, we report the development of a novel DNAzyme that can efficiently cle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01559-w
更新日期:2017-05-09 00:00:00
abstract::A singular adaptive phenotype of a parthenogenetic insect species (Acyrthosiphon pisum) was selected in cold conditions and is characterized by a remarkable apparition of a greenish colour. The aphid pigments involve carotenoid genes well defined in chloroplasts and cyanobacteria and amazingly present in the aphid gen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00579
更新日期:2012-01-01 00:00:00