Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.

abstract：:Night shift work can associate with an increased risk for depression. As night workers experience a 'misalignment' between their circadian system and daily sleep-wake behaviors, with negative health consequences, we investigated whether exposure to circadian misalignment underpins mood vulnerability in simulated shift...

journal_title：Scientific reports

authors： Chellappa SL,Morris CJ,Scheer FAJL

更新日期：2020-10-29 00:00:00

abstract：:Visual evoked potential-based brain-computer interfaces (BCIs) have been widely investigated because of their easy system configuration and high information transfer rate (ITR). However, the uncomfortable flicker or brightness modulation of existing methods restricts the practical interactivity of BCI applications. In...

journal_title：Scientific reports

authors： Han C,Xu G,Xie J,Chen C,Zhang S

更新日期：2018-04-11 00:00:00

abstract：:Development of artificial materials for the facilitation of cartilage regeneration remains an important challenge in orthopedic practice. Our study investigates the potential for neocartilage formation within a synthetic polyester scaffold based on the polymerization of high internal phase emulsions. The fabrication o...

journal_title：Scientific reports

authors： Naranda J,Sušec M,Maver U,Gradišnik L,Gorenjak M,Vukasović A,Ivković A,Rupnik MS,Vogrin M,Krajnc P

更新日期：2016-06-24 00:00:00

abstract：:Replacing precious and nondurable Pt catalysts with cheap materials is a key issue for commercialization of fuel cells. In the case of oxygen reduction reaction (ORR) catalysts for direct methanol fuel cell (DMFC), the methanol tolerance is also an important concern. Here, we develop AlN nanowires with diameters of ab...

journal_title：Scientific reports

authors： Lei M,Wang J,Li JR,Wang YG,Tang HL,Wang WJ

更新日期：2014-08-11 00:00:00

abstract：:There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...

journal_title：Scientific reports

authors： Melli M,West M,Hickman S,Dhuey S,Lin D,Khorasaninejad M,Chang C,Jolly S,Tae H,Poliakov E,St Hilaire P,Cabrini S,Peroz C,Klug M

更新日期：2020-11-26 00:00:00

abstract：:While the worldwide standardization of agricultural production has been advocated and recommended, relatively little research has focused on the ecological significance of such a shift. The ecological concerns stemming from the standardization of agricultural production may require new methodology. In this study, we c...

journal_title：Scientific reports

authors： Wan NF,Zhang MY,Jiang JX,Ji XY,Hao-Zhang

更新日期：2016-02-22 00:00:00

abstract：:The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an ...

journal_title：Scientific reports

authors： Zhang Y,El-Far M,Dupuy FP,Abdel-Hakeem MS,He Z,Procopio FA,Shi Y,Haddad EK,Ancuta P,Sekaly RP,Said EA

更新日期：2016-07-07 00:00:00

abstract：:A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS mice recapitulate craniofacial abnormalities and upper airway ob...

journal_title：Scientific reports

authors： Takahashi T,Sakai N,Iwasaki T,Doyle TC,Mobley WC,Nishino S

更新日期：2020-12-07 00:00:00

abstract：:The bulk-insulating topological insulators with tunable surface states are necessary for applications in spintronics and quantum computation. Here we present theoretical evidence for modulating the topological surface states and achieving the insulating bulk states in solid-solution (Bi(1-x)Sb(x))(2)Te(3). Our results...

journal_title：Scientific reports

authors： Niu C,Dai Y,Zhu Y,Ma Y,Yu L,Han S,Huang B

更新日期：2012-01-01 00:00:00

abstract：:Core-shell nanoparticles often exhibit improved catalytic properties due to the lattice strain created in these core-shell particles. Herein, we demonstrate the synthesis of core-shell Au@Pd nanoparticles from their core-shell Au@Ag/Pd parents. This strategy begins with the preparation of core-shell Au@Ag nanoparticle...

journal_title：Scientific reports

authors： Chen D,Li C,Liu H,Ye F,Yang J

更新日期：2015-07-06 00:00:00

abstract：:The optical gain and spontaneous emission characteristics of low In-content AlInN-delta-GaN quantum wells (QWs) are analyzed for deep ultraviolet (UV) light emitting diodes (LEDs) and lasers. Our analysis shows a large increase in the dominant transverse electric (TE) polarized spontaneous emission rate and optical ga...

