Abstract：
:Dorso-ventral (DV) countershading is a highly-conserved pigmentary adaptation in vertebrates. In mammals, spatially regulated expression of agouti-signaling protein (ASIP) generates the difference in shading by driving a switch between the production of chemically-distinct melanins in melanocytes in dorsal and ventral regions. In contrast, fish countershading seemed to result from a patterned DV distribution of differently-coloured cell-types (chromatophores). Despite the cellular differences in the basis for counter-shading, previous observations suggested that Agouti signaling likely played a role in this patterning process in fish. To test the hypotheses that Agouti regulated counter-shading in fish, and that this depended upon spatial regulation of the numbers of each chromatophore type, we engineered asip1 homozygous knockout mutant zebrafish. We show that loss-of-function asip1 mutants lose DV countershading, and that this results from changed numbers of multiple pigment cell-types in the skin and on scales. Our findings identify asip1 as key in the establishment of DV countershading in fish, but show that the cellular mechanism for translating a conserved signaling gradient into a conserved pigmentary phenotype has been radically altered in the course of evolution.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cal L,Suarez-Bregua P,Comesaña P,Owen J,Braasch I,Kelsh R,Cerdá-Reverter JM,Rotllant Jdoi
10.1038/s41598-019-40251-zsubject
Has Abstractpub_date
2019-03-05 00:00:00pages
3449issue
1issn
2045-2322pii
10.1038/s41598-019-40251-zjournal_volume
9pub_type
杂志文章abstract：:Recently, graphene nanomesh (GNM) has attracted great attentions due to its unique porous structure, abundant active sites, finite band gap and possesses potential applications in the fields of electronics, gas sensor/storage, catalysis, etc. Therefore, diverse GNMs with different physical and chemical properties are ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32310
更新日期：2016-08-26 00:00:00
abstract：:Transparent anti-fogging and self-cleaning coatings are of great interest for many applications, including solar panels, windshields and displays or lenses to be used in humid environments. In this paper, we report on the simultaneous synthesis, at atmospheric pressure, of anatase TiO2 nanoparticles and low-temperatur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27526-7
更新日期：2018-06-25 00:00:00
abstract：:Amino acid biosynthesis pathways observed in nature typically require enzymes that are made with the amino acids they produce. For example, Escherichia coli produces cysteine from serine via two enzymes that contain cysteine: serine acetyltransferase (CysE) and O-acetylserine sulfhydrylase (CysK/CysM). To solve this c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19920-y
更新日期：2018-01-29 00:00:00
abstract：:Precisely controlling the protein-nanomaterial interactions at selective sites is crucial in engineering biomolecule composite architectures with tailored nanostructures and functions for a variety of biomedical applications. This strategy, however, is only beginning to be explored. Here, we demonstrate the facet-spec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05084
更新日期：2014-05-28 00:00:00
abstract：:The dependency property and self-recovery of failure nodes both have great effects on the robustness of networks during the cascading process. Existing investigations focused mainly on the failure mechanism of static dependency groups without considering the time-dependency of interdependent nodes and the recovery mec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37749
更新日期：2016-11-28 00:00:00
abstract：:Effective promotion of air filtration applications proposed for fibers requires their real nanoscale diameter, optimized pore structure, and high service strength; however, creating such filter medium has proved to be a tremendous challenge. This study first establishes a strategy to design and fabricate novel poly(m-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40550
更新日期：2017-01-11 00:00:00
abstract：:The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The results showed that Ac-MPS have potential ability to relieve the hypertriglyceridemia and preventing oxidative...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35706-8
更新日期：2018-11-30 00:00:00
abstract：:In crystalline metals at small scales, the dislocation density will be increased by stochastic events of dislocation network, leading to a universal power law for various material structures. In this work, we develop a model obeyed by a probability distribution of dislocation density to describe the dislocation format...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39242
更新日期：2016-12-15 00:00:00
abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05510
更新日期：2014-07-01 00:00:00
abstract：:Gadoxetic acid (Gd-EOB-DTPA) is a paramagnetic MRI contrast agent with raising popularity and has been used for evaluation of imaging-based liver function in recent years. In order to verify whether liver function as determined by real-time breath analysis using the intravenous administration of 13C-methacetin can be ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27401-5
更新日期：2018-06-13 00:00:00
abstract：:Both between- and within-individual variation in behaviour can be important in determining mating opportunities and reproductive outcomes. Such behavioural variability can be induced by environmental conditions, especially if individuals vary in their tolerance levels or resource allocation patterns. We tested the eff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27651-3
更新日期：2018-06-19 00:00:00
abstract：:Asbestos is a potent carcinogen associated with malignant mesothelioma and lung cancer but its carcinogenic mechanisms are still poorly understood. Asbestos toxicity is ascribed to its particular physico-chemical characteristics, and one of them is the presence of and ability to adsorb iron, which may cause an alterat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01123
更新日期：2013-01-01 00:00:00
