Fluorometric assay for phenotypic differentiation of drug-resistant HIV mutants.

abstract：:Tobacco hairy root (HR) cultures, which have been widely used for the heterologous production of target compounds, have an innate capacity to bioconvert exogenous t-resveratrol (t-R) into t-piceatannol (t-Pn) and t-pterostilbene (t-Pt). We established genetically engineered HR carrying the gene encoding stilbene synth...

journal_title：Scientific reports

authors： Hidalgo D,Georgiev M,Marchev A,Bru-Martínez R,Cusido RM,Corchete P,Palazon J

更新日期：2017-12-21 00:00:00

abstract：:Staphylococcus aureus infection is a rising public health care threat. S. aureus is believed to have elaborate regulatory networks that orchestrate its virulence. Despite its importance, the systematic understanding of the transcriptional landscape of S. aureus is limited. Here, we describe the primary transcriptome l...

journal_title：Scientific reports

authors： Choe D,Szubin R,Dahesh S,Cho S,Nizet V,Palsson B,Cho BK

更新日期：2018-02-02 00:00:00

abstract：:Just as the topology of the Fermi surface defines the properties of the free electrons in metals and semiconductors, the geometry of the iso-frequency surface in the phase space of the propagating electromagnetic waves, determines the optical properties of the corresponding optical materials. Furthermore, in the direc...

journal_title：Scientific reports

authors： Ishii S,Narimanov E

更新日期：2015-12-16 00:00:00

abstract：:We examined whether blood lead levels (BLLs) were associated with reproductive hormone levels in a cross-sectional study using data from the SPECT-China study. We selected 2286 men and 1571 postmenopausal women without hormone replacement therapy. BLLs, blood cadmium, total testosterone (TT), oestradiol (E2), luteiniz...

journal_title：Scientific reports

authors： Chen C,Wang N,Zhai H,Nie X,Sun H,Han B,Li Q,Chen Y,Cheng J,Xia F,Zhao L,Zheng Y,Shen Z,Lu Y

更新日期：2016-11-29 00:00:00

abstract：:The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680SPRRAR↓SV687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target cells. The insertion is absent in other CoV-s of the same clade, includ...

journal_title：Scientific reports

authors： Örd M,Faustova I,Loog M

更新日期：2020-10-09 00:00:00

abstract：:Polarimetric imaging has proved its value in medical diagnostics, bionics, remote sensing, astronomy, and in many other wide fields. Pixel-level solid monolithically integrated polarimetric imaging photo-detectors are the trend for infrared polarimetric imaging devices. For better polarimetric imaging performance the ...

journal_title：Scientific reports

authors： Li Q,Li Z,Li N,Chen X,Chen P,Shen X,Lu W

更新日期：2014-09-11 00:00:00

abstract：:Ultrasonic mating signals in moths are argued to have evolved via exploitation of the receivers' sensory bias towards bat echolocation calls. We have demonstrated that female moths of the Asian corn borer are unable to distinguish between the male courtship song and bat calls. Females react to both the male song and b...

journal_title：Scientific reports

authors： Nakano R,Takanashi T,Surlykke A,Skals N,Ishikawa Y

更新日期：2013-01-01 00:00:00

abstract：:This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibe...

journal_title：Scientific reports

authors： Terao N,Koizumi H,Kojima K,Yamagishi T,Yamamoto Y,Yoshii K,Kitazawa K,Hiraga A,Toda M,Kinoshita S,Sotozono C,Hamuro J

更新日期：2018-07-12 00:00:00

abstract：:There are a number of psychological phenomena in which dramatic emotional responses are evoked by seemingly innocuous perceptual stimuli. A well known example is the 'uncanny valley' effect whereby a near human-looking artifact can trigger feelings of eeriness and repulsion. Although such phenomena are reasonably well...

journal_title：Scientific reports

authors： Moore RK

更新日期：2012-01-01 00:00:00

abstract：:Soil physical properties and soil organic carbon (SOC) are considered as important factors of soil quality. Arable land, grassland, and forest land coexist in the saline-alkali reclamation area of the Yellow River Delta (YRD), China. Such different land uses strongly influence the services of ecosystem to induce soil ...

journal_title：Scientific reports

authors： Jiao S,Li J,Li Y,Xu Z,Kong B,Li Y,Shen Y

更新日期：2020-11-23 00:00:00

abstract：:Accumulating evidence indicates the absence of paternally derived miRNAs, piwiRNAs, and proteins may be one important factor contributing to developmental failure in somatic cell cloned embryos. In the present study, we found microRNA-449b (miR-449b) was highly expressed in sperm. Target gene predictions and experimen...

