当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Circulating miRNA-21 as a diagnostic biomarker in elderly patients with type 2 cardiorenal syndrome.

Circulating miRNA-21 as a diagnostic biomarker in elderly patients with type 2 cardiorenal syndrome.

Abstract：

:Circulating miRNAs have attracted attention as serum biomarkers for several diseases. In this study, we aimed to evaluate the diagnostic value of circulating miRNA-21 (miR-21) as a novel biomarker for elderly patients with type 2 cardiorenal syndrome (CRS-2). A total of 157 elderly patients with chronic heart failure (CHF) were recruited for the study. According to an estimated glomerular filtration rate (eGFR) cut-off of 60 ml/min/1.73 m2, 84 patients (53.5%) and 73 patients (46.5%) were assigned to the CRS group and the CHF group, respectively. Expression levels of serum miR-21 and biomarkers for CRS, such as kidney injury factor-1 (KIM-1), neutrophil gelatinase-related apolipoprotein (NGAL), cystatin C (Cys C), amino-terminal pro-B-type natriuretic peptide (NT-proBNP), N-acetyl-κ-D-glucosaminidase (NAG), and heart-type fatty acid-binding protein (H-FABP), were detected. Serum miR-21, KIM-1, NGAL, Cys C, NT-proBNP and H-FABP levels were significantly higher in the CRS group than in the CHF group (P < 0.01), whereas NAG expression was not significantly different between the two groups (P > 0.05). Cys C, H-FABP and eGFR correlated significantly with miR-21 expression, but correlations with miR-21 were not significant for NT-proBNP, NGAL, NAG and KIM-1. Moreover, multivariate logistic regression found that serum miR-21, increased serum Cys C, serum KIM-1, hyperlipidaemia and ejection fraction (EF) were independent influencing factors for CRS (P < 0.05). The AUC of miR-21 based on the receiver operating characteristic (ROC) curve was 0.749, with a sensitivity of 55.95% and a specificity of 84.93%. Furthermore, combining miR-21 with Cys C enhanced the AUC to 0.902, with a sensitivity of 88.1% and a specificity of 83.6% (P < 0.001). Our findings suggest that circulating miR-21 has medium diagnostic value in CRS-2. The combined assessment of miR-21 and Cys C has good clinical value in elderly patients with CRS-2.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang Y,Liang Y,Zhao W,Fu G,Li Q,Min X,Guo Y

doi

10.1038/s41598-020-61836-z

subject

Has Abstract

pub_date

2020-03-17 00:00:00

pages

4894

issue

1

issn

2045-2322

pii

10.1038/s41598-020-61836-z

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • DOSCATs: Double standards for protein quantification.

    abstract：:The two most common techniques for absolute protein quantification are based on either mass spectrometry (MS) or on immunochemical techniques, such as western blotting (WB). Western blotting is most often used for protein identification or relative quantification, but can also be deployed for absolute quantification i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45570

    authors： Bennett RJ,Simpson DM,Holman SW,Ryan S,Brownridge P,Eyers CE,Colyer J,Beynon RJ

    更新日期：2017-04-03 00:00:00

  • Morphological Variability and Distinct Protein Profiles of Cultured and Endosymbiotic Symbiodinium cells Isolated from Exaiptasia pulchella.

    abstract：:Symbiodinium is a dinoflagellate that plays an important role in the physiology of the symbiotic relationships of Cnidarians such as corals and sea anemones. However, it is very difficult to cultivate free-living dinoflagellates after being isolated from the host, as they are very sensitive to environmental changes. H...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15353

    authors： Pasaribu B,Weng LC,Lin IP,Camargo E,Tzen JT,Tsai CH,Ho SL,Lin MR,Wang LH,Chen CS,Jiang PL

    更新日期：2015-10-20 00:00:00

  • HIV-1 Tat-induced diarrhea evokes an enteric glia-dependent neuroinflammatory response in the central nervous system.

    abstract：:Despite the effectiveness of combined anti-retroviral therapy, human immunodeficiency virus (HIV) infected-patients frequently report diarrhea and neuropsychological deficits. It is claimed that the viral HIV-1 Trans activating factor (HIV-1 Tat) protein is responsible for both diarrhea and neurotoxic effects, but the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05245-9

    authors： Esposito G,Capoccia E,Gigli S,Pesce M,Bruzzese E,D'Alessandro A,Cirillo C,di Cerbo A,Cuomo R,Seguella L,Steardo L,Sarnelli G