journal_title：Scientific reports

authors： Tan CK,Sun W,Borovac D,Tansu N

更新日期：2016-03-10 00:00:00

abstract：:Smoking aggravates HIV-1 pathogenesis and leads to decreased responses to antiretroviral therapy. In this study, we aim to find a molecular mechanism that would explain smoking-induced HIV-1 replication. Benzo(a)pyrene (BaP), a major carcinogen in cigarette, requires metabolic activation through cytochrome P450s (CYPs...

journal_title：Scientific reports

authors： Ranjit S,Sinha N,Kodidela S,Kumar S

更新日期：2018-07-10 00:00:00

abstract：:Both heart rate (HR) and brain functioning involve the integrated output of a multitude of regulatory mechanisms, that are not quantified adequately by linear approximations such as means and standard deviations. It was therefore considered whether non-linear measures of HR complexity are more strongly associated with...

journal_title：Scientific reports

authors： Young H,Benton D

更新日期：2015-11-13 00:00:00

abstract：:Capacitive, inductive and resistive loads of an ion-trap system, which can be modelled as LCR circuits, are important to know for building a high accuracy experiment. Accurate estimation of these loads is necessary for delivering the desired radio frequency (RF) signal to an ion trap via an RF resonator. Of particular...

journal_title：Scientific reports

authors： Sharma L,Roy A,Panja S,Ojha VN,De S

更新日期：2018-11-15 00:00:00

abstract：:Mouse models have contributed to the bulk of knowledge on Systemic Lupus Erythematosus (SLE). Nevertheless, substantial differences exist between human and mouse immune system. We aimed to establish and characterise a SLE model mediated by human immune system. Injection of pristane into immunodeficient mice reconstitu...

journal_title：Scientific reports

authors： Gunawan M,Her Z,Liu M,Tan SY,Chan XY,Tan WWS,Dharmaraaja S,Fan Y,Ong CB,Loh E,Chang KTE,Tan TC,Chan JKY,Chen Q

更新日期：2017-11-30 00:00:00

abstract：:Panax ginseng (GS) and Veratrum nigrum (VN) are representative of incompatible pairs in "eighteen antagonistic medicaments" that have been recorded in the Chinese medicinal literature for over 2,000 years. However, evidence linking interference effects with combination use is scare. Based on the estrogen-like effect o...

journal_title：Scientific reports

authors： Xu Y,Ding J,An JN,Qu YK,Li X,Ma XP,Zhang YM,Dai GJ,Lin N

更新日期：2016-05-27 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) and genes associated with susceptibility to hepatitis B virus (HBV) infection that have been identified by genome-wide association studies explain only a limited portion of the known heritability, indicating more genetic variants remain to be discovered. In this study, we adopted...

journal_title：Scientific reports

authors： Jiang X,Zhang B,Zhao J,Xu Y,Han H,Su K,Tao J,Fan R,Zhao X,Li L,Li MD

更新日期：2019-09-17 00:00:00

abstract：:Although the clinical importance of extragraft bone formation (ExGBF) and bridging (ExGBB) has been reported, few studies have investigated the biomechanical influences of ExGBF on the motion segment. In this study, ExGBF was simulated at the C5-C6 motion segment after anterior cervical discectomy and fusion using a d...

journal_title：Scientific reports

authors： Park WM,Jin YJ

更新日期：2019-12-11 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve hMSCs survival may be of high relevance in tissue engineering. Carnitine palmitoyltransferase 1 C (CPT1C) is a pseudoenz...

journal_title：Scientific reports

authors： Roa-Mansergas X,Fadó R,Atari M,Mir JF,Muley H,Serra D,Casals N

更新日期：2018-05-03 00:00:00

abstract：:Recent research in filamentous fungi has revealed that the motility of an endocytic organelle early endosome (EE) has a versatile role in many physiological functions. Here, to further examine the motility of EEs in the industrially important fungus Aspergillus oryzae, we visualized these organelles via the Rab5 homol...

