Abstract:
:Enhanced carotid body (CB) chemoreflex function is strongly related to cardiorespiratory disorders and disease progression in heart failure (HF). The mechanisms underlying CB sensitization during HF are not fully understood, however previous work indicates blood flow per se can affect CB function. Then, we hypothesized that the CB-mediated chemoreflex drive will be enhanced only in low output HF but not in high output HF. Myocardial infarcted rats and aorto-caval fistulated rats were used as a low output HF model (MI-CHF) and as a high output HF model (AV-CHF), respectively. Blood flow supply to the CB region was decreased only in MI-CHF rats compared to Sham and AV-CHF rats. MI-CHF rats exhibited a significantly enhanced hypoxic ventilatory response compared to AV-CHF rats. However, apnea/hypopnea incidence was similarly increased in both MI-CHF and AV-CHF rats compared to control. Kruppel-like factor 2 expression, a flow sensitive transcription factor, was reduced in the CBs of MI-CHF rats but not in AV-CHF rats. Our results indicate that in the setting of HF, potentiation of the CB chemoreflex is strongly associated with a reduction in cardiac output and may not be related to other pathophysiological consequences of HF.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Del Rio R,Andrade DC,Toledo C,Diaz HS,Lucero C,Arce-Alvarez A,Marcus NJ,Schultz HDdoi
10.1038/s41598-017-08142-3subject
Has Abstractpub_date
2017-08-14 00:00:00pages
8035issue
1issn
2045-2322pii
10.1038/s41598-017-08142-3journal_volume
7pub_type
杂志文章abstract::The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a systematic investigation of birth season dependencies among pets and spec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25199-w
更新日期:2018-05-17 00:00:00
abstract::Breast cancer is a major cause of cancer mortality worldwide. Fascin-1 (FSCN1) is an actin-binding protein found in mammalian cells, including endothelial, neuronal and mesenchymal cells. FSCN1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the associatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16196-6
更新日期:2017-11-21 00:00:00
abstract::The number of magnetoelectric multiferroic materials reported to date is scarce, as magnetic structures that break inversion symmetry and induce an improper ferroelectric polarization typically arise through subtle competition between different magnetic interactions. The (NH4)2[FeCl5(H2O)] compound is a rare case wher...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14475
更新日期:2015-09-29 00:00:00
abstract::Untreated pathological cardiac hypertrophy, which can be caused by sustained systemic hypertension, may lead to heart failure. In the present study, we investigated whether AS-1 had attenuating effects on hypertension-induced cardiac hypertrophy, and whether this process was mediated by the regulation of miRNA-143. To...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42936-x
更新日期:2019-04-23 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-48627-x
更新日期:2019-08-28 00:00:00
abstract::Hand, foot and mouth disease (HFMD) is a substantial burden throughout Asia, but the effects of temperature pattern on HFMD risk are inconsistent. To quantify the effect of temperature on HFMD incidence, Wuhan was chosen as the study site because of its high temperature variability and high HFMD incidence. Daily serie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20318-z
更新日期:2018-01-31 00:00:00
abstract::Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. However, direct evidence regarding its involvement in cartilage development remains elusive. In this report, we establish an in vivo role of Esrra in cartilage development during embryogenesis in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18011
更新日期:2015-12-10 00:00:00
abstract::Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. However the utility of BRET is limited by the requirement that the fusion protei...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03486-2
更新日期:2017-06-09 00:00:00
abstract::Pinus pinaster bark, an abundant by-product from the timber industry, has been studied as a potential low-cost adsorbent for the removal of Congo red (CR) dye from wastewaters. Surface morphological and physico-chemical characteristics of pine bark were analysed using Fourier transform infrared (FTIR) spectroscopy, sc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53046-z
更新日期:2019-11-11 00:00:00
abstract::Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31198
更新日期:2016-08-09 00:00:00
abstract::The increasing antibiotic resistance evolved by Helicobacter pylori has alarmingly reduced the eradication rates of first-line therapies. To overcome the current circulating resistome, we selected a novel potential therapeutic target in order to identify new candidate drugs for treating H. pylori infection. We screene...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47746-9
更新日期:2019-08-05 00:00:00
abstract::Urinary concentrations of the major progesterone (P4) metabolite pregnanediol-3-glucuronide (PDG) are used to confirm ovulation. We aimed to determine whether automated immunoassay of urinary P4 was as efficacious as PDG to confirm ovulation. Daily urine samples from 20 cycles in 14 healthy women in whom ovulation was...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36051-6
更新日期:2018-12-04 00:00:00
abstract::Intercellular adhesion plays a major role in tissue development and homeostasis. Yet, technologies to measure mature cell-cell contacts are not available. We introduce a methodology based on fluidic probe force microscopy to assess cell-cell adhesion forces after formation of mature intercellular contacts in cell mono...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46152
更新日期:2017-04-10 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-40320-3
更新日期:2019-03-12 00:00:00