    更新日期：2017-08-10 00:00:00

  • Dysregulated Neurotransmission induces Trans-synaptic degeneration in reconstructed Neuronal Networks.

    abstract：:Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain injury and stroke indicat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29918-1

    authors： Deleglise B,Lassus B,Soubeyre V,Doulazmi M,Brugg B,Vanhoutte P,Peyrin JM

    更新日期：2018-08-02 00:00:00

  • Zinc Resistance Mechanisms of P1B-type ATPases in Sinorhizobium meliloti CCNWSX0020.

    abstract：:The Sinorhizobium meliloti (S. meliloti) strain CCNWSX0020 displayed tolerance to high levels exposures of multiple metals and growth promotion of legume plants grown in metal-contaminated soil. However, the mechanism of metal-resistant strain remains unknown. We used five P1B-ATPases deletions by designating as ∆copA...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29355

    authors： Lu M,Li Z,Liang J,Wei Y,Rensing C,Wei G

    更新日期：2016-07-05 00:00:00

  • Effects of FSH and the weather during induced ovulation and timed artificial insemination to increase jenny conception rates.

    abstract：:Experiments were conducted to improve jenny conception rates through induced ovulation and timed insemination. Jennies in control, hCG and LH groups were injected intramuscularly with saline alone or saline containing hCG or LH, respectively, when the dominant follicle diameter reached 35 mm. Then, follicle developmen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39757-3

    authors： Chang ZL,Li BX,Liu B,Yao L,Yu J,Jiang GM,Tan JH

    更新日期：2019-03-01 00:00:00

  • Genomic insights into the population structure and history of the Irish Travellers.

    abstract：:The Irish Travellers are a population with a history of nomadism; consanguineous unions are common and they are socially isolated from the surrounding, 'settled' Irish people. Low-resolution genetic analysis suggests a common Irish origin between the settled and the Traveller populations. What is not known, however, i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42187

    authors： Gilbert E,Carmi S,Ennis S,Wilson JF,Cavalleri GL

    更新日期：2017-02-09 00:00:00

  • Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.

    abstract：:Chronic sleep fragmentation (SF) commonly occurs in human populations, and although it does not involve circadian shifts or sleep deprivation, it markedly alters feeding behaviors ultimately promoting obesity and insulin resistance. These symptoms are known to be related to the host gut microbiota. Mice were exposed t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35405

    authors： Poroyko VA,Carreras A,Khalyfa A,Khalyfa AA,Leone V,Peris E,Almendros I,Gileles-Hillel A,Qiao Z,Hubert N,Farré R,Chang EB,Gozal D

    更新日期：2016-10-14 00:00:00

  • Establishment of induced pluripotent stem cells from normal B cells and inducing AID expression in their differentiation into hematopoietic progenitor cells.

    abstract：:B cell derived induced pluripotent stem cells (BiPSCs) were recently established from peripheral blood B cells by the simultaneous transfection of Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) and C/EBPα using a Sendai virus vector. Here, using a different method, we established BiPSCs with immunoglobulin heavy chain (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01627-1

    authors： Kawamura F,Inaki M,Katafuchi A,Abe Y,Tsuyama N,Kurosu Y,Yanagi A,Higuchi M,Muto S,Yamaura T,Suzuki H,Noji H,Suzuki S,Yoshida MA,Sasatani M,Kamiya K,Onodera M,Sakai A

    更新日期：2017-05-10 00:00:00

  • Author Correction: Deep-sea Sediment Resuspension by Internal Solitary Waves in the Northern South China Sea.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-019-53956-y

    authors： Jia Y,Tian Z,Shi X,Liu JP,Chen J,Liu X,Ye R,Ren Z,Tian J

    更新日期：2019-11-21 00:00:00

  • Impact of the severity of restrictive spirometric pattern on nutrition, physical activity, and quality of life: results from a nationally representative database.

    abstract：:The general disease burden associated with the restrictive spirometric pattern (RSP) is substantial. However, the impact of RSP by its severity on general health problems and quality of life has not been well elucidated. This study aimed to analyse nutrition, physical activity, and quality of life in subjects who part...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76777-w

    authors： Chung SJ,Kim HI,Yang B,Kim T,Sim YS,Kang HK,Kim SH,Yoon HJ,Choi H,Lee H

    更新日期：2020-11-12 00:00:00

  • VISTA: VIsual Semantic Tissue Analysis for pancreatic disease quantification in murine cohorts.

    abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78061-3

    authors： Ternes L,Huang G,Lanciault C,Thibault G,Riggers R,Gray JW,Muschler J,Chang YH

    更新日期：2020-12-01 00:00:00

  • Grafting cucumber onto luffa improves drought tolerance by increasing ABA biosynthesis and sensitivity.

    abstract：:Balancing stomata-dependent CO2 assimilation and transpiration is a key challenge for increasing crop productivity and water use efficiency under drought stress for sustainable crop production worldwide. Here, we show that cucumber and luffa plants with luffa as rootstock have intrinsically increased water use efficie...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20212

    authors： Liu S,Li H,Lv X,Ahammed GJ,Xia X,Zhou J,Shi K,Asami T,Yu J,Zhou Y

    更新日期：2016-02-02 00:00:00

  • Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance.

    abstract：:Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained co...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00185

    authors： Supervie V,Barrett M,Kahn JS,Musuka G,Moeti TL,Busang L,Blower S

    更新日期：2011-01-01 00:00:00

  • Fluorometric assay for phenotypic differentiation of drug-resistant HIV mutants.

    abstract：:Convenient drug-resistance testing of viral mutants is indispensable to effective treatment of viral infection. We developed a novel fluorometric assay for phenotypic differentiation of drug-resistant mutants of human immunodeficiency virus-I protease (HIV-PR) which uses enzymatic and peptide-specific fluorescence (FL...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10323

    authors： Zhu Q,Yu Z,Kabashima T,Yin S,Dragusha S,El-Mahdy AF,Ejupi V,Shibata T,Kai M

    更新日期：2015-05-19 00:00:00

  • Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994-2014: origin and evolution of the virus in the region.

    abstract：:More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the autho...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26036-w

    authors： Balka G,Podgórska K,Brar MS,Bálint Á,Cadar D,Celer V,Dénes L,Dirbakova Z,Jedryczko A,Márton L,Novosel D,Petrović T,Sirakov I,Szalay D,Toplak I,Leung FC,Stadejek T

    更新日期：2018-05-17 00:00:00

  • The greenhouse gas offset potential from seagrass restoration.

    abstract：:Awarding CO2 offset credits may incentivize seagrass restoration projects and help reverse greenhouse gas (GHG) emissions from global seagrass loss. However, no study has quantified net GHG removal from the atmosphere from a seagrass restoration project, which would require coupled Corg stock and GHG flux enhancement ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64094-1

    authors： Oreska MPJ,McGlathery KJ,Aoki LR,Berger AC,Berg P,Mullins L

    更新日期：2020-04-30 00:00:00

  • Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling.

    abstract：:Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4CMTB) an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36242-1

    authors： Schofield ZV,Croker D,Robertson AAB,Massey NL,Donovan C,Tee E,Edwards D,Woodruff TM,Halai R,Hansbro PM,Cooper MA

    更新日期：2018-12-13 00:00:00

  • Fluorescent and Magnetic Mesoporous Hybrid Material: A Chemical and Biological Nanosensor for Hg(2+) Ions.

    abstract：:We introduce "sense, track and separate" approach for the removal of Hg(2+) ion from aqueous media using highly ordered and magnetic mesoporous ferrosilicate nanocages functionalised with rhodamine fluorophore derivative. These functionalised materials offer both fluorescent and magnetic properties in a single system ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21820

    authors： Suresh M,Anand C,Frith JE,Dhawale DS,Subramaniam VP,Strounina E,Sathish CI,Yamaura K,Cooper-White JJ,Vinu A

    更新日期：2016-02-25 00:00:00

  • Differentially expressed microRNAs between cattleyak and yak testis.

    abstract：:Cattleyak are interspecific hybrids between cattle and yak, exhibiting the same prominent adaptability as yak and much higher performances than yak. However, male infertility of cattleyak resulted from spermatogenic arrest has greatly restricted their effective utilization in yak breeding. In past decades, much work h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18607-0

    authors： Xu C,Wu S,Zhao W,Mipam T,Liu J,Liu W,Yi C,Shah MA,Yu S,Cai X

    更新日期：2018-01-12 00:00:00

  • Nutritional status of honey bee (Apis mellifera L.) workers across an agricultural land-use gradient.

