Synergistic combination of two antimicrobial agents closing each other's mutant selection windows to prevent antimicrobial resistance.

abstract：:Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and Epi...

journal_title：Scientific reports

authors： Pecori F,Yokota I,Hanamatsu H,Miura T,Ogura C,Ota H,Furukawa JI,Oki S,Yamamoto K,Yoshie O,Nishihara S

更新日期：2021-01-14 00:00:00

abstract：:Our mind's eye and the role of internal attention in mental life and suffering has intrigued scholars for centuries. Yet, experimental study of internal attention has been elusive due to our limited capacity to control the timing and content of internal stimuli. We thus developed the Simulated Thoughts Paradigm (STP) ...

journal_title：Scientific reports

authors： Amir I,Ruimi L,Bernstein A

更新日期：2021-01-26 00:00:00

abstract：:Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as...

journal_title：Scientific reports

authors： Pletsch-Borba L,Grafetstätter M,Hüsing A,González Maldonado S,Kloss M,Groß ML,Johnson T,Sookthai D,Bugert P,Kaaks R,Kühn T

更新日期：2019-02-28 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) is an important foodborne pathogen. The increasing incidence of non-O157 STEC has posed a great risk to public health. Besides the Shiga toxin (Stx), the adherence factor, intimin, coded by eae gene plays a critical role in STEC pathogenesis. In this study, we investigated...

journal_title：Scientific reports

authors： Yang X,Sun H,Fan R,Fu S,Zhang J,Matussek A,Xiong Y,Bai X

更新日期：2020-02-24 00:00:00

abstract：:There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two species of Cryptococcus have differences in pathogenicity, diagnosis,...

journal_title：Scientific reports

authors： Hu S,Gu F,Chen M,Wang C,Li J,Yang J,Wang G,Zhou Z,Yang Y

更新日期：2020-07-27 00:00:00

abstract：:Schizophrenia is a common neuropsychiatric disorder with a lifetime risk of 1%. Accumulation of common polygenic variations has been found to be an important risk factor. Recent studies showed a role for the enrichment of minor alleles (MAs) of SNPs in complex diseases such as Parkinson's disease. Here we similarly st...

journal_title：Scientific reports

authors： He P,Lei X,Yuan D,Zhu Z,Huang S

更新日期：2017-09-15 00:00:00

abstract：:Remodeling of the collagen architecture in the extracellular matrix (ECM) has been implicated in ovarian cancer. To quantify these alterations we implemented a form of 3D texture analysis to delineate the fibrillar morphology observed in 3D Second Harmonic Generation (SHG) microscopy image data of normal (1) and high ...

journal_title：Scientific reports

authors： Wen B,Campbell KR,Tilbury K,Nadiarnykh O,Brewer MA,Patankar M,Singh V,Eliceiri KW,Campagnola PJ

更新日期：2016-10-21 00:00:00

abstract：:After domestication in the Near East around 10,000 years ago several founder crops, flax included, spread to European latitudes. On reaching northerly latitudes the architecture of domesticated flax became more suitable to fiber production over oil, with longer stems, smaller seeds and fewer axillary branches. Latitud...

journal_title：Scientific reports

authors： Gutaker RM,Zaidem M,Fu YB,Diederichsen A,Smith O,Ware R,Allaby RG

更新日期：2019-01-30 00:00:00

abstract：:Caloric restriction (CR) is known to promote health and longevity, likely via modification of the gut microbiota (GM). However, functional and metabolic changes induced in the GM during CR are still unidentified. Here, we investigated the short- and long-term effects of CR on the rat GM using a metaproteogenomic appro...

journal_title：Scientific reports

authors： Tanca A,Abbondio M,Palomba A,Fraumene C,Marongiu F,Serra M,Pagnozzi D,Laconi E,Uzzau S

更新日期：2018-10-03 00:00:00

abstract：:The CRISPR system holds much promise for successful genome engineering, but therapeutic, industrial, and research applications will place high demand on improving the specificity and efficiency of this tool. CT-Finder (http://bioinfolab.miamioh.edu/ct-finder) is a web service to help users design guide RNAs (gRNAs) op...