journal_title：Scientific reports

authors： Wang M,Gao Y,Qu P,Qing S,Qiao F,Zhang Y,Mager J,Wang Y

更新日期：2017-10-17 00:00:00

abstract：:Immobilized preys are routinely used in agro-ecological exposure studies to quantify predation of pests under field conditions, but this method has not been validated. Our purpose was to determine the validity of using immobilized adults of the major rice pest Nilaparvata lugens, brown plant hopper (BPH), as sentinels...

journal_title：Scientific reports

authors： Zou Y,de Kraker J,Bianchi FJ,van Telgen MD,Xiao H,van der Werf W

更新日期：2017-02-17 00:00:00

abstract：:Long-term high-fat diet (HFD) consumption leads to not only obese-insulin resistance, but also impaired left ventricular (LV) function. Vagus nerve stimulation (VNS) has been shown to exert cardioprotection. However, its effects on the heart and metabolic parameters under obese-insulin resistant condition is not known...

journal_title：Scientific reports

authors： Samniang B,Shinlapawittayatorn K,Chunchai T,Pongkan W,Kumfu S,Chattipakorn SC,KenKnight BH,Chattipakorn N

更新日期：2016-02-01 00:00:00

abstract：:Plants respond to drought stress through the ABA dependent and independent pathways, which in turn modulate transcriptional regulatory hubs. Here, we employed Illumina RNA-Seq to analyze a total of 18 cDNA libraries from leaves, sap, and roots of papaya plants under drought stress. Reference and de novo transcriptomic...

journal_title：Scientific reports

authors： Gamboa-Tuz SD,Pereira-Santana A,Zamora-Briseño JA,Castano E,Espadas-Gil F,Ayala-Sumuano JT,Keb-Llanes MÁ,Sanchez-Teyer F,Rodríguez-Zapata LC

更新日期：2018-09-28 00:00:00

abstract：:Water Droplet Erosion (WDE) as a material degradation phenomenon has been a concern in power generation industries for decades. Steam turbine blades and the compressor blades of gas turbines that use water injection usually suffer from WDE. The present work focuses on studying erosion resistance of TiAl as a potential...

journal_title：Scientific reports

authors： Mahdipoor MS,Kirols HS,Kevorkov D,Jedrzejowski P,Medraj M

更新日期：2015-09-22 00:00:00

abstract：:The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic instability and increased DNA lesions. Here, we used a combination of molecular imaging and biochem...

journal_title：Scientific reports

authors： Gilmore BL,Liang Y,Winton CE,Patel K,Karageorge V,Varano AC,Dearnaley W,Sheng Z,Kelly DF

更新日期：2017-03-06 00:00:00

abstract：:We selected four Populus euphratica Oliv. forest plots (100 m × 100 m) in the upper reaches of the Tarim River in the Xinjiang Uygur Autonomous Region of China. Each of the four forest plots was chosen to represent a different growth and death stage of P. euphratica forest: juvenile forest, mature forest, dying forest...

journal_title：Scientific reports

authors： Miao N,Jiao P,Tao W,Li M,Li Z,Hu B,Moermond TC

更新日期：2020-02-21 00:00:00

abstract：:Despite major advances in targeted melanoma therapies, drug resistance limits their efficacy. Long noncoding RNAs (lncRNAs) are transcriptome elements that do not encode proteins but are important regulatory molecules. LncRNAs have been implicated in cancer development and response to different therapeutics and are th...

journal_title：Scientific reports

authors： Sanlorenzo M,Vujic I,Esteve-Puig R,Lai K,Vujic M,Lin K,Posch C,Dimon M,Moy A,Zekhtser M,Johnston K,Gho D,Ho W,Gajjala A,Oses Prieto J,Burlingame A,Daud A,Rappersberger K,Ortiz-Urda S

更新日期：2018-07-19 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer-related death worldwide. Although many molecular-targeted drugs for NSCLC have been developed in recent years, the 5-year survival rate of patients with NSCLC remains low. Therefore, an improved understanding of the molecular mechanisms underlying...

journal_title：Scientific reports

authors： Hirono T,Jingushi K,Nagata T,Sato M,Minami K,Aoki M,Takeda AH,Umehara T,Egawa H,Nakatsuji Y,Kitae K,Ueda Y,Hase H,Yamamoto M,Shinsato Y,Kawahara K,Furukawa T,Tsujikawa K

更新日期：2019-05-06 00:00:00

abstract：:Next generation sequencing panels have been developed for hereditary cancer, although there is some debate about their cost-effectiveness compared to exome sequencing. The performance of two panels is compared to exome sequencing. Twenty-four patients were selected: ten with identified mutations (control set) and four...