    abstract：:Land use, habitat, and forage quality have emerged as critical factors influencing the health, productivity, and survival of honey bee colonies. However, characterization of the mechanistic relationship between differential land-use conditions and ultimate outcomes for honey bee colonies has been elusive. We assessed ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52485-y

    authors： Smart MD,Otto CRV,Lundgren JG

    更新日期：2019-11-07 00:00:00

  • Multiplexed detection of RNA using MERFISH and branched DNA amplification.

    abstract：:Multiplexed error-robust fluorescence in situ hybridization (MERFISH) allows simultaneous imaging of numerous RNA species in their native cellular environment and hence spatially resolved single-cell transcriptomic measurements. However, the relatively modest brightness of signals from single RNA molecules can become ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43943-8

    authors： Xia C,Babcock HP,Moffitt JR,Zhuang X

    更新日期：2019-05-22 00:00:00

  • Characterization of the GntR family regulator HpaR1 of the crucifer black rot pathogen Xanthomonas campestris pathovar campestris.

    abstract：:The GntR family transcription regulator HpaR1 identified from Xanthomonas campestris pv. campestris has been previously shown to positively regulate the genes responsible for hypersensitive reaction and pathogenicity and to autorepress its own expression. Here, we demonstrated that HpaR1 is a global regulator that pos...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19862

    authors： Su HZ,Wu L,Qi YH,Liu GF,Lu GT,Tang JL

    更新日期：2016-01-28 00:00:00

  • Heat Transport Compensation in Atmosphere and Ocean over the Past 22,000 Years.

    abstract：:The Earth's climate has experienced dramatic changes over the past 22,000 years; however, the total meridional heat transport (MHT) of the climate system remains stable. A 22,000-year-long simulation using an ocean-atmosphere coupled model shows that the changes in atmosphere and ocean MHT are significant but tend to ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16661

    authors： Yang H,Zhao Y,Liu Z,Li Q,He F,Zhang Q

    更新日期：2015-11-16 00:00:00

  • Transparent, flexible supercapacitors from nano-engineered carbon films.

    abstract：:Here we construct mechanically flexible and optically transparent thin film solid state supercapacitors by assembling nano-engineered carbon electrodes, prepared in porous templates, with morphology of interconnected arrays of complex shapes and porosity. The highly textured graphitic films act as electrode and curren...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00773

    authors： Jung HY,Karimi MB,Hahm MG,Ajayan PM,Jung YJ

    更新日期：2012-01-01 00:00:00

  • Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes.

    abstract：:Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrPC into misfolded and aggregating PrPSc is the central event in prion disease, an alternative hypothesis suggests ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39213-2

    authors： Czech A,Konarev PV,Goebel I,Svergun DI,Wills PR,Ignatova Z

    更新日期：2019-02-21 00:00:00

  • Dietary delphinidin inhibits human colorectal cancer metastasis associating with upregulation of miR-204-3p and suppression of the integrin/FAK axis.

    abstract：:Delphinidin is a flavonoid belonging to dietary anthocyanidin family that has been reported to possess diverse anti-tumoral activities. However, the effects of delphinidin on colorectal cancer (CRC) cells and the underlying mechanisms are not fully understood. Thus, we aimed to investigate the anti-cancer activity of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55505-z

    authors： Huang CC,Hung CH,Hung TW,Lin YC,Wang CJ,Kao SH

    更新日期：2019-12-12 00:00:00

  • Polarity-inverted lateral overgrowth and selective wet-etching and regrowth (PILOSWER) of GaN.

    abstract：:On an SiO2-patterned c-plane sapphire substrate, GaN domains were grown with their polarity controlled in accordance with the pattern. While N-polar GaN was grown on hexagonally arranged circular openings, Ga-polar GaN was laterally overgrown on mask regions due to polarity inversion occurring at the boundary of the c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22424-4

    authors： Jang D,Jue M,Kim D,Kim HS,Lee H,Kim C

    更新日期：2018-03-07 00:00:00

  • Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.

    abstract：:Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04375-4

    authors： Offenburger SL,Bensaddek D,Murillo AB,Lamond AI,Gartner A

    更新日期：2017-06-28 00:00:00

  • Rigorous formulation of space-charge wake function and impedance by solving the three-dimensional Poisson equation.

    abstract：:In typical numerical simulations, the space-charge force is calculated by slicing a beam into many longitudinal segments and by solving the two-dimensional Poisson equation in each segment. This method neglects longitudinal leakage of the space-charge force to nearby segments owing to its longitudinal spread over 1/γ....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30960-2

    authors： Shobuda Y,Chin YH

    更新日期：2018-08-24 00:00:00