abstract：:Photoacoustic tomography (PAT) offers three-dimensional (3D) structural and functional imaging of living biological tissue with label-free, optical absorption contrast. These attributes lend PAT imaging to a wide variety of applications in clinical medicine and preclinical research. Despite advances in live animal ima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01113
更新日期：2013-01-01 00:00:00
abstract：:We focus on the impacts of technological spillovers and environmental awareness in a two-echelon supply chain with one-single supplier and one-single manufacturer to reduce carbon emission. In this supply chain, carbon abatement investment becomes one of key factors of cutting costs and improving profits, which is red...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03270-2
更新日期：2017-06-08 00:00:00
abstract：:For over 60 years, our oceans have been a reservoir for exponentially increasing amounts of plastic waste. Plastic has been documented at all levels of the marine food web, from the deepest oceanic trenches to the most far-flung beaches. Here, we present data on the presence of significant quantities of plastic on the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43375-4
更新日期：2019-05-16 00:00:00
abstract：:Electrohydrodynamic (EHD) jet printing has a variety of benefits compared to conventional inkjet techniques, such as high resolution and the ability to work with high-viscosity pastes. In this work, Ag nanoparticles with 4000 cPs were chosen because they are printable on various substrates for electronic devices. The ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45504-5
更新日期：2019-06-24 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-64153-7
更新日期：2020-04-29 00:00:00
abstract：:Given a reaction-diffusion system interacting via a complex network, we propose two different techniques to modify the network topology while preserving its dynamical behaviour. In the region of parameters where the homogeneous solution gets spontaneously destabilized, perturbations grow along the unstable directions ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34372-0
更新日期：2018-11-01 00:00:00
abstract：:Large spin splitting at Rashba interface, giving rise to strong spin-momentum locking, is essential for efficient spin-to-charge conversion. Recently, a Cu/Bismuth oxide (Bi2O3) interface has been found to exhibit an efficient spin-to-charge conversion similar to a Ag/Bi interface with large Rashba spin splitting. How...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23787-4
更新日期：2018-04-03 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-018-20340-1
更新日期：2018-01-23 00:00:00
abstract：:Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we dem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27473
更新日期：2016-06-07 00:00:00
abstract：:The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14562
更新日期：2015-10-01 00:00:00
abstract：:Enhanced carotid body (CB) chemoreflex function is strongly related to cardiorespiratory disorders and disease progression in heart failure (HF). The mechanisms underlying CB sensitization during HF are not fully understood, however previous work indicates blood flow per se can affect CB function. Then, we hypothesize...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08142-3
更新日期：2017-08-14 00:00:00
abstract：:Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in ferrimagnetic and ferromagnetic materials of various structures strongly imply a general phenomenon of fundamental atom-laser interaction. Rotating an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41294
更新日期：2017-01-24 00:00:00
abstract：:Gold nanoparticles have particular properties distinct from those of bulk gold crystals, and such nanoparticles are used in various applications in optics, catalysis, and drug delivery. Many reports on microbial synthesis of gold nanoparticles have appeared. However, the molecular details (reduction and dispersion) of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34626
更新日期：2016-10-11 00:00:00
abstract：:Mediterranean Sea ecosystems are considered as hotspots of biological introductions, exposed to possible negative effects of non-indigenous species. In such temperate marine ecosystems, macroalgae may be dominant, with a great percentage of their diversity represented by introduced species. Their interaction with temp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42625
更新日期：2017-02-20 00:00:00
abstract：:First-generation adenovirus vectors (FG AdVs) are widely used in basic studies and gene therapy. However, virus-associated (VA) RNAs that act as small-interference RNAs are indeed transcribed from the vector genome. These VA RNAs can trigger the innate immune response. Moreover, VA RNAs are processed to functional vir...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01136
更新日期：2013-01-01 00:00:00
abstract：:In day-to-day life, humans usually perceive the location of sound sources as outside their heads. This externalized auditory spatial perception can be reproduced through headphones by recreating the sound pressure generated by the source at the listener's eardrums. This requires the acoustical features of the recordin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37342
更新日期：2016-11-17 00:00:00
abstract：:Existing understanding of molecular composition of sputum and its role in tuberculosis patients is variously limited to its diagnostic potential. We sought to identify infection induced sputum proteome alteration in active/non tuberculosis patients (A/NTB) and their role in altered lung patho-physiology. Out of the st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37662-9
更新日期：2019-01-31 00:00:00
abstract：:TiNb6O17 and TiNb2O7 were synthesized using a solid-state method. The techniques were used to assess the electrochemical performance and lithium diffusion kinetics of TiNb6O17 related to the unit cell volume with TiNb2O7. The charge-discharge curves and cyclic voltammetry revealed TiNb6O17 to have a similar redox pote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16711-9
更新日期：2017-11-30 00:00:00
