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Hepatobiliary MRI: Signal intensity based assessment of liver function correlated to 13C-Methacetin breath test.

Abstract：

:Gadoxetic acid (Gd-EOB-DTPA) is a paramagnetic MRI contrast agent with raising popularity and has been used for evaluation of imaging-based liver function in recent years. In order to verify whether liver function as determined by real-time breath analysis using the intravenous administration of 13C-methacetin can be estimated quantitatively from Gd-EOB-DTPA-enhanced MRI using signal intensity (SI) values. 110 patients underwent Gd-EOB-DTPA-enhanced 3-T MRI and, for the evaluation of liver function, a 13C-methacetin breath test (13C-MBT). SI values from before (SIpre) and 20 min after (SIpost) contrast media injection were acquired by T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat suppression. The relative enhancement (RE) between the plain and contrast-enhanced SI values was calculated and evaluated in a correlation analysis of 13C-MBT values to SIpost and RE to obtain a SI-based estimation of 13C-MBT values. The simple regression model showed a log-linear correlation of 13C-MBT values with SIpost and RE (p < 0.001). Stratified by 3 different categories of 13C-MBT readouts, there was a constant significant decrease in both SIpost (p ≤ 0.002) and RE (p ≤ 0.033) with increasing liver disease progression as assessed by the 13C-MBT. Liver function as determined using real-time 13C-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MRI using SI-based indices.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Haimerl M,Probst U,Poelsterl S,Beyer L,Fellner C,Selgrad M,Hornung M,Stroszczynski C,Wiggermann P

doi

10.1038/s41598-018-27401-5

subject

Has Abstract

pub_date

2018-06-13 00:00:00

pages

9078

issue

1

issn

2045-2322

pii

10.1038/s41598-018-27401-5

journal_volume

8

pub_type

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