journal_title：Scientific reports

authors： Togo Y,Higuchi Y,Katakura Y,Takegawa K

更新日期：2017-11-17 00:00:00

abstract：:Regret results from comparing non-optimal outcomes containing both gain and loss parts to better alternatives during decision-making. The present fMRI study aimed to explore whether levels of regret could change when gain or loss part of a non-optimal outcome was focused during a sequential risk taking task, i.e. the ...

journal_title：Scientific reports

authors： Liu Z,Li L,Zheng L,Xu M,Zhou FA,Guo X

更新日期：2017-02-01 00:00:00

abstract：:At 50 kg in estimated weight, the extinct Siamogale melilutra is larger than all living otters, and ranks among the largest fossil otters. The biomechanical capability of S. melilutra jaws as related to their large size is unknown but crucial to reconstructing the species' potentially unique ecological niche. Here we ...

journal_title：Scientific reports

authors： Tseng ZJ,Su DF,Wang X,White SC,Ji X

更新日期：2017-11-09 00:00:00

abstract：:Patients with schizophrenia have a higher risk for cardiovascular disease (CVD) than the general population. Research has suggested that autonomic imbalance is a common pathway to increased morbidity and mortality for CVD. Heart rate variability (HRV) analysis is a non-invasive method that assesses autonomic imbalance...

journal_title：Scientific reports

authors： Wang J,Liu YS,Zhu WX,Zhang FQ,Zhou ZH

更新日期：2014-12-09 00:00:00

abstract：:The development of high energy-density lithium-ion secondary batteries as storage batteries in vehicles is attracting increasing attention. In this study, high-voltage bipolar stacked batteries with a quasi-solid-state electrolyte containing a Li-Glyme complex were prepared, and the performance of the device was evalu...

journal_title：Scientific reports

authors： Gambe Y,Sun Y,Honma I

更新日期：2015-03-09 00:00:00

abstract：:Pigment organelles known as melanosomes disperse or aggregate in a melanophore in response to hormones. These movements are mediated by the microtubule motors kinesin-2 and cytoplasmic dynein. However, the force generation mechanism of dynein, unlike that of kinesin, is not well understood. In this study, to address t...

journal_title：Scientific reports

authors： Hasegawa S,Sagawa T,Ikeda K,Okada Y,Hayashi K

更新日期：2019-03-25 00:00:00

abstract：:Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cell-VEGFA with short-...

journal_title：Scientific reports

authors： Becker S,Wang H,Simmons AB,Suwanmanee T,Stoddard GJ,Kafri T,Hartnett ME

更新日期：2018-01-31 00:00:00

abstract：:Bronchoconstrictive airway disorders such as asthma are characterized by inflammation and increases in reactive oxygen species (ROS), which produce a highly oxidative environment. β2-adrenergic receptor (β2AR) agonists are a mainstay of clinical therapy for asthma and provide bronchorelaxation upon inhalation. We have...

journal_title：Scientific reports

authors： Rambacher KM,Moniri NH

更新日期：2020-02-19 00:00:00

abstract：:Three dimensional (3D) co-cultures to mimic cellular dynamics have brought significant impacts in tissue engineering approaches for biomedical research. Herein, we present a novel sample holder combined with time-lapse fluorescence imaging technique, referred as 4D live cell imaging, allowing direct visualization of v...

journal_title：Scientific reports

authors： Septiadi D,Bourquin J,Durantie E,Petri-Fink A,Rothen-Rutishauser B

更新日期：2018-06-29 00:00:00

abstract：:With the great development of sequencing technologies and systematic methods, our understanding of evolutionary relationships at deeper levels within the tree of life has greatly improved over the last decade. However, the current taxonomic methodology is insufficient to describe the growing levels of diversity in bot...

journal_title：Scientific reports

authors： Wu HY,Wang YH,Xie Q,Ke YL,Bu WJ

更新日期：2016-06-17 00:00:00

abstract：:Women who have previously had an induced abortion (IA) before their first birth have been associated with preterm birth (PTB). However, previous studies on the PTB are inconsistent. Therefore, the aim of this study was to clarify the association between IA and PTB and low birth weight (LBW) for first-time mothers. A t...

journal_title：Scientific reports

authors： Ke L,Lin W,Liu Y,Ou W,Lin Z

更新日期：2018-03-29 00:00:00