journal_title：Scientific reports

authors： Zhu H,Misel L,Graham M,Robinson ML,Liang C

更新日期：2016-05-23 00:00:00

abstract：:Conversion of lignocellulosic biomass to biofuels and biomaterials suffers from high production costs associated with biomass pretreatment and enzymatic hydrolysis. In-planta expression of lignocellulose-digesting enzymes is a promising approach to reduce these cost elements. However, this approach faces a number of c...

journal_title：Scientific reports

authors： Mir BA,Myburg AA,Mizrachi E,Cowan DA

更新日期：2017-09-13 00:00:00

abstract：:Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delaye...

journal_title：Scientific reports

authors： Santos VSDSD,Zortea M,Alves RL,Naziazeno CCDS,Saldanha JS,Carvalho SDCR,Leite AJDC,Torres ILDS,Souza A,Calvetti PÜ,Fregni F,Caumo W

更新日期：2018-08-20 00:00:00

abstract：:Fundamental understanding of guest gas replacement in hydrate reservoirs is crucial for the enhanced recovery of natural gas and carbon dioxide (CO2) sequestration. To gain physical insight into this exchange process, this work aims at developing and validating a clathrate hydrate model for gas replacement. Most of th...

journal_title：Scientific reports

authors： Palodkar AV,Jana AK

更新日期：2019-12-11 00:00:00

abstract：:Alpha melanocyte stimulating hormone (α-MSH) and Forkhead box C2 protein (Foxc2) enhance lipolysis in multiple tissues. However, their relationship in adipose fatty acid oxidation (FAO) remains unclear. Here, we demonstrated that α-MSH and Foxc2 increased palmitate oxidation to CO2 in white (WAT) and brown adipose tis...

journal_title：Scientific reports

authors： Gan L,Liu Z,Chen Y,Dan Luo,Feng F,Liu G,Sun C

更新日期：2016-11-07 00:00:00

abstract：:This study investigates the relationship between objective cognitive impairment (OCI), subjective cognitive complaints and depressive symptoms in men and women with classical and non-classical Fabry disease (FD). Cognitive functioning was assessed using a neuropsychological test battery, subjective cognitive complaint...

journal_title：Scientific reports

authors： Körver S,Geurtsen GJ,Hollak CEM,van Schaik IN,Longo MGF,Lima MR,Vedolin L,Dijkgraaf MGW,Langeveld M

更新日期：2019-01-17 00:00:00

abstract：:Estuarine-coastal ecosystems are rich areas of the global ocean with elevated rates of organic matter production supporting major fisheries. Net and gross primary production (NPP, GPP) are essential properties of these ecosystems, characterized by high spatial, seasonal, and inter-annual variability associated with cl...

journal_title：Scientific reports

authors： Harding LW Jr,Mallonee ME,Perry ES,David Miller W,Adolf JE,Gallegos CL,Paerl HW

更新日期：2020-02-06 00:00:00

abstract：:The chloride gradient plays an important role in regulating cell volume, membrane potential, pH, secretion, and the reversal potential of inhibitory glycine and GABAA receptors. Measurement of intracellular chloride activity, [Formula: see text], using liquid membrane ion-selective microelectrodes (ISM), however, has ...

journal_title：Scientific reports

authors： DiFranco M,Quinonez M,Dziedzic RM,Spokoyny AM,Cannon SC

更新日期：2019-12-11 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit anti-HBV CTL activity in patients with chronic HBV infection (CHB). However, the ongoing anti-HBV CD8(+) T cell...

journal_title：Scientific reports

authors： Wang Y,Zhang Z,Ji D,Chen GF,Feng X,Gong LL,Guo J,Li ZW,Chen CF,Zhao BB,Li ZG,Li QJ,Yan HP,Sempowski G,Wang FS,He YW

更新日期：2015-07-22 00:00:00

abstract：:This paper has been retracted at the request of the authors. ...

journal_title：Scientific reports

authors： Wang W,Jia YL,Li YC,Jing CQ,Guo X,Shang XF,Zhao CP,Wang TY

更新日期：2018-09-04 00:00:00

abstract：:One key ability of human brain is invariant object recognition, which refers to rapid and accurate recognition of objects in the presence of variations such as size, rotation and position. Despite decades of research into the topic, it remains unknown how the brain constructs invariant representations of objects. Prov...