abstract::Layered Sn-based chalcogenides and heterostructures are widely used in batteries and photocatalysis, but its utilizations in a supercapacitor is limited by its structural instability and low conductivity. Here, SnSx thin films are directly and conformally deposited on a three-dimensional (3D) Ni-foam (NF) substrate by...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46679-7
更新日期:2019-07-15 00:00:00
abstract::p53 is a representative transcription factor that activates multiple target genes. To realize stimulus-dependent specificities, p53 has to recognize targets with structural variety, of which molecular mechanisms are largely unknown. Here, we conducted a series of long-time scale (totally more than 100-ms) coarse-grain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17107
更新日期:2015-11-24 00:00:00
abstract::Metallic silver nickel oxide honeycomb nanoarrays were synthesized via a surfactant-assisted hydrothermal route. The crystal structure of the Ag/NiO nanoarrays was confirmed by X-ray diffraction. X-ray photoelectron spectroscopy confirmed the valance state of the nickel, oxygen, and metallic silver. The morphological ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41446-0
更新日期:2019-03-19 00:00:00
abstract::In this study, 111 Cryptosporidium parvum IId isolates from several species of animals in China, Sweden, and Egypt were subtyped by multilocus sequence typing (MLST). One to eleven subtypes were detected at each of the 12 microsatellite, minisatellite, and single nucleotide polymorphism (SNP) loci, forming 25 MLST sub...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04208
更新日期:2014-02-27 00:00:00
abstract::To determine whether regular cervical dilatation is effective for preventing cervical stenosis, and to identify the associated risk factors, in postmenopausal women after LEEP. This was a prospective randomized clinical trial in postmenopausal women who underwent LEEP at our hospital between August 2018 and May 2019. ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-65170-2
更新日期:2020-05-22 00:00:00
abstract::Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-020-58459-9
更新日期:2020-01-31 00:00:00
abstract::Paeonia ostii, a member of tree peony, is an emerging oil crop with important medical and oil uses and widely cultivated in China. Dissolving the genetic diversity and domestication history of this species is important for further genetic improvements and deployments. We firstly selected 29 simple sequence repeats (SS...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04744-z
更新日期:2017-07-13 00:00:00
abstract::Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31-5...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25670-8
更新日期:2018-05-08 00:00:00
abstract::Medication-related osteonecrosis of the jaw (MRONJ) represents a complication of bisphosphonate treatment that responds poorly to standard treatment. In a retrospective cohort study we investigated a possible role of Actinomyces spp. in the pathogenesis of MRONJ. Deep biopsies of necrotic bone were collected during su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31604
更新日期:2016-08-17 00:00:00
abstract::CD8+ T cells directed against beta cell autoantigens are considered relevant for the pathogenesis of type 1 diabetes. Using single cell T cell receptor sequencing of CD8+ T cells specific for the IGRP265-273 epitope, we examined whether there was expansion of clonotypes and sharing of T cell receptor chains in autorea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44661
更新日期:2017-03-16 00:00:00
abstract::Lonicera japonica Thunb, rich in chlorogenic acid (CHA), is used for viral upper respiratory tract infection treatment caused by influenza virus, parainfluenza virus, and respiratory syncytial virus, ect in China. It was reported that CHA reduced serum hepatitis B virus level and death rate of influenza virus-infected...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45723
更新日期:2017-04-10 00:00:00
abstract::Drugs of abuse represent a growing public health crisis. Accumulating evidence indicates that gabapentin (GBP), a prescription drug, is prone to misuse, abuse, withdrawal, and dependence. Commonly, drugs of abuse modulate the dopaminergic system to induce addiction. In this study, we used the conditioned place prefere...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67318-6
更新日期:2020-06-26 00:00:00
abstract::The concept of brain circuit disorders has been proposed for a variety of neuropsychiatric diseases, characterized by pathological disturbances of neuronal networks including changes in oscillatory signaling of re-entrant cortico-subcortical loops in the basal ganglia system. Parts of this circuitry play a pivotal rol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15872-x
更新日期:2017-11-14 00:00:00
abstract::Microbeam radiation therapy is a novel preclinical technique, which uses synchrotron-generated X-rays for the treatment of brain tumours and drug-resistant epilepsies. In order to safely translate this approach to humans, a more in-depth knowledge of the long-term radiobiology of microbeams in healthy tissues is requi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14757-3
更新日期:2017-10-30 00:00:00
abstract::Aldosterone and the Mineralocorticoid Receptor (MR) control hydroelectrolytic homeostasis and alterations of mineralocorticoid signaling pathway are involved in the pathogenesis of numerous human diseases, justifying the need to decipher molecular events controlling MR expression level. Here, we show in renal cells th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04838-8
更新日期:2017-07-06 00:00:00
abstract::Tropopause temperatures (TPTs) control the amount of stratospheric water vapour, which influences chemistry, radiation and circulation in the stratosphere, and is also an important driver of surface climate. Decadal variability and long-term trends in tropical TPTs as well as stratospheric water vapour are largely unk...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29537
更新日期:2016-07-12 00:00:00