journal_title：Scientific reports

authors： Feliubadaló L,Tonda R,Gausachs M,Trotta JR,Castellanos E,López-Doriga A,Teulé À,Tornero E,Del Valle J,Gel B,Gut M,Pineda M,González S,Menéndez M,Navarro M,Capellá G,Gut I,Serra E,Brunet J,Beltran S,Lázaro C

更新日期：2017-01-04 00:00:00

abstract：:Modern flow cytometry instruments have become vital tools for high-throughput analysis of single cells. However, as issues with the cellular labeling techniques often used in flow cytometry have become more of a concern, the development of label-free modalities for cellular analysis is increasingly desired. Non-linear...

journal_title：Scientific reports

authors： Collier BB,Awasthi S,Lieu DK,Chan JW

更新日期：2015-05-29 00:00:00

abstract：:Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5'-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 path...

journal_title：Scientific reports

authors： Barile A,Nogués I,di Salvo ML,Bunik V,Contestabile R,Tramonti A

更新日期：2020-08-12 00:00:00

abstract：:Quantum phase transition is one of the most interesting aspects in quantum many-body systems. Recently, geometric quantum discord has been introduced to signature the critical behavior of various quantum systems. However, it is well-known that topological quantum phase transition can not be described by the convention...

journal_title：Scientific reports

authors： Shan CJ,Cheng WW,Liu JB,Cheng YS,Liu TK

更新日期：2014-03-26 00:00:00

abstract：:Spectrometers now offer the field strengths necessary to visualize mammalian cells but were not designed to accommodate imaging of live tissues. As such, spectrometers pose significant challenges--the most evident of which are spatial limitations--to conducting experiments in living tissue. This limitation becomes pro...

journal_title：Scientific reports

authors： Flint JJ,Menon K,Hansen B,Forder J,Blackband SJ

更新日期：2015-12-15 00:00:00

abstract：:Fire blight, caused by the enterobacterium Erwinia amylovora, is a destructive disease, which can affect most members of the Rosaceae family. Since no significant genomic differences have been found by others to explain differences in virulence, we used here a gel-based proteomic approach to elucidate mechanisms and k...

journal_title：Scientific reports

authors： Holtappels M,Noben JP,Van Dijck P,Valcke R

更新日期：2018-08-03 00:00:00

abstract：:Pathogenic meningococci have acquired a 24 kb capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and associated capsule transport genes flanked by repetitive Regions D and D'. Regions D and D' contain an intact gene encoding a UDP-galactose epimerase (galE1) and a truncated ...

journal_title：Scientific reports

authors： Bartley SN,Mowlaboccus S,Mullally CA,Stubbs KA,Vrielink A,Maiden MC,Harrison OB,Perkins TT,Kahler CM

更新日期：2017-03-14 00:00:00

abstract：:As an important online information retaining and processing function, working memory plays critical roles in many other cognitive functions. Several long-term factors, such as age, addiction and diseases, have been affirmed to impair working memory, but whether or how the short-term factors, like painful stimuli or em...

journal_title：Scientific reports

authors： Chen M,Wang YZ,Ma CC,Li QZ,Zhou H,Fu J,Yang QQ,Zhang YM,Liu Y,Cao JL

更新日期：2017-07-03 00:00:00

abstract：:We demonstrate fluorescent Fe embedded magnetic nanodiamonds by ion implantation and two-step annealing. The diamond characteristics with a highly ordered core and a graphite surface layer are maintained after the implantation process. After the two-step annealing process, a bright red fluorescence associated with nit...

journal_title：Scientific reports

authors： Lin BR,Kunuku S,Chen CH,Chen TY,Hsiao TY,Yu HK,Chang YJ,Liao LC,Niu H,Lee CP

更新日期：2019-02-04 00:00:00

abstract：:Patterns of temperature fluctuations in nature affect numerous biological processes, yet, empirical studies often utilize constant temperature treatments. This can limit our understanding of how thermally sensitive species respond to ecologically relevant temperatures. Research on turtles with temperature-dependent se...

journal_title：Scientific reports

authors： Carter AW,Sadd BM,Tuberville TD,Paitz RT,Bowden RM

更新日期：2018-01-08 00:00:00

abstract：:This study aimed to evaluate the application value of diffusion-weighted imaging (DWI) for assessing paradoxical puborectalis syndrome (PPS) in patients with obstructive defecation syndrome (ODS). The medical records of 72 ODS patients who underwent magnetic resonance (MR)-DWI and MR-defecography were retrospectively ...

journal_title：Scientific reports

authors： Liu G,Cui Z,Dai Y,Yao Q,Xu J,Wu G

更新日期：2017-06-07 00:00:00