journal_title：Scientific reports

authors： Karimi-Rouzbahani H,Bagheri N,Ebrahimpour R

更新日期：2017-10-31 00:00:00

abstract：:Maintaining vigilance over long periods of time is especially critical in performing fundamental everyday activities and highly responsible professional tasks (e.g., driving, performing surgery or piloting). Here, we investigated the role of aerobic fitness as a crucial factor related to the vigilance capacity. To thi...

journal_title：Scientific reports

authors： Luque-Casado A,Perakakis P,Ciria LF,Sanabria D

更新日期：2016-06-08 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In...

journal_title：Scientific reports

authors： Park HW,Park CG,Park M,Lee SH,Park HR,Lim J,Paek SH,Choy YB

更新日期：2020-06-12 00:00:00

abstract：:Two-stage anaerobic digestion of palm oil mill effluent (POME) is a promising method for converting the waste from the largest agricultural industry in Southeast Asia into a clean and sustainable energy. This study investigates the degradation of acid-rich effluent from the dark fermentation stage for the production o...

journal_title：Scientific reports

authors： Mahmod SS,Azahar AM,Luthfi AAI,Abdul PM,Mastar MS,Anuar N,Takriff MS,Jahim JMD

更新日期：2020-06-08 00:00:00

abstract：:Photoreceptor degeneration due to retinitis pigmentosa (RP) is a primary cause of inherited retinal blindness. Photoreceptor cell-replacement may hold the potential for repair in a completely degenerate retina by reinstating light sensitive cells to form connections that relay information to downstream retinal layers....

journal_title：Scientific reports

authors： Barnea-Cramer AO,Wang W,Lu SJ,Singh MS,Luo C,Huo H,McClements ME,Barnard AR,MacLaren RE,Lanza R

更新日期：2016-07-13 00:00:00

abstract：:Irisin is conventionally regarded as a myokine involved in the browning of white adipose tissue, energy expenditure and glucose tolerance. Its potential link to fat accumulation and metabolic dysfunction is debated. We sought to explore the relationship between circulating irisin and components of body composition in ...

journal_title：Scientific reports

authors： Mai S,Grugni G,Mele C,Vietti R,Vigna L,Sartorio A,Aimaretti G,Scacchi M,Marzullo P

更新日期：2020-01-23 00:00:00

abstract：:Large-strain elastic superhydrophobicity is highly desirable for its enhanced use performance and functional reliability in mechanically dynamic environments, but remains challenging to develop. Here we have, for the first time, proven that an elastic fibrous membrane after surface hydrophobization can maintain superh...

journal_title：Scientific reports

authors： Zhou H,Wang H,Niu H,Lin T

更新日期：2015-10-29 00:00:00

abstract：:A synthetic monoketone analog of curcumin, termed 3, 5-bis (2-flurobenzylidene) piperidin-4-one (EF24), has been reported to inhibit the growth of a variety of cancer cells both in vitro and in vivo. However, whether EF24 has anticancer effects on cholangiocarcinoma (CCA) cells and the mechanisms remain to be investig...

journal_title：Scientific reports

authors： Yin DL,Liang YJ,Zheng TS,Song RP,Wang JB,Sun BS,Pan SH,Qu LD,Liu JR,Jiang HC,Liu LX

更新日期：2016-08-30 00:00:00

abstract：:An analysis of Candida albicans ABC transporters identified conserved related α-helical sequence motifs immediately C-terminal of each Walker A sequence. Despite the occurrence of these motifs in ABC subfamilies of other yeasts and higher eukaryotes, their roles in protein function remained unexplored. In this study w...

journal_title：Scientific reports

authors： Rawal MK,Banerjee A,Shah AH,Khan MF,Sen S,Saxena AK,Monk BC,Cannon RD,Bhatnagar R,Mondal AK,Prasad R

更新日期：2016-06-02 00:00:00

abstract：:Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...

journal_title：Scientific reports

authors： Perera I,Fukushima A,Akabane T,Horiguchi G,Seneweera S,Hirotsu N

更新日期：2019-10-16 00:00:00

abstract：:With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by nanoparticles have been rare...

journal_title：Scientific reports

authors： Qi W,Tian L,An W,Wu Q,Liu J,Jiang C,Yang J,Tang B,Zhang Y,Xie K,Wang X,Li Z,Wu W

更新日期：2017-06-06 